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Items: 18

1.

The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.

Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ, Morrow DM, Davenport EA, Lozinskaya IM, Guss J, Basilla JB, Negron LK, Klein M, Willette RN, Fries RE, Jensen TC, Xu X, Schnackenberg CG, Marino JP Jr.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. doi: 10.1016/j.bmcl.2013.06.047. Epub 2013 Jun 26.

PMID:
23886683
2.

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype.

Ivashchenko CY, Pipes GC, Lozinskaya IM, Lin Z, Xiaoping X, Needle S, Grygielko ET, Hu E, Toomey JR, Lepore JJ, Willette RN.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H913-22. doi: 10.1152/ajpheart.00819.2012. Epub 2013 Jul 5.

3.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

4.

Characterizing the role of Thr352 in the inhibition of the large conductance Ca2+-activated K+ channels by 1-[1-hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone.

Gordon E, Semus SF, Lozinskaya IM, Lin Z, Xu X.

J Pharmacol Exp Ther. 2010 Aug;334(2):402-9. doi: 10.1124/jpet.110.166017. Epub 2010 Apr 29.

PMID:
20430843
5.

Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells.

Xu X, Gordon E, Lin Z, Lozinskaya IM, Chen Y, Thorneloe KS.

Channels (Austin). 2009 May-Jun;3(3):156-60. Epub 2009 May 24.

PMID:
19411839
6.

1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone, a potent and highly selective small molecule blocker of the large-conductance voltage-gated and calcium-dependent K+ channel.

Zeng H, Gordon E, Lin Z, Lozinskaya IM, Willette RN, Xu X.

J Pharmacol Exp Ther. 2008 Oct;327(1):168-77. doi: 10.1124/jpet.108.139733. Epub 2008 Jun 30.

PMID:
18591221
7.

Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.

Willette RN, Bao W, Nerurkar S, Yue TL, Doe CP, Stankus G, Turner GH, Ju H, Thomas H, Fishman CE, Sulpizio A, Behm DJ, Hoffman S, Lin Z, Lozinskaya I, Casillas LN, Lin M, Trout RE, Votta BJ, Thorneloe K, Lashinger ES, Figueroa DJ, Marquis R, Xu X.

J Pharmacol Exp Ther. 2008 Aug;326(2):443-52. doi: 10.1124/jpet.107.134551. Epub 2008 May 22. Erratum in: J Pharmacol Exp Ther. 2011 Jul;338(1):408-9.

PMID:
18499744
8.

Ca2+ channel inactivation in small mesenteric arteries of WKY and SHR.

Cox RH, Lozinskaya IM.

Am J Hypertens. 2008 Apr;21(4):406-12. doi: 10.1038/ajh.2007.73. Epub 2008 Jan 31. Erratum in: Am J Hypertens. 2012 Sep;25(9):1036-7.

PMID:
18246058
9.

2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.

Gordon E, Lozinskaya IM, Lin Z, Semus SF, Blaney FE, Willette RN, Xu X.

Mol Pharmacol. 2008 Mar;73(3):639-51. Epub 2007 Nov 27.

PMID:
18042732
10.

Acetic acid opens large-conductance Ca2+-activated K+ channels in guinea pig detrusor smooth muscle cells.

Ghatta S, Lozinskaya I, Lin Z, Gordon E, Willette RN, Brooks DP, Xu X.

Eur J Pharmacol. 2007 Jun 1;563(1-3):203-8. Epub 2007 Feb 27.

PMID:
17382925
11.

Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

Zeng H, Lozinskaya IM, Lin Z, Willette RN, Brooks DP, Xu X.

J Pharmacol Exp Ther. 2006 Nov;319(2):957-62. Epub 2006 Aug 23.

PMID:
16928897
13.

Ramipril treatment alters Ca(2+) and K(+) channels in small mesenteric arteries from Wistar-Kyoto and spontaneously hypertensive rats.

Cox RH, Lozinskaya I, Matsuda K, Dietz NJ.

Am J Hypertens. 2002 Oct;15(10 Pt 1):879-90.

PMID:
12372675
14.

Differences in K+ current components in mesenteric artery myocytes from WKY and SHR.

Cox RH, Lozinskaya I, Dietz NJ.

Am J Hypertens. 2001 Sep;14(9 Pt 1):897-907.

PMID:
11587156
15.
16.
17.

Augmented calcium currents in mesenteric artery branches of the spontaneously hypertensive rat.

Cox RH, Lozinskaya IM.

Hypertension. 1995 Dec;26(6 Pt 2):1060-4.

PMID:
7498968
18.

Basic studies of local adsorption in burn treatment.

Sakhno LA, Nikolaev VG, Lozinskaya IA, Yudin VM, Vovyanko SI.

Biomater Artif Cells Immobilization Biotechnol. 1991;19(1):111-28.

PMID:
1751663

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