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Items: 9

1.

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).

Pergola C, Gerstmeier J, Mönch B, Çalışkan B, Luderer S, Weinigel C, Barz D, Maczewsky J, Pace S, Rossi A, Sautebin L, Banoglu E, Werz O.

Br J Pharmacol. 2014 Jun;171(12):3051-64. doi: 10.1111/bph.12625.

2.

Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

Schaible AM, Filosa R, Temml V, Krauth V, Matteis M, Peduto A, Bruno F, Luderer S, Roviezzo F, Di Mola A, de Rosa M, D'Agostino B, Weinigel C, Barz D, Koeberle A, Pergola C, Schuster D, Werz O.

Br J Pharmacol. 2014 May;171(9):2399-412. doi: 10.1111/bph.12592.

3.

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.

Filosa R, Peduto A, Aparoy P, Schaible AM, Luderer S, Krauth V, Petronzi C, Massa A, de Rosa M, Reddanna P, Werz O.

Eur J Med Chem. 2013 Sep;67:269-79. doi: 10.1016/j.ejmech.2013.06.039. Epub 2013 Jun 27.

PMID:
23871907
4.

Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.

Elkady M, Nieß R, Schaible AM, Bauer J, Luderer S, Ambrosi G, Werz O, Laufer SA.

J Med Chem. 2012 Oct 25;55(20):8958-62. doi: 10.1021/jm3010543. Epub 2012 Oct 9.

PMID:
22992107
5.

A dialysis patient with a life-threatening hyperkalaemia due to the use of a low-salt spread.

van der Steen M, Luderer S, Veltman B.

Neth J Med. 2012 Sep;70(7):330-1. No abstract available.

6.

Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).

Banoglu E, Çalişkan B, Luderer S, Eren G, Özkan Y, Altenhofen W, Weinigel C, Barz D, Gerstmeier J, Pergola C, Werz O.

Bioorg Med Chem. 2012 Jun 15;20(12):3728-41. doi: 10.1016/j.bmc.2012.04.048. Epub 2012 May 1.

PMID:
22607880
7.

Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.

Calışkan B, Luderer S, Özkan Y, Werz O, Banoglu E.

Eur J Med Chem. 2011 Oct;46(10):5021-33. doi: 10.1016/j.ejmech.2011.08.009. Epub 2011 Aug 11.

PMID:
21868137
8.

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase.

Pergola C, Jazzar B, Rossi A, Buehring U, Luderer S, Dehm F, Northoff H, Sautebin L, Werz O.

J Pharmacol Exp Ther. 2011 Jul;338(1):205-13. doi: 10.1124/jpet.111.180794. Epub 2011 Mar 29.

PMID:
21447614
9.

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

Karg EM, Luderer S, Pergola C, Bühring U, Rossi A, Northoff H, Sautebin L, Troschütz R, Werz O.

J Med Chem. 2009 Jun 11;52(11):3474-83. doi: 10.1021/jm900212y.

PMID:
19492852

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