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Retinoic Acid and Depressive Disorders: Evidence and Possible Neurobiological Mechanisms.

Hu P, van Dam AM, Wang Y, Lucassen PJ, Zhou JN.

Neurosci Biobehav Rev. 2020 Feb 15. pii: S0149-7634(20)30001-4. doi: 10.1016/j.neubiorev.2020.02.013. [Epub ahead of print] Review.


Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis.

Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues MM, Kelada F, Phan M, Zhou JN, Swaab DF, Pang Z, Lucassen PJ, Roepke TA, Samuels BA.

J Neurosci. 2020 Feb 11. pii: 2410-19. doi: 10.1523/JNEUROSCI.2410-19.2020. [Epub ahead of print]


Adult neurogenesis, human after all (again): Classic, optimized, and future approaches.

Lucassen PJ, Fitzsimons CP, Salta E, Maletic-Savatic M.

Behav Brain Res. 2020 Mar 2;381:112458. doi: 10.1016/j.bbr.2019.112458. Epub 2019 Dec 30. Review.


Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide.

Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF.

J Psychiatr Res. 2020 Feb;121:31-38. doi: 10.1016/j.jpsychires.2019.11.002. Epub 2019 Nov 9.


Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines.

Lesuis SL, Timmermans W, Lucassen PJ, Hoogenraad CC, Krugers HJ.

J Neuroendocrinol. 2020 Jan;32(1):e12811. doi: 10.1111/jne.12811. Epub 2019 Dec 5.


Early Life Adversity and Adult Social Behavior: Focus on Arginine Vasopressin and Oxytocin as Potential Mediators.

Kompier NF, Keysers C, Gazzola V, Lucassen PJ, Krugers HJ.

Front Behav Neurosci. 2019 Jul 26;13:143. doi: 10.3389/fnbeh.2019.00143. eCollection 2019. Review.


Early life stress amplifies fear responses and hippocampal synaptic potentiation in the APPswe/PS1dE9 Alzheimer mouse model.

Lesuis SL, Lucassen PJ, Krugers HJ.

Neuroscience. 2019 Jul 11. pii: S0306-4522(19)30484-1. doi: 10.1016/j.neuroscience.2019.07.012. [Epub ahead of print]


Suicide Is a Confounder in Postmortem Studies on Depression.

Zhao J, Lucassen PJ, Swaab DF.

Biol Psychiatry. 2019 Nov 15;86(10):e37-e40. doi: 10.1016/j.biopsych.2019.04.015. Epub 2019 Jun 18. No abstract available.


Circadian glucocorticoid oscillations preserve a population of adult hippocampal neural stem cells in the aging brain.

Schouten M, Bielefeld P, Garcia-Corzo L, Passchier EMJ, Gradari S, Jungenitz T, Pons-Espinal M, Gebara E, Martín-Suárez S, Lucassen PJ, De Vries HE, Trejo JL, Schwarzacher SW, De Pietri Tonelli D, Toni N, Mira H, Encinas JM, Fitzsimons CP.

Mol Psychiatry. 2019 Jun 20. doi: 10.1038/s41380-019-0440-2. [Epub ahead of print]


Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort.

Low DY, Lefèvre-Arbogast S, González-Domínguez R, Urpi-Sarda M, Micheau P, Petera M, Centeno D, Durand S, Pujos-Guillot E, Korosi A, Lucassen PJ, Aigner L, Proust-Lima C, Hejblum BP, Helmer C, Andres-Lacueva C, Thuret S, Samieri C, Manach C.

Mol Nutr Food Res. 2019 Sep;63(18):e1900177. doi: 10.1002/mnfr.201900177. Epub 2019 Jul 9.


Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies.

Bielefeld P, Durá I, Danielewicz J, Lucassen PJ, Baekelandt V, Abrous DN, Encinas JM, Fitzsimons CP.

Behav Brain Res. 2019 Oct 17;372:112032. doi: 10.1016/j.bbr.2019.112032. Epub 2019 Jun 12. Review.


Co-administration of Anti microRNA-124 and -137 Oligonucleotides Prevents Hippocampal Neural Stem Cell Loss Upon Non-convulsive Seizures.

Bielefeld P, Schouten M, Meijer GM, Breuk MJ, Geijtenbeek K, Karayel S, Tiaglik A, Vuuregge AH, Willems RAL, Witkamp D, Lucassen PJ, Encinas JM, Fitzsimons CP.

Front Mol Neurosci. 2019 Feb 19;12:31. doi: 10.3389/fnmol.2019.00031. eCollection 2019.


Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice.

Lesuis SL, Kaplick PM, Lucassen PJ, Krugers HJ.

Neuropharmacology. 2019 May 15;150:175-183. doi: 10.1016/j.neuropharm.2019.02.023. Epub 2019 Feb 19.


Increasing availability of ω-3 fatty acid in the early-life diet prevents the early-life stress-induced cognitive impairments without affecting metabolic alterations.

Yam KY, Schipper L, Reemst K, Ruigrok SR, Abbink MR, Hoeijmakers L, Naninck EFG, Zarekiani P, Oosting A, Van der Beek EM, Lucassen PJ, Korosi A.

FASEB J. 2019 Apr;33(4):5729-5740. doi: 10.1096/fj.201802297R. Epub 2019 Jan 23.


Early life stress impairs fear memory and synaptic plasticity; a potential role for GluN2B.

Lesuis SL, Lucassen PJ, Krugers HJ.

Neuropharmacology. 2019 May 1;149:195-203. doi: 10.1016/j.neuropharm.2019.01.010. Epub 2019 Jan 11.


Limits to human neurogenesis-really?

Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF.

Mol Psychiatry. 2019 Jan 7. doi: 10.1038/s41380-018-0337-5. [Epub ahead of print] No abstract available.


CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model.

Gao S, Zhang T, Jin L, Liang D, Fan G, Song Y, Lucassen PJ, Yu R, Swaab DF.

Cereb Cortex. 2019 Aug 14;29(9):3752-3765. doi: 10.1093/cercor/bhy254.


Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve.

Lesuis SL, Hoeijmakers L, Korosi A, de Rooij SR, Swaab DF, Kessels HW, Lucassen PJ, Krugers HJ.

Alzheimers Res Ther. 2018 Sep 19;10(1):95. doi: 10.1186/s13195-018-0422-7. Review.


Effects of corticosterone on mild auditory fear conditioning and extinction; role of sex and training paradigm.

Lesuis SL, Catsburg LAE, Lucassen PJ, Krugers HJ.

Learn Mem. 2018 Sep 17;25(10):544-549. doi: 10.1101/lm.047811.118. Print 2018 Oct.


Potentiation of antiseizure and neuroprotective efficacy of standard nerve agent treatment by addition of tariquidar.

Meerhoff GF, Vester SM, Hesseling P, Klaassen SD, Cornelissen AS, Lucassen PJ, Joosen MJA.

Neurotoxicology. 2018 Sep;68:167-176. doi: 10.1016/j.neuro.2018.08.005. Epub 2018 Aug 18.


The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior.

Motta-Teixeira LC, Machado-Nils AV, Battagello DS, Diniz GB, Andrade-Silva J, Silva S Jr, Matos RA, do Amaral FG, Xavier GF, Bittencourt JC, Reiter RJ, Lucassen PJ, Korosi A, Cipolla-Neto J.

Horm Behav. 2018 Sep;105:146-156. doi: 10.1016/j.yhbeh.2018.08.006. Epub 2018 Sep 1.


Serotonin transporter occupancy by the SSRI citalopram predicts default-mode network connectivity.

Schrantee A, Lucassen PJ, Booij J, Reneman L.

Eur Neuropsychopharmacol. 2018 Oct;28(10):1173-1179. doi: 10.1016/j.euroneuro.2018.07.099. Epub 2018 Aug 4.


A preclinical perspective on the enhanced vulnerability to Alzheimer's disease after early-life stress.

Hoeijmakers L, Lesuis SL, Krugers H, Lucassen PJ, Korosi A.

Neurobiol Stress. 2018 Feb 23;8:172-185. doi: 10.1016/j.ynstr.2018.02.003. eCollection 2018 Feb. Review.


Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide.

Zhao J, Verwer RWH, Gao SF, Qi XR, Lucassen PJ, Kessels HW, Swaab DF.

J Psychiatr Res. 2018 Jul;102:261-274. doi: 10.1016/j.jpsychires.2018.04.020. Epub 2018 Apr 30.


Human Adult Neurogenesis: Evidence and Remaining Questions.

Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J.

Cell Stem Cell. 2018 Jul 5;23(1):25-30. doi: 10.1016/j.stem.2018.04.004. Epub 2018 Apr 19. Review.


Early-Life Stress Does Not Aggravate Spatial Memory or the Process of Hippocampal Neurogenesis in Adult and Middle-Aged APP/PS1 Mice.

Hoeijmakers L, Amelianchik A, Verhaag F, Kotah J, Lucassen PJ, Korosi A.

Front Aging Neurosci. 2018 Mar 7;10:61. doi: 10.3389/fnagi.2018.00061. eCollection 2018.


Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice.

Lesuis SL, Weggen S, Baches S, Lucassen PJ, Krugers HJ.

Transl Psychiatry. 2018 Mar 1;8(1):53. doi: 10.1038/s41398-018-0101-2.


Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice.

van Campen JS, Hessel EVS, Bohmbach K, Rizzi G, Lucassen PJ, Lakshmi Turimella S, Umeoka EHL, Meerhoff GF, Braun KPJ, de Graan PNE, Joëls M.

Front Endocrinol (Lausanne). 2018 Jan 26;9:3. doi: 10.3389/fendo.2018.00003. eCollection 2018.


The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis.

Hoeijmakers L, Meerhoff GF, de Vries JW, Ruigrok SR, van Dam AM, van Leuven F, Korosi A, Lucassen PJ.

Neurobiol Aging. 2018 Jan;61:112-123. doi: 10.1016/j.neurobiolaging.2017.09.013. Epub 2017 Sep 22.


Ghrelin and hypothalamic NPY/AgRP expression in mice are affected by chronic early-life stress exposure in a sex-specific manner.

Yam KY, Ruigrok SR, Ziko I, De Luca SN, Lucassen PJ, Spencer SJ, Korosi A.

Psychoneuroendocrinology. 2017 Dec;86:73-77. doi: 10.1016/j.psyneuen.2017.09.006. Epub 2017 Sep 7.


Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients.

Solleveld MM, Schrantee A, Puts NAJ, Reneman L, Lucassen PJ.

Neuroimage Clin. 2017 Jun 2;15:812-818. doi: 10.1016/j.nicl.2017.06.003. eCollection 2017.


Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential.

Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ.

Stress. 2017 Sep;20(5):421-448. doi: 10.1080/10253890.2017.1343296. Epub 2017 Jul 12.


Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age.

Lesuis SL, van Hoek BACE, Lucassen PJ, Krugers HJ.

Neurobiol Learn Mem. 2017 Oct;144:27-35. doi: 10.1016/j.nlm.2017.05.016. Epub 2017 Jun 1.


Early-life stress diminishes the increase in neurogenesis after exercise in adult female mice.

Abbink MR, Naninck EFG, Lucassen PJ, Korosi A.

Hippocampus. 2017 Aug;27(8):839-844. doi: 10.1002/hipo.22745. Epub 2017 Jun 6.


Transcription factor oscillations in neural stem cells: Implications for accurate control of gene expression.

Bielefeld P, Schouten M, Lucassen PJ, Fitzsimons CP.

Neurogenesis (Austin). 2017 Feb 10;4(1):e1262934. doi: 10.1080/23262133.2016.1262934. eCollection 2017. Review.


Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate.

Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, Booij J, Lucassen PJ, Reneman L.

PLoS One. 2017 Feb 27;12(2):e0172776. doi: 10.1371/journal.pone.0172776. eCollection 2017.


Early life adversity: Lasting consequences for emotional learning.

Krugers HJ, Arp JM, Xiong H, Kanatsou S, Lesuis SL, Korosi A, Joels M, Lucassen PJ.

Neurobiol Stress. 2016 Nov 27;6:14-21. doi: 10.1016/j.ynstr.2016.11.005. eCollection 2017 Feb. Review.


Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice.

Yam KY, Naninck EFG, Abbink MR, la Fleur SE, Schipper L, van den Beukel JC, Grefhorst A, Oosting A, van der Beek EM, Lucassen PJ, Korosi A.

Psychoneuroendocrinology. 2017 Mar;77:186-195. doi: 10.1016/j.psyneuen.2016.12.012. Epub 2016 Dec 23.


Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model.

Hoeijmakers L, Ruigrok SR, Amelianchik A, Ivan D, van Dam AM, Lucassen PJ, Korosi A.

Brain Behav Immun. 2017 Jul;63:160-175. doi: 10.1016/j.bbi.2016.12.023. Epub 2016 Dec 25.


The Indispensable Roles of Microglia and Astrocytes during Brain Development.

Reemst K, Noctor SC, Lucassen PJ, Hol EM.

Front Hum Neurosci. 2016 Nov 8;10:566. eCollection 2016. Review.


Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease.

Lesuis SL, Maurin H, Borghgraef P, Lucassen PJ, Van Leuven F, Krugers HJ.

Oncotarget. 2016 Jun 28;7(26):39118-39135. doi: 10.18632/oncotarget.9776.


Early micronutrient supplementation protects against early stress-induced cognitive impairments.

Naninck EF, Oosterink JE, Yam KY, de Vries LP, Schierbeek H, van Goudoever JB, Verkaik-Schakel RN, Plantinga JA, Plosch T, Lucassen PJ, Korosi A.

FASEB J. 2017 Feb;31(2):505-518. doi: 10.1096/fj.201600834R. Epub 2016 Oct 21.


Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?

Hoeijmakers L, Heinen Y, van Dam AM, Lucassen PJ, Korosi A.

Front Hum Neurosci. 2016 Aug 9;10:398. doi: 10.3389/fnhum.2016.00398. eCollection 2016. Review.


Multi-omics profile of the mouse dentate gyrus after kainic acid-induced status epilepticus.

Schouten M, Bielefeld P, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP.

Sci Data. 2016 Aug 16;3:160068. doi: 10.1038/sdata.2016.68.


Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment.

Kandola A, Hendrikse J, Lucassen PJ, Yücel M.

Front Hum Neurosci. 2016 Jul 29;10:373. doi: 10.3389/fnhum.2016.00373. eCollection 2016. Review.


Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.

Schrantee A, Tamminga HG, Bouziane C, Bottelier MA, Bron EE, Mutsaerts HJ, Zwinderman AH, Groote IR, Rombouts SA, Lindauer RJ, Klein S, Niessen WJ, Opmeer BC, Boer F, Lucassen PJ, Andersen SL, Geurts HM, Reneman L.

JAMA Psychiatry. 2016 Sep 1;73(9):955-62. doi: 10.1001/jamapsychiatry.2016.1572.


Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide.

Zhao J, Verwer RW, van Wamelen DJ, Qi XR, Gao SF, Lucassen PJ, Swaab DF.

J Psychiatr Res. 2016 Nov;82:8-15. doi: 10.1016/j.jpsychires.2016.06.017. Epub 2016 Jun 29.


Circadian and ultradian glucocorticoid rhythmicity: Implications for the effects of glucocorticoids on neural stem cells and adult hippocampal neurogenesis.

Fitzsimons CP, Herbert J, Schouten M, Meijer OC, Lucassen PJ, Lightman S.

Front Neuroendocrinol. 2016 Apr;41:44-58. doi: 10.1016/j.yfrne.2016.05.001. Epub 2016 May 24. Review.


Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior.

Hu P, Wang Y, Liu J, Meng FT, Qi XR, Chen L, van Dam AM, Joëls M, Lucassen PJ, Zhou JN.

Hippocampus. 2016 Jul;26(7):911-23. doi: 10.1002/hipo.22574. Epub 2016 Mar 7.


Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - What do we need to know?

Herbert J, Lucassen PJ.

Front Neuroendocrinol. 2016 Apr;41:153-71. doi: 10.1016/j.yfrne.2015.12.001. Epub 2015 Dec 30. Review.


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