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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.

Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM.

Cell Rep. 2019 Jun 11;27(11):3269-3283.e6. doi: 10.1016/j.celrep.2019.05.040.


The hidden cost of genetic resistance to HIV-1.

Luban J.

Nat Med. 2019 Jun;25(6):878-879. doi: 10.1038/s41591-019-0481-8. No abstract available.


Enhanced Cas12a editing in mammalian cells and zebrafish.

Liu P, Luk K, Shin M, Idrizi F, Kwok S, Roscoe B, Mintzer E, Suresh S, Morrison K, Frazão JB, Bolukbasi MF, Ponnienselvan K, Luban J, Zhu LJ, Lawson ND, Wolfe SA.

Nucleic Acids Res. 2019 May 7;47(8):4169-4180. doi: 10.1093/nar/gkz184.


Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.

Boucher JI, Whitfield TW, Dauphin A, Nachum G, Hollins C, Zeldovich KB, Swanstrom R, Schiffer CA, Luban J, Bolon DNA.

Mol Biol Evol. 2019 Apr 1;36(4):798-810. doi: 10.1093/molbev/msz022.


Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.

Gawron MA, Duval M, Carbone C, Jaiswal S, Wallace A, Martin JC 3rd, Dauphin A, Brehm MA, Greiner DL, Shultz LD, Luban J, Cavacini LA.

J Immunol. 2019 Feb 1;202(3):799-804. doi: 10.4049/jimmunol.1801085. Epub 2018 Dec 28.


Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines.

McCauley SM, Kim K, Nowosielska A, Dauphin A, Yurkovetskiy L, Diehl WE, Luban J.

Nat Commun. 2018 Dec 13;9(1):5305. doi: 10.1038/s41467-018-07753-2.


Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.

Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J.

Nat Microbiol. 2018 Dec;3(12):1354-1361. doi: 10.1038/s41564-018-0256-x. Epub 2018 Oct 8.


Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon.

Donnard E, Vangala P, Afik S, McCauley S, Nowosielska A, Kucukural A, Tabak B, Zhu X, Diehl W, McDonel P, Yosef N, Luban J, Garber M.

Cell Syst. 2018 Mar 28;6(3):381-394.e7. doi: 10.1016/j.cels.2018.01.002. Epub 2018 Feb 14.


The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.

Morger D, Zosel F, Bühlmann M, Züger S, Mittelviefhaus M, Schuler B, Luban J, Grütter MG.

J Virol. 2018 Feb 12;92(5). pii: e01541-17. doi: 10.1128/JVI.01541-17. Print 2018 Mar 1.


HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.

Quitadamo B, Peters PJ, Repik A, O'Connell O, Mou Z, Koch M, Somasundaran M, Brody R, Luzuriaga K, Wallace A, Wang S, Lu S, McCauley S, Luban J, Duenas-Decamp M, Gonzalez-Perez MP, Clapham PR.

J Virol. 2018 Jan 2;92(2). pii: e00841-17. doi: 10.1128/JVI.00841-17. Print 2018 Jan 15.


Optimization by infusion of multiple reaction monitoring transitions for sensitive quantification of peptides by liquid chromatography/mass spectrometry.

Alghanem B, Nikitin F, Stricker T, Duchoslav E, Luban J, Strambio-De-Castillia C, Muller M, Lisacek F, Varesio E, Hopfgartner G.

Rapid Commun Mass Spectrom. 2017 May 15;31(9):753-761. doi: 10.1002/rcm.7839.


Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.

Diehl WE, Lin AE, Grubaugh ND, Carvalho LM, Kim K, Kyawe PP, McCauley SM, Donnard E, Kucukural A, McDonel P, Schaffner SF, Garber M, Rambaut A, Andersen KG, Sabeti PC, Luban J.

Cell. 2016 Nov 3;167(4):1088-1098.e6. doi: 10.1016/j.cell.2016.10.014.


End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.

Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M.

Genome Res. 2016 Oct;26(10):1397-1410. Epub 2016 Jul 28.


Closing the net on retroviruses.

Luban J.

Elife. 2016 Jul 7;5. pii: e18243. doi: 10.7554/eLife.18243.


HIV-1 capsid is involved in post-nuclear entry steps.

Chen NY, Zhou L, Gane PJ, Opp S, Ball NJ, Nicastro G, Zufferey M, Buffone C, Luban J, Selwood D, Diaz-Griffero F, Taylor I, Fassati A.

Retrovirology. 2016 Apr 23;13:28. doi: 10.1186/s12977-016-0262-0.


TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.

Lascano J, Uchil PD, Mothes W, Luban J.

J Virol. 2015 Oct 14;90(1):308-16. doi: 10.1128/JVI.02496-15. Print 2016 Jan 1.


HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.

Rosa A, Chande A, Ziglio S, De Sanctis V, Bertorelli R, Goh SL, McCauley SM, Nowosielska A, Antonarakis SE, Luban J, Santoni FA, Pizzato M.

Nature. 2015 Oct 8;526(7572):212-7. doi: 10.1038/nature15399. Epub 2015 Sep 30.


Ranking Fragment Ions Based on Outlier Detection for Improved Label-Free Quantification in Data-Independent Acquisition LC-MS/MS.

Bilbao A, Zhang Y, Varesio E, Luban J, Strambio-De-Castillia C, Lisacek F, Hopfgartner G.

J Proteome Res. 2015 Nov 6;14(11):4581-93. doi: 10.1021/acs.jproteome.5b00394. Epub 2015 Oct 14.


The Use of Variable Q1 Isolation Windows Improves Selectivity in LC-SWATH-MS Acquisition.

Zhang Y, Bilbao A, Bruderer T, Luban J, Strambio-De-Castillia C, Lisacek F, Hopfgartner G, Varesio E.

J Proteome Res. 2015 Oct 2;14(10):4359-71. doi: 10.1021/acs.jproteome.5b00543. Epub 2015 Sep 3.


Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.

Pizzato M, McCauley SM, Neagu MR, Pertel T, Firrito C, Ziglio S, Dauphin A, Zufferey M, Berthoux L, Luban J.

PLoS Pathog. 2015 Jul 16;11(7):e1005050. doi: 10.1371/journal.ppat.1005050. eCollection 2015 Jul.


Optimization of human dendritic cell sample preparation for mass spectrometry-based proteomic studies.

Zhang Y, Bottinelli D, Lisacek F, Luban J, Strambio-De-Castillia C, Varesio E, Hopfgartner G.

Anal Biochem. 2015 Sep 1;484:40-50. doi: 10.1016/j.ab.2015.05.007. Epub 2015 May 15.


Processing strategies and software solutions for data-independent acquisition in mass spectrometry.

Bilbao A, Varesio E, Luban J, Strambio-De-Castillia C, Hopfgartner G, Müller M, Lisacek F.

Proteomics. 2015 Mar;15(5-6):964-80. doi: 10.1002/pmic.201400323. Epub 2015 Feb 2. Review.


Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.

Reinhard C, Bottinelli D, Kim B, Luban J.

Retrovirology. 2014 Feb 1;11:12. doi: 10.1186/1742-4690-11-12.


TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.

Singh R, Patel V, Mureithi MW, Naranbhai V, Ramsuran D, Tulsi S, Hiramen K, Werner L, Mlisana K, Altfeld M, Luban J, Kasprowicz V, Dheda K, Abdool Karim SS, Ndung'u T.

J Virol. 2014 Apr;88(8):4291-303. doi: 10.1128/JVI.03603-13. Epub 2014 Jan 29.


Overcoming current limitations in humanized mouse research.

Brehm MA, Shultz LD, Luban J, Greiner DL.

J Infect Dis. 2013 Nov;208 Suppl 2:S125-30. doi: 10.1093/infdis/jit319. Review.


The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating.

Yang Y, Luban J, Diaz-Griffero F.

Methods Mol Biol. 2014;1087:29-36. doi: 10.1007/978-1-62703-670-2_3.


Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay.

Xu H, Franks T, Gibson G, Huber K, Rahm N, Strambio De Castillia C, Luban J, Aiken C, Watkins S, Sluis-Cremer N, Ambrose Z.

Retrovirology. 2013 Jul 9;10:70. doi: 10.1186/1742-4690-10-70.


TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.

De Iaco A, Santoni F, Vannier A, Guipponi M, Antonarakis S, Luban J.

Retrovirology. 2013 Feb 15;10:20. doi: 10.1186/1742-4690-10-20.


HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.

Santoni FA, Guerra J, Luban J.

Retrovirology. 2012 Dec 20;9:111. doi: 10.1186/1742-4690-9-111.


More than one way to TRIM a capsid.

Luban J.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19517-8. doi: 10.1073/pnas.1217596109. Epub 2012 Nov 13. No abstract available.


The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5α.

Miyamoto T, Nakayama EE, Yokoyama M, Ibe S, Takehara S, Kono K, Yokomaku Y, Pizzato M, Luban J, Sugiura W, Sato H, Shioda T.

PLoS One. 2012;7(10):e47757. doi: 10.1371/journal.pone.0047757. Epub 2012 Oct 19.


Innate immune sensing of HIV-1 by dendritic cells.

Luban J.

Cell Host Microbe. 2012 Oct 18;12(4):408-18. doi: 10.1016/j.chom.2012.10.002. Review.


TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J, Mothes W.

J Virol. 2013 Jan;87(1):257-72. doi: 10.1128/JVI.01804-12. Epub 2012 Oct 17.


TRIM5 and the Regulation of HIV-1 Infectivity.

Luban J.

Mol Biol Int. 2012;2012:426840. doi: 10.1155/2012/426840. Epub 2012 May 30.


TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.

Grütter MG, Luban J.

Curr Opin Virol. 2012 Apr;2(2):142-50. doi: 10.1016/j.coviro.2012.02.003. Epub 2012 Mar 5. Review.


Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.

Lai RP, Yan J, Heeney J, McClure MO, Göttlinger H, Luban J, Pizzato M.

PLoS Pathog. 2011 Dec;7(12):e1002442. doi: 10.1371/journal.ppat.1002442. Epub 2011 Dec 15.


TRIM5α associates with proteasomal subunits in cells while in complex with HIV-1 virions.

Lukic Z, Hausmann S, Sebastian S, Rucci J, Sastri J, Robia SL, Luban J, Campbell EM.

Retrovirology. 2011 Nov 12;8:93. doi: 10.1186/1742-4690-8-93.


Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.

Pertel T, Reinhard C, Luban J.

Retrovirology. 2011 Jun 22;8:49. doi: 10.1186/1742-4690-8-49.


TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J.

Nature. 2011 Apr 21;472(7343):361-5. doi: 10.1038/nature09976.


TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.

Kajaste-Rudnitski A, Marelli SS, Pultrone C, Pertel T, Uchil PD, Mechti N, Mothes W, Poli G, Luban J, Vicenzi E.

J Virol. 2011 May;85(10):5183-96. doi: 10.1128/JVI.02302-10. Epub 2011 Feb 23.


Deciphering the code for retroviral integration target site selection.

Santoni FA, Hartley O, Luban J.

PLoS Comput Biol. 2010 Nov 24;6(11):e1001008. doi: 10.1371/journal.pcbi.1001008.


Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney.

Suñé G, Sarró E, Puigmulé M, López-Hellín J, Zufferey M, Pertel T, Luban J, Meseguer A.

PLoS One. 2010 Nov 10;5(11):e13930. doi: 10.1371/journal.pone.0013930.


Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.

Singh R, Gaiha G, Werner L, McKim K, Mlisana K, Luban J, Walker BD, Karim SS, Brass AL, Ndung'u T; CAPRISA Acute Infection Study Team.

J Virol. 2011 Jan;85(1):208-16. doi: 10.1128/JVI.01810-10. Epub 2010 Oct 27.


Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation.

Bernasconi R, Soldà T, Galli C, Pertel T, Luban J, Molinari M.

PLoS One. 2010 Sep 28;5(9). pii: e13008. doi: 10.1371/journal.pone.0013008.


p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.

O'Connor C, Pertel T, Gray S, Robia SL, Bakowska JC, Luban J, Campbell EM.

J Virol. 2010 Jun;84(12):5997-6006. doi: 10.1128/JVI.02412-09. Epub 2010 Mar 31.


Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.

Sokolskaja E, Olivari S, Zufferey M, Strambio-De-Castillia C, Pizzato M, Luban J.

J Virol. 2010 May;84(9):4851-5. doi: 10.1128/JVI.01699-09. Epub 2010 Feb 24.


Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.

van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17019-24. doi: 10.1073/pnas.0903036106. Epub 2009 Sep 17.

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