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Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.

McAlpine W, Sun L, Wang KW, Liu A, Jain R, San Miguel M, Wang J, Zhang Z, Hayse B, McAlpine SG, Choi JH, Zhong X, Ludwig S, Russell J, Zhan X, Choi M, Li X, Tang M, Moresco EMY, Beutler B, Turer E.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11523-E11531. doi: 10.1073/pnas.1814753115. Epub 2018 Nov 15.


Molecular and Functional Profiles of Exosomes From HPV(+) and HPV(-) Head and Neck Cancer Cell Lines.

Ludwig S, Sharma P, Theodoraki MN, Pietrowska M, Yerneni SS, Lang S, Ferrone S, Whiteside TL.

Front Oncol. 2018 Oct 12;8:445. doi: 10.3389/fonc.2018.00445. eCollection 2018.


Electric compound action potentials (ECAPs) and impedances in an open and closed operative site during cochlear implantation.

Christov F, Gluth MB, Lahti SJ, Ludwig S, Hans S, Holtmann LC, Lang S, Arweiler-Harbeck D.

Cochlear Implants Int. 2019 Jan;20(1):23-30. doi: 10.1080/14670100.2018.1534667. Epub 2018 Oct 23.


Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.

Krischuns T, Günl F, Henschel L, Binder M, Willemsen J, Schloer S, Rescher U, Gerlt V, Zimmer G, Nordhoff C, Ludwig S, Brunotte L.

Front Immunol. 2018 Sep 28;9:2229. doi: 10.3389/fimmu.2018.02229. eCollection 2018.


Randomized clinical trial to evaluate the efficacy of prostaglandin F to treat purulent vaginal discharge in lactating dairy cows.

Borchardt S, Ludwig S, Heuwieser W.

J Dairy Sci. 2018 Dec;101(12):11403-11412. doi: 10.3168/jds.2018-14765. Epub 2018 Oct 3.


The class I myosin MYO1D binds to lipid and protects against colitis.

McAlpine W, Wang KW, Choi JH, San Miguel M, McAlpine SG, Russell J, Ludwig S, Li X, Tang M, Zhan X, Choi M, Wang T, Bu CH, Murray AR, Moresco EMY, Turer EE, Beutler B.

Dis Model Mech. 2018 Sep 27;11(9). pii: dmm035923. doi: 10.1242/dmm.035923.


The Efficacy of Liposomal Bupivacaine in Lumbar Spine Surgery.

Brown L, Weir T, Shasti M, Yousaf O, Yousaf I, Tannous O, Koh E, Banagan K, Gelb D, Ludwig S.

Int J Spine Surg. 2018 Aug 31;12(4):434-440. doi: 10.14444/5052. eCollection 2018 Aug.


Laparoscopic Bilateral Cervicosacropexy and Vaginosacropexy: New Surgical Treatment Option in Women with Pelvic Organ Prolapse and Urinary Incontinence.

Rexhepi S, Rexhepi E, Stumm M, Mallmann P, Ludwig S.

J Endourol. 2018 Nov;32(11):1058-1064. doi: 10.1089/end.2018.0474.


Fire severity effects on soil carbon and nutrients and microbial processes in a Siberian larch forest.

Ludwig SM, Alexander HD, Kielland K, Mann PJ, Natali SM, Ruess RW.

Glob Chang Biol. 2018 Dec;24(12):5841-5852. doi: 10.1111/gcb.14455. Epub 2018 Oct 19.


Late activation of the Raf/MEK/ERK pathway is required for translocation of the respiratory syncytial virus F protein to the plasma membrane and efficient viral replication.

Preugschas HF, Hrincius ER, Mewis C, Tran GVQ, Ludwig S, Ehrhardt C.

Cell Microbiol. 2018 Sep 17:e12955. doi: 10.1111/cmi.12955. [Epub ahead of print]


Biomechanical evaluation of lumbar lateral interbody fusion for the treatment of adjacent segment disease.

Shasti M, Koenig SJ, Nash AB, Bahrami S, Jauregui JJ, O'Hara NN, Jazini E, Gelb DE, Ludwig SC.

Spine J. 2018 Sep 7. pii: S1529-9430(18)31121-5. doi: 10.1016/j.spinee.2018.09.002. [Epub ahead of print]


A Polymer-Based Extended Release System for Stable, Long-term Intracochlear Drug Delivery.

Pierstorff E, Chen S, Chaparro MP, Cortez JM Jr, Chen YJ, Ryu SY, Tsai SM, Baum MM, Yang WW, Kalinec F, Smith T, Ludwig S, Slattery WH.

Otol Neurotol. 2018 Oct;39(9):1195-1202. doi: 10.1097/MAO.0000000000001977.


A successful multidisciplinary approach for treatment and for preserving the reproductive potential in a rare case of acute lymphocytic leukemia during pregnancy.

Salama M, Isachenko E, Ludwig S, Einzmann T, Rahimi G, Mallmann P, Isachenko V.

Gynecol Endocrinol. 2018 Sep 4:1-4. doi: 10.1080/09513590.2018.1498833. [Epub ahead of print]


In Vitro Models to Study Influenza Virus and Staphylococcus aureus Super-Infection on a Molecular Level.

Bruchhagen C, van Krüchten A, Klemm C, Ludwig S, Ehrhardt C.

Methods Mol Biol. 2018;1836:375-386. doi: 10.1007/978-1-4939-8678-1_18.


Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice.

Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, Siegwart DJ, Moresco EMY, Zhang H, Boger DL, Beutler B.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8698-E8706. doi: 10.1073/pnas.1809232115. Epub 2018 Aug 27.


Outcomes of Multilevel Vertebrectomy for Spondylodiscitis.

Ackshota N, Nash A, Bussey I, Shasti M, Brown L, Vishwanath V, Malik Z, Banagan KE, Koh EY, Ludwig SC, Gelb DE.

Spine J. 2018 Aug 3. pii: S1529-9430(18)30640-5. doi: 10.1016/j.spinee.2018.06.361. [Epub ahead of print]


Utilization of intraoperative neuromonitoring throughout the United States over a recent decade: an analysis of the nationwide inpatient sample.

Laratta JL, Shillingford JN, Ha A, Lombardi JM, Reddy HP, Saifi C, Ludwig SC, Lehman RA, Lenke LG.

J Spine Surg. 2018 Jun;4(2):211-219. doi: 10.21037/jss.2018.04.05.


Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus.

Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U.

MBio. 2018 Jul 24;9(4). pii: e01345-18. doi: 10.1128/mBio.01345-18.


Women in Global Health-Germany network.

Ludwig S, Dhatt R, Kickbusch I.

Lancet. 2018 Jul 14;392(10142):120-121. doi: 10.1016/S0140-6736(18)31205-4. No abstract available.


The clinically approved MEK inhibitor Trametinib efficiently blocks influenza A virus propagation and cytokine expression.

Schräder T, Dudek SE, Schreiber A, Ehrhardt C, Planz O, Ludwig S.

Antiviral Res. 2018 Sep;157:80-92. doi: 10.1016/j.antiviral.2018.07.006. Epub 2018 Jul 7.


How can we teach medical students to choose wisely? A randomised controlled cross-over study of video- versus text-based case scenarios.

Ludwig S, Schuelper N, Brown J, Anders S, Raupach T.

BMC Med. 2018 Jul 6;16(1):107. doi: 10.1186/s12916-018-1090-y.


Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.

Bruchhagen C, Jarick M, Mewis C, Hertlein T, Niemann S, Ohlsen K, Peters G, Planz O, Ludwig S, Ehrhardt C.

Sci Rep. 2018 Jun 14;8(1):9114. doi: 10.1038/s41598-018-27445-7.


Five-year results of a clinical pilot study utilizing a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis.

Mlyavykh S, Ludwig SC, Kepler CK, Anderson DG.

J Neurosurg Spine. 2018 Sep;29(3):241-249. doi: 10.3171/2017.11.SPINE16664. Epub 2018 Jun 1.


Applying Developmentally Supportive Principles to Diapering in the NICU: What We Know.

Esser M, Dore S, Fitzgerald F, Kelley K, Kuller J, Ludwig S, Peterman D.

Neonatal Netw. 2018 May 1;37(3):149-154. doi: 10.1891/0730-0832.37.3.149.


Oncolytic influenza virus infection restores immunocompetence of lung tumor-associated alveolar macrophages.

Masemann D, Köther K, Kuhlencord M, Varga G, Roth J, Lichty BD, Rapp UR, Wixler V, Ludwig S.

Oncoimmunology. 2018 Feb 12;7(5):e1423171. doi: 10.1080/2162402X.2017.1423171. eCollection 2018.


Oscillatory EEG signatures of postponed somatosensory decisions.

Ludwig S, Herding J, Blankenburg F.

Hum Brain Mapp. 2018 May 2. doi: 10.1002/hbm.24198. [Epub ahead of print]


Frequency and Acceptability of Adverse Events After Anterior Cervical Discectomy and Fusion: A Survey Study From the Cervical Spine Research Society.

Wilson JR, Radcliff K, Schroeder G, Booth M, Lucasti C, Fehlings M, Ahmad N, Vaccaro A, Arnold P, Sciubba D, Ching A, Smith J, Shaffrey C, Singh K, Darden B, Daffner S, Cheng I, Ghogawala Z, Ludwig S, Buchowski J, Brodke D, Wang J, Lehman RA, Hilibrand A, Yoon T, Grauer J, Dailey A, Steinmetz M, Harrop JS.

Clin Spine Surg. 2018 Jun;31(5):E270-E277. doi: 10.1097/BSD.0000000000000645.


Low-Density Pedicle Screw Constructs for Adolescent Idiopathic Scoliosis: Evaluation of Effectiveness and Cost.

Tannous OO, Banagan KE, Belin EJ, Jazini E, Weir TB, Ludwig SC, Gelb DE.

Global Spine J. 2018 Apr;8(2):114-120. doi: 10.1177/2192568217735507. Epub 2017 Oct 5.


Atlas Fractures: Diagnosis, Current Treatment Recommendations, and Implications for Elderly Patients.

Smith RM, Bhandutia AK, Jauregui JJ, Shasti M, Ludwig SC.

Clin Spine Surg. 2018 Aug;31(7):278-284. doi: 10.1097/BSD.0000000000000631.


Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.


High-Throughput Sequencing Strategy for Microsatellite Genotyping Using Neotropical Fish as a Model.

Pimentel JSM, Carmo AO, Rosse IC, Martins APV, Ludwig S, Facchin S, Pereira AH, Brandão-Dias PFP, Abreu NL, Kalapothakis E.

Front Genet. 2018 Mar 9;9:73. doi: 10.3389/fgene.2018.00073. eCollection 2018.


Corrigendum to "Prognostic Impact of Interleukin-1 Receptor Antagonist in Patients with documented Coronary Artery Disease" [Int. J. Cardiol. 257 (2018) 24-29].

Schofer N, Ludwig S, Rübsamen N, Schnabel R, Lackner KJ, Ruprecht HJ, Bickel C, Landmesser U, Blankenberg S, Zeller T.

Int J Cardiol. 2018 Jun 15;261:239. doi: 10.1016/j.ijcard.2018.03.012. Epub 2018 Mar 21. No abstract available.


Mortality Rates After Posterior C1-2 Fusion for Displaced Type II Odontoid Fractures in Octogenarians.

Clark S, Nash A, Shasti M, Brown L, Jauregui JJ, Mistretta K, Koh E, Banagan K, Ludwig S, Gelb D.

Spine (Phila Pa 1976). 2018 Sep 15;43(18):E1077-E1081. doi: 10.1097/BRS.0000000000002637.


Pay-for-performance incentive program in a large dental group practice.

Conrad DA, Milgrom P, Shirtcliff RM, Bailit HL, Ludwig S, Dysert J, Allen G, Cunha-Cruz J.

J Am Dent Assoc. 2018 May;149(5):348-352. doi: 10.1016/j.adaj.2017.11.018. Epub 2018 Mar 8.


Immunoaffinity-based isolation of melanoma cell-derived exosomes from plasma of patients with melanoma.

Sharma P, Ludwig S, Muller L, Hong CS, Kirkwood JM, Ferrone S, Whiteside TL.

J Extracell Vesicles. 2018 Feb 15;7(1):1435138. doi: 10.1080/20013078.2018.1435138. eCollection 2018.


Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients.

Scheuch G, Canisius S, Nocker K, Hofmann T, Naumann R, Pleschka S, Ludwig S, Welte T, Planz O.

Emerg Microbes Infect. 2018 Mar 7;7(1):21. doi: 10.1038/s41426-018-0023-3.


Moving a mountain: Practical insights into mastering a major curriculum reform at a large European medical university.

Maaz A, Hitzblech T, Arends P, Degel A, Ludwig S, Mossakowski A, Mothes R, Breckwoldt J, Peters H.

Med Teach. 2018 May;40(5):453-460. doi: 10.1080/0142159X.2018.1440077. Epub 2018 Mar 5.


The Four-and-a-Half LIM Domain Protein 2 Supports Influenza A Virus-Induced Lung Inflammation by Restricting the Host Adaptive Immune Response.

Masemann D, Leite Dantas R, Sitnik S, Schied T, Nordhoff C, Ludwig S, Wixler V.

Am J Pathol. 2018 May;188(5):1236-1245. doi: 10.1016/j.ajpath.2018.02.004. Epub 2018 Feb 17.


Dual-Color Bioluminescent Sensor Proteins for Therapeutic Drug Monitoring of Antitumor Antibodies.

van Rosmalen M, Ni Y, Vervoort DFM, Arts R, Ludwig SKJ, Merkx M.

Anal Chem. 2018 Mar 6;90(5):3592-3599. doi: 10.1021/acs.analchem.8b00041. Epub 2018 Feb 22.


Occurrence of Staphylococcus aureus in swine and swine workplace environments on industrial and antibiotic-free hog operations in North Carolina, USA: A One Health pilot study.

Davis MF, Pisanic N, Rhodes SM, Brown A, Keller H, Nadimpalli M, Christ A, Ludwig S, Ordak C, Spicer K, Love DC, Larsen J, Wright A, Blacklin S, Flowers B, Stewart J, Sexton KG, Rule AM, Heaney CD.

Environ Res. 2018 May;163:88-96. doi: 10.1016/j.envres.2017.12.010. Epub 2018 Feb 22.


Staphylococcus aureus triggers a shift from influenza virus-induced apoptosis to necrotic cell death.

van Krüchten A, Wilden JJ, Niemann S, Peters G, Löffler B, Ludwig S, Ehrhardt C.

FASEB J. 2018 May;32(5):2779-2793. doi: 10.1096/fj.201701006R. Epub 2018 Jan 11.


Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease.

Schofer N, Ludwig S, Rübsamen N, Schnabel R, Lackner KJ, Ruprecht HJ, Bickel C, Landmesser U, Blankenberg S, Zeller T.

Int J Cardiol. 2018 Apr 15;257:24-29. doi: 10.1016/j.ijcard.2018.01.055. Epub 2018 Feb 1. Erratum in: Int J Cardiol. 2018 Mar 21;:.


Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.

Wang T, Bu CH, Hildebrand S, Jia G, Siggs OM, Lyon S, Pratt D, Scott L, Russell J, Ludwig S, Murray AR, Moresco EMY, Beutler B.

Nat Commun. 2018 Jan 30;9(1):441. doi: 10.1038/s41467-017-02806-4.


Immunomodulatory Nonstructural Proteins of Influenza A Viruses.

Klemm C, Boergeling Y, Ludwig S, Ehrhardt C.

Trends Microbiol. 2018 Jul;26(7):624-636. doi: 10.1016/j.tim.2017.12.006. Epub 2018 Jan 17. Review.


Vemurafenib Limits Influenza A Virus Propagation by Targeting Multiple Signaling Pathways.

Holzberg M, Boergeling Y, Schräder T, Ludwig S, Ehrhardt C.

Front Microbiol. 2017 Dec 14;8:2426. doi: 10.3389/fmicb.2017.02426. eCollection 2017.


Recurrence of malignancy-associated venous thromboembolism among patients treated with rivaroxaban compared to enoxaparin.

Nicklaus MD, Ludwig SL, Kettle JK.

J Oncol Pharm Pract. 2018 Apr;24(3):185-189. doi: 10.1177/1078155217690922. Epub 2017 Feb 17.


Care delivery and compensation system changes: a case study of organizational readiness within a large dental care practice organization in the United States.

Cunha-Cruz J, Milgrom P, Huebner CE, Scott J, Ludwig S, Dysert J, Mitchell M, Allen G, Shirtcliff RM.

BMC Oral Health. 2017 Dec 20;17(1):157. doi: 10.1186/s12903-017-0448-4.


Gamma and Beta Oscillations in Human MEG Encode the Contents of Vibrotactile Working Memory.

von Lautz AH, Herding J, Ludwig S, Nierhaus T, Maess B, Villringer A, Blankenburg F.

Front Hum Neurosci. 2017 Dec 4;11:576. doi: 10.3389/fnhum.2017.00576. eCollection 2017.


Postoperative Deep Vein Thrombosis, Pulmonary Embolism, and Myocardial Infarction: Complications After Therapeutic Anticoagulation in the Patient With Spine Trauma.

Shiu B, Le E, Jazini E, Weir TB, Costales T, Caffes N, Paryavi E, O'Hara N, Gelb DE, Koh EY, Ludwig SC.

Spine (Phila Pa 1976). 2018 Jul 1;43(13):E766-E772. doi: 10.1097/BRS.0000000000002513.


Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease.

Gäbel G, Northoff BH, Weinzierl I, Ludwig S, Hinterseher I, Wilfert W, Teupser D, Doderer SA, Bergert H, Schönleben F, Lindeman JHN, Holdt LM.

J Am Heart Assoc. 2017 Nov 30;6(12). pii: e006798. doi: 10.1161/JAHA.117.006798.

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