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Items: 33

1.

Rapid Characterization of Formulated Pharmaceuticals Using Fast MAS 1H Solid-State NMR Spectroscopy.

Hirsh DA, Wijesekara AV, Carnahan SL, Hung I, Lubach JW, Nagapudi K, Rossini AJ.

Mol Pharm. 2019 Jul 1;16(7):3121-3132. doi: 10.1021/acs.molpharmaceut.9b00343. Epub 2019 Jun 4.

PMID:
31095913
2.

Impact of Method of Preparation of Amorphous Solid Dispersions on Mechanical Properties: Comparison of Coprecipitation and Spray Drying.

Hou HH, Rajesh A, Pandya KM, Lubach JW, Muliadi A, Yost E, Jia W, Nagapudi K.

J Pharm Sci. 2019 Feb;108(2):870-879. doi: 10.1016/j.xphs.2018.09.008. Epub 2018 Sep 19.

PMID:
30244013
3.

Understanding Phase Behavior of Nearly Energetically Equivalent Polymorphs To Achieve Controlled Crystallization for a Nav1.7 Pain Inhibitor Compound.

Chakravarty P, DiPasquale AG, Stumpf A, Lubach JW, Nagapudi K.

Mol Pharm. 2018 Nov 5;15(11):5072-5080. doi: 10.1021/acs.molpharmaceut.8b00658. Epub 2018 Sep 28.

PMID:
30216726
4.

In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound.

Kou D, Zhang C, Yiu H, Ng T, Lubach JW, Janson M, Mao C, Durk M, Chinn L, Winter H, Wigman L, Yehl P.

Mol Pharm. 2018 Apr 2;15(4):1607-1617. doi: 10.1021/acs.molpharmaceut.7b01143. Epub 2018 Mar 19.

PMID:
29522347
5.
6.

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.

Crawford JJ, Johnson AR, Misner DL, Belmont LD, Castanedo G, Choy R, Coraggio M, Dong L, Eigenbrot C, Erickson R, Ghilardi N, Hau J, Katewa A, Kohli PB, Lee W, Lubach JW, McKenzie BS, Ortwine DF, Schutt L, Tay S, Wei B, Reif K, Liu L, Wong H, Young WB.

J Med Chem. 2018 Mar 22;61(6):2227-2245. doi: 10.1021/acs.jmedchem.7b01712. Epub 2018 Feb 23.

PMID:
29457982
7.

Exploring Molecular Speciation and Crystallization Mechanism of Amorphous 2-Phenylamino Nicotinic Acid.

Kalra A, Lubach JW, Munson EJ, Li T.

Pharm Res. 2018 Feb 7;35(3):51. doi: 10.1007/s11095-018-2346-0.

PMID:
29417314
8.

In Situ Salt Formation during Melt Extrusion for Improved Chemical Stability and Dissolution Performance of a Meloxicam-Copovidone Amorphous Solid Dispersion.

Haser A, Cao T, Lubach JW, Zhang F.

Mol Pharm. 2018 Mar 5;15(3):1226-1237. doi: 10.1021/acs.molpharmaceut.7b01057. Epub 2018 Feb 19.

PMID:
29412681
9.

Enhancing the resolution of 1H and 13C solid-state NMR spectra by reduction of anisotropic bulk magnetic susceptibility broadening.

Hanrahan MP, Venkatesh A, Carnahan SL, Calahan JL, Lubach JW, Munson EJ, Rossini AJ.

Phys Chem Chem Phys. 2017 Oct 25;19(41):28153-28162. doi: 10.1039/c7cp04223j.

PMID:
29022618
10.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.

Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, DiPaolo J, Reif K, Scheerens H, Schmitt A, Wong H, Xiong JM, Xu J, Zhao Z, Zhou F, Currie KS, Young WB.

ACS Med Chem Lett. 2017 May 3;8(6):608-613. doi: 10.1021/acsmedchemlett.7b00103. eCollection 2017 Jun 8.

11.

Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State.

Kalra A, Tishmack P, Lubach JW, Munson EJ, Taylor LS, Byrn SR, Li T.

Mol Pharm. 2017 Jun 5;14(6):2126-2137. doi: 10.1021/acs.molpharmaceut.7b00245. Epub 2017 May 17.

PMID:
28485947
12.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

Katewa A, Wang Y, Hackney JA, Huang T, Suto E, Ramamoorthi N, Austin CD, Bremer M, Chen JZ, Crawford JJ, Currie KS, Blomgren P, DeVoss J, DiPaolo JA, Hau J, Johnson A, Lesch J, DeForge LE, Lin Z, Liimatta M, Lubach JW, McVay S, Modrusan Z, Nguyen A, Poon C, Wang J, Liu L, Lee WP, Wong H, Young WB, Townsend MJ, Reif K.

JCI Insight. 2017 Apr 6;2(7):e90111. doi: 10.1172/jci.insight.90111.

13.

Correction to "Characterization of the Particle Size and Polydispersity of Dicumarol Using Solid-State NMR Spectroscopy".

Dempah KE, Lubach JW, Munson EJ.

Mol Pharm. 2017 Apr 3;14(4):1319. doi: 10.1021/acs.molpharmaceut.7b00194. Epub 2017 Mar 22. No abstract available.

PMID:
28328222
14.

Characterization of the Particle Size and Polydispersity of Dicumarol Using Solid-State NMR Spectroscopy.

Dempah KE, Lubach JW, Munson EJ.

Mol Pharm. 2017 Mar 6;14(3):856-865. doi: 10.1021/acs.molpharmaceut.6b01073. Epub 2017 Feb 15. Erratum in: Mol Pharm. 2017 Apr 3;14(4):1319.

PMID:
28166408
15.

A rational approach towards development of amorphous solid dispersions: Experimental and computational techniques.

Chakravarty P, Lubach JW, Hau J, Nagapudi K.

Int J Pharm. 2017 Mar 15;519(1-2):44-57. doi: 10.1016/j.ijpharm.2017.01.003. Epub 2017 Jan 4.

PMID:
28063904
16.

Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy.

Song Y, Zemlyanov D, Chen X, Su Z, Nie H, Lubach JW, Smith D, Byrn S, Pinal R.

Int J Pharm. 2016 Dec 5;514(2):456-464. doi: 10.1016/j.ijpharm.2016.06.126. Epub 2016 Jun 28.

PMID:
27370910
17.

Probing the Distribution of Water in a Multi-Component System by Solid-State NMR Spectroscopy.

Mistry P, Chakravarty P, Lubach JW.

Pharm Res. 2016 Oct;33(10):2470-80. doi: 10.1007/s11095-016-1972-7. Epub 2016 Jun 20.

PMID:
27324960
18.

Acid-Base Interactions of Polystyrene Sulfonic Acid in Amorphous Solid Dispersions Using a Combined UV/FTIR/XPS/ssNMR Study.

Song Y, Zemlyanov D, Chen X, Nie H, Su Z, Fang K, Yang X, Smith D, Byrn S, Lubach JW.

Mol Pharm. 2016 Feb 1;13(2):483-92. doi: 10.1021/acs.molpharmaceut.5b00708. Epub 2015 Dec 30.

PMID:
26716395
19.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Eigenbrot C, Gallion S, Johnson AR, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Wang X, Wong H, Xiong JM, Xu J, Yu C, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-579. doi: 10.1016/j.bmcl.2015.11.076. Epub 2015 Nov 24.

PMID:
26675441
20.

Solid-State Characterization of Novel Propylene Glycol Ester Solvates Isolated from Lipid Formulations.

Chakravarty P, Kothari S, Deese A, Lubach JW.

Mol Pharm. 2015 Jul 6;12(7):2551-7. doi: 10.1021/mp5007695. Epub 2015 Jun 3.

PMID:
26013841
21.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

Young WB, Barbosa J, Blomgren P, Bremer MC, Crawford JJ, Dambach D, Gallion S, Hymowitz SG, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Maurer B, Mitchell SA, Ortwine DF, Di Paolo J, Reif K, Scheerens H, Schmitt A, Sowell CG, Wang X, Wong H, Xiong JM, Xu J, Zhao Z, Currie KS.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1333-7. doi: 10.1016/j.bmcl.2015.01.032. Epub 2015 Feb 7.

PMID:
25701252
22.

Investigation of drug-excipient interactions in lapatinib amorphous solid dispersions using solid-state NMR spectroscopy.

Song Y, Yang X, Chen X, Nie H, Byrn S, Lubach JW.

Mol Pharm. 2015 Mar 2;12(3):857-66. doi: 10.1021/mp500692a. Epub 2015 Jan 28.

PMID:
25585133
23.

The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199.

Choo EF, Boggs J, Zhu C, Lubach JW, Catron ND, Jenkins G, Souers AJ, Voorman R.

Drug Metab Dispos. 2014 Feb;42(2):207-12. doi: 10.1124/dmd.113.055053. Epub 2013 Nov 8.

PMID:
24212376
24.

Characterization of a water-solid interaction in a partially ordered system.

Chakravarty P, Lubach JW.

Mol Pharm. 2013 Nov 4;10(11):4294-300. doi: 10.1021/mp400369u. Epub 2013 Sep 30.

PMID:
24079669
25.

Investigation of the rat model for preclinical evaluation of pH-dependent oral absorption in humans.

Lubach JW, Chen JZ, Hau J, Imperio J, Coraggio M, Liu L, Wong H.

Mol Pharm. 2013 Nov 4;10(11):3997-4004. doi: 10.1021/mp400283j. Epub 2013 Aug 20.

PMID:
23961831
26.

Carbon-deuterium rotational-echo double-resonance NMR spectroscopy of lyophilized aspartame formulations.

Luthra SA, Utz M, Gorman EM, Pikal MJ, Munson EJ, Lubach JW.

J Pharm Sci. 2012 Jan;101(1):283-90. doi: 10.1002/jps.22769. Epub 2011 Sep 20.

PMID:
21935954
27.

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.

Liu L, Halladay JS, Shin Y, Wong S, Coraggio M, La H, Baumgardner M, Le H, Gopaul S, Boggs J, Kuebler P, Davis JC Jr, Liao XC, Lubach JW, Deese A, Sowell CG, Currie KS, Young WB, Khojasteh SC, Hop CE, Wong H.

Drug Metab Dispos. 2011 Oct;39(10):1840-9. doi: 10.1124/dmd.111.040840. Epub 2011 Jul 8.

PMID:
21742900
28.

Characterization of prednisolone in controlled porosity osmotic pump pellets using solid-state NMR spectroscopy.

Sotthivirat S, Lubach JW, Haslam JL, Munson EJ, Stella VJ.

J Pharm Sci. 2007 May;96(5):1008-17.

PMID:
17455361
29.
30.

Multiple-sample probe for solid-state NMR studies of pharmaceuticals.

Nelson BN, Schieber LJ, Barich DH, Lubach JW, Offerdahl TJ, Lewis DH, Heinrich JP, Munson EJ.

Solid State Nucl Magn Reson. 2006 Feb;29(1-3):204-13. Epub 2005 Oct 24.

PMID:
16246531
31.

Effects of sucrose and mannitol on asparagine deamidation rates of model peptides in solution and in the solid state.

Li B, O'Meara MH, Lubach JW, Schowen RL, Topp EM, Munson EJ, Borchardt RT.

J Pharm Sci. 2005 Aug;94(8):1723-35.

PMID:
15986465
32.

Mechanochromism of piroxicam accompanied by intermolecular proton transfer probed by spectroscopic methods and solid-phase changes.

Sheth AR, Lubach JW, Munson EJ, Muller FX, Grant DJ.

J Am Chem Soc. 2005 May 11;127(18):6641-51.

PMID:
15869285
33.

Solid-state NMR studies of pharmaceutical solids in polymer matrices.

Lubach JW, Padden BE, Winslow SL, Salsbury JS, Masters DB, Topp EM, Munson EJ.

Anal Bioanal Chem. 2004 Mar;378(6):1504-10.

PMID:
15214410

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