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Progression-free Survival Outcome Is Independent of Objective Response in Patients With Estrogen Receptor-positive, Human Epidermal Growth Factor Receptor 2-negative Advanced Breast Cancer Treated With Palbociclib Plus Letrozole Compared With Letrozole: Analysis From PALOMA-2.

Rugo HS, Finn RS, Gelmon K, Joy AA, Harbeck N, Castrellon A, Mukai H, Walshe JM, Mori A, Gauthier E, Lu DR, Bananis E, Martin M, Diéras V.

Clin Breast Cancer. 2019 Sep 5. pii: S1526-8209(19)30668-8. doi: 10.1016/j.clbc.2019.08.009. [Epub ahead of print]


Biomarker Analyses of Response to Cyclin-Dependent Kinase 4/6 Inhibition and Endocrine Therapy in Women with Treatment-Naïve Metastatic Breast Cancer.

Finn RS, Liu Y, Zhu Z, Martin M, Rugo HS, Diéras V, Im SA, Gelmon KA, Harbeck N, Lu DR, Gauthier E, Huang Bartlett C, Slamon DJ.

Clin Cancer Res. 2020 Jan 1;26(1):110-121. doi: 10.1158/1078-0432.CCR-19-0751. Epub 2019 Sep 16.


Efficacy and safety of palbociclib plus endocrine therapy in North American women with hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.

Gelmon KA, Cristofanilli M, Rugo HS, DeMichele AM, Joy AA, Castrellon A, Sleckman B, Mori A, Theall KP, Lu DR, Huang X, Bananis E, Finn RS, Slamon DJ.

Breast J. 2019 Aug 25. doi: 10.1111/tbj.13516. [Epub ahead of print]


Palbociclib with Letrozole in Postmenopausal Women with ER+/HER2- Advanced Breast Cancer: Hematologic Safety Analysis of the Randomized PALOMA-2 Trial.

Diéras V, Harbeck N, Joy AA, Gelmon K, Ettl J, Verma S, Lu DR, Gauthier E, Schnell P, Mori A, Rugo HS, Finn RS.

Oncologist. 2019 Dec;24(12):1514-1525. doi: 10.1634/theoncologist.2019-0019. Epub 2019 Jun 19.


Palbociclib Plus Letrozole as First-Line Therapy in Postmenopausal Asian Women With Metastatic Breast Cancer: Results From the Phase III, Randomized PALOMA-2 Study.

Im SA, Mukai H, Park IH, Masuda N, Shimizu C, Kim SB, Im YH, Ohtani S, Huang Bartlett C, Lu DR, Iyer S, Mori Y, Mori A, Gauthier E, Finn RS, Toi M.

J Glob Oncol. 2019 May;5:1-19. doi: 10.1200/JGO.18.00173.


[Curriculum design and practice of Genetics blended course under the principle of constructive alignment].

Wu YH, Fan HH, Qian R, Zeng Y, Yao Y, Lin J, Lu DR, Ding Y, Qiao SY.

Yi Chuan. 2019 May 20;41(5):439-446. doi: 10.16288/j.yczz.19-035. Chinese.


[Effects of CSN4 knockdown on proliferation and apoptosis of breast cancer MDA-MB-231 cells].

Yu TL, Cai DL, Zhu GF, Ye XJ, Min TS, Chen HY, Lu DR, Chen HM.

Yi Chuan. 2019 Apr 20;41(4):318-326. doi: 10.16288/j.yczz.18-278. Chinese.


Detection of the clarithromycin resistance of Helicobacter pylori in gastric mucosa by the amplification refractory mutation system combined with quantitative real-time PCR.

Zhang XY, Shen WX, Chen CF, Sheng HH, Cheng H, Li J, Hu F, Lu DR, Gao HJ.

Cancer Med. 2019 Apr;8(4):1633-1640. doi: 10.1002/cam4.1986. Epub 2019 Mar 12.


Affinity Maturation of the Anti-Citrullinated Protein Antibody Paratope Drives Epitope Spreading and Polyreactivity in Rheumatoid Arthritis.

Kongpachith S, Lingampalli N, Ju CH, Blum LK, Lu DR, Elliott SE, Mao R, Robinson WH.

Arthritis Rheumatol. 2019 Apr;71(4):507-517. doi: 10.1002/art.40760. Epub 2019 Feb 27.


Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up.

Rugo HS, Finn RS, Diéras V, Ettl J, Lipatov O, Joy AA, Harbeck N, Castrellon A, Iyer S, Lu DR, Mori A, Gauthier ER, Bartlett CH, Gelmon KA, Slamon DJ.

Breast Cancer Res Treat. 2019 Apr;174(3):719-729. doi: 10.1007/s10549-018-05125-4. Epub 2019 Jan 10.


Palbociclib in combination with letrozole in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: PALOMA-2 subgroup analysis of Japanese patients.

Mukai H, Shimizu C, Masuda N, Ohtani S, Ohno S, Takahashi M, Yamamoto Y, Nishimura R, Sato N, Ohsumi S, Iwata H, Mori Y, Hashigaki S, Muramatsu Y, Nagasawa T, Umeyama Y, Lu DR, Toi M.

Int J Clin Oncol. 2019 Mar;24(3):274-287. doi: 10.1007/s10147-018-1353-9. Epub 2018 Dec 4.


[The development of genetics teaching in China in the last four decades and its future prospect].

Chen F, Lu DR, Zhang FX, Zhang GF.

Yi Chuan. 2018 Oct 20;40(10):916-923. doi: 10.16288/j.yczz.18-171. Review. Chinese.


Expanded-Access Study of Palbociclib in Combination With Letrozole for Treatment of Postmenopausal Women With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer.

Stearns V, Brufsky AM, Verma S, Cotter MJ, Lu DR, Dequen F, Joy AA.

Clin Breast Cancer. 2018 Dec;18(6):e1239-e1245. doi: 10.1016/j.clbc.2018.07.007. Epub 2018 Jul 30.


Long-term Pooled Safety Analysis of Palbociclib in Combination With Endocrine Therapy for HR+/HER2- Advanced Breast Cancer.

Diéras V, Rugo HS, Schnell P, Gelmon K, Cristofanilli M, Loi S, Colleoni M, Lu DR, Mori A, Gauthier E, Huang Bartlett C, Slamon DJ, Turner NC, Finn RS.

J Natl Cancer Inst. 2019 Apr 1;111(4):419-430. doi: 10.1093/jnci/djy109.


T Cell-Dependent Affinity Maturation and Innate Immune Pathways Differentially Drive Autoreactive B Cell Responses in Rheumatoid Arthritis.

Lu DR, McDavid AN, Kongpachith S, Lingampalli N, Glanville J, Ju CH, Gottardo R, Robinson WH.

Arthritis Rheumatol. 2018 Nov;70(11):1732-1744. doi: 10.1002/art.40578. Epub 2018 Sep 24.


Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma.

Yun DP, Wang YQ, Meng DL, Ji YY, Chen JX, Chen HY, Lu DR.

Oncol Rep. 2018 Mar;39(3):1011-1022. doi: 10.3892/or.2018.6225. Epub 2018 Jan 22.


Impact of palbociclib plus letrozole on patient-reported health-related quality of life: results from the PALOMA-2 trial.

Rugo HS, Diéras V, Gelmon KA, Finn RS, Slamon DJ, Martin M, Neven P, Shparyk Y, Mori A, Lu DR, Bhattacharyya H, Bartlett CH, Iyer S, Johnston S, Ettl J, Harbeck N.

Ann Oncol. 2018 Apr 1;29(4):888-894. doi: 10.1093/annonc/mdy012.


Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer.

Durairaj C, Ruiz-Garcia A, Gauthier ER, Huang X, Lu DR, Hoffman JT, Finn RS, Joy AA, Ettl J, Rugo HS, Zheng J, Wilner KD, Wang DD.

Anticancer Drugs. 2018 Mar;29(3):271-280. doi: 10.1097/CAD.0000000000000589.


Clinical considerations of the role of palbociclib in the management of advanced breast cancer patients with and without visceral metastases.

Turner NC, Finn RS, Martin M, Im SA, DeMichele A, Ettl J, Diéras V, Moulder S, Lipatov O, Colleoni M, Cristofanilli M, Lu DR, Mori A, Giorgetti C, Iyer S, Bartlett CH, Gelmon KA.

Ann Oncol. 2018 Mar 1;29(3):669-680. doi: 10.1093/annonc/mdx797.


Application of AFP whole blood one-step rapid detection kit in screening for HCC in Qidong.

Jin J, Zhang XY, Shi JL, Xue XF, Lu LL, Lu JH, Jiang XP, Hu JF, Duan BS, Yang CQ, Lu DR, Lu DL, Chen JG, Gao HJ.

Am J Cancer Res. 2017 Jun 1;7(6):1384-1388. eCollection 2017.


Association between polymorphisms of autophagy pathway and responses in non-small cell lung cancer patients treated with platinum-based chemotherapy.

Wang SM, Song X, Zhao XY, Chen HY, Wang JC, Wu JJ, Gao ZQ, Qian J, Bai CX, Li Q, Han BH, Lu DR.

Yi Chuan. 2017 Mar 20;39(3):250-262. doi: 10.16288/j.yczz.16-294.


Palbociclib and Letrozole in Advanced Breast Cancer.

Finn RS, Martin M, Rugo HS, Jones S, Im SA, Gelmon K, Harbeck N, Lipatov ON, Walshe JM, Moulder S, Gauthier E, Lu DR, Randolph S, Diéras V, Slamon DJ.

N Engl J Med. 2016 Nov 17;375(20):1925-1936.


IFIT1 polymorphisms predict interferon-α treatment efficiency for hepatitis B virus infection.

Xie DY, Wang SM, Yang JM, Wang LH, Chen HY, Huai C, Shang J, Mao Q, Lei CL, Luo GH, Qian J, Lu DR.

World J Gastroenterol. 2016 Nov 28;22(44):9813-9821.


Sunitinib in pancreatic neuroendocrine tumors: updated progression-free survival and final overall survival from a phase III randomized study.

Faivre S, Niccoli P, Castellano D, Valle JW, Hammel P, Raoul JL, Vinik A, Van Cutsem E, Bang YJ, Lee SH, Borbath I, Lombard-Bohas C, Metrakos P, Smith D, Chen JS, Ruszniewski P, Seitz JF, Patyna S, Lu DR, Ishak KJ, Raymond E.

Ann Oncol. 2017 Feb 1;28(2):339-343. doi: 10.1093/annonc/mdw561.


Locked nucleic acid couples with Fok I nucleases to target and cleave hepatitis B virus's gene in vitro.

Ma L, Chen HY, Zhu HX, Li W, Lu DR.

Yi Chuan. 2016 Apr;38(4):350-9. doi: 10.16288/j.yczz.15-435.


[The applications of thermostable ligase chain reaction in facilitating DNA recombination].

Zhou XD, Song X, Huai C, Sun HY, Chen HY, Lu DR.

Yi Chuan. 2016 Feb;38(2):163-9. doi: 10.16288/j.yczz.15-428. Chinese.


[A quick and efficient method to generate hemophilia B mouse models by the CRISPR/Cas system].

Wang QH, Huai C, Sun R, Zhuang H, Chen HY, Fei J, Lu DR.

Yi Chuan. 2015 Nov;37(11):1143-8. doi: 10.16288/j.yczz.15-117. Chinese.


FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia.

de Claro RA, McGinn KM, Verdun N, Lee SL, Chiu HJ, Saber H, Brower ME, Chang CJ, Pfuma E, Habtemariam B, Bullock J, Wang Y, Nie L, Chen XH, Lu DR, Al-Hakim A, Kane RC, Kaminskas E, Justice R, Farrell AT, Pazdur R.

Clin Cancer Res. 2015 Aug 15;21(16):3586-90. doi: 10.1158/1078-0432.CCR-14-2225.


Prostate cancer antigen 3 and genetic risk score as markers for the detection of prostate cancer in the Chinese population.

Wei HM, Chen HT, Wang P, Wu YS, Na R, Liu F, Sun JS, Jiang DK, Lu DR, Xu J.

Asian J Androl. 2015 Jan-Feb;17(1):168-70. doi: 10.4103/1008-682X.143245. No abstract available.


Street-experienced peripheral B cells traffic to the brain.

Lu DR, Robinson WH.

Sci Transl Med. 2014 Aug 6;6(248):248fs31. doi: 10.1126/scitranslmed.3009919.


Barcode-enabled sequencing of plasmablast antibody repertoires in rheumatoid arthritis.

Tan YC, Kongpachith S, Blum LK, Ju CH, Lahey LJ, Lu DR, Cai X, Wagner CA, Lindstrom TM, Sokolove J, Robinson WH.

Arthritis Rheumatol. 2014 Oct;66(10):2706-15. doi: 10.1002/art.38754.


[Extraction of sperm DNA from mixed stain by the modified differential lysis method combined with silicon bead method].

Han HJ, Zhang YH, Yang M, Yi H, Yang GY, Jia DT, Lu DR.

Fa Yi Xue Za Zhi. 2014 Feb;30(1):50-1, 54. Chinese.


Identifying functional anti-Staphylococcus aureus antibodies by sequencing antibody repertoires of patient plasmablasts.

Lu DR, Tan YC, Kongpachith S, Cai X, Stein EA, Lindstrom TM, Sokolove J, Robinson WH.

Clin Immunol. 2014 May-Jun;152(1-2):77-89. doi: 10.1016/j.clim.2014.02.010. Epub 2014 Mar 1.


Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma.

Hutson TE, Escudier B, Esteban E, Bjarnason GA, Lim HY, Pittman KB, Senico P, Niethammer A, Lu DR, Hariharan S, Motzer RJ.

J Clin Oncol. 2014 Mar 10;32(8):760-7. doi: 10.1200/JCO.2013.50.3961. Epub 2013 Dec 2.


Density gradient separation of carborane-containing liposome from low density lipoprotein and detection by inductively coupled plasma spectrometry.

Alanazi FK, Lu DR, Shakeel F, Haq N.

J Liposome Res. 2014 Mar;24(1):53-8. doi: 10.3109/08982104.2013.833224. Epub 2013 Sep 5.


[Exploration on human blood type case in teaching practice of genetics].

Pi Y, Li XY, Huai C, Wang SM, Qiao SY, Lu DR.

Yi Chuan. 2013 Aug;35(8):1040-4. Chinese.


[Duplex genotyping of CYP2C19*2 and CYP2C19*3 by high-resolution melting curve analysis].

Cao CG, Sun HY, Zhou FF, Wang SM, Chen HY, Lu DR.

Yi Chuan. 2013 Jul;35(7):923-30. Chinese.


[Analysis of cloud spectral structure characteristics based on cloud profile radar data].

Han Y, Lü DR.

Guang Pu Xue Yu Guang Pu Fen Xi. 2013 Apr;33(4):911-5. Chinese.


XBP1 promoter polymorphism modulates platinum-based chemotherapy gastrointestinal toxicity for advanced non-small cell lung cancer patients.

Peng J, Chen YY, Yang LX, Zhao XY, Gao ZQ, Yang J, Wu WT, Wang HJ, Wang JC, Qian J, Chen HY, Jin L, Bai CX, Han BH, Lu DR.

Lung Cancer. 2013 Jun;80(3):333-8. doi: 10.1016/j.lungcan.2013.02.012. Epub 2013 Mar 16.


VCP gene variation predicts outcome of advanced non-small-cell lung cancer platinum-based chemotherapy.

Peng J, Yang LX, Zhao XY, Gao ZQ, Yang J, Wu WT, Wang HJ, Wang JC, Qian J, Chen HY, Jin L, Bai CX, Han BH, Wang WM, Lu DR.

Tumour Biol. 2013 Apr;34(2):953-61. doi: 10.1007/s13277-012-0631-9. Epub 2013 Feb 15.


[Screening and identification of 36 new STR loci in human Y chromosome].

Peng DB, Jiang ZW, Sun SP, Li CH, Lu DR.

Yi Chuan. 2012 Nov;34(11):1409-16. Chinese.


Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population.

Gui MH, Li X, Jiang SF, Gao J, Lu DR, Gao X.

Diabetes Res Clin Pract. 2012 Sep;97(3):499-504. doi: 10.1016/j.diabres.2012.05.011. Epub 2012 Jun 28.


Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release.

Pan YJ, Chen YY, Wang DR, Wei C, Guo J, Lu DR, Chu CC, Wang CC.

Biomaterials. 2012 Sep;33(27):6570-9. doi: 10.1016/j.biomaterials.2012.05.062. Epub 2012 Jun 15.


Interspecific germline transmission of cultured primordial germ cells.

van de Lavoir MC, Collarini EJ, Leighton PA, Fesler J, Lu DR, Harriman WD, Thiyagasundaram TS, Etches RJ.

PLoS One. 2012;7(5):e35664. doi: 10.1371/journal.pone.0035664. Epub 2012 May 21.


The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population.

Li XM, Ling Y, Lu DR, Lu ZQ, Liu Y, Chen HY, Gao X.

Hypertens Res. 2012 Oct;35(10):994-9. doi: 10.1038/hr.2012.79. Epub 2012 May 17.


[Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population].

Zhang XB, Zhao ZH, Chen HY, Wang JC, Qian J, Yang YJ, Wei QY, Huang J, Lu DR.

Yi Chuan. 2011 Aug;33(8):886-94. Chinese.


Association of the aldosterone synthase gene -344T>C polymorphism with essential hypertension and glucose homeostasis: a case-control study in a Han Chinese population.

Li XM, Ling Y, Lu DR, Lu ZQ, Yi QL, Liu Y, Chen HY, Gao X.

Clin Exp Pharmacol Physiol. 2011 Sep;38(9):598-604. doi: 10.1111/j.1440-1681.2011.05555.x.


Association between fibroblast growth factor receptor 4 polymorphisms and risk of hepatocellular carcinoma.

Yang Y, Zhou Y, Lu M, An Y, Li R, Chen Y, Lu DR, Jin L, Zhou WP, Qian J, Wang HY.

Mol Carcinog. 2012 Jul;51(7):515-21. doi: 10.1002/mc.20805. Epub 2011 Jun 7.


[High-resolution melting analysis for the detection of EGFR mutations in circulating DNA of lung cancer patients].

Zhao J, Peng QX, Yang BH, Lu DR.

Zhonghua Yi Xue Za Zhi. 2011 Mar 15;91(10):674-8. Chinese.


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