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[The China National GeneBank─owned by all, completed by all and shared by all].

Wang B, Liu F, Zhang EC, Wo CL, Chen J, Qian PY, Lu HR, Zeng WJ, Chen T, Wei JP, Wan Q, Wang R, Xu X.

Yi Chuan. 2019 Aug 20;41(8):761-772. doi: 10.16288/j.yczz.19-148. Chinese.


Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons.

Kreir M, De Bondt A, Van den Wyngaert I, Teuns G, Lu HR, Gallacher DJ.

Eur J Pharmacol. 2019 Sep 5;858:172474. doi: 10.1016/j.ejphar.2019.172474. Epub 2019 Jun 22.


RNA interference-mediated knockdown of 3, 4-dihydroxyphenylacetaldehyde synthase affects larval development and adult survival in the mosquito Aedes aegypti.

Chen J, Lu HR, Zhang L, Liao CH, Han Q.

Parasit Vectors. 2019 Jun 24;12(1):311. doi: 10.1186/s13071-019-3568-7.


Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.

Lu HR, Zeng H, Kettenhofen R, Guo L, Kopljar I, van Ammel K, Tekle F, Teisman A, Zhai J, Clouse H, Pierson J, Furniss M, Lagrutta A, Sannajust F, Gallacher DJ.

Toxicol Sci. 2019 Aug 1;170(2):345-356. doi: 10.1093/toxsci/kfz102.


Development of a Human iPSC Cardiomyocyte-Based Scoring System for Cardiac Hazard Identification in Early Drug Safety De-risking.

Kopljar I, Lu HR, Van Ammel K, Otava M, Tekle F, Teisman A, Gallacher DJ.

Stem Cell Reports. 2018 Dec 11;11(6):1365-1377. doi: 10.1016/j.stemcr.2018.11.007.


Prognostic value of electrocardiographic time intervals and QT rate dependence in hypertrophic cardiomyopathy.

Robyns T, Nuyens D, Lu HR, Gallacher DJ, Vandenberk B, Garweg C, Ector J, Pagourelias E, Van Cleemput J, Janssens S, Willems R.

J Electrocardiol. 2018 Nov - Dec;51(6):1077-1083. doi: 10.1016/j.jelectrocard.2018.09.005. Epub 2018 Sep 12.


Monitoring reperfused myocardial infarction with delayed left ventricular systolic dysfunction in rabbits by longitudinal imaging.

Feng Y, Hemmeryckx B, Frederix L, Lox M, Wu J, Heggermont W, Lu HR, Gallacher D, Oyen R, Lijnen HR, Ni Y.

Quant Imaging Med Surg. 2018 Sep;8(8):754-769. doi: 10.21037/qims.2018.09.05.


International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment.

Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G.

Cell Rep. 2018 Sep 25;24(13):3582-3592. doi: 10.1016/j.celrep.2018.08.079.


Evaluation of cardiac arrhythmic risks using a rabbit model of left ventricular systolic dysfunction.

Hemmeryckx B, Feng Y, Frederix L, Lox M, Trenson S, Vreeken R, Lu HR, Gallacher D, Ni Y, Lijnen HR.

Eur J Pharmacol. 2018 Aug 5;832:145-155. doi: 10.1016/j.ejphar.2018.05.026. Epub 2018 May 18.


Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study.

Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, Levesque P, Lu HR, Guillon JM, Wu JC, Li Y, Luerman G, Anson B, Guo L, Clements M, Abassi YA, Ross J, Pierson J, Gintant G.

Toxicol Sci. 2018 Aug 1;164(2):550-562. doi: 10.1093/toxsci/kfy110.


Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?

Kreir M, Van Deuren B, Versweyveld S, De Bondt A, Van den Wyngaert I, Van der Linde H, Lu HR, Teuns G, Gallacher DJ.

Toxicol Appl Pharmacol. 2018 May 1;346:45-57. doi: 10.1016/j.taap.2018.03.028. Epub 2018 Mar 26.


Impact of calcium-sensitive dyes on the beating properties and pharmacological responses of human iPS-derived cardiomyocytes using the calcium transient assay.

Kopljar I, Hermans AN, Teisman A, Gallacher DJ, Lu HR.

J Pharmacol Toxicol Methods. 2018 May - Jun;91:80-86. doi: 10.1016/j.vascn.2018.02.004. Epub 2018 Feb 6.


[The Experience of Caring for a Child Suffering From Incontinent Dermatitis].

Lu HR, Chen YJ, Ko YF.

Hu Li Za Zhi. 2017 Dec;64(6):112-118. doi: 10.6224/JN.000090. Chinese.


Response of Robyns to the Tse's letter to editor.

Robyns T, Lu HR, Gallacher DJ, Garweg C, Ector J, Willems R, Janssens S, Nuyens D.

Ann Noninvasive Electrocardiol. 2017 Nov;22(6). doi: 10.1111/anec.12515. No abstract available.


Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity.

Passini E, Britton OJ, Lu HR, Rohrbacher J, Hermans AN, Gallacher DJ, Greig RJH, Bueno-Orovio A, Rodriguez B.

Front Physiol. 2017 Sep 12;8:668. doi: 10.3389/fphys.2017.00668. eCollection 2017.


Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias.

Lu HR, Hortigon-Vinagre MP, Zamora V, Kopljar I, De Bondt A, Gallacher DJ, Smith G.

J Pharmacol Toxicol Methods. 2017 Sep;87:53-67. doi: 10.1016/j.vascn.2017.05.001. Epub 2017 May 10.


Validation of different staging systems for hepatocellular carcinoma in a cohort of 249 patients undergoing radiotherapy.

Zhou ZR, Liu M, Lu HR, Li YF, Liang SX, Zhang CY.

Oncotarget. 2017 Jul 11;8(28):46523-46531. doi: 10.18632/oncotarget.14881.


Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.

Kopljar I, De Bondt A, Vinken P, Teisman A, Damiano B, Goeminne N, Van den Wyngaert I, Gallacher DJ, Lu HR.

Br J Pharmacol. 2017 Nov;174(21):3766-3779. doi: 10.1111/bph.13713. Epub 2017 Feb 8.


Efficacy of three-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus.

Wu FX, Lu HR, Zhu SL, Li ZH, Zou L, Bai T, Chen J, Yang TB, Liang SX.

Onco Targets Ther. 2016 Dec 1;9:7141-7147. eCollection 2016.


Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model.

Lu HR, Gallacher DJ, Yan GX.

J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:151-60. doi: 10.1016/j.vascn.2016.06.006. Epub 2016 Jun 29.


Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR.

Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31.


Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop.

Rodriguez B, Carusi A, Abi-Gerges N, Ariga R, Britton O, Bub G, Bueno-Orovio A, Burton RA, Carapella V, Cardone-Noott L, Daniels MJ, Davies MR, Dutta S, Ghetti A, Grau V, Harmer S, Kopljar I, Lambiase P, Lu HR, Lyon A, Minchole A, Muszkiewicz A, Oster J, Paci M, Passini E, Severi S, Taggart P, Tinker A, Valentin JP, Varro A, Wallman M, Zhou X.

Europace. 2016 Sep;18(9):1287-98. doi: 10.1093/europace/euv320. Epub 2015 Nov 29.


[Adenosine Al Receptor Mediated Neuroprotection of Shenmai Injection on Rat Cerebral Ischemia/Reperfusion Injury: an Experimental Study].

Lu HR, Song SW, Han KY, Liu HP, Chen SD, Wang JL, Dai QX.

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Sep;35(9):1109-12. Chinese.


Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study.

Lin HJ, Du LZ, Ma XL, Shi LP, Pan JH, Tong XM, Li QP, Zhou JG, Yi B, Liu L, Chen YB, Wei QF, Wu HQ, Li M, Liu CQ, Gao XR, Xia SW, Li WB, Yan CY, He L, Liang K, Zhou XY, Han SP, Lyu Q, Qiu YP, Li W, Chen DM, Lu HR, Liu XH, Liu H, Lin ZL, Liu L, Zhu JJ, Xiong H, Yue SJ, Zhuang SQ.

Chin Med J (Engl). 2015 Oct 20;128(20):2743-50. doi: 10.4103/0366-6999.167312.


High Throughput Measurement of Ca++ Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds.

Lu HR, Whittaker R, Price JH, Vega R, Pfeiffer ER, Cerignoli F, Towart R, Gallacher DJ.

Toxicol Sci. 2015 Dec;148(2):503-16. doi: 10.1093/toxsci/kfv201. Epub 2015 Sep 9.


Evaluation of Index of Cardio-Electrophysiological Balance (iCEB) as a New Biomarker for the Identification of Patients at Increased Arrhythmic Risk.

Robyns T, Lu HR, Gallacher DJ, Garweg C, Ector J, Willems R, Janssens S, Nuyens D.

Ann Noninvasive Electrocardiol. 2016 May;21(3):294-304. doi: 10.1111/anec.12309. Epub 2015 Aug 25.


Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis.

Li LN, Jiang KT, Tan P, Wang AH, Kong QY, Wang CY, Lu HR, Wang J.

Asian Pac J Cancer Prev. 2015;16(9):4077-80.


[Anatomy study on the fixation technique of buttress plate in the posterior column of the acetabulum].

Lü HR, He ZY, Wang GC, He JC.

Zhongguo Gu Shang. 2014 Apr;27(4):321-5. Chinese.


Effect of rosiglitazone on liver structure and function in genetically diabetic Akita mice.

Hemmeryckx B, Gaekens M, Gallacher DJ, Lu HR, Lijnen HR.

Basic Clin Pharmacol Toxicol. 2013 Nov;113(5):353-60. doi: 10.1111/bcpt.12104. Epub 2013 Jul 11.


Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology.

Britton OJ, Bueno-Orovio A, Van Ammel K, Lu HR, Towart R, Gallacher DJ, Rodriguez B.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):E2098-105. doi: 10.1073/pnas.1304382110. Epub 2013 May 20.


Hydrogen/deuterium exchange mass spectrometry and site-directed disulfide cross-linking suggest an important dynamic interface between the two lysostaphin domains.

Lu HR, Gu MG, Huang Q, Huang JJ, Lu WY, Lu H, Huang QS.

Antimicrob Agents Chemother. 2013 Apr;57(4):1872-81. doi: 10.1128/AAC.02348-12. Epub 2013 Feb 4.


A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).

Lu HR, Yan GX, Gallacher DJ.

J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):250-259. doi: 10.1016/j.vascn.2013.01.003. Epub 2013 Jan 19.


[Establishment of the human papillomavirus type 31 positive cervical cancer cell line].

Yi JB, Mai ZG, Lu HR, Zhang G, Zhou ZP.

Bing Du Xue Bao. 2012 Sep;28(5):554-9. Chinese.


Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes.

Braam SR, Tertoolen L, Casini S, Matsa E, Lu HR, Teisman A, Passier R, Denning C, Gallacher DJ, Towart R, Mummery CL.

Stem Cell Res. 2013 Jan;10(1):48-56. doi: 10.1016/j.scr.2012.08.007. Epub 2012 Sep 7.


Complex patterns of human antisera reactivity to novel 2009 H1N1 and historical H1N1 influenza strains.

Carter DM, Lu HR, Bloom CE, Crevar CJ, Cherry JL, Lipman DJ, Ross TM.

PLoS One. 2012;7(7):e39435. doi: 10.1371/journal.pone.0039435. Epub 2012 Jul 17.


Direct effects of arsenic trioxide on action potentials in isolated cardiac tissues: importance of the choice of species, type of cardiac tissue and perfusion time.

Lu HR, Vlaminckx E, Cools F, Gallacher DJ.

J Pharmacol Toxicol Methods. 2012 Sep;66(2):135-44. doi: 10.1016/j.vascn.2012.03.002. Epub 2012 Mar 15.


[In vitro effect of iron overload on bone marrow cell function by inducing the reactive oxygen species].

Xie F, Zhao MF, Li YM, Zhu HB, Jiang Y, Xu XN, Xiao X, Mu J, Liu PJ, Lü HR.

Zhonghua Xue Ye Xue Za Zhi. 2011 Sep;32(9):606-9. Chinese.


Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?

Lu HR, Hermans AN, Gallacher DJ.

Br J Pharmacol. 2012 Jun;166(4):1490-502. doi: 10.1111/j.1476-5381.2012.01880.x.


Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2.

Eichenbaum G, Pugsley MK, Gallacher DJ, Towart R, McIntyre G, Shukla U, Davenport JM, Lu HR, Rohrbacher J, Hillsamer V.

Br J Pharmacol. 2012 Jul;166(5):1694-707. doi: 10.1111/j.1476-5381.2012.01874.x.


Enzyme kinetics and molecular modeling studies of G6PD(Mahidol) associated with acute hemolytic anemia.

Lu HR, Tang QL, Wang X, Li HJ, Li DY, Yang YF, Tong SF, Zhang CH, Zhu YC.

Indian J Biochem Biophys. 2011 Oct;48(5):316-24.


[Clinical significance of leukemia stem/progenitor cell related gene expression in acute leukemia].

Zhu HB, Zhao MF, Xie F, Xiao X, Xu XN, Mu J, Yang JW, Liu PJ, Lü HR, Li YM.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Oct;19(5):1150-5. Chinese.


Baculovirus-produced influenza virus-like particles in mammalian cells protect mice from lethal influenza challenge.

Tang XC, Lu HR, Ross TM.

Viral Immunol. 2011 Aug;24(4):311-9. doi: 10.1089/vim.2011.0016.


Hemagglutinin displayed baculovirus protects against highly pathogenic influenza.

Tang XC, Lu HR, Ross TM.

Vaccine. 2010 Oct 4;28(42):6821-31. doi: 10.1016/j.vaccine.2010.08.040. Epub 2010 Aug 18.


Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers.

Lu HR, Rohrbacher J, Vlaminckx E, Van Ammel K, Yan GX, Gallacher DJ.

Br J Pharmacol. 2010 May;160(1):60-76. doi: 10.1111/j.1476-5381.2010.00646.x. Epub 2010 Mar 22.


[Feasible study of the minimal-invasive surgical treatment for the pelvis fractures].

Lü HR, He ZY, Li G, Wang GC, Zhang JJ.

Zhongguo Gu Shang. 2008 Nov;21(11):818-21. Chinese.


Rofecoxib impairs adipose tissue development in a murine model of nutritionally induced obesity.

Lijnen HR, Van Hoef B, Lu HR, Gallacher DJ.

Thromb Haemost. 2008 Aug;100(2):338-42.


Prothrombotic effect of Rofecoxib in a murine venous thrombosis model.

Nagai N, Hoylaerts MF, Gallacher DJ, Lu HR, Lijnen HR.

Thromb Res. 2008;122(5):668-73. doi: 10.1016/j.thromres.2008.04.016. Epub 2008 Jun 20.


Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines.

Lu HR, Vlaminckx E, Hermans AN, Rohrbacher J, Van Ammel K, Towart R, Pugsley M, Gallacher DJ.

Br J Pharmacol. 2008 Aug;154(7):1427-38. doi: 10.1038/bjp.2008.191. Epub 2008 May 19.


In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.

Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.

Eur J Pharmacol. 2007 Dec 22;577(1-3):222-32.


Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: beyond QT prolongation.

Lu HR, Vlaminckx E, Gallacher DJ.

J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):1-8. Epub 2007 Jul 17.


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