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Items: 21

1.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

2.

Defining new mechanistic roles for αII spectrin in cardiac function.

Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud G, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ.

J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7.

PMID:
31064843
3.

Protein Phosphatase 2A Regulates Cardiac Na+ Channels.

El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ.

Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350.

PMID:
30602331
4.

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.

5.

Arrhythmogenic Substrates for Atrial Fibrillation in Obesity.

Lubbers ER, Price MV, Mohler PJ.

Front Physiol. 2018 Oct 22;9:1482. doi: 10.3389/fphys.2018.01482. eCollection 2018. Review.

6.

Advancements in the use of gene therapy for cardiac arrhythmia.

Murphy NP, Lubbers ER, Mohler PJ.

Heart Rhythm. 2017 Jul;14(7):1061-1062. doi: 10.1016/j.hrthm.2017.03.041. Epub 2017 Apr 4. No abstract available.

7.

Roles and regulation of protein phosphatase 2A (PP2A) in the heart.

Lubbers ER, Mohler PJ.

J Mol Cell Cardiol. 2016 Dec;101:127-133. doi: 10.1016/j.yjmcc.2016.11.003. Epub 2016 Nov 8. Review.

8.

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ.

Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11.

PMID:
27298202
9.

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

10.

Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.

Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE.

Gerontology. 2016;62(2):163-72. doi: 10.1159/000439050. Epub 2015 Sep 16.

11.

Defining the links between oxidative stress-based biomarkers and postoperative atrial fibrillation.

Lubbers ER, Murphy NP, Mohler PJ.

J Am Heart Assoc. 2015 May 20;4(5). pii: 002110. doi: 10.1161/JAHA.115.002110. No abstract available.

12.

GH action influences adipogenesis of mouse adipose tissue-derived mesenchymal stem cells.

Olarescu NC, Berryman DE, Householder LA, Lubbers ER, List EO, Benencia F, Kopchick JJ, Bollerslev J.

J Endocrinol. 2015 Jul;226(1):13-23. doi: 10.1530/JOE-15-0012. Epub 2015 May 5.

13.

Male bovine GH transgenic mice have decreased adiposity with an adipose depot-specific increase in immune cell populations.

Benencia F, Harshman S, Duran-Ortiz S, Lubbers ER, List EO, Householder L, Al-Naeeli M, Liang X, Welch L, Kopchick JJ, Berryman DE.

Endocrinology. 2015 May;156(5):1794-803. doi: 10.1210/en.2014-1794. Epub 2014 Dec 18.

14.

Growth hormone receptor antagonist transgenic mice are protected from hyperinsulinemia and glucose intolerance despite obesity when placed on a HF diet.

Yang T, Householder LA, Lubbers ER, List EO, Troike K, Vesel C, Duran-Ortiz S, Kopchick JJ, Berryman DE.

Endocrinology. 2015 Feb;156(2):555-64. doi: 10.1210/en.2014-1617. Epub 2014 Nov 18.

15.

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL.

Aging (Albany NY). 2014 Jul;6(7):575-86.

16.

Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.

Sackmann-Sala L, Berryman DE, Lubbers ER, Zhang H, Vesel CB, Troike KM, Gosney ES, List EO, Kopchick JJ.

J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):34-43. doi: 10.1093/gerona/glt110. Epub 2013 Jul 20.

17.

A dwarf mouse model with decreased GH/IGF-1 activity that does not experience life-span extension: potential impact of increased adiposity, leptin, and insulin with advancing age.

Berryman DE, Lubbers ER, Magon V, List EO, Kopchick JJ.

J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):131-41. doi: 10.1093/gerona/glt069. Epub 2013 May 21.

18.

The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice.

List EO, Berryman DE, Funk K, Gosney ES, Jara A, Kelder B, Wang X, Kutz L, Troike K, Lozier N, Mikula V, Lubbers ER, Zhang H, Vesel C, Junnila RK, Frank SJ, Masternak MM, Bartke A, Kopchick JJ.

Mol Endocrinol. 2013 Mar;27(3):524-35. doi: 10.1210/me.2012-1330. Epub 2013 Jan 24.

19.

Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity?

Lubbers ER, List EO, Jara A, Sackman-Sala L, Cordoba-Chacon J, Gahete MD, Kineman RD, Boparai R, Bartke A, Kopchick JJ, Berryman DE.

J Endocrinol. 2013 Feb 25;216(3):363-74. doi: 10.1530/JOE-12-0505. Print 2013 Mar.

20.

Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice.

Sackmann-Sala L, Berryman DE, Lubbers ER, Vesel CB, Troike KM, List EO, Munn RD, Ikeno Y, Kopchick JJ.

Age (Dordr). 2012 Oct;34(5):1225-37. Epub 2011 Sep 29.

21.

Heterogeneity among white adipose tissue depots in male C57BL/6J mice.

Sackmann-Sala L, Berryman DE, Munn RD, Lubbers ER, Kopchick JJ.

Obesity (Silver Spring). 2012 Jan;20(1):101-11. doi: 10.1038/oby.2011.235. Epub 2011 Jul 21.

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