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LRRC14 attenuates Toll-like receptor-mediated NF-kappaB signaling through disruption of IKK complex.
Wu C, Yang Y, Ou J, Zhu L, Zhao W, Cui J. Wu C, et al. Exp Cell Res. 2016 Sep 10;347(1):65-73. doi: 10.1016/j.yexcr.2016.07.011. Epub 2016 Jul 15. Exp Cell Res. 2016. PMID: 27426725
Expression of LRRC14 resulted in decreased activation of NF-kappaB, whereas knockdown of LRRC14 enhanced NF-kappaB activation as well as the production of inflammatory cytokines. ...In addition, our data showed that TLR signaling led to lower expression of LRRC14 …
Expression of LRRC14 resulted in decreased activation of NF-kappaB, whereas knockdown of LRRC14 enhanced NF-kappaB activation …
The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter.
Uwanogho DA, Yasin SA, Starling B, Price J. Uwanogho DA, et al. Gene. 2010 Jan 1;449(1-2):103-17. doi: 10.1016/j.gene.2009.08.011. Epub 2009 Aug 28. Gene. 2010. PMID: 19720120
Here we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a novel member of the LRR gene family, on the opposite strand. Regulation of Lrrc14 expression is highly complex, involving multiple promo …
Here we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14; a nov …
Genetic Signatures of Selection for Cashmere Traits in Chinese Goats.
Jin M, Lu J, Fei X, Lu Z, Quan K, Liu Y, Chu M, Di R, Wang H, Wei C. Jin M, et al. Animals (Basel). 2020 Oct 18;10(10):1905. doi: 10.3390/ani10101905. Animals (Basel). 2020. PMID: 33080940 Free PMC article.
Several genes were related to hair follicle development, such as TRPS1, WDR74, LRRC14, SPTLC3, IGF1R, PADI2, FOXP1, WNT10A and CSN3. Gene enrichment analysis of these cashmere trait-associated genes related 67 enriched signaling pathways that mainly participate in hair fol …
Several genes were related to hair follicle development, such as TRPS1, WDR74, LRRC14, SPTLC3, IGF1R, PADI2, FOXP1, WNT10A and CSN3. …
Identification of genes showing altered DNA methylation and gene expression in the renal proximal tubular cells of rats treated with ochratoxin A for 13 weeks.
Ozawa S, Ojiro R, Tang Q, Zou X, Woo GH, Yoshida T, Shibutani M. Ozawa S, et al. J Appl Toxicol. 2023 Oct;43(10):1533-1548. doi: 10.1002/jat.4495. Epub 2023 May 22. J Appl Toxicol. 2023. PMID: 37162024
Other genes that did not cluster under any GO term included Lrrc14 involved in NF-kappaB-mediated inflammation, Gen1 linked to DNA repair, Has1 related to chromosomal aberration, and Anxa3 involved in tumor development and progression. ...
Other genes that did not cluster under any GO term included Lrrc14 involved in NF-kappaB-mediated inflammation, Gen1 linked to DNA re …
High density genome wide genotyping-by-sequencing and association identifies common and low frequency SNPs, and novel candidate genes influencing cow milk traits.
Ibeagha-Awemu EM, Peters SO, Akwanji KA, Imumorin IG, Zhao X. Ibeagha-Awemu EM, et al. Sci Rep. 2016 Aug 10;6:31109. doi: 10.1038/srep31109. Sci Rep. 2016. PMID: 27506634 Free PMC article.
Novel potential candidate genes for milk traits or mammary gland functions include ERCC6, TONSL, NPAS2, ACER3, ITGB4, GGT6, ACOX3, MECR, ADAM12, ACHE, LRRC14, FUK, NPRL3, EVL, SLCO3A1, PSMA4, FTO, ADCK5, PP1R16A and TEP1. ...
Novel potential candidate genes for milk traits or mammary gland functions include ERCC6, TONSL, NPAS2, ACER3, ITGB4, GGT6, ACOX3, MECR, ADA …