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Items: 1 to 50 of 61

1.

Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation".

Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A.

J Am Chem Soc. 2019 May 8;141(18):7644. doi: 10.1021/jacs.9b03833. Epub 2019 Apr 24. No abstract available.

PMID:
31017404
2.

Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase.

Häckh M, Lucas X, Marolt M, Leadlay PF, Müller M, Günther S, Lüdeke S.

Chembiochem. 2019 May 2;20(9):1150-1154. doi: 10.1002/cbic.201800799. Epub 2019 Mar 1.

PMID:
30600894
3.

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.

Lucas X, Van Molle I, Ciulli A.

J Med Chem. 2018 Aug 23;61(16):7387-7393. doi: 10.1021/acs.jmedchem.8b00842. Epub 2018 Aug 8.

4.

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation.

Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A.

J Am Chem Soc. 2018 Jul 25;140(29):9299-9313. doi: 10.1021/jacs.8b05807. Epub 2018 Jul 12. Erratum in: J Am Chem Soc. 2019 May 8;141(18):7644.

5.

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

Soares P, Lucas X, Ciulli A.

Bioorg Med Chem. 2018 Jul 15;26(11):2992-2995. doi: 10.1016/j.bmc.2018.03.034. Epub 2018 Mar 23.

6.

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A.

ACS Chem Biol. 2018 Apr 20;13(4):915-921. doi: 10.1021/acschembio.7b01093. Epub 2018 Mar 20.

7.

Simple storage (CO2-free) of porcine morulae for up to three days maintains the in vitro viability and developmental competence.

Martinez CA, Nohalez A, Parrilla I, Lucas X, Sanchez-Osorio J, Roca J, Cuello C, Rodriguez-Martinez H, Martinez EA, Gil MA.

Theriogenology. 2018 Mar 1;108:229-238. doi: 10.1016/j.theriogenology.2017.12.001. Epub 2017 Dec 7.

8.

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

Hügle M, Lucas X, Ostrovskyi D, Regenass P, Gerhardt S, Einsle O, Hau M, Jung M, Breit B, Günther S, Wohlwend D.

Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12476-12480. doi: 10.1002/anie.201705516. Epub 2017 Sep 7.

PMID:
28766825
9.

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.

Bortoluzzi A, Amato A, Lucas X, Blank M, Ciulli A.

Biochem J. 2017 May 4;474(10):1633-1651. doi: 10.1042/BCJ20161053.

10.

Structural basis of PROTAC cooperative recognition for selective protein degradation.

Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A.

Nat Chem Biol. 2017 May;13(5):514-521. doi: 10.1038/nchembio.2329. Epub 2017 Mar 13.

11.

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

Lucas X, Ciulli A.

Curr Opin Struct Biol. 2017 Jun;44:101-110. doi: 10.1016/j.sbi.2016.12.015. Epub 2017 Jan 25. Review.

PMID:
28130986
12.

Comparison between ultrasonographic findings of benign and malignant canine mammary gland tumours using B-mode, colour Doppler, power Doppler and spectral Doppler.

Soler M, Dominguez E, Lucas X, Novellas R, Gomes-Coelho KV, Espada Y, Agut A.

Res Vet Sci. 2016 Aug;107:141-146. doi: 10.1016/j.rvsc.2016.05.015. Epub 2016 May 31.

PMID:
27473987
13.

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Schmidtkunz K, Jung M, Schüle R, Einsle O, Günther S, Wohlwend D.

Data Brief. 2016 Apr 11;7:1370-4. doi: 10.1016/j.dib.2016.04.009. eCollection 2016 Jun.

14.

A thorough anion-π interaction study in biomolecules: on the importance of cooperativity effects.

Lucas X, Bauzá A, Frontera A, Quiñonero D.

Chem Sci. 2016 Feb 1;7(2):1038-1050. doi: 10.1039/c5sc01386k. Epub 2015 Jun 5.

15.

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).

Hügle M, Lucas X, Weitzel G, Ostrovskyi D, Breit B, Gerhardt S, Einsle O, Günther S, Wohlwend D.

J Med Chem. 2016 Feb 25;59(4):1518-30. doi: 10.1021/acs.jmedchem.5b01267. Epub 2016 Jan 14.

PMID:
26731611
16.

StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes.

Klementz D, Döring K, Lucas X, Telukunta KK, Erxleben A, Deubel D, Erber A, Santillana I, Thomas OS, Bechthold A, Günther S.

Nucleic Acids Res. 2016 Jan 4;44(D1):D509-14. doi: 10.1093/nar/gkv1319. Epub 2015 Nov 28.

17.

Target Fishing by Cross-Docking to Explain Polypharmacological Effects.

Patel H, Lucas X, Bendik I, Günther S, Merfort I.

ChemMedChem. 2015 Jul;10(7):1209-17. doi: 10.1002/cmdc.201500123. Epub 2015 Jun 1.

PMID:
26033840
18.

The purchasable chemical space: a detailed picture.

Lucas X, Grüning BA, Bleher S, Günther S.

J Chem Inf Model. 2015 May 26;55(5):915-24. doi: 10.1021/acs.jcim.5b00116. Epub 2015 Apr 30.

PMID:
25894297
19.

Clinical use of deslorelin (GnRH agonist) in companion animals: a review.

Lucas X.

Reprod Domest Anim. 2014 Oct;49 Suppl 4:64-71. doi: 10.1111/rda.12388. Review.

PMID:
25277434
20.

Using chiral molecules as an approach to address low-druggability recognition sites.

Lucas X, Günther S.

J Comput Chem. 2014 Nov 5;35(29):2114-21. doi: 10.1002/jcc.23726. Epub 2014 Sep 16.

PMID:
25223950
21.

Effects of rapid cooling prior to freezing on the quality of canine cryopreserved spermatozoa.

Rodenas C, Parrilla I, Roca J, Martinez EA, Lucas X.

J Reprod Dev. 2014;60(5):355-61. Epub 2014 Jul 21.

22.

Quality of chilled and cold-stored (5 °C) canine spermatozoa submitted to different rapid cooling rates.

Rodenas C, Parrilla I, Roca J, Martinez EA, Lucas X.

Theriogenology. 2014 Sep 1;82(4):621-6. doi: 10.1016/j.theriogenology.2014.05.022. Epub 2014 Jun 4.

PMID:
24985357
23.

Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling.

Kiske C, Erxleben A, Lucas X, Willmann L, Klementz D, Günther S, Römer W, Kammerer B.

Rapid Commun Mass Spectrom. 2014 Jul 15;28(13):1459-67. doi: 10.1002/rcm.6920.

PMID:
24861595
24.

Targeting the BET family for the treatment of leukemia.

Lucas X, Günther S.

Epigenomics. 2014 Apr;6(2):153-5. doi: 10.2217/epi.14.5. No abstract available.

25.

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.

Lucas X, Wohlwend D, Hügle M, Schmidtkunz K, Gerhardt S, Schüle R, Jung M, Einsle O, Günther S.

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. doi: 10.1002/anie.201307652. Epub 2013 Nov 24. No abstract available.

PMID:
24272870
26.

The effects of hoechst 33342 staining and the male sample donor on the sorting efficiency of canine spermatozoa.

Rodenas C, Lucas X, Tarantini T, Del Olmo D, Roca J, Vazquez JM, Martinez EA, Parrilla I.

Reprod Domest Anim. 2014 Feb;49(1):115-21. doi: 10.1111/rda.12238. Epub 2013 Oct 1.

PMID:
24118597
27.

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies.

Lucas X, Simon S, Schubert R, Günther S.

PLoS One. 2013 Apr 9;8(4):e60679. doi: 10.1371/journal.pone.0060679. Print 2013.

28.

StreptomeDB: a resource for natural compounds isolated from Streptomyces species.

Lucas X, Senger C, Erxleben A, Grüning BA, Döring K, Mosch J, Flemming S, Günther S.

Nucleic Acids Res. 2013 Jan;41(Database issue):D1130-6. doi: 10.1093/nar/gks1253. Epub 2012 Nov 28.

29.

Colour and pulsed Doppler ultrasonographic study of the canine testis.

Carrillo JD, Soler M, Lucas X, Agut A.

Reprod Domest Anim. 2012 Aug;47(4):655-9. doi: 10.1111/j.1439-0531.2011.01937.x. Epub 2011 Nov 28.

PMID:
22117645
30.

Unusual systemic metastases of malignant seminoma in a dog.

Lucas X, Rodenas C, Cuello C, Gil MA, Parrilla I, Soler M, Belda E, Agut A.

Reprod Domest Anim. 2012 Aug;47(4):e59-61. doi: 10.1111/j.1439-0531.2011.01927.x. Epub 2011 Nov 2.

PMID:
22044725
31.

Effects of Hoechst 33342 staining and ultraviolet irradiation on the developmental competence of in vitro-matured porcine oocytes.

Maside C, Gil MA, Cuello C, Sanchez-Osorio J, Parrilla I, Lucas X, Caamaño JN, Vazquez JM, Roca J, Martinez EA.

Theriogenology. 2011 Dec;76(9):1667-75. doi: 10.1016/j.theriogenology.2011.06.032. Epub 2011 Aug 26.

PMID:
21872317
32.

The effects of atracurium on bispectral index (BIS) values in dogs anaesthetized with isoflurane.

Belda E, Laredo FG, Lucas X, Agut A, Escobar M, Soler M.

Vet J. 2012 May;192(2):189-92. doi: 10.1016/j.tvjl.2011.05.021. Epub 2011 Jul 20.

PMID:
21764340
33.

The role of the ethynyl substituent on the π-π stacking affinity of benzene: a theoretical study.

Lucas X, Quiñonero D, Frontera A, Deyà PM.

Chemphyschem. 2011 Feb 7;12(2):283-8. doi: 10.1002/cphc.201000891. Epub 2010 Dec 22.

PMID:
21275020
34.

Substituent effects in ion-pi interactions: fine-tuning via the ethynyl group.

Lucas X, Frontera A, Quiñonero D, Deyà PM.

J Phys Chem A. 2010 Feb 4;114(4):1926-30. doi: 10.1021/jp9089672.

PMID:
20043658
35.

Pentoxifylline added to freezing or post-thaw extenders does not improve the survival or in vitro fertilising capacity of boar spermatozoa.

Gil MA, Hernandez M, Roca J, Almiñana C, Lucas X, Cuello C, Vazquez JM, Martínez EA.

Reproduction. 2010 Mar;139(3):557-64. doi: 10.1530/REP-09-0274. Epub 2009 Dec 23.

PMID:
20032214
36.

Vitrification and warming of in vivo-derived porcine embryos in a chemically defined medium.

Sanchez-Osorio J, Cuello C, Gil MA, Parrilla I, Maside C, Almiñana C, Lucas X, Roca J, Vazquez JM, Martinez EA.

Theriogenology. 2010 Feb;73(3):300-8. doi: 10.1016/j.theriogenology.2009.07.031. Epub 2009 Nov 13.

PMID:
19913897
37.

Optimal characteristics of spermatozoa for semen technologies in pigs.

Parrilla I, Vazquez JM, Caballero I, Gil MA, Hernandez M, Roca J, Lucas X, Martinez EA.

Soc Reprod Fertil Suppl. 2009;66:37-50. Review.

PMID:
19848265
38.

Counterintuitive substituent effect of the ethynyl group in ion-pi interactions.

Lucas X, Quiñonero D, Frontera A, Deyà PM.

J Phys Chem A. 2009 Sep 24;113(38):10367-75. doi: 10.1021/jp905701p.

PMID:
19757849
39.

Very long-range effects: cooperativity between anion-pi and hydrogen-bonding interactions.

Lucas X, Estarellas C, Escudero D, Frontera A, Quiñonero D, Deyà PM.

Chemphyschem. 2009 Sep 14;10(13):2256-64. doi: 10.1002/cphc.200900157.

PMID:
19572370
40.

Late abscess formation caused by silk suture following hysterectomy in a female dog.

Boza S, Lucas X, Zarelli M, Soler M, Belda E, Agut A.

Reprod Domest Anim. 2010 Oct;45(5):934-6. doi: 10.1111/j.1439-0531.2009.01366.x.

PMID:
19392671
41.

Effect of the cryoprotectant concentration on the in vitro embryo development and cell proliferation of OPS-vitrified porcine blastocysts.

Cuello C, Sanchez-Osorio J, Almiñana C, Gil MA, Perals ML, Lucas X, Roca J, Vazquez JM, Martinez EA.

Cryobiology. 2008 Jun;56(3):189-94. doi: 10.1016/j.cryobiol.2008.02.005. Epub 2008 Feb 29.

PMID:
18381210
42.

Characterization of glycoside residues of porcine zona pellucida and ooplasm during follicular development and atresia.

Pastor LM, Lucas X, Pallares J, Bernal-Mañas CM, Martinez EA, Roca J, Vazquez JM, Morales E, Beltran E, Zuasti A, Ferrer C.

Mol Reprod Dev. 2008 Sep;75(9):1473-83. doi: 10.1002/mrd.20886.

PMID:
18288675
43.

Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats.

Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A.

Vet Rec. 2008 Jan 19;162(3):82-7.

PMID:
18204032
44.

A urethrorectal fistula due to prostatic abscess associated with urolithiasis in a dog.

Agut A, Lucas X, Castro A, De Membiela F, Soler M, Belda E.

Reprod Domest Anim. 2006 Jun;41(3):247-50.

PMID:
16689890
45.

Improving the efficiency of sperm technologies in pigs: the value of deep intrauterine insemination.

Vazquez JM, Martinez EA, Roca J, Gil MA, Parrilla I, Cuello C, Carvajal G, Lucas X, Vazquez JL.

Theriogenology. 2005 Jan 15;63(2):536-47. Review.

PMID:
15626415
46.

Influence of follicle size on the penetrability of immature pig oocytes for homologous in vitro penetration assay.

Lucas X, Martínez EA, Roca J, Vázquez JM, Gil MA, Pastor LM, Alabart JL.

Theriogenology. 2003 Sep 1;60(4):659-67.

PMID:
12832015
47.

Uterine rupture in a cat.

Lucas X, Agut A, Ramis G, Belda E, Soler M.

Vet Rec. 2003 Mar 8;152(10):301-2. No abstract available.

PMID:
12650475
48.

Fertility of weaned sows after deep intrauterine insemination with a reduced number of frozen-thawed spermatozoa.

Roca J, Carvajal G, Lucas X, Vazquez JM, Martinez EA.

Theriogenology. 2003 Jun;60(1):77-87.

PMID:
12620582
49.

Motility characteristics and fertilizing capacity of boar spermatozoa stained with Hoechst 33342.

Vazquez JM, Martinez EA, Parrilla I, Gil MA, Lucas X, Roca J.

Reprod Domest Anim. 2002 Dec;37(6):369-74.

PMID:
12464077
50.

Deep intrauterine insemination and embryo transfer in pigs.

Martinez EA, Vazquez JM, Roca J, Lucas X, Gil MA, Vazquez JL.

Reprod Suppl. 2001;58:301-11. Review.

PMID:
11980198

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