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Epigenome-wide association study of leukocyte telomere length.

Lee Y, Sun D, Ori APS, Lu AT, Seeboth A, Harris SE, Deary IJ, Marioni RE, Soerensen M, Mengel-From J, Hjelmborg J, Christensen K, Wilson JG, Levy D, Reiner AP, Chen W, Li S, Harris JR, Magnus P, Aviv A, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Aug 26;11(16):5876-5894. doi: 10.18632/aging.102230. Epub 2019 Aug 26.


DNA methylation-based estimator of telomere length.

Lu AT, Seeboth A, Tsai PC, Sun D, Quach A, Reiner AP, Kooperberg C, Ferrucci L, Hou L, Baccarelli AA, Li Y, Harris SE, Corley J, Taylor A, Deary IJ, Stewart JD, Whitsel EA, Assimes TL, Chen W, Li S, Mangino M, Bell JT, Wilson JG, Aviv A, Marioni RE, Raj K, Horvath S.

Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. doi: 10.18632/aging.102173. Epub 2019 Aug 18.


Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels.

Lee Y, Choufani S, Weksberg R, Wilson SL, Yuan V, Burt A, Marsit C, Lu AT, Ritz B, Bohlin J, Gjessing HK, Harris JR, Magnus P, Binder AM, Robinson WP, Jugessur A, Horvath S.

Aging (Albany NY). 2019 Jun 24;11(12):4238-4253. doi: 10.18632/aging.102049.


Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.

Horvath S, Lu AT, Cohen H, Raj K.

Aging (Albany NY). 2019 May 26;11(10):3238-3249. doi: 10.18632/aging.101976.


Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson's Disease.

Chuang YH, Lu AT, Paul KC, Folle AD, Bronstein JM, Bordelon Y, Horvath S, Ritz B.

J Parkinsons Dis. 2019;9(2):389-400. doi: 10.3233/JPD-181549.


DNA methylation GrimAge strongly predicts lifespan and healthspan.

Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S.

Aging (Albany NY). 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684.


Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies.

Horvath S, Oshima J, Martin GM, Lu AT, Quach A, Cohen H, Felton S, Matsuyama M, Lowe D, Kabacik S, Wilson JG, Reiner AP, Maierhofer A, Flunkert J, Aviv A, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Ferrucci L, Matsuyama S, Raj K.

Aging (Albany NY). 2018 Jul 26;10(7):1758-1775. doi: 10.18632/aging.101508.


An epigenetic biomarker of aging for lifespan and healthspan.

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S.

Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414.


GWAS of epigenetic aging rates in blood reveals a critical role for TERT.

Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, Joehanes R, Murabito JM, Kiel DP, Tsai PC, Yet I, Bell JT, Mangino M, Tanaka T, McRae AF, Marioni RE, Visscher PM, Wray NR, Deary IJ, Levine ME, Quach A, Assimes T, Tsao PS, Absher D, Stewart JD, Li Y, Reiner AP, Hou L, Baccarelli AA, Whitsel EA, Aviv A, Cardona A, Day FR, Wareham NJ, Perry JRB, Ong KK, Raj K, Lunetta KL, Horvath S.

Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5.


Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.

Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S.

Nat Commun. 2017 May 18;8:15353. doi: 10.1038/ncomms15353.


Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.

Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S.

Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168.


DNA methylation-based measures of biological age: meta-analysis predicting time to death.

Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S.

Aging (Albany NY). 2016 Sep 28;8(9):1844-1865. doi: 10.18632/aging.101020.


An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.

Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL, Absher D, Assimes TL.

Genome Biol. 2016 Aug 11;17(1):171. doi: 10.1186/s13059-016-1030-0.


Menopause accelerates biological aging.

Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, Ritz BR, Absher D, Assimes TL, Horvath S.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9327-32. doi: 10.1073/pnas.1604558113. Epub 2016 Jul 25.


Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S.

Nat Commun. 2016 Feb 2;7:10561. doi: 10.1038/ncomms10561.


The cerebellum ages slowly according to the epigenetic clock.

Horvath S, Mah V, Lu AT, Woo JS, Choi OW, Jasinska AJ, Riancho JA, Tung S, Coles NS, Braun J, Vinters HV, Coles LS.

Aging (Albany NY). 2015 May;7(5):294-306.


Identifying rare-variant associations in parent-child trios using a Gaussian support vector machine.

Lu AT, Cantor RM.

BMC Proc. 2014 Jun 17;8(Suppl 1 Genetic Analysis Workshop 18Vanessa Olmo):S98. doi: 10.1186/1753-6561-8-S1-S98. eCollection 2014.


Applications of machine learning and data mining methods to detect associations of rare and common variants with complex traits.

Lu AT, Austin E, Bonner A, Huang HH, Cantor RM.

Genet Epidemiol. 2014 Sep;38 Suppl 1:S81-5. doi: 10.1002/gepi.21830.


Support for calcium channel gene defects in autism spectrum disorders.

Lu AT, Dai X, Martinez-Agosto JA, Cantor RM.

Mol Autism. 2012 Dec 15;3(1):18. doi: 10.1186/2040-2392-3-18.


Characteristics of colorectal cancer survival in an urban county hospital.

Lam VK, Lu AT, Kouzminova N, Lin AY.

J Gastrointest Cancer. 2013 Mar;44(1):68-72. doi: 10.1007/s12029-012-9446-6.


Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine Leiomyomata.

Eggert SL, Huyck KL, Somasundaram P, Kavalla R, Stewart EA, Lu AT, Painter JN, Montgomery GW, Medland SE, Nyholt DR, Treloar SA, Zondervan KT, Heath AC, Madden PA, Rose L, Buring JE, Ridker PM, Chasman DI, Martin NG, Cantor RM, Morton CC.

Am J Hum Genet. 2012 Oct 5;91(4):621-8. doi: 10.1016/j.ajhg.2012.08.009.


Combining information from 3 anatomic regions in the diagnosis of glaucoma with time-domain optical coherence tomography.

Wang M, Lu AT, Varma R, Schuman JS, Greenfield DS, Huang D; Advanced Imaging for Glaucoma Study Group.

J Glaucoma. 2014 Mar;23(3):129-35. doi: 10.1097/IJG.0b013e318264b941.


Does optic nerve head size variation affect circumpapillary retinal nerve fiber layer thickness measurement by optical coherence tomography?

Huang D, Chopra V, Lu AT, Tan O, Francis B, Varma R; Advanced Imaging for Glaucoma Study-AIGS Group.

Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4990-7. doi: 10.1167/iovs.11-8214.


Prediction of serotonin transporter promoter polymorphism genotypes from single nucleotide polymorphism arrays using machine learning methods.

Lu AT, Bakker S, Janson E, Cichon S, Cantor RM, Ophoff RA.

Psychiatr Genet. 2012 Aug;22(4):182-8. doi: 10.1097/YPG.0b013e328353ae23.


QTL replication and targeted association highlight the nerve growth factor gene for nonverbal communication deficits in autism spectrum disorders.

Lu AT, Yoon J, Geschwind DH, Cantor RM.

Mol Psychiatry. 2013 Feb;18(2):226-35. doi: 10.1038/mp.2011.155. Epub 2011 Nov 22.


Effect of KRAS mutational status in advanced colorectal cancer on the outcomes of anti-epidermal growth factor receptor monoclonal antibody therapy: a systematic review and meta-analysis.

Lin AY, Buckley NS, Lu AT, Kouzminova NB, Salpeter SR.

Clin Colorectal Cancer. 2011 Mar 1;10(1):63-9. doi: 10.3816/CCC.2011.n.009. Review.


Allowing for sex differences increases power in a GWAS of multiplex Autism families.

Lu AT, Cantor RM.

Mol Psychiatry. 2012 Feb;17(2):215-22. doi: 10.1038/mp.2010.127. Epub 2010 Dec 14.


Outbreak of neonatal gastroenteritis associated with astrovirus serotype 1 at a hospital in Inner Mongolia, China.

Li CY, Liu N, Guo WD, Yu Q, Wang WR, Song ZZ, Yan H, Luo Y, Lu AT, Li HY, Zhu L, Duan ZJ.

J Clin Microbiol. 2010 Nov;48(11):4306-9. doi: 10.1128/JCM.00797-10. Epub 2010 Sep 1.


Gene expression profiles as predictors of poor outcomes in stage II colorectal cancer: A systematic review and meta-analysis.

Lu AT, Salpeter SR, Reeve AE, Eschrich S, Johnston PG, Barrier AJ, Bertucci F, Buckley NS, Salpeter EE, Lin AY.

Clin Colorectal Cancer. 2009 Oct;8(4):207-14. doi: 10.3816/CCC.2009.n.035. Review.


Reproducibility of tear meniscus measurement by Fourier-domain optical coherence tomography: a pilot study.

Zhou S, Li Y, Lu AT, Liu P, Tang M, Yiu SC, Huang D.

Ophthalmic Surg Lasers Imaging. 2009 Sep-Oct;40(5):442-7. doi: 10.3928/15428877-20090901-01.


Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography.

Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D.

Ophthalmology. 2009 Dec;116(12):2305-14.e1-2. doi: 10.1016/j.ophtha.2009.05.025. Epub 2009 Sep 10.


Keratoconus diagnosis with optical coherence tomography pachymetry mapping.

Li Y, Meisler DM, Tang M, Lu AT, Thakrar V, Reiser BJ, Huang D.

Ophthalmology. 2008 Dec;115(12):2159-66. doi: 10.1016/j.ophtha.2008.08.004. Epub 2008 Nov 5.


Nicotine aerosol generation from thermally reversible zinc halide complexes using the Staccato system.

Simis K, Lei M, Lu AT, Sharma KC, Hale RL, Timmons R, Cassella J.

Drug Dev Ind Pharm. 2008 Sep;34(9):936-42. doi: 10.1080/03639040802149061 .


Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy.

Alasil T, Tan O, Lu AT, Huang D, Sadun AA.

Ophthalmic Surg Lasers Imaging. 2008 Jul-Aug;39(4 Suppl):S71-9. doi: 10.3928/15428877-20080715-03.


Combining nerve fiber layer parameters to optimize glaucoma diagnosis with optical coherence tomography.

Lu AT, Wang M, Varma R, Schuman JS, Greenfield DS, Smith SD, Huang D; Advanced Imaging for Glaucoma Study Group.

Ophthalmology. 2008 Aug;115(8):1352-7, 1357.e1-2. doi: 10.1016/j.ophtha.2008.01.011. Epub 2008 Jun 2.


Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder.

Lu AT, Ogdie MN, Järvelin MR, Moilanen IK, Loo SK, McCracken JT, McGough JJ, Yang MH, Peltonen L, Nelson SF, Cantor RM, Smalley SL.

Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1488-94. doi: 10.1002/ajmg.b.30693.


Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis.

Tan O, Li G, Lu AT, Varma R, Huang D; Advanced Imaging for Glaucoma Study Group.

Ophthalmology. 2008 Jun;115(6):949-56. Epub 2007 Nov 5.


Weighted variance FBAT: a powerful method for including covariates in FBAT analyses.

Lu AT, Cantor RM.

Genet Epidemiol. 2007 May;31(4):327-37.


The effect of film thickness on thermal aerosol generation.

Myers DJ, Timmons RD, Lu AT, Hale RL, Solas DW, Soni P, Rabinowitz JD.

Pharm Res. 2007 Feb;24(2):336-42. Epub 2006 Dec 19.


A 12-year follow-up study of psychiatric symptomatology among cocaine-dependent men.

Herbeck DM, Hser YI, Lu AT, Stark ME, Paredes A.

Addict Behav. 2006 Nov;31(11):1974-87. Epub 2006 Feb 28.


Cell surface expression of single chain antibodies with applications to imaging of gene expression in vivo.

Northrop JP, Bednarski M, Barbieri SO, Lu AT, Nguyen D, Varadarajan J, Osen M, Li KC, Star-Lack J.

Eur J Nucl Med Mol Imaging. 2003 Sep;30(9):1292-8. Epub 2003 Jun 25.


A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH.

J Med Chem. 2002 Dec 5;45(25):5492-505.


Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format.

Silen JL, Lu AT, Solas DW, Gore MA, MacLean D, Shah NH, Coffin JM, Bhinderwala NS, Wang Y, Tsutsui KT, Look GC, Campbell DA, Hale RL, Navre M, DeLuca-Flaherty CR.

Antimicrob Agents Chemother. 1998 Jun;42(6):1447-53.


Dissolution modeling: factors affecting the dissolution rates of polydisperse powders.

Lu AT, Frisella ME, Johnson KC.

Pharm Res. 1993 Sep;10(9):1308-14.


Light-directed, spatially addressable parallel chemical synthesis.

Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D.

Science. 1991 Feb 15;251(4995):767-73.


Case for diagnosis. AIDS.

Macher AM, Parisi JE, Aksamit AJ, Smirniotopoulos JG, Chase R, Lu AT, Bauserman SC, Grant KF, Nelson AM, Connor DH.

Mil Med. 1986 May;151(5):M25-32. No abstract available.


Sustained downgaze deviation. Two cases without structural pretectal lesions.

Keane JR, Rawlinson RG, Lu AT.

Neurology. 1976 Jun;26(6 PT 1):594-5.


Neurocutaneous melanosis with malignant leptomeningeal melanoma. A case with metastases outside the nervous system.

Kaplan AM, Itabashi HH, Hanelin LG, Lu AT.

Arch Neurol. 1975 Oct;32(10):669-71.


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