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Effects of sequentially applied single and combined temozolomide, hydroxychloroquine and AT101 treatment in a long-term stimulation glioblastoma in vitro model.

Adamski V, Schmitt C, Ceynowa F, Adelung R, Lucius R, Synowitz M, Hattermann K, Held-Feindt J.

J Cancer Res Clin Oncol. 2018 Aug;144(8):1475-1485. doi: 10.1007/s00432-018-2680-y. Epub 2018 Jun 1.


Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models.

Tode J, Richert E, Koinzer S, Klettner A, von der Burchard C, Brinkmann R, Lucius R, Roider J.

Transl Vis Sci Technol. 2018 May 1;7(3):2. doi: 10.1167/tvst.7.3.2. eCollection 2018 May.


Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation.

Böttcher MA, Held-Feindt J, Synowitz M, Lucius R, Traulsen A, Hattermann K.

BMC Cancer. 2018 Apr 3;18(1):376. doi: 10.1186/s12885-018-4281-1.


Long-term treatment with anti-VEGF does not induce cell aging in primary retinal pigment epithelium.

Schottler J, Randoll N, Lucius R, Caliebe A, Roider J, Klettner A.

Exp Eye Res. 2018 Jun;171:1-11. doi: 10.1016/j.exer.2018.03.002. Epub 2018 Mar 6.


Dormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment.

Adamski V, Hempelmann A, Flüh C, Lucius R, Synowitz M, Hattermann K, Held-Feindt J.

Oncotarget. 2017 Nov 18;8(64):108064-108078. doi: 10.18632/oncotarget.22514. eCollection 2017 Dec 8.


Determination of VEGF, collagen type 1 and versican in the discus articularis of the temporomandibular joint in relation to dental status.

Michaelis M, Lucius R, Wiltfang J, Birkenfeld F.

J Craniomaxillofac Surg. 2018 Jan;46(1):67-74. doi: 10.1016/j.jcms.2017.09.013. Epub 2017 Sep 21.


Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.


Spatial and Cellular Expression Patterns of Erythropoietin-Receptor and Erythropoietin during a 42-Day Post-Lesional Time Course after Graded Thoracic Spinal Cord Impact Lesions in the Rat.

Cohrs G, Goerden S, Lucius R, Synowitz M, Mehdorn HM, Held-Feindt J, Knerlich-Lukoschus F.

J Neurotrauma. 2018 Feb 1;35(3):593-607. doi: 10.1089/neu.2017.4981. Epub 2018 Jan 5.


Dual RNA-seq reveals no plastic transcriptional response of the coccidian parasite Eimeria falciformis to host immune defenses.

Ehret T, Spork S, Dieterich C, Lucius R, Heitlinger E.

BMC Genomics. 2017 Sep 5;18(1):686. doi: 10.1186/s12864-017-4095-6.


The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16.

Adamski V, Mentlein R, Lucius R, Synowitz M, Held-Feindt J, Hattermann K.

Int J Mol Sci. 2017 Jul 8;18(7). pii: E1468. doi: 10.3390/ijms18071468.


The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments.

Schneppenheim J, Loock AC, Hüttl S, Schweizer M, Lüllmann-Rauch R, Oberg HH, Arnold P, Lehmann CHK, Dudziak D, Kabelitz D, Lucius R, Lennon-Duménil AM, Saftig P, Schröder B.

J Immunol. 2017 Jul 1;199(1):172-185. doi: 10.4049/jimmunol.1601533. Epub 2017 May 26.


Meprin β and BMP-1 are differentially regulated by CaCl2.

Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P.

Cell Calcium. 2017 Jul;65:8-13. doi: 10.1016/j.ceca.2017.03.005. Epub 2017 Mar 19.


Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.


Distribution Pattern of the Superior and Inferior Labial Arteries: Impact for Safe Upper and Lower Lip Augmentation Procedures.

Cotofana S, Pretterklieber B, Lucius R, Frank K, Haas M, Schenck TL, Gleiser C, Weyers I, Wedel T, Pretterklieber M.

Plast Reconstr Surg. 2017 May;139(5):1075-1082. doi: 10.1097/PRS.0000000000003244.


Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.

FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21.


Deficiency of the DSPP-cleaving enzymes meprin α and meprin β does not result in dentin malformation in mice.

Arnold P, Koopmann L, Peters F, Birkenfeld F, Goff SV, Damm T, Qin C, Moali C, Lucius R, Becker-Pauly C.

Cell Tissue Res. 2017 Feb;367(2):351-358. doi: 10.1007/s00441-016-2498-3. Epub 2016 Sep 15.


A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth.

Lamprecht C, Taale M, Paulowicz I, Westerhaus H, Grabosch C, Schuchardt A, Mecklenburg M, Böttner M, Lucius R, Schulte K, Adelung R, Selhuber-Unkel C.

ACS Appl Mater Interfaces. 2016 Jun 22;8(24):14980-5. doi: 10.1021/acsami.6b00778. Epub 2016 Jun 9.


A Helminth Protease Inhibitor Modulates the Lipopolysaccharide-Induced Proinflammatory Phenotype of Microglia in vitro.

Behrendt P, Arnold P, Brueck M, Rickert U, Lucius R, Hartmann S, Klotz C, Lucius R.

Neuroimmunomodulation. 2016;23(2):109-21. doi: 10.1159/000444756. Epub 2016 Apr 19.


Trefoil factor 3 shows anti-inflammatory effects on activated microglia.

Arnold P, Rickert U, Helmers AK, Spreu J, Schneppenheim J, Lucius R.

Cell Tissue Res. 2016 Jul;365(1):3-11. doi: 10.1007/s00441-016-2370-5. Epub 2016 Feb 22.


Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling.

Hattermann K, Gebhardt H, Krossa S, Ludwig A, Lucius R, Held-Feindt J, Mentlein R.

Elife. 2016 Jan 21;5:e10820. doi: 10.7554/eLife.10820.


Mechanical resistance of the periorbita and the orbital floor complex--are isolated orbital floor fractures only a soft tissue problem?

Birkenfeld F, Behrens E, Flörke C, Rohnen M, Wieker H, Kern M, Lucius R, Wiltfang J.

Int J Oral Maxillofac Surg. 2016 Mar;45(3):279-83. doi: 10.1016/j.ijom.2015.10.015. Epub 2015 Nov 12.


Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.

Arroyo-Olarte RD, Brouwers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N.

PLoS Biol. 2015 Nov 13;13(11):e1002288. doi: 10.1371/journal.pbio.1002288. eCollection 2015.


Macrophages in bone fracture healing: Their essential role in endochondral ossification.

Schlundt C, El Khassawna T, Serra A, Dienelt A, Wendler S, Schell H, van Rooijen N, Radbruch A, Lucius R, Hartmann S, Duda GN, Schmidt-Bleek K.

Bone. 2018 Jan;106:78-89. doi: 10.1016/j.bone.2015.10.019. Epub 2015 Oct 31.


Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii.

Nitzsche R, Zagoriy V, Lucius R, Gupta N.

J Biol Chem. 2016 Jan 1;291(1):126-41. doi: 10.1074/jbc.M114.624619. Epub 2015 Oct 30.


Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells.

Kuehne A, Emmert H, Soehle J, Winnefeld M, Fischer F, Wenck H, Gallinat S, Terstegen L, Lucius R, Hildebrand J, Zamboni N.

Mol Cell. 2015 Aug 6;59(3):359-71. doi: 10.1016/j.molcel.2015.06.017. Epub 2015 Jul 16.


Erythropoietin and CCL3 antagonise their functional properties during neuroinflammation.

Hattermann K, Knerlich-Lukoschus F, Lucius R, Mehdorn M, Held-Feindt J.

Neurol Res. 2015 Nov;37(11):1025-8. doi: 10.1179/1743132815Y.0000000070. Epub 2015 Jul 16.


Intensive rearing of male calves during the first three weeks of life has long-term effects on number of islets of Langerhans and insulin stained area in the pancreas.

Prokop L, Kaske M, Maccari P, Lucius R, Kunz HJ, Wiedemann S.

J Anim Sci. 2015 Mar;93(3):988-98. doi: 10.2527/jas.2014-8144.


Calcium negatively regulates meprin β activity and attenuates substrate cleavage.

Arnold P, Schmidt F, Prox J, Zunke F, Pietrzik C, Lucius R, Becker-Pauly C.

FASEB J. 2015 Aug;29(8):3549-57. doi: 10.1096/fj.15-272310. Epub 2015 May 8.


The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.

Speck N, Brandsch C, Schmidt N, Yazdekhasti N, Hirche F, Lucius R, Rimbach G, Stangl GI, Reiss K.

J Nutr. 2015 Jun;145(6):1218-26. doi: 10.3945/jn.115.211375. Epub 2015 Apr 29.


A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.

Ziegler T, Rausch S, Steinfelder S, Klotz C, Hepworth MR, Kühl AA, Burda PC, Lucius R, Hartmann S.

J Immunol. 2015 Feb 15;194(4):1555-64. doi: 10.4049/jimmunol.1401217. Epub 2015 Jan 14.


Intracellular pathways following uptake of bevacizumab in RPE cells.

Aboul Naga SH, Dithmer M, Chitadze G, Kabelitz D, Lucius R, Roider J, Klettner A.

Exp Eye Res. 2015 Feb;131:29-41. doi: 10.1016/j.exer.2014.12.010. Epub 2014 Dec 19.


Detection of the genial spinal canal in atrophic mandibles with a CBCT: a cadaver study.

Birkenfeld F, Becker M, Sasse M, Gassling V, Lucius R, Wiltfang J, Kern M.

Dentomaxillofac Radiol. 2015;44(3):20140290. doi: 10.1259/dmfr.20140290. Epub 2014 Nov 20.


Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.

O'Regan NL, Steinfelder S, Venugopal G, Rao GB, Lucius R, Srikantam A, Hartmann S.

PLoS Negl Trop Dis. 2014 Oct 2;8(10):e3206. doi: 10.1371/journal.pntd.0003206. eCollection 2014 Oct.


The genome of Eimeria falciformis--reduction and specialization in a single host apicomplexan parasite.

Heitlinger E, Spork S, Lucius R, Dieterich C.

BMC Genomics. 2014 Aug 20;15:696. doi: 10.1186/1471-2164-15-696.


Therapeutic potential of larval excretory/secretory proteins of the pig whipworm Trichuris suis in allergic disease.

Ebner F, Hepworth MR, Rausch S, Janek K, Niewienda A, Kühl A, Henklein P, Lucius R, Hamelmann E, Hartmann S.

Allergy. 2014 Nov;69(11):1489-97. doi: 10.1111/all.12496. Epub 2014 Sep 6.


The retinal pigment epithelium (RPE) induces FasL and reduces iNOS and Cox2 in primary monocytes.

Hettich C, Wilker S, Mentlein R, Lucius R, Roider J, Klettner A.

Graefes Arch Clin Exp Ophthalmol. 2014 Nov;252(11):1747-54. doi: 10.1007/s00417-014-2742-z. Epub 2014 Jul 25.


Retinal pigment epithelium cells alter the pro-inflammatory response of retinal microglia to TLR-3 stimulation.

Klettner A, Hamann T, Schlüter K, Lucius R, Roider J.

Acta Ophthalmol. 2014 Dec;92(8):e621-9. doi: 10.1111/aos.12472. Epub 2014 Jun 15.


Effects of the chemokine CXCL12 and combined internalization of its receptors CXCR4 and CXCR7 in human MCF-7 breast cancer cells.

Hattermann K, Holzenburg E, Hans F, Lucius R, Held-Feindt J, Mentlein R.

Cell Tissue Res. 2014 Jul;357(1):253-66. doi: 10.1007/s00441-014-1823-y. Epub 2014 Apr 26.


Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways.

Arnold P, Mojumder D, Detoledo J, Lucius R, Wilms H.

Clin Pharmacol. 2014 Feb 24;6:35-42. doi: 10.2147/CPAA.S35033. eCollection 2014. Review.


Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii.

Hartmann A, Hellmund M, Lucius R, Voelker DR, Gupta N.

J Biol Chem. 2014 Mar 7;289(10):6809-24. doi: 10.1074/jbc.M113.509406. Epub 2014 Jan 15.


Glial Cell Line-Derived Neurotrophic Factor Family Members Reduce Microglial Activation via Inhibiting p38MAPKs-Mediated Inflammatory Responses.

Rickert U, Grampp S, Wilms H, Spreu J, Knerlich-Lukoschus F, Held-Feindt J, Lucius R.

J Neurodegener Dis. 2014;2014:369468. doi: 10.1155/2014/369468. Epub 2014 Jun 9.


Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNγ-regulated host pathways for the parasite development.

Schmid M, Heitlinger E, Spork S, Mollenkopf HJ, Lucius R, Gupta N.

Mucosal Immunol. 2014 Jul;7(4):969-82. doi: 10.1038/mi.2013.115. Epub 2013 Dec 25.


Leakage of fluid around endotracheal tube cuffs: a cadaver study.

Birkenfeld F, Lucius R, Ewald K.

Korean J Anesthesiol. 2013 Nov;65(5):438-41. doi: 10.4097/kjae.2013.65.5.438. Epub 2013 Nov 29.


Paneth cells as a site of origin for intestinal inflammation.

Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS.

Nature. 2013 Nov 14;503(7475):272-6. doi: 10.1038/nature12599. Epub 2013 Oct 2.


The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging.

Egbert M, Ruetze M, Sattler M, Wenck H, Gallinat S, Lucius R, Weise JM.

J Dermatol Sci. 2014 Jan;73(1):40-8. doi: 10.1016/j.jdermsci.2013.08.010. Epub 2013 Sep 3.


Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of the parasite cAMP for host-cell invasion and stage differentiation.

Hartmann A, Arroyo-Olarte RD, Imkeller K, Hegemann P, Lucius R, Gupta N.

J Biol Chem. 2013 May 10;288(19):13705-17. doi: 10.1074/jbc.M113.465583. Epub 2013 Mar 22.


UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin.

Tang S, Lucius R, Wenck H, Gallinat S, Weise JM.

J Dermatol Sci. 2013 Apr;70(1):42-8. doi: 10.1016/j.jdermsci.2013.01.008. Epub 2013 Feb 4.


Dynein light chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth.

Qureshi BM, Hofmann NE, Arroyo-Olarte RD, Nickl B, Hoehne W, Jungblut PR, Lucius R, Scheerer P, Gupta N.

FASEB J. 2013 Mar;27(3):1034-47. doi: 10.1096/fj.11-180992. Epub 2012 Dec 11.


Increased intraosseous temperature caused by ultrasonic devices during bone surgery and the influences of working pressure and cooling irrigation.

Birkenfeld F, Becker ME, Harder S, Lucius R, Kern M.

Int J Oral Maxillofac Implants. 2012 Nov-Dec;27(6):1382-8.


A nematode immunomodulator suppresses grass pollen-specific allergic responses by controlling excessive Th2 inflammation.

Daniłowicz-Luebert E, Steinfelder S, Kühl AA, Drozdenko G, Lucius R, Worm M, Hamelmann E, Hartmann S.

Int J Parasitol. 2013 Mar;43(3-4):201-10. doi: 10.1016/j.ijpara.2012.10.014. Epub 2012 Nov 19.


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