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Items: 1 to 50 of 113

1.

Emerging Frontiers in Microbiome Engineering.

Inda ME, Broset E, Lu TK, de la Fuente-Nunez C.

Trends Immunol. 2019 Oct;40(10):952-973. doi: 10.1016/j.it.2019.08.007. Epub 2019 Oct 7. Review.

PMID:
31601521
2.

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis.

Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK.

Cell. 2019 Oct 3;179(2):459-469.e9. doi: 10.1016/j.cell.2019.09.015.

PMID:
31585083
3.

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA.

Wang J, Alvin Chew BL, Lai Y, Dong H, Xu L, Balamkundu S, Cai WM, Cui L, Liu CF, Fu XY, Lin Z, Shi PY, Lu TK, Luo D, Jaffrey SR, Dedon PC.

Nucleic Acids Res. 2019 Nov 18;47(20):e130. doi: 10.1093/nar/gkz751.

PMID:
31504804
4.

Gene networks that compensate for crosstalk with crosstalk.

Müller IE, Rubens JR, Jun T, Graham D, Xavier R, Lu TK.

Nat Commun. 2019 Sep 6;10(1):4028. doi: 10.1038/s41467-019-12021-y.

5.

Single-Nucleotide-Resolution Computing and Memory in Living Cells.

Farzadfard F, Gharaei N, Higashikuni Y, Jung G, Cao J, Lu TK.

Mol Cell. 2019 Aug 22;75(4):769-780.e4. doi: 10.1016/j.molcel.2019.07.011.

PMID:
31442423
6.

Synthetic Genetic Circuits for Self-Actuated Cellular Nanomaterial Fabrication Devices.

Olmez TT, Sahin Kehribar E, Isilak ME, Lu TK, Seker UOS.

ACS Synth Biol. 2019 Sep 20;8(9):2152-2162. doi: 10.1021/acssynbio.9b00235. Epub 2019 Aug 28.

PMID:
31419103
7.

Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants with Extended Antibacterial Properties.

Oshiro KGN, Cândido ES, Chan LY, Torres MDT, Monges BED, Rodrigues SG, Porto WF, Ribeiro SM, Henriques ST, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL, Cardoso MH.

J Med Chem. 2019 Sep 12;62(17):8140-8151. doi: 10.1021/acs.jmedchem.9b00915. Epub 2019 Aug 26.

PMID:
31411881
8.

Cell-based biosensors for immunology, inflammation, and allergy.

Inda ME, Mimee M, Lu TK.

J Allergy Clin Immunol. 2019 Sep;144(3):645-647. doi: 10.1016/j.jaci.2019.07.024. Epub 2019 Jul 31. No abstract available.

PMID:
31376406
9.

A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS).

Wu MR, Nissim L, Stupp D, Pery E, Binder-Nissim A, Weisinger K, Enghuus C, Palacios SR, Humphrey M, Zhang Z, Maria Novoa E, Kellis M, Weiss R, Rabkin SD, Tabach Y, Lu TK.

Nat Commun. 2019 Jun 28;10(1):2880. doi: 10.1038/s41467-019-10912-8.

10.

CRISPR/Cas-based devices for mammalian synthetic biology.

Kim T, Lu TK.

Curr Opin Chem Biol. 2019 Oct;52:23-30. doi: 10.1016/j.cbpa.2019.04.015. Epub 2019 May 25. Review.

PMID:
31136835
11.

Small-molecule control of antibody N-glycosylation in engineered mammalian cells.

Chang MM, Gaidukov L, Jung G, Tseng WA, Scarcelli JJ, Cornell R, Marshall JK, Lyles JL, Sakorafas P, Chu AA, Cote K, Tzvetkova B, Dolatshahi S, Sumit M, Mulukutla BC, Lauffenburger DA, Figueroa B Jr, Summers NM, Lu TK, Weiss R.

Nat Chem Biol. 2019 Jul;15(7):730-736. doi: 10.1038/s41589-019-0288-4. Epub 2019 May 20.

PMID:
31110306
12.

Challenges in IBD Research: Novel Technologies.

Dhyani M, Joshi N, Bemelman WA, Gee MS, Yajnik V, D'Hoore A, Traverso G, Donowitz M, Mostoslavsky G, Lu TK, Lineberry N, Niessen HG, Peer D, Braun J, Delaney CP, Dubinsky MC, Guillory AN, Pereira M, Shtraizent N, Honig G, Polk DB, Hurtado-Lorenzo A, Karp JM, Michelassi F.

Inflamm Bowel Dis. 2019 May 16;25(Supplement_2):S24-S30. doi: 10.1093/ibd/izz077.

PMID:
31095703
13.

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential.

Cândido ES, Cardoso MH, Chan LY, Torres MDT, Oshiro KGN, Porto WF, Ribeiro SM, Haney EF, Hancock REW, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL.

ACS Infect Dis. 2019 Jul 12;5(7):1081-1086. doi: 10.1021/acsinfecdis.9b00073. Epub 2019 May 1.

PMID:
31016969
14.

Modular genetic design of multi-domain functional amyloids: insights into self-assembly and functional properties.

Cui M, Qi Q, Gurry T, Zhao T, An B, Pu J, Gui X, Cheng AA, Zhang S, Xun D, Becce M, Briatico-Vangosa F, Liu C, Lu TK, Zhong C.

Chem Sci. 2019 Feb 15;10(14):4004-4014. doi: 10.1039/c9sc00208a. eCollection 2019 Apr 14.

15.

Selective antibacterial activity of the cationic peptide PaDBS1R6 against Gram-negative bacteria.

Fensterseifer ICM, Felício MR, Alves ESF, Cardoso MH, Torres MDT, Matos CO, Silva ON, Lu TK, Freire MV, Neves NC, Gonçalves S, Lião LM, Santos NC, Porto WF, de la Fuente-Nunez C, Franco OL.

Biochim Biophys Acta Biomembr. 2019 Jul 1;1861(7):1375-1387. doi: 10.1016/j.bbamem.2019.03.016. Epub 2019 Mar 26.

PMID:
30926365
16.

Directing curli polymerization with DNA origami nucleators.

Mao X, Li K, Liu M, Wang X, Zhao T, An B, Cui M, Li Y, Pu J, Li J, Wang L, Lu TK, Fan C, Zhong C.

Nat Commun. 2019 Mar 27;10(1):1395. doi: 10.1038/s41467-019-09369-6.

17.

Engineering advanced cancer therapies with synthetic biology.

Wu MR, Jusiak B, Lu TK.

Nat Rev Cancer. 2019 Apr;19(4):187-195. doi: 10.1038/s41568-019-0121-0. Review.

PMID:
30837696
18.

Human cathelicidin peptide LL-37 as a therapeutic antiviral targeting Venezuelan equine encephalitis virus infections.

Ahmed A, Siman-Tov G, Keck F, Kortchak S, Bakovic A, Risner K, Lu TK, Bhalla N, de la Fuente-Nunez C, Narayanan A.

Antiviral Res. 2019 Apr;164:61-69. doi: 10.1016/j.antiviral.2019.02.002. Epub 2019 Feb 8.

PMID:
30738837
19.

Publisher Correction: Encryption and steganography of synthetic gene circuits.

Purcell O, Wang J, Siuti P, Lu TK.

Nat Commun. 2019 Jan 8;10(1):154. doi: 10.1038/s41467-018-07844-0.

20.

Peptide Design Principles for Antimicrobial Applications.

Torres MDT, Sothiselvam S, Lu TK, de la Fuente-Nunez C.

J Mol Biol. 2019 Aug 23;431(18):3547-3567. doi: 10.1016/j.jmb.2018.12.015. Epub 2019 Jan 3. Review.

PMID:
30611750
21.

Comparison of Integrases Identifies Bxb1-GA Mutant as the Most Efficient Site-Specific Integrase System in Mammalian Cells.

Jusiak B, Jagtap K, Gaidukov L, Duportet X, Bandara K, Chu J, Zhang L, Weiss R, Lu TK.

ACS Synth Biol. 2019 Jan 18;8(1):16-24. doi: 10.1021/acssynbio.8b00089. Epub 2019 Jan 9.

PMID:
30609349
22.

Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates.

Torres MDT, Pedron CN, Higashikuni Y, Kramer RM, Cardoso MH, Oshiro KGN, Franco OL, Silva Junior PI, Silva FD, Oliveira Junior VX, Lu TK, de la Fuente-Nunez C.

Commun Biol. 2018 Dec 7;1:221. doi: 10.1038/s42003-018-0224-2. eCollection 2018.

23.

Programmable and printable Bacillus subtilis biofilms as engineered living materials.

Huang J, Liu S, Zhang C, Wang X, Pu J, Ba F, Xue S, Ye H, Zhao T, Li K, Wang Y, Zhang J, Wang L, Fan C, Lu TK, Zhong C.

Nat Chem Biol. 2019 Jan;15(1):34-41. doi: 10.1038/s41589-018-0169-2. Epub 2018 Dec 3.

PMID:
30510190
24.

Encryption and steganography of synthetic gene circuits.

Purcell O, Wang J, Siuti P, Lu TK.

Nat Commun. 2018 Nov 22;9(1):4942. doi: 10.1038/s41467-018-07144-7. Erratum in: Nat Commun. 2019 Jan 8;10(1):154.

25.

Bacteriophage Therapy Testing Against Shigella flexneri in a Novel Human Intestinal Organoid-Derived Infection Model.

Llanos-Chea A, Citorik RJ, Nickerson KP, Ingano L, Serena G, Senger S, Lu TK, Fasano A, Faherty CS.

J Pediatr Gastroenterol Nutr. 2019 Apr;68(4):509-516. doi: 10.1097/MPG.0000000000002203.

PMID:
30418409
26.

A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.

Cardoso MH, Cândido ES, Chan LY, Der Torossian Torres M, Oshiro KGN, Rezende SB, Porto WF, Lu TK, de la Fuente-Nunez C, Craik DJ, Franco OL.

ACS Infect Dis. 2018 Dec 14;4(12):1727-1736. doi: 10.1021/acsinfecdis.8b00219. Epub 2018 Nov 1.

PMID:
30346140
27.

Artificial Repeat-Structured siRNA Precursors as Tunable Regulators for Saccharomyces cerevisiae.

Purcell O, Cao J, Müller IE, Chen YC, Lu TK.

ACS Synth Biol. 2018 Oct 19;7(10):2403-2412. doi: 10.1021/acssynbio.8b00185. Epub 2018 Sep 14.

PMID:
30176724
28.

Emerging applications for DNA writers and molecular recorders.

Farzadfard F, Lu TK.

Science. 2018 Aug 31;361(6405):870-875. doi: 10.1126/science.aat9249. Review.

PMID:
30166483
29.

Identification of Novel Cryptic Multifunctional Antimicrobial Peptides from the Human Stomach Enabled by a Computational-Experimental Platform.

Pane K, Cafaro V, Avitabile A, Torres MT, Vollaro A, De Gregorio E, Catania MR, Di Maro A, Bosso A, Gallo G, Zanfardino A, Varcamonti M, Pizzo E, Di Donato A, Lu TK, de la Fuente-Nunez C, Notomista E.

ACS Synth Biol. 2018 Sep 21;7(9):2105-2115. doi: 10.1021/acssynbio.8b00084. Epub 2018 Aug 20.

PMID:
30124040
30.

Phage-Based Applications in Synthetic Biology.

Lemire S, Yehl KM, Lu TK.

Annu Rev Virol. 2018 Sep 29;5(1):453-476. doi: 10.1146/annurev-virology-092917-043544. Epub 2018 Jul 12. Review.

PMID:
30001182
31.

An ingestible bacterial-electronic system to monitor gastrointestinal health.

Mimee M, Nadeau P, Hayward A, Carim S, Flanagan S, Jerger L, Collins J, McDonnell S, Swartwout R, Citorik RJ, Bulović V, Langer R, Traverso G, Chandrakasan AP, Lu TK.

Science. 2018 May 25;360(6391):915-918. doi: 10.1126/science.aas9315.

32.

Emerging Paradigms for Synthetic Design of Functional Amyloids.

Wang Y, Pu J, An B, Lu TK, Zhong C.

J Mol Biol. 2018 Oct 12;430(20):3720-3734. doi: 10.1016/j.jmb.2018.04.012. Epub 2018 Apr 25. Review.

PMID:
29702108
33.

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design.

Porto WF, Irazazabal L, Alves ESF, Ribeiro SM, Matos CO, Pires ÁS, Fensterseifer ICM, Miranda VJ, Haney EF, Humblot V, Torres MDT, Hancock REW, Liao LM, Ladram A, Lu TK, de la Fuente-Nunez C, Franco OL.

Nat Commun. 2018 Apr 16;9(1):1490. doi: 10.1038/s41467-018-03746-3.

34.

A multi-landing pad DNA integration platform for mammalian cell engineering.

Gaidukov L, Wroblewska L, Teague B, Nelson T, Zhang X, Liu Y, Jagtap K, Mamo S, Tseng WA, Lowe A, Das J, Bandara K, Baijuraj S, Summers NM, Lu TK, Zhang L, Weiss R.

Nucleic Acids Res. 2018 May 4;46(8):4072-4086. doi: 10.1093/nar/gky216.

35.

Yeast-Based Synthetic Biology Platform for Antimicrobial Peptide Production.

Cao J, de la Fuente-Nunez C, Ou RW, Torres MT, Pande SG, Sinskey AJ, Lu TK.

ACS Synth Biol. 2018 Mar 16;7(3):896-902. doi: 10.1021/acssynbio.7b00396. Epub 2018 Feb 12.

PMID:
29366323
36.

Versatile and on-demand biologics co-production in yeast.

Cao J, Perez-Pinera P, Lowenhaupt K, Wu MR, Purcell O, de la Fuente-Nunez C, Lu TK.

Nat Commun. 2018 Jan 8;9(1):77. doi: 10.1038/s41467-017-02587-w.

37.

Neuromicrobiology: How Microbes Influence the Brain.

de la Fuente-Nunez C, Meneguetti BT, Franco OL, Lu TK.

ACS Chem Neurosci. 2018 Feb 21;9(2):141-150. doi: 10.1021/acschemneuro.7b00373. Epub 2017 Dec 28. Review.

PMID:
29220570
38.

3D Printing of Living Responsive Materials and Devices.

Liu X, Yuk H, Lin S, Parada GA, Tang TC, Tham E, de la Fuente-Nunez C, Lu TK, Zhao X.

Adv Mater. 2018 Jan;30(4). doi: 10.1002/adma.201704821. Epub 2017 Dec 5.

PMID:
29205532
39.

Roadmap on semiconductor-cell biointerfaces.

Tian B, Xu S, Rogers JA, Cestellos-Blanco S, Yang P, Carvalho-de-Souza JL, Bezanilla F, Liu J, Bao Z, Hjort M, Cao Y, Melosh N, Lanzani G, Benfenati F, Galli G, Gygi F, Kautz R, Gorodetsky AA, Kim SS, Lu TK, Anikeeva P, Cifra M, Krivosudský O, Havelka D, Jiang Y.

Phys Biol. 2018 Mar 9;15(3):031002. doi: 10.1088/1478-3975/aa9f34. Review.

40.

Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy.

Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK.

Cell. 2017 Nov 16;171(5):1138-1150.e15. doi: 10.1016/j.cell.2017.09.049. Epub 2017 Oct 19.

41.

An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli.

Cleto S, Lu TK.

MBio. 2017 Oct 10;8(5). pii: e01474-17. doi: 10.1128/mBio.01474-17.

42.

Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.

Chen YC, Farzadfard F, Gharaei N, Chen WCW, Cao J, Lu TK.

Mol Cell. 2017 Oct 5;68(1):247-257.e5. doi: 10.1016/j.molcel.2017.09.014.

43.

Contact guidance and collective migration in the advancing epithelial monolayer.

Lee G, Atia L, Lan B, Sharma Y, Nissim L, Wu MR, Pery E, Lu TK, Park CY, Butler JP, Fredberg JJ.

Connect Tissue Res. 2018 Jul;59(4):309-315. doi: 10.1080/03008207.2017.1384471. Epub 2017 Oct 17.

44.

Production of Functional Anti-Ebola Antibodies in Pichia pastoris.

Purcell O, Opdensteinen P, Chen W, Lowenhaupt K, Brown A, Hermann M, Cao J, Tenhaef N, Kallweit E, Kastilan R, Sinskey AJ, Perez-Pinera P, Buyel JF, Lu TK.

ACS Synth Biol. 2017 Dec 15;6(12):2183-2190. doi: 10.1021/acssynbio.7b00234. Epub 2017 Aug 17.

PMID:
28786662
45.

Advancing therapeutic applications of synthetic gene circuits.

Higashikuni Y, Chen WC, Lu TK.

Curr Opin Biotechnol. 2017 Oct;47:133-141. doi: 10.1016/j.copbio.2017.06.011. Epub 2017 Aug 17. Review.

PMID:
28750201
46.

Ciprofloxacin-nitroxide hybrids with potential for biofilm control.

Verderosa AD, de la Fuente-Núñez C, Mansour SC, Cao J, Lu TK, Hancock REW, Fairfull-Smith KE.

Eur J Med Chem. 2017 Sep 29;138:590-601. doi: 10.1016/j.ejmech.2017.06.058. Epub 2017 Jun 28.

PMID:
28709125
47.

Next-generation precision antimicrobials: towards personalized treatment of infectious diseases.

de la Fuente-Nunez C, Torres MD, Mojica FJ, Lu TK.

Curr Opin Microbiol. 2017 Jun;37:95-102. doi: 10.1016/j.mib.2017.05.014. Epub 2017 Jun 14. Review.

48.

Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.

An B, Wang X, Cui M, Gui X, Mao X, Liu Y, Li K, Chu C, Pu J, Ren S, Wang Y, Zhong G, Lu TK, Liu C, Zhong C.

ACS Nano. 2017 Jul 25;11(7):6985-6995. doi: 10.1021/acsnano.7b02298. Epub 2017 Jun 19.

PMID:
28609612
49.

Antimicrobial peptides: Role in human disease and potential as immunotherapies.

de la Fuente-Núñez C, Silva ON, Lu TK, Franco OL.

Pharmacol Ther. 2017 Oct;178:132-140. doi: 10.1016/j.pharmthera.2017.04.002. Epub 2017 Apr 21. Review.

PMID:
28435091
50.

A Modular Toolkit for Generating Pichia pastoris Secretion Libraries.

Obst U, Lu TK, Sieber V.

ACS Synth Biol. 2017 Jun 16;6(6):1016-1025. doi: 10.1021/acssynbio.6b00337. Epub 2017 Mar 15.

PMID:
28252957

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