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Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice.

Clookey SL, Welly RJ, Shay D, Woodford ML, Fritsche KL, Rector RS, Padilla J, Lubahn DB, Vieira-Potter VJ.

Front Physiol. 2019 Feb 5;10:9. doi: 10.3389/fphys.2019.00009. eCollection 2019.


Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells.

Sun GY, Li R, Yang B, Fritsche KL, Beversdorf DQ, Lubahn DB, Geng X, Lee JC, Greenlief CM.

Int J Mol Sci. 2019 Feb 21;20(4). pii: E932. doi: 10.3390/ijms20040932.


Estrogen receptor-α signaling maintains immunometabolic function in males and is obligatory for exercise-induced amelioration of nonalcoholic fatty liver.

Winn NC, Jurrissen TJ, Grunewald ZI, Cunningham RP, Woodford ML, Kanaley JA, Lubahn DB, Manrique-Acevedo C, Rector RS, Vieira-Potter VJ, Padilla J.

Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E156-E167. doi: 10.1152/ajpendo.00259.2018. Epub 2018 Dec 4.


27-Hydroxycholesterol Is an Estrogen Receptor β-Selective Negative Allosteric Modifier of 17β-Estradiol Binding.

Starkey NJE, Li Y, Drenkhahn-Weinaug SK, Liu J, Lubahn DB.

Endocrinology. 2018 May 1;159(5):1972-1981. doi: 10.1210/en.2018-00081.


Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells.

Song H, Lu Y, Qu Z, Mossine VV, Martin MB, Hou J, Cui J, Peculis BA, Mawhinney TP, Cheng J, Greenlief CM, Fritsche K, Schmidt FJ, Walter RB, Lubahn DB, Sun GY, Gu Z.

Sci Rep. 2016 Oct 13;6:35323. doi: 10.1038/srep35323.


An Investigation into the Immunomodulatory Activities of Sutherlandia frutescens in Healthy Mice.

Lei W, Browning JD Jr, Eichen PA, Folk WR, Sun GY, Lubahn DB, Fritsche KL.

PLoS One. 2016 Aug 30;11(8):e0160994. doi: 10.1371/journal.pone.0160994. eCollection 2016.


Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2.

Chuang DY, Simonyi A, Cui J, Lubahn DB, Gu Z, Sun GY.

Neuromolecular Med. 2016 Sep;18(3):415-25. doi: 10.1007/s12017-016-8419-5. Epub 2016 Jun 23.


Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells.

Sun GY, Li R, Cui J, Hannink M, Gu Z, Fritsche KL, Lubahn DB, Simonyi A.

Neuromolecular Med. 2016 Sep;18(3):241-52. doi: 10.1007/s12017-016-8411-0. Epub 2016 May 21.


Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes.

Ajit D, Simonyi A, Li R, Chen Z, Hannink M, Fritsche KL, Mossine VV, Smith RE, Dobbs TK, Luo R, Folk WR, Gu Z, Lubahn DB, Weisman GA, Sun GY.

Neurochem Int. 2016 Jul;97:49-56. doi: 10.1016/j.neuint.2016.05.004. Epub 2016 May 7.


Corrigendum: Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status.

Javurek AB, Spollen WG, Mann Ali AM, Johnson SA, Lubahn DB, Bivens NJ, Bromert KH, Ellersieck MR, Givan SA, Rosenfeld CS.

Sci Rep. 2016 Apr 29;6:25216. doi: 10.1038/srep25216. No abstract available.


Discovery of a Novel Seminal Fluid Microbiome and Influence of Estrogen Receptor Alpha Genetic Status.

Javurek AB, Spollen WG, Ali AM, Johnson SA, Lubahn DB, Bivens NJ, Bromert KH, Ellersieck MR, Givan SA, Rosenfeld CS.

Sci Rep. 2016 Mar 14;6:23027. doi: 10.1038/srep23027. Erratum in: Sci Rep. 2016 Apr 29;6:25216.


Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.

Lu Y, Starkey N, Lei W, Li J, Cheng J, Folk WR, Lubahn DB.

PLoS One. 2015 Dec 28;10(12):e0145507. doi: 10.1371/journal.pone.0145507. eCollection 2015.


Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells.

Lu Y, Li J, Cheng J, Lubahn DB.

BMC Mol Biol. 2015 Dec 1;16:21. doi: 10.1186/s12867-015-0049-1.


Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor β.

Lu Y, Li J, Cheng J, Lubahn DB.

BMC Mol Biol. 2015 Nov 23;16:19. doi: 10.1186/s12867-015-0047-3.


Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages.

Lei W, Browning JD Jr, Eichen PA, Brownstein KJ, Folk WR, Sun GY, Lubahn DB, Rottinghaus GE, Fritsche KL.

Int Immunopharmacol. 2015 Dec;29(2):254-262. doi: 10.1016/j.intimp.2015.11.012. Epub 2015 Nov 12.


Antiproliferative and Antiestrogenic Activities of Bonediol an Alkyl Catechol from Bonellia macrocarpa.

Moo-Puc R, Caamal-Fuentes E, Peraza-Sánchez SR, Slusarz A, Jackson G, Drenkhahn SK, Lubahn DB.

Biomed Res Int. 2015;2015:847457. doi: 10.1155/2015/847457. Epub 2015 Oct 18.


Inhibition of Gli/hedgehog signaling in prostate cancer cells by "cancer bush" Sutherlandia frutescens extract.

Lin H, Jackson GA, Lu Y, Drenkhahn SK, Brownstein KJ, Starkey NJ, Lamberson WR, Fritsche KL, Mossine VV, Besch-Williford CL, Folk WR, Zhang Y, Lubahn DB.

Cell Biol Int. 2016 Feb;40(2):131-42. doi: 10.1002/cbin.10544. Epub 2015 Oct 6.


Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway.

Lei W, Browning JD Jr, Eichen PA, Lu CH, Mossine VV, Rottinghaus GE, Folk WR, Sun GY, Lubahn DB, Fritsche KL.

J Ethnopharmacol. 2015 Aug 22;172:247-53. doi: 10.1016/j.jep.2015.06.013. Epub 2015 Jun 18.


From Gigabyte to Kilobyte: A Bioinformatics Protocol for Mining Large RNA-Seq Transcriptomics Data.

Li J, Hou J, Sun L, Wilkins JM, Lu Y, Niederhuth CE, Merideth BR, Mawhinney TP, Mossine VV, Greenlief CM, Walker JC, Folk WR, Hannink M, Lubahn DB, Birchler JA, Cheng J.

PLoS One. 2015 Apr 22;10(4):e0125000. doi: 10.1371/journal.pone.0125000. eCollection 2015.


Inhibition of microglial activation by elderberry extracts and its phenolic components.

Simonyi A, Chen Z, Jiang J, Zong Y, Chuang DY, Gu Z, Lu CH, Fritsche KL, Greenlief CM, Rottinghaus GE, Thomas AL, Lubahn DB, Sun GY.

Life Sci. 2015 May 1;128:30-8. doi: 10.1016/j.lfs.2015.01.037. Epub 2015 Mar 2.


Effects of Elderberry Juice from Different Genotypes on Oxidative and Inflammatory Responses in Microglial Cells.

Jiang JM, Zong Y, Chuang DY, Lei W, Lu CH, Gu Z, Fritsche KL, Thomas AL, Lubahn DB, Simonyi A, Sun GY.

Acta Hortic. 2015 Jan 12;1061:281-288.


Proteomic analysis of the effects of aged garlic extract and its FruArg component on lipopolysaccharide-induced neuroinflammatory response in microglial cells.

Zhou H, Qu Z, Mossine VV, Nknolise DL, Li J, Chen Z, Cheng J, Greenlief CM, Mawhinney TP, Brown PN, Fritsche KL, Hannink M, Lubahn DB, Sun GY, Gu Z.

PLoS One. 2014 Nov 24;9(11):e113531. doi: 10.1371/journal.pone.0113531. eCollection 2014.


Dietary Sutherlandia and elderberry mitigate cerebral ischemia-induced neuronal damage and attenuate p47phox and phospho-ERK1/2 expression in microglial cells.

Chuang DY, Cui J, Simonyi A, Engel VA, Chen S, Fritsche KL, Thomas AL, Applequist WL, Folk WR, Lubahn DB, Sun AY, Sun GY, Gu Z.

ASN Neuro. 2014 Oct 16;6(6). pii: 1759091414554946. doi: 10.1177/1759091414554946. Print 2014.


Proteomic quantification and site-mapping of S-nitrosylated proteins using isobaric iodoTMT reagents.

Qu Z, Meng F, Bomgarden RD, Viner RI, Li J, Rogers JC, Cheng J, Greenlief CM, Cui J, Lubahn DB, Sun GY, Gu Z.

J Proteome Res. 2014 Jul 3;13(7):3200-11. doi: 10.1021/pr401179v. Epub 2014 Jun 13.


The role of estrogen signaling in a mouse model of inflammatory bowel disease: a Helicobacter hepaticus model.

Cook LC, Hillhouse AE, Myles MH, Lubahn DB, Bryda EC, Davis JW, Franklin CL.

PLoS One. 2014 Apr 7;9(4):e94209. doi: 10.1371/journal.pone.0094209. eCollection 2014.


Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells.

Jiang J, Chuang DY, Zong Y, Patel J, Brownstein K, Lei W, Lu CH, Simonyi A, Gu Z, Cui J, Rottinghaus GE, Fritsche KL, Lubahn DB, Folk WR, Sun GY.

PLoS One. 2014 Feb 25;9(2):e89748. doi: 10.1371/journal.pone.0089748. eCollection 2014.


NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells.

Qu Z, Meng F, Zhou H, Li J, Wang Q, Wei F, Cheng J, Greenlief CM, Lubahn DB, Sun GY, Liu S, Gu Z.

J Neuroinflammation. 2014 Jan 28;11:17. doi: 10.1186/1742-2094-11-17.


Inhibition of hedgehog/Gli signaling by botanicals: a review of compounds with potential hedgehog pathway inhibitory activities.

Drenkhahn SK, Jackson GA, Slusarz A, Starkey NJ, Lubahn DB.

Curr Cancer Drug Targets. 2013 Jun;13(5):580-95. Review.


Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells.

Chuang DY, Chan MH, Zong Y, Sheng W, He Y, Jiang JH, Simonyi A, Gu Z, Fritsche KL, Cui J, Lee JC, Folk WR, Lubahn DB, Sun AY, Sun GY.

J Neuroinflammation. 2013 Jan 29;10:15. doi: 10.1186/1742-2094-10-15.


Aggressive prostate cancer is prevented in ERαKO mice and stimulated in ERβKO TRAMP mice.

Slusarz A, Jackson GA, Day JK, Shenouda NS, Bogener JL, Browning JD, Fritsche KL, MacDonald RS, Besch-Williford CL, Lubahn DB.

Endocrinology. 2012 Sep;153(9):4160-70. doi: 10.1210/en.2012-1030. Epub 2012 Jun 29.


The neuroprotective effects of apocynin.

Simonyi A, Serfozo P, Lehmidi TM, Cui J, Gu Z, Lubahn DB, Sun AY, Sun GY.

Front Biosci (Elite Ed). 2012 Jan 1;4:2183-93. Review.


Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice.

Saleiro D, Murillo G, Lubahn DB, Kopelovich L, Korach KS, Mehta RG.

Cancer Prev Res (Phila). 2010 Sep;3(9):1198-204. doi: 10.1158/1940-6207.CAPR-10-0044. Epub 2010 Aug 17.


Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer.

Slusarz A, Shenouda NS, Sakla MS, Drenkhahn SK, Narula AS, MacDonald RS, Besch-Williford CL, Lubahn DB.

Cancer Res. 2010 Apr 15;70(8):3382-90. doi: 10.1158/0008-5472.CAN-09-3012.


Estrogen receptor ESR1 is indispensable for the induction of persistent vaginal change by neonatal 5alpha-dihydrotestosterone exposure in mice.

Miyagawa S, Katsu Y, Ohta Y, Sudo T, Lubahn DB, Iguchi T.

Biol Reprod. 2010 Mar;82(3):497-503. doi: 10.1095/biolreprod.109.081315. Epub 2009 Oct 28.


Morphological comparison of the testis and efferent ductules between wild-type and estrogen receptor alpha knockout mice during postnatal development.

Lee KH, Park JH, Bunick D, Lubahn DB, Bahr JM.

J Anat. 2009 Jun;214(6):916-25. doi: 10.1111/j.1469-7580.2009.01080.x.


Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice.

Cleveland AG, Oikarinen SI, Bynoté KK, Marttinen M, Rafter JJ, Gustafsson JA, Roy SK, Pitot HC, Korach KS, Lubahn DB, Mutanen M, Gould KA.

Carcinogenesis. 2009 Sep;30(9):1581-90. doi: 10.1093/carcin/bgp132. Epub 2009 Jun 11.


Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice.

Brown M, Ning J, Ferreira JA, Bogener JL, Lubahn DB.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E854-61. doi: 10.1152/ajpendo.90696.2008. Epub 2009 Jan 27.


Impact on bone of an estrogen receptor-alpha gene loss of function mutation.

Smith EP, Specker B, Bachrach BE, Kimbro KS, Li XJ, Young MF, Fedarko NS, Abuzzahab MJ, Frank GR, Cohen RM, Lubahn DB, Korach KS.

J Clin Endocrinol Metab. 2008 Aug;93(8):3088-96. doi: 10.1210/jc.2007-2397. Epub 2008 May 27.


Estrogen receptor-alpha deficiency attenuates autoimmune disease in (NZB x NZW)F1 mice.

Bynoté KK, Hackenberg JM, Korach KS, Lubahn DB, Lane PH, Gould KA.

Genes Immun. 2008 Mar;9(2):137-52. doi: 10.1038/sj.gene.6364458. Epub 2008 Jan 17.


Genistein affects HER2 protein concentration, activation, and promoter regulation in BT-474 human breast cancer cells.

Sakla MS, Shenouda NS, Ansell PJ, Macdonald RS, Lubahn DB.

Endocrine. 2007 Aug;32(1):69-78. Epub 2007 Oct 2.


ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

Zhou W, Lo SC, Liu JH, Hannink M, Lubahn DB.

Mol Cell Endocrinol. 2007 Nov 15;278(1-2):52-62. Epub 2007 Aug 31.


Phytosterol Pygeum africanum regulates prostate cancer in vitro and in vivo.

Shenouda NS, Sakla MS, Newton LG, Besch-Williford C, Greenberg NM, MacDonald RS, Lubahn DB.

Endocrine. 2007 Feb;31(1):72-81.


Estrogen receptor-alpha mediates estrogen protection from angiotensin II-induced hypertension in conscious female mice.

Xue B, Pamidimukkala J, Lubahn DB, Hay M.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1770-6. Epub 2006 Dec 1.


Estrogenic regulation of host immunity against an estrogen receptor-negative human breast cancer.

Curran EM, Judy BM, Duru NA, Wang HQ, Vergara LA, Lubahn DB, Estes DM.

Clin Cancer Res. 2006 Oct 1;12(19):5641-7. Epub 2006 Sep 25.


Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta.

Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB.

J Clin Endocrinol Metab. 2006 Feb;91(2):569-79. Epub 2005 Dec 6.


Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha.

Ansell PJ, Lo SC, Newton LG, Espinosa-Nicholas C, Zhang DD, Liu JH, Hannink M, Lubahn DB.

Mol Cell Endocrinol. 2005 Nov 24;243(1-2):27-34. Epub 2005 Sep 28.


Estrogen receptor alpha is required for mammary development and the induction of mammary hyperplasia and epigenetic alterations in the aromatase transgenic mice.

Tekmal RR, Liu YG, Nair HB, Jones J, Perla RP, Lubahn DB, Korach KS, Kirma N.

J Steroid Biochem Mol Biol. 2005 May;95(1-5):9-15.


Estrogen receptor-alpha mediates estrogen facilitation of baroreflex heart rate responses in conscious mice.

Pamidimukkala J, Xue B, Newton LG, Lubahn DB, Hay M.

Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1063-70. Epub 2004 Nov 18.

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