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Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence.

Ohashi M, Korsakova E, Allen D, Lee P, Fu K, Vargas BS, Cinkornpumin J, Salas C, Park JC, Germanguz I, Langerman J, Chronis C, Kuoy E, Tran S, Xiao X, Pellegrini M, Plath K, Lowry WE.

Stem Cell Reports. 2018 May 8;10(5):1453-1463. doi: 10.1016/j.stemcr.2018.04.001.


A small molecule screen to identify regulators of let-7 targets.

Cinkornpumin J, Roos M, Nguyen L, Liu X, Gaeta X, Lin S, Chan DN, Liu A, Gregory RI, Jung M, Chute J, Zhu H, Lowry WE.

Sci Rep. 2017 Nov 21;7(1):15973. doi: 10.1038/s41598-017-16258-9.


Topical Inhibition of the Electron Transport Chain Can Stimulate the Hair Cycle.

Miranda M, Christofk H, Jones DL, Lowry WE.

J Invest Dermatol. 2018 Apr;138(4):968-972. doi: 10.1016/j.jid.2017.10.021. Epub 2017 Oct 26. No abstract available.


Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.

Moon H, Donahue LR, Choi E, Scumpia PO, Lowry WE, Grenier JK, Zhu J, White AC.

Cell Stem Cell. 2017 Nov 2;21(5):665-678.e6. doi: 10.1016/j.stem.2017.09.001. Epub 2017 Oct 12.


Differentiation of RPE cells from integration-free iPS cells and their cell biological characterization.

Hazim RA, Karumbayaram S, Jiang M, Dimashkie A, Lopes VS, Li D, Burgess BL, Vijayaraj P, Alva-Ornelas JA, Zack JA, Kohn DB, Gomperts BN, Pyle AD, Lowry WE, Williams DS.

Stem Cell Res Ther. 2017 Oct 2;8(1):217. doi: 10.1186/s13287-017-0652-9.


Manipulation of neural progenitor fate through the oxygen sensing pathway.

Xie Y, Lowry WE.

Methods. 2018 Jan 15;133:44-53. doi: 10.1016/j.ymeth.2017.08.018. Epub 2017 Aug 31. Review.


Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J.

Nat Cell Biol. 2017 Sep;19(9):1027-1036. doi: 10.1038/ncb3593. Epub 2017 Aug 14.


Lactate dehydrogenase activity drives hair follicle stem cell activation.

Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE.

Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14.


Defining Transcriptional Regulatory Mechanisms for Primary let-7 miRNAs.

Gaeta X, Le L, Lin Y, Xie Y, Lowry WE.

PLoS One. 2017 Jan 4;12(1):e0169237. doi: 10.1371/journal.pone.0169237. eCollection 2017.


Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach.

Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST.

Data Brief. 2016 Nov 24;10:202-209. eCollection 2017 Feb.


Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation.

Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJP, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K.

Cell Rep. 2017 Jan 3;18(1):54-67. doi: 10.1016/j.celrep.2016.11.054. Epub 2016 Dec 16.


RNA editing as an activator of self-renewal in cancer.

Germanguz I, Lowry WE.

Stem Cell Investig. 2016 Oct 31;3:68. eCollection 2016. No abstract available.


Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.

Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR.

Cell Stem Cell. 2016 Oct 6;19(4):476-490. doi: 10.1016/j.stem.2016.08.008. Epub 2016 Sep 8.


Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain.

Moshayedi P, Nih LR, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST.

Biomaterials. 2016 Oct;105:145-55. doi: 10.1016/j.biomaterials.2016.07.028. Epub 2016 Aug 2.


Exploiting Mouse Models to Study Ras-Induced Cutaneous Squamous Cell Carcinoma.

Lowry WE, Flores A, White AC.

J Invest Dermatol. 2016 Aug;136(8):1543-8. doi: 10.1016/j.jid.2016.03.017. Epub 2016 May 7. Review.


Identifying gene expression modules that define human cell fates.

Germanguz I, Listgarten J, Cinkornpumin J, Solomon A, Gaeta X, Lowry WE.

Stem Cell Res. 2016 May;16(3):712-24. doi: 10.1016/j.scr.2016.04.008. Epub 2016 Apr 13.


Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell-induced squamous cell carcinoma.

Flores A, Grant W, White AC, Scumpia P, Takahashi R, Lowry WE.

Exp Dermatol. 2016 Sep;25(9):733-5. doi: 10.1111/exd.13037. Epub 2016 Jun 30. No abstract available.


Hmga2 is dispensable for cutaneous squamous cell carcinoma.

White A, Flores A, Ong J, Lowry WE.

Exp Dermatol. 2016 May;25(5):409-12. doi: 10.1111/exd.12978.


Creating Conditions for Policy Change in National Parks: Contrasting Cases in Yellowstone and Yosemite.

Yochim MJ, Lowry WR.

Environ Manage. 2016 May;57(5):1041-53. doi: 10.1007/s00267-016-0677-3. Epub 2016 Feb 16.


The expansion of thymopoiesis in neonatal mice is dependent on expression of high mobility group a 2 protein (Hmga2).

Berent-Maoz B, Montecino-Rodriguez E, Fice M, Casero D, Seet CS, Crooks GM, Lowry W, Dorshkind K.

PLoS One. 2015 May 1;10(5):e0125414. doi: 10.1371/journal.pone.0125414. eCollection 2015.


Defining the role of oxygen tension in human neural progenitor fate.

Xie Y, Zhang J, Lin Y, Gaeta X, Meng X, Wisidagama DR, Cinkornpumin J, Koehler CM, Malone CS, Teitell MA, Lowry WE.

Stem Cell Reports. 2014 Nov 11;3(5):743-57. doi: 10.1016/j.stemcr.2014.09.021. Epub 2014 Oct 30.


Hydrogel design of experiments methodology to optimize hydrogel for iPSC-NPC culture.

Lam J, Carmichael ST, Lowry WE, Segura T.

Adv Healthc Mater. 2015 Mar 11;4(4):534-9. doi: 10.1002/adhm.201400410. Epub 2014 Nov 5.


let-7 miRNAs can act through notch to regulate human gliogenesis.

Patterson M, Gaeta X, Loo K, Edwards M, Smale S, Cinkornpumin J, Xie Y, Listgarten J, Azghadi S, Douglass SM, Pellegrini M, Lowry WE.

Stem Cell Reports. 2014 Nov 11;3(5):758-73. doi: 10.1016/j.stemcr.2014.08.015. Epub 2014 Oct 3.


Refining the role for adult stem cells as cancer cells of origin.

White AC, Lowry WE.

Trends Cell Biol. 2015 Jan;25(1):11-20. doi: 10.1016/j.tcb.2014.08.008. Epub 2014 Sep 18. Review.


Stem cell quiescence acts as a tumour suppressor in squamous tumours.

White AC, Khuu JK, Dang CY, Hu J, Tran KV, Liu A, Gomez S, Zhang Z, Yi R, Scumpia P, Grigorian M, Lowry WE.

Nat Cell Biol. 2014 Jan;16(1):99-107. doi: 10.1038/ncb2889. Epub 2013 Dec 15.


Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status.

Awe JP, Lee PC, Ramathal C, Vega-Crespo A, Durruthy-Durruthy J, Cooper A, Karumbayaram S, Lowry WE, Clark AT, Zack JA, Sebastiano V, Kohn DB, Pyle AD, Martin MG, Lipshutz GS, Phelps PE, Pera RA, Byrne JA.

Stem Cell Res Ther. 2013 Jul 26;4(4):87. doi: 10.1186/scrt246.


-Oh no! hiPSCs misplace their 5hmCs.

Lowry WE.

Cell Stem Cell. 2013 Jul 3;13(1):10-1. doi: 10.1016/j.stem.2013.06.007.


Sequential addition of reprogramming factors improves efficiency.

Gaeta X, Xie Y, Lowry WE.

Nat Cell Biol. 2013 Jul;15(7):725-7. doi: 10.1038/ncb2800.


SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs.

Lee P, Martin NT, Nakamura K, Azghadi S, Amiri M, Ben-David U, Perlman S, Gatti RA, Hu H, Lowry WE.

Nat Commun. 2013;4:1824. doi: 10.1038/ncomms2824.


The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation.

Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A.

EMBO J. 2013 May 15;32(10):1393-408. doi: 10.1038/emboj.2013.78. Epub 2013 Apr 12.


PTK7 marks the first human developmental EMT in vitro.

Chan DN, Azghadi SF, Feng J, Lowry WE.

PLoS One. 2012;7(11):e50432. doi: 10.1371/journal.pone.0050432. Epub 2012 Nov 28.


From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.

Karumbayaram S, Lee P, Azghadi SF, Cooper AR, Patterson M, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE.

Stem Cells Transl Med. 2012 Jan;1(1):36-43. doi: 10.5966/sctm.2011-0001. Epub 2011 Dec 7.


Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo.

Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B.

J Virol. 2013 Feb;87(4):2094-108. doi: 10.1128/JVI.02032-12. Epub 2012 Nov 28. Erratum in: J Virol. 2013 Apr;87(8):4794.


Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?

Lowry WE.

Curr Opin Genet Dev. 2012 Oct;22(5):429-34. doi: 10.1016/j.gde.2012.07.003. Epub 2012 Oct 15. Review.


Dynamic distribution of linker histone H1.5 in cellular differentiation.

Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK.

PLoS Genet. 2012;8(8):e1002879. doi: 10.1371/journal.pgen.1002879. Epub 2012 Aug 30.


Physically associated synthetic hydrogels with long-term covalent stabilization for cell culture and stem cell transplantation.

Zhang J, Tokatlian T, Zhong J, Ng QK, Patterson M, Lowry WE, Carmichael ST, Segura T.

Adv Mater. 2011 Nov 16;23(43):5098-103. doi: 10.1002/adma.201103349. Epub 2011 Oct 14. No abstract available.


Defining the nature of human pluripotent stem cell progeny.

Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE.

Cell Res. 2012 Jan;22(1):178-93. doi: 10.1038/cr.2011.133. Epub 2011 Aug 16.


E-cadherin, a new mixer in the Yamanaka cocktail.

Lowry WE.

EMBO Rep. 2011 Jul 1;12(7):613-4. doi: 10.1038/embor.2011.117. No abstract available.


Defining the origins of Ras/p53-mediated squamous cell carcinoma.

White AC, Tran K, Khuu J, Dang C, Cui Y, Binder SW, Lowry WE.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7425-30. doi: 10.1073/pnas.1012670108. Epub 2011 Apr 18.


Progress in understanding reprogramming to the induced pluripotent state.

Plath K, Lowry WE.

Nat Rev Genet. 2011 Apr;12(4):253-65. doi: 10.1038/nrg2955. Review.


Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.

Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT, Plath K, Lowry WE, Benvenisty N.

Cell Stem Cell. 2010 Oct 8;7(4):521-31. doi: 10.1016/j.stem.2010.07.017.


Female human iPSCs retain an inactive X chromosome.

Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K.

Cell Stem Cell. 2010 Sep 3;7(3):329-42. doi: 10.1016/j.stem.2010.06.024. Epub 2010 Aug 19.


Molecular analyses of human induced pluripotent stem cells and embryonic stem cells.

Chin MH, Pellegrini M, Plath K, Lowry WE.

Cell Stem Cell. 2010 Aug 6;7(2):263-9. doi: 10.1016/j.stem.2010.06.019.


Roadblocks en route to the clinical application of induced pluripotent stem cells.

Lowry WE, Quan WL.

J Cell Sci. 2010 Mar 1;123(Pt 5):643-51. doi: 10.1242/jcs.054304.


Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.

Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG.

Hum Mol Genet. 2010 Apr 15;19(8):1603-17. doi: 10.1093/hmg/ddq036. Epub 2010 Jan 27.


Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.

Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K, Lowry WE.

Cell Stem Cell. 2009 Jul 2;5(1):111-23. doi: 10.1016/j.stem.2009.06.008.


Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.

Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE.

Stem Cells. 2009 Apr;27(4):806-11. doi: 10.1002/stem.31.


Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.

Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT.

Stem Cells. 2009 Apr;27(4):783-95. doi: 10.1002/stem.13.

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