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Items: 33


Inflammation Resolution and the Induction of Granulocyte Apoptosis by Cyclin-Dependent Kinase Inhibitor Drugs.

Cartwright JA, Lucas CD, Rossi AG.

Front Pharmacol. 2019 Feb 19;10:55. doi: 10.3389/fphar.2019.00055. eCollection 2019. Review.


A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.

Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, Cohen AH, Gaultier A, Conrads TP, Kim M, Elliott MR, Ravichandran KS.

Nat Immunol. 2019 Feb;20(2):141-151. doi: 10.1038/s41590-018-0293-x. Epub 2019 Jan 14.


Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential.

Potey PM, Rossi AG, Lucas CD, Dorward DA.

J Pathol. 2019 Apr;247(5):672-685. doi: 10.1002/path.5221. Epub 2019 Feb 15. Review.


Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation.

Felton JM, Lucas CD, Dorward DA, Duffin R, Kipari T, Vermeren S, Robb CT, MacLeod KG, Serrels B, Schwarze J, Haslett C, Dransfield I, Rossi AG.

J Allergy Clin Immunol. 2018 Dec;142(6):1884-1893.e6. doi: 10.1016/j.jaci.2018.01.029. Epub 2018 Feb 8.


Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ.

Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15.


Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.

Dorward DA, Lucas CD, Doherty MK, Chapman GB, Scholefield EJ, Conway Morris A, Felton JM, Kipari T, Humphries DC, Robb CT, Simpson AJ, Whitfield PD, Haslett C, Dhaliwal K, Rossi AG.

Thorax. 2017 Oct;72(10):928-936. doi: 10.1136/thoraxjnl-2017-210030. Epub 2017 May 3.


Increasing use of CTPA for the investigation of suspected pulmonary embolism.

Sharma S, Lucas CD.

Postgrad Med. 2017 Mar;129(2):193-197. doi: 10.1080/00325481.2017.1281084. Epub 2017 Jan 20.


The cyclin-dependent kinase inhibitor AT7519 accelerates neutrophil apoptosis in sepsis-related acute respiratory distress syndrome.

Dorward DA, Felton JM, Robb CT, Craven T, Kipari T, Walsh TS, Haslett C, Kefala K, Rossi AG, Lucas CD.

Thorax. 2017 Feb;72(2):182-185. doi: 10.1136/thoraxjnl-2016-209229. Epub 2016 Oct 24.


Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo.

Hoodless LJ, Lucas CD, Duffin R, Denvir MA, Haslett C, Tucker CS, Rossi AG.

Sci Rep. 2016 Nov 11;5:36980. doi: 10.1038/srep36980.


Non-small-cell lung carcinoma (not otherwise specified) rates are not influenced solely by pathologists' decisions on the use of immunohistochemistry.

Chapman GB, Dorward DA, Lucas CD, Wallace WA.

Histopathology. 2017 Feb;70(3):500-501. doi: 10.1111/his.13074. Epub 2016 Nov 7. No abstract available.


11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice.

Coutinho AE, Kipari TM, Zhang Z, Esteves CL, Lucas CD, Gilmour JS, Webster SP, Walker BR, Hughes J, Savill JS, Seckl JR, Rossi AG, Chapman KE.

Endocrinology. 2016 Jul;157(7):2928-36. doi: 10.1210/en.2016-1118. Epub 2016 May 4.


The role of formylated peptides and formyl peptide receptor 1 in governing neutrophil function during acute inflammation.

Dorward DA, Lucas CD, Chapman GB, Haslett C, Dhaliwal K, Rossi AG.

Am J Pathol. 2015 May;185(5):1172-84. doi: 10.1016/j.ajpath.2015.01.020. Epub 2015 Mar 17. Review.


Wogonin induces eosinophil apoptosis and attenuates allergic airway inflammation.

Lucas CD, Dorward DA, Sharma S, Rennie J, Felton JM, Alessandri AL, Duffin R, Schwarze J, Haslett C, Rossi AG.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):626-36. doi: 10.1164/rccm.201408-1565OC.


Eosinophils in the lung - modulating apoptosis and efferocytosis in airway inflammation.

Felton JM, Lucas CD, Rossi AG, Dransfield I.

Front Immunol. 2014 Jul 1;5:302. doi: 10.3389/fimmu.2014.00302. eCollection 2014. Review.


Assays of eosinophil apoptosis and phagocytic uptake.

Dorward DA, Sharma S, Alessandri AL, Rossi AG, Lucas CD.

Methods Mol Biol. 2014;1178:177-95. doi: 10.1007/978-1-4939-1016-8_16.


Systemic lupus erythematosus complicating simple silicosis.

Lucas CD, Amft N, Reid PT.

Occup Med (Lond). 2014 Jul;64(5):387-90. doi: 10.1093/occmed/kqu060. Epub 2014 Jun 10.


Swimming against the tide: drugs drive neutrophil reverse migration.

Lucas CD, Hoodless LJ, Rossi AG.

Sci Transl Med. 2014 Feb 26;6(225):225fs9. doi: 10.1126/scitranslmed.3008666. No abstract available.


Assessment of neutrophil apoptosis.

Dorward DA, Rossi AG, Dransfield I, Lucas CD.

Methods Mol Biol. 2014;1124:159-80. doi: 10.1007/978-1-62703-845-4_10.


Apoptotic cell clearance: basic biology and therapeutic potential.

Poon IK, Lucas CD, Rossi AG, Ravichandran KS.

Nat Rev Immunol. 2014 Mar;14(3):166-80. doi: 10.1038/nri3607. Epub 2014 Jan 31. Review.


Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.

Lucas CD, Dorward DA, Tait MA, Fox S, Marwick JA, Allen KC, Robb CT, Hirani N, Haslett C, Duffin R, Rossi AG.

Mucosal Immunol. 2014 Jul;7(4):857-68. doi: 10.1038/mi.2013.102. Epub 2013 Nov 27.


Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments.

Marwick JA, Dorward DA, Lucas CD, Jones KO, Sheldrake TA, Fox S, Ward C, Murray J, Brittan M, Hirani N, Duffin R, Dransfield I, Haslett C, Rossi AG.

J Leukoc Biol. 2013 Dec;94(6):1285-92. doi: 10.1189/jlb.0912462. Epub 2013 Aug 20.


Technical advance: autofluorescence-based sorting: rapid and nonperturbing isolation of ultrapure neutrophils to determine cytokine production.

Dorward DA, Lucas CD, Alessandri AL, Marwick JA, Rossi F, Dransfield I, Haslett C, Dhaliwal K, Rossi AG.

J Leukoc Biol. 2013 Jul;94(1):193-202. doi: 10.1189/jlb.0113040. Epub 2013 May 10.


Resolution of inflammation: mechanisms and opportunity for drug development.

Alessandri AL, Sousa LP, Lucas CD, Rossi AG, Pinho V, Teixeira MM.

Pharmacol Ther. 2013 Aug;139(2):189-212. doi: 10.1016/j.pharmthera.2013.04.006. Epub 2013 Apr 11. Review.


Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

Gray RD, Lucas CD, MacKellar A, Li F, Hiersemenzel K, Haslett C, Davidson DJ, Rossi AG.

J Inflamm (Lond). 2013 Mar 21;10(1):12. doi: 10.1186/1476-9255-10-12.


Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

Montanaro G, Bertinaria M, Rolando B, Fruttero R, Lucas CD, Dorward DA, Rossi AG, Megson IL, Gasco A.

Bioorg Med Chem. 2013 Apr 1;21(7):2107-16. doi: 10.1016/j.bmc.2013.01.009. Epub 2013 Jan 16.


Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway.

Lucas CD, Allen KC, Dorward DA, Hoodless LJ, Melrose LA, Marwick JA, Tucker CS, Haslett C, Duffin R, Rossi AG.

FASEB J. 2013 Mar;27(3):1084-94. doi: 10.1096/fj.12-218990. Epub 2012 Nov 29.


Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.

Leitch AE, Lucas CD, Marwick JA, Duffin R, Haslett C, Rossi AG.

Cell Death Differ. 2012 Dec;19(12):1950-61. doi: 10.1038/cdd.2012.80. Epub 2012 Jun 29.


Imaging inflammation: molecular strategies to visualize key components of the inflammatory cascade, from initiation to resolution.

Dorward DA, Lucas CD, Rossi AG, Haslett C, Dhaliwal K.

Pharmacol Ther. 2012 Aug;135(2):182-99. doi: 10.1016/j.pharmthera.2012.05.006. Epub 2012 May 22. Review.


Editorial: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution.

Leitch AE, Lucas CD, Rossi AG.

J Leukoc Biol. 2011 Nov;90(5):841-3. doi: 10.1189/jlb.0511222. No abstract available.


Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation.

Alessandri AL, Duffin R, Leitch AE, Lucas CD, Sheldrake TA, Dorward DA, Hirani N, Pinho V, de Sousa LP, Teixeira MM, Lyons JF, Haslett C, Rossi AG.

PLoS One. 2011;6(9):e25683. doi: 10.1371/journal.pone.0025683. Epub 2011 Sep 30.


Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition.

MacKinnon AC, Tufail-Hanif U, Lucas CD, Jodrell D, Haslett C, Sethi T.

Br J Cancer. 2005 Feb 14;92(3):522-31.


The role of natural color additives in food allergy.

Lucas CD, Hallagan JB, Taylor SL.

Adv Food Nutr Res. 2001;43:195-216. Review.


The FEMA GRAS assessment of trans-anethole used as a flavouring substance. Flavour and Extract Manufacturer's Association.

Newberne P, Smith RL, Doull J, Goodman JI, Munro IC, Portoghese PS, Wagner BM, Weil CS, Woods LA, Adams TB, Lucas CD, Ford RA.

Food Chem Toxicol. 1999 Jul;37(7):789-811.


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