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Items: 1 to 50 of 95

1.

HDAC3 deficiency promotes liver cancer through a defect in H3K9ac/H3K9me3 transition.

Ji H, Zhou Y, Zhuang X, Zhu Y, Wu Z, Lu Y, Li S, Zeng Y, Lu QR, Huo Y, Shi Y, Bu H.

Cancer Res. 2019 May 16. pii: canres.3767.2018. doi: 10.1158/0008-5472.CAN-18-3767. [Epub ahead of print]

PMID:
31097476
2.

RUNX represses Pmp22 to drive neurofibromagenesis.

Hall A, Choi K, Liu W, Rose J, Zhao C, Yu Y, Na Y, Cai Y, Coover RA, Lin Y, Dombi E, Kim M, Levanon D, Groner Y, Boscolo E, Pan D, Liu PP, Lu QR, Ratner N, Huang G, Wu J.

Sci Adv. 2019 Apr 24;5(4):eaau8389. doi: 10.1126/sciadv.aau8389. eCollection 2019 Apr.

3.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.

Weng Q, Wang J, Wang J, He D, Cheng Z, Zhang F, Verma R, Xu L, Dong X, Liao Y, He X, Potter A, Zhang L, Zhao C, Xin M, Zhou Q, Aronow BJ, Blackshear PJ, Rich JN, He Q, Zhou W, Suvà ML, Waclaw RR, Potter SS, Yu G, Lu QR.

Cell Stem Cell. 2019 May 2;24(5):707-723.e8. doi: 10.1016/j.stem.2019.03.006. Epub 2019 Apr 11.

PMID:
30982771
4.

Developmental origins and oncogenic pathways in malignant brain tumors.

Lu QR, Qian L, Zhou X.

Wiley Interdiscip Rev Dev Biol. 2019 Jul;8(4):e342. doi: 10.1002/wdev.342. Epub 2019 Apr 3. Review.

PMID:
30945456
5.

A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism.

Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR, Zhao TJ, Chen Y.

Cell Rep. 2019 Mar 12;26(11):2984-2997.e4. doi: 10.1016/j.celrep.2019.02.060.

6.

Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice.

Peng D, Si D, Zhang R, Liu J, Gou H, Xia Y, Tian D, Dai J, Yang K, Liu E, Shi Y, Lu QR, Zou L, Fu Z.

Genes Dis. 2017 Oct 25;4(4):204-214. doi: 10.1016/j.gendis.2017.10.001. eCollection 2017 Dec.

7.

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.

Marie C, Clavairoly A, Frah M, Hmidan H, Yan J, Zhao C, Van Steenwinckel J, Daveau R, Zalc B, Hassan B, Thomas JL, Gressens P, Ravassard P, Moszer I, Martin DM, Lu QR, Parras C.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8246-E8255. doi: 10.1073/pnas.1802620115. Epub 2018 Aug 14.

8.

Clinical and genetic spectrum of a large cohort of children with epilepsy in China.

Yang L, Kong Y, Dong X, Hu L, Lin Y, Chen X, Ni Q, Lu Y, Wu B, Wang H, Lu QR, Zhou W.

Genet Med. 2019 Mar;21(3):564-571. doi: 10.1038/s41436-018-0091-8. Epub 2018 Jun 21.

PMID:
29930392
9.

Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.

Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, Xu L, Ma Z, Dong X, Lin Y, Koenig S, Nait-Oumesmar B, Martin DM, Wu LN, Xin M, Zhou W, Parras C, Lu QR.

Dev Cell. 2018 Jun 18;45(6):753-768.e8. doi: 10.1016/j.devcel.2018.05.022.

10.

The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner.

Jiang M, Rao R, Wang J, Wang J, Xu L, Wu LM, Chan JR, Wang H, Lu QR.

Glia. 2018 Sep;66(9):1947-1959. doi: 10.1002/glia.23449. Epub 2018 May 3.

PMID:
29722913
11.

Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation.

Merten N, Fischer J, Simon K, Zhang L, Schröder R, Peters L, Letombe AG, Hennen S, Schrage R, Bödefeld T, Vermeiren C, Gillard M, Mohr K, Lu QR, Brüstle O, Gomeza J, Kostenis E.

Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5. doi: 10.1016/j.chembiol.2018.03.012. Epub 2018 Apr 26.

PMID:
29706593
12.

Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway.

Lu XF, Cao XY, Zhu YJ, Wu ZR, Zhuang X, Shao MY, Xu Q, Zhou YJ, Ji HJ, Lu QR, Shi YJ, Zeng Y, Bu H.

Cell Death Dis. 2018 Mar 14;9(3):398. doi: 10.1038/s41419-018-0428-x.

13.

Mesenchymal Stem Cells Protect Against Hypoxia-Ischemia Brain Damage by Enhancing Autophagy Through Brain Derived Neurotrophic Factor/Mammalin Target of Rapamycin Signaling Pathway.

Zheng Z, Zhang L, Qu Y, Xiao G, Li S, Bao S, Lu QR, Mu D.

Stem Cells. 2018 Jul;36(7):1109-1121. doi: 10.1002/stem.2808. Epub 2018 Mar 5.

PMID:
29451335
14.

Lenalidomide regulates CNS autoimmunity by promoting M2 macrophages polarization.

Weng Q, Wang J, Wang J, Wang J, Sattar F, Zhang Z, Zheng J, Xu Z, Zhao M, Liu X, Yang L, Hao G, Fang L, Lu QR, Yang B, He Q.

Cell Death Dis. 2018 Feb 14;9(2):251. doi: 10.1038/s41419-018-0290-x.

15.

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Wu LMN, Deng Y, Wang J, Zhao C, Wang J, Rao R, Xu L, Zhou W, Choi K, Rizvi TA, Remke M, Rubin JB, Johnson RL, Carroll TJ, Stemmer-Rachamimov AO, Wu J, Zheng Y, Xin M, Ratner N, Lu QR.

Cancer Cell. 2018 Feb 12;33(2):292-308.e7. doi: 10.1016/j.ccell.2018.01.005.

16.

microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease.

Moyano AL, Steplowski J, Wang H, Son KN, Rapolti DI, Marshall J, Elackattu V, Marshall MS, Hebert AK, Reiter CR, Ulloa V, Pituch KC, Givogri MI, Lu QR, Lipton HL, Bongarzone ER.

Mol Ther. 2018 Mar 7;26(3):730-743. doi: 10.1016/j.ymthe.2018.01.008. Epub 2018 Jan 17.

17.

A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration.

He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR.

Nat Med. 2018 Mar;24(3):338-351. doi: 10.1038/nm.4483. Epub 2018 Feb 12.

18.

Epigenetic modifications-insight into oligodendrocyte lineage progression, regeneration, and disease.

Gregath A, Lu QR.

FEBS Lett. 2018 Apr;592(7):1063-1078. doi: 10.1002/1873-3468.12999. Epub 2018 Feb 22. Review.

19.

Age-Dependent Decline in Fate Switch from NG2 Cells to Astrocytes After Olig2 Deletion.

Zuo H, Wood WM, Sherafat A, Hill RA, Lu QR, Nishiyama A.

J Neurosci. 2018 Feb 28;38(9):2359-2371. doi: 10.1523/JNEUROSCI.0712-17.2018. Epub 2018 Jan 30.

20.

Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development.

He L, Yu K, Lu F, Wang J, Wu LN, Zhao C, Li Q, Zhou X, Liu H, Mu D, Xin M, Qiu M, Lu QR.

J Neurosci. 2018 Feb 7;38(6):1575-1587. doi: 10.1523/JNEUROSCI.2674-17.2018. Epub 2018 Jan 11.

21.

Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair.

Koreman E, Sun X, Lu QR.

Mol Cell Neurosci. 2018 Mar;87:18-26. doi: 10.1016/j.mcn.2017.11.010. Epub 2017 Dec 15. Review.

22.

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal.

Mateo JL, van den Berg DLC, Haeussler M, Drechsel D, Gaber ZB, Castro DS, Robson P, Lu QR, Crawford GE, Flicek P, Ettwiller L, Wittbrodt J, Guillemot F, Martynoga B.

Genome Res. 2017 Dec;27(12):2129. doi: 10.1101/gr.231845.117. No abstract available.

23.

YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.

Sakabe M, Fan J, Odaka Y, Liu N, Hassan A, Duan X, Stump P, Byerly L, Donaldson M, Hao J, Fruttiger M, Lu QR, Zheng Y, Lang RA, Xin M.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10918-10923. doi: 10.1073/pnas.1704030114. Epub 2017 Sep 25.

24.

Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice.

Li Z, Peng Y, Hufnagel RB, Hu YC, Zhao C, Queme LF, Khuchua Z, Driver AM, Dong F, Lu QR, Lindquist DM, Jankowski MP, Stottmann RW, Kao WWY, Huang T.

Hum Mol Genet. 2017 Oct 1;26(19):3776-3791. doi: 10.1093/hmg/ddx262.

25.

Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas.

Kosty J, Lu F, Kupp R, Mehta S, Lu QR.

Cell Cycle. 2017 Sep 17;16(18):1654-1660. doi: 10.1080/15384101.2017.1361062. Epub 2017 Aug 14. Review.

26.

Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity.

Weng Q, Wang J, Wang J, Tan B, Wang J, Wang H, Zheng T, Lu QR, Yang B, He Q.

Sci Rep. 2017 May 11;7(1):1705. doi: 10.1038/s41598-017-01732-1.

27.

A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination.

Deng Y, Wu LMN, Bai S, Zhao C, Wang H, Wang J, Xu L, Sakabe M, Zhou W, Xin M, Lu QR.

Nat Commun. 2017 Apr 26;8:15161. doi: 10.1038/ncomms15161.

28.

miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS.

Wang H, Moyano AL, Ma Z, Deng Y, Lin Y, Zhao C, Zhang L, Jiang M, He X, Ma Z, Lu F, Xin M, Zhou W, Yoon SO, Bongarzone ER, Lu QR.

Dev Cell. 2017 Mar 27;40(6):566-582.e5. doi: 10.1016/j.devcel.2017.03.001.

29.

lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.

He D, Wang J, Lu Y, Deng Y, Zhao C, Xu L, Chen Y, Hu YC, Zhou W, Lu QR.

Neuron. 2017 Jan 18;93(2):362-378. doi: 10.1016/j.neuron.2016.11.044. Epub 2016 Dec 29.

30.

Corrigendum: Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR.

Nat Commun. 2016 Nov 22;7:13767. doi: 10.1038/ncomms13767. No abstract available.

31.

Corrigendum: Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal.

Mateo JL, van den Berg DL, Haeussler M, Drechsel D, Gaber ZB, Castro DS, Robson P, Lu QR, Crawford GE, Flicek P, Ettwiller L, Wittbrodt J, Guillemot F, Martynoga B.

Genome Res. 2016 Nov;26(11):1626. No abstract available.

32.

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y.

J Neurosci. 2016 Oct 12;36(41):10560-10573.

33.

Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum.

Ju J, Liu Q, Zhang Y, Liu Y, Jiang M, Zhang L, He X, Peng C, Zheng T, Lu QR, Li H.

Sci Rep. 2016 Jul 29;6:30711. doi: 10.1038/srep30711.

34.

Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes.

Jiang M, Liu L, He X, Wang H, Lin W, Wang H, Yoon SO, Wood TL, Lu QR.

Nat Commun. 2016 Jul 15;7:12185. doi: 10.1038/ncomms12185. Erratum in: Nat Commun. 2016 Nov 22;7:13767.

35.

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination.

Wu LM, Wang J, Conidi A, Zhao C, Wang H, Ford Z, Zhang L, Zweier C, Ayee BG, Maurel P, Zwijsen A, Chan JR, Jankowski MP, Huylebroeck D, Lu QR.

Nat Neurosci. 2016 Aug;19(8):1060-72. doi: 10.1038/nn.4322. Epub 2016 Jun 13.

36.

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR.

PLoS Biol. 2016 May 23;14(5):e1002467. doi: 10.1371/journal.pbio.1002467. eCollection 2016 May.

37.

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.

Lu F, Chen Y, Zhao C, Wang H, He D, Xu L, Wang J, He X, Deng Y, Lu EE, Liu X, Verma R, Bu H, Drissi R, Fouladi M, Stemmer-Rachamimov AO, Burns D, Xin M, Rubin JB, Bahassi EM, Canoll P, Holland EC, Lu QR.

Cancer Cell. 2016 May 9;29(5):669-683. doi: 10.1016/j.ccell.2016.03.027.

38.

Activation of oligodendroglial Stat3 is required for efficient remyelination.

Steelman AJ, Zhou Y, Koito H, Kim S, Payne HR, Lu QR, Li J.

Neurobiol Dis. 2016 Jul;91:336-46. doi: 10.1016/j.nbd.2016.03.023. Epub 2016 Apr 6.

39.

The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.

Rao R, Salloum R, Xin M, Lu QR.

Cell Cycle. 2016 May 18;15(10):1325-30. doi: 10.1080/15384101.2016.1164371. Review.

40.

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.

Dries DR, Zhu Y, Brooks MM, Forero DA, Adachi M, Cenik B, West JM, Han YH, Yu C, Arbella J, Nordin A, Adolfsson R, Del-Favero J, Lu QR, Callaerts P, Birnbaum SG, Yu G.

J Biol Chem. 2016 May 27;291(22):11647-56. doi: 10.1074/jbc.M116.715078. Epub 2016 Mar 23.

41.

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, Parry L, Goldman SA, Clevers H, Lu QR.

Nat Commun. 2016 Mar 9;7:10883. doi: 10.1038/ncomms10883.

42.

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination.

He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR.

Nat Neurosci. 2016 May;19(5):678-689. doi: 10.1038/nn.4258. Epub 2016 Feb 29.

43.

Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.

Hoffman LM, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani AK, Brudno M, Kumar SS, Drissi R, Dexheimer P, Salloum R, Chow L, Hummel T, Stevenson C, Lu QR, Jones B, Witte D, Aronow B, Hawkins CE, Fouladi M.

Acta Neuropathol Commun. 2016 Feb 9;4:13. doi: 10.1186/s40478-016-0283-x.

44.

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR.

Dev Cell. 2016 Feb 8;36(3):316-30. doi: 10.1016/j.devcel.2016.01.002.

45.

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.

Hoffman LM, DeWire M, Ryall S, Buczkowicz P, Leach J, Miles L, Ramani A, Brudno M, Kumar SS, Drissi R, Dexheimer P, Salloum R, Chow L, Hummel T, Stevenson C, Lu QR, Jones B, Witte D, Aronow B, Hawkins CE, Fouladi M.

Acta Neuropathol Commun. 2016 Jan 4;4:1. doi: 10.1186/s40478-015-0269-0. Erratum in: Acta Neuropathol Commun. 2016;4:13.

46.

Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development.

Diao HJ, Low WC, Lu QR, Chew SY.

Biomaterials. 2015 Nov;70:105-14. doi: 10.1016/j.biomaterials.2015.08.029. Epub 2015 Aug 18.

47.

Transcriptional and Epigenetic Regulation of Oligodendrocyte Development and Myelination in the Central Nervous System.

Emery B, Lu QR.

Cold Spring Harb Perspect Biol. 2015 Jul 1;7(9):a020461. doi: 10.1101/cshperspect.a020461. Review.

48.

Gorlin syndrome and desmoplastic medulloblastoma: Report of 3 cases with unfavorable clinical course and novel mutations.

Gururangan S, Robinson G, Ellison DW, Wu G, He X, Lu QR, McLendon R, Grant G, Driscoll T, Neuberg R.

Pediatr Blood Cancer. 2015 Oct;62(10):1855-8. doi: 10.1002/pbc.25560. Epub 2015 May 4.

49.

G-Protein Gαs controls medulloblastoma initiation by suppressing sonic hedgehog signaling.

He X, Lu QR.

Mol Cell Oncol. 2014 Dec 1;2(2):e975070. doi: 10.4161/23723556.2014.975070. eCollection 2015 Apr-Jun.

50.

Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region.

Liu W, Zhou H, Liu L, Zhao C, Deng Y, Chen L, Wu L, Mandrycky N, McNabb CT, Peng Y, Fuchs PN, Lu J, Sheen V, Qiu M, Mao M, Lu QR.

Neurobiol Dis. 2015 May;77:106-16. doi: 10.1016/j.nbd.2015.02.021. Epub 2015 Mar 5.

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