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Items: 1 to 50 of 145

1.

The moral argument for heritable genome editing requires an inappropriately deterministic view of genetics.

Horton R, Lucassen AM.

J Med Ethics. 2019 Mar 12. pii: medethics-2019-105390. doi: 10.1136/medethics-2019-105390. [Epub ahead of print]

PMID:
30862707
2.

Recent developments in genetic/genomic medicine.

Horton RH, Lucassen AM.

Clin Sci (Lond). 2019 Mar 5;133(5):697-708. doi: 10.1042/CS20180436. Print 2019 Mar 15. Review.

3.

Expanded carrier screening for autosomal recessive conditions in health care: Arguments for a couple-based approach and examination of couples' views.

Plantinga M, Birnie E, Schuurmans J, Buitenhuis AH, Boersma E, Lucassen AM, Verkerk MA, van Langen IM, Ranchor AV.

Prenat Diagn. 2019 Feb 12. doi: 10.1002/pd.5437. [Epub ahead of print]

PMID:
30756401
4.

Feasibility of couple-based expanded carrier screening offered by general practitioners.

Schuurmans J, Birnie E, van den Heuvel LM, Plantinga M, Lucassen A, van der Kolk DM, Abbott KM, Ranchor AV, Diemers AD, van Langen IM.

Eur J Hum Genet. 2019 Feb 11. doi: 10.1038/s41431-019-0351-3. [Epub ahead of print]

PMID:
30742054
5.

A validated PROM in genetic counselling: the psychometric properties of the Dutch version of the Genetic Counselling Outcome Scale.

Voorwinden JS, Plantinga M, Krijnen W, Ausems M, Knoers N, Velthuizen M, Birnie E, Lucassen AM, van Langen IM, Ranchor AV.

Eur J Hum Genet. 2019 Jan 25. doi: 10.1038/s41431-018-0318-9. [Epub ahead of print]

PMID:
30683928
6.

Fostering trust in healthcare: Participants' experiences, views, and concerns about the 100,000 genomes project.

Dheensa S, Lucassen A, Fenwick A.

Eur J Med Genet. 2018 Nov 29. pii: S1769-7212(18)30352-5. doi: 10.1016/j.ejmg.2018.11.024. [Epub ahead of print]

PMID:
30503854
7.

Recontacting patients in clinical genetics services: recommendations of the European Society of Human Genetics.

Carrieri D, Howard HC, Benjamin C, Clarke AJ, Dheensa S, Doheny S, Hawkins N, Halbersma-Konings TF, Jackson L, Kayserili H, Kelly SE, Lucassen AM, Mendes Á, Rial-Sebbag E, Stefánsdóttir V, Turnpenny PD, van El CG, van Langen IM, Cornel MC, Forzano F; European Society of Human Genetics.

Eur J Hum Genet. 2019 Feb;27(2):169-182. doi: 10.1038/s41431-018-0285-1. Epub 2018 Oct 11.

8.

In Defense of Best Interests: When Parents and Clinicians Disagree.

Coulson-Smith P, Fenwick A, Lucassen A.

Am J Bioeth. 2018 Aug;18(8):67-69. doi: 10.1080/15265161.2018.1485766. No abstract available.

9.

Toxicity and Toxicokinetic Study of Subcutaneously Administered RPh201 in Minipigs.

Ramot Y, Hazan Z, Lucassen A, Adamsky K, Ross V, Young N, Saunders M, Ehall H, Nyska A.

Toxicol Pathol. 2018 Aug;46(6):693-705. doi: 10.1177/0192623318786428. Epub 2018 Jul 15.

PMID:
30009686
10.

When genomic medicine reveals misattributed genetic relationships-the debate about disclosure revisited.

Wright CF, Parker M, Lucassen AM.

Genet Med. 2019 Jan;21(1):97-101. doi: 10.1038/s41436-018-0023-7. Epub 2018 Jun 14.

11.

Using a genetic test result in the care of family members: how does the duty of confidentiality apply?

Parker M, Lucassen A.

Eur J Hum Genet. 2018 Jul;26(7):955-959. doi: 10.1038/s41431-018-0138-y. Epub 2018 Apr 27.

12.

Recontacting or not recontacting? A survey of current practices in clinical genetics centres in Europe.

Sirchia F, Carrieri D, Dheensa S, Benjamin C, Kayserili H, Cordier C, van El CG, Turnpenny PD, Melegh B, Mendes Á, Halbersma-Konings TF, van Langen IM, Lucassen AM, Clarke AJ, Forzano F, Kelly SE.

Eur J Hum Genet. 2018 Jul;26(7):946-954. doi: 10.1038/s41431-018-0131-5. Epub 2018 Apr 23.

PMID:
29681620
13.

Alerting relatives about heritable risks: the limits of confidentiality.

Lucassen A, Gilbar R.

BMJ. 2018 Apr 5;361:k1409. doi: 10.1136/bmj.k1409. No abstract available.

14.

Towards a national genomics medicine service: the challenges facing clinical-research hybrid practices and the case of the 100 000 genomes project.

Dheensa S, Samuel G, Lucassen AM, Farsides B.

J Med Ethics. 2018 Jun;44(6):397-403. doi: 10.1136/medethics-2017-104588. Epub 2018 Mar 1.

15.

The Road to Clinical Fantasy: A UK Perspective.

Fenwick A, Coulson-Smith P, Lucassen A.

Am J Bioeth. 2018 Jan;18(1):26-27. doi: 10.1080/15265161.2017.1401166. No abstract available.

PMID:
29313782
16.

Toxicity and toxicokinetic study of RPh201 in Sprague-Dawley rats.

Ramot Y, Hazan Z, Lucassen A, Adamsky K, Santhosh Kumar DP, Vijayasarathi SK, Krishnappa H, Seervi MS, Nyska A.

Food Chem Toxicol. 2018 Feb;112:168-177. doi: 10.1016/j.fct.2017.12.036. Epub 2017 Dec 27.

PMID:
29288761
17.

Disclosure of genetic information to relatives: balancing confidentiality and relatives' interests.

Lucassen A, Gilbar R.

J Med Genet. 2018 Apr;55(4):285-286. doi: 10.1136/jmedgenet-2017-104843. Epub 2017 Nov 10. No abstract available.

PMID:
29127257
18.

Limitations and Pitfalls of Using Family Letters to Communicate Genetic Risk: a Qualitative Study with Patients and Healthcare Professionals.

Dheensa S, Lucassen A, Fenwick A.

J Genet Couns. 2018 Jun;27(3):689-701. doi: 10.1007/s10897-017-0164-x. Epub 2017 Nov 1.

19.

Responsible implementation of expanded carrier screening.

Henneman L, Borry P, Chokoshvili D, Cornel MC, van El CG, Forzano F, Hall A, Howard HC, Janssens S, Kayserili H, Lakeman P, Lucassen A, Metcalfe SA, Vidmar L, de Wert G, Dondorp WJ, Peterlin B.

Eur J Hum Genet. 2017 Nov;25(11):1291. doi: 10.1038/ejhg.2017.159.

20.

Healthcare professionals' and patients' perspectives on consent to clinical genetic testing: moving towards a more relational approach.

Samuel GN, Dheensa S, Farsides B, Fenwick A, Lucassen A.

BMC Med Ethics. 2017 Aug 8;18(1):47. doi: 10.1186/s12910-017-0207-8.

21.

Recontacting in clinical practice: the views and expectations of patients in the United Kingdom.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 Oct;25(10):1106-1112. doi: 10.1038/ejhg.2017.122. Epub 2017 Aug 2.

22.

Expanded carrier screening: what determines intended participation and can this be influenced by message framing and narrative information?

Voorwinden JS, Buitenhuis AH, Birnie E, Lucassen AM, Verkerk MA, van Langen IM, Plantinga M, Ranchor AV.

Eur J Hum Genet. 2017 Jun;25(7):793-800. doi: 10.1038/ejhg.2017.74. Epub 2017 May 3.

23.

A 'joint venture' model of recontacting in clinical genomics: challenges for responsible implementation.

Dheensa S, Carrieri D, Kelly S, Clarke A, Doheny S, Turnpenny P, Lucassen A.

Eur J Med Genet. 2017 Jul;60(7):403-409. doi: 10.1016/j.ejmg.2017.05.001. Epub 2017 May 10.

24.

How do clinical genetics consent forms address the familial approach to confidentiality and incidental findings? A mixed-methods study.

Dheensa S, Crawford G, Salter C, Parker M, Fenwick A, Lucassen A.

Fam Cancer. 2018 Jan;17(1):155-166. doi: 10.1007/s10689-017-9994-9.

25.

Recontacting in clinical genetics and genomic medicine? We need to talk about it.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 May;25(5):520-521. doi: 10.1038/ejhg.2017.8. Epub 2017 Feb 8. No abstract available.

26.

Approaching confidentiality at a familial level in genomic medicine: a focus group study with healthcare professionals.

Dheensa S, Fenwick A, Lucassen A.

BMJ Open. 2017 Feb 3;7(2):e012443. doi: 10.1136/bmjopen-2016-012443.

27.

Recontacting in clinical practice: an investigation of the views of healthcare professionals and clinical scientists in the United Kingdom.

Carrieri D, Dheensa S, Doheny S, Clarke AJ, Turnpenny PD, Lucassen AM, Kelly SE.

Eur J Hum Genet. 2017 Feb;25(3):275-279. doi: 10.1038/ejhg.2016.188. Epub 2017 Jan 4.

28.

Predictive Genetic Testing of Children for Adult-Onset Conditions: Negotiating Requests with Parents.

Fenwick A, Plantinga M, Dheensa S, Lucassen A.

J Genet Couns. 2017 Apr;26(2):244-250. doi: 10.1007/s10897-016-0018-y. Epub 2016 Sep 28.

29.

Population-based preconception carrier screening: how potential users from the general population view a test for 50 serious diseases.

Plantinga M, Birnie E, Abbott KM, Sinke RJ, Lucassen AM, Schuurmans J, Kaplan S, Verkerk MA, Ranchor AV, van Langen IM.

Eur J Hum Genet. 2016 Oct;24(10):1417-23. doi: 10.1038/ejhg.2016.43. Epub 2016 May 11.

30.

Responsible implementation of expanded carrier screening.

Henneman L, Borry P, Chokoshvili D, Cornel MC, van El CG, Forzano F, Hall A, Howard HC, Janssens S, Kayserili H, Lakeman P, Lucassen A, Metcalfe SA, Vidmar L, de Wert G, Dondorp WJ, Peterlin B.

Eur J Hum Genet. 2016 Jun;24(6):e1-e12. doi: 10.1038/ejhg.2015.271. Epub 2016 Mar 16. Erratum in: Eur J Hum Genet. 2017 Nov;25(11):1291.

31.

Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans.

Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, FitzPatrick DR; UK10K Consortium, Wilson DI, Mital S, Hurles ME.

Am J Hum Genet. 2016 Mar 3;98(3):592. doi: 10.1016/j.ajhg.2016.02.016. Epub 2016 Mar 3. No abstract available.

32.

Recontact in clinical practice: a survey of clinical genetics services in the United Kingdom.

Carrieri D, Lucassen AM, Clarke AJ, Dheensa S, Doheny S, Turnpenny PD, Kelly SE.

Genet Med. 2016 Sep;18(9):876-81. doi: 10.1038/gim.2015.194. Epub 2016 Feb 18.

33.

Relative Risk and Relatives' Risks in Genomic Medicine.

Fenwick A, Shkedi-Rafid S, Lucassen A.

Am J Bioeth. 2016;16(2):25-7. doi: 10.1080/15265161.2015.1120809. No abstract available.

PMID:
26832087
34.

I Had Genetic Testing for Alzheimer's Disease Without My Consent.

Lucassen A.

Narrat Inq Bioeth. 2015 Winter;5(3):214-6. doi: 10.1353/nib.2015.0071. No abstract available.

PMID:
26752571
35.

'Is this knowledge mine and nobody else's? I don't feel that.' Patient views about consent, confidentiality and information-sharing in genetic medicine.

Dheensa S, Fenwick A, Lucassen A.

J Med Ethics. 2016 Mar;42(3):174-9. doi: 10.1136/medethics-2015-102781. Epub 2016 Jan 7.

36.

What results to disclose, when, and who decides? Healthcare professionals' views on prenatal chromosomal microarray analysis.

Shkedi-Rafid S, Fenwick A, Dheensa S, Wellesley D, Lucassen AM.

Prenat Diagn. 2016 Mar;36(3):252-9. doi: 10.1002/pd.4772. Epub 2016 Feb 17.

37.

Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.

Dondorp W, de Wert G, Bombard Y, Bianchi DW, Bergmann C, Borry P, Chitty LS, Fellmann F, Forzano F, Hall A, Henneman L, Howard HC, Lucassen A, Ormond K, Peterlin B, Radojkovic D, Rogowski W, Soller M, Tibben A, Tranebjærg L, van El CG, Cornel MC.

Eur J Hum Genet. 2015 Nov;23(11):1592. doi: 10.1038/ejhg.2015.109. No abstract available.

38.

Health-care professionals' responsibility to patients' relatives in genetic medicine: a systematic review and synthesis of empirical research.

Dheensa S, Fenwick A, Shkedi-Rafid S, Crawford G, Lucassen A.

Genet Med. 2016 Apr;18(4):290-301. doi: 10.1038/gim.2015.72. Epub 2015 Jun 25. Review.

39.

Telemedicine uptake among Genetics Professionals in Europe: room for expansion.

Otten E, Birnie E, Lucassen AM, Ranchor AV, Van Langen IM.

Eur J Hum Genet. 2016 Feb;24(2):157-63. doi: 10.1038/ejhg.2015.83. Epub 2015 Apr 22.

40.

Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Summary and recommendations.

Dondorp W, de Wert G, Bombard Y, Bianchi DW, Bergmann C, Borry P, Chitty LS, Fellmann F, Forzano F, Hall A, Henneman L, Howard HC, Lucassen A, Ormond K, Peterlin B, Radojkovic D, Rogowski W, Soller M, Tibben A, Tranebjærg L, van El CG, Cornel MC.

Eur J Hum Genet. 2015 Apr 1. doi: 10.1038/ejhg.2015.56. [Epub ahead of print] No abstract available.

41.

Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening.

Dondorp W, de Wert G, Bombard Y, Bianchi DW, Bergmann C, Borry P, Chitty LS, Fellmann F, Forzano F, Hall A, Henneman L, Howard HC, Lucassen A, Ormond K, Peterlin B, Radojkovic D, Rogowski W, Soller M, Tibben A, Tranebjærg L, van El CG, Cornel MC; European Society of Human Genetics; American Society of Human Genetics.

Eur J Hum Genet. 2015 Nov;23(11):1438-50. doi: 10.1038/ejhg.2015.57. Epub 2015 Mar 18. Erratum in: Eur J Hum Genet. 2015 Nov;23(11):1592.

42.

Detection and Identification of the Keto-Hydroperoxide (HOOCH2OCHO) and Other Intermediates during Low-Temperature Oxidation of Dimethyl Ether.

Moshammer K, Jasper AW, Popolan-Vaida DM, Lucassen A, Diévart P, Selim H, Eskola AJ, Taatjes CA, Leone SR, Sarathy SM, Ju Y, Dagaut P, Kohse-Höinghaus K, Hansen N.

J Phys Chem A. 2015 Jul 16;119(28):7361-74. doi: 10.1021/acs.jpca.5b00101. Epub 2015 Mar 5.

PMID:
25695304
43.

Rescue obligations and collective approaches: complexities in genomics.

Fenwick A, Dheensa S, Crawford G, Shkedi-Rafid S, Lucassen A.

Am J Bioeth. 2015;15(2):23-5. doi: 10.1080/15265161.2014.990763. No abstract available.

PMID:
25674952
44.

Narrative Symposium: Patient and Research Participant experiences with Genetic Testing.

Davis D, Foye S, Hartz SM, Keirns CC, Lietz CM, Lucassen A, Savard J, Strong KA, Sunde K, Young MJ; Anonymous One; Anonymous Two.

Narrat Inq Bioeth. 2015;5(3):203-228. doi: 10.1353/nib.2015.0092.

PMID:
30100594
45.

Is there a duty to recontact in light of new genetic technologies? A systematic review of the literature.

Otten E, Plantinga M, Birnie E, Verkerk MA, Lucassen AM, Ranchor AV, Van Langen IM.

Genet Med. 2015 Aug;17(8):668-78. doi: 10.1038/gim.2014.173. Epub 2014 Dec 11. Review.

PMID:
25503495
46.

Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice.

Shkedi-Rafid S, Fenwick A, Dheensa S, Lucassen AM.

Eur J Hum Genet. 2015 Oct;23(10):1281-5. doi: 10.1038/ejhg.2014.221. Epub 2014 Nov 5.

47.

Defining and managing incidental findings in genetic and genomic practice.

Shkedi-Rafid S, Dheensa S, Crawford G, Fenwick A, Lucassen A.

J Med Genet. 2014 Nov;51(11):715-23. doi: 10.1136/jmedgenet-2014-102435. Epub 2014 Sep 16. Review.

PMID:
25228303
48.

The challenges of genome analysis in the health care setting.

Lucassen A, Houlston RS.

Genes (Basel). 2014 Jul 22;5(3):576-85. doi: 10.3390/genes5030576.

49.

Prenatal diagnosis of chromosomal imbalances.

Wellesley DG, Lucassen A.

Arch Dis Child Fetal Neonatal Ed. 2014 Jul;99(4):F338-41. Epub 2014 Mar 5. Review.

PMID:
24792776
50.

Rare variants in NR2F2 cause congenital heart defects in humans.

Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LC, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, Fitzpatrick DF; UK10K Consortium, Wilson DI, Mital S, Hurles ME.

Am J Hum Genet. 2014 Apr 3;94(4):574-85. doi: 10.1016/j.ajhg.2014.03.007. Erratum in: Am J Hum Genet. 2016 Mar 3;98(3):592. Low, Jacoba [corrected to Louw, Jacoba]. Am J Hum Genet. 2014 Jul 3;95(1):126.

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