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Items: 1 to 50 of 75

1.

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel syndrome.

Llorens-Agost M, Luessing J, van Beneden A, Eykelenboom J, O'Reilly D, Bicknell LS, Reynolds JJ, van Koegelenberg M, Hurles ME, Brady AF, Jackson AP, Stewart GS, Lowndes NF.

Hum Mutat. 2018 Dec;39(12):1847-1853. doi: 10.1002/humu.23648. Epub 2018 Sep 24.

PMID:
30199583
2.

The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs.

Calvo-Asensio I, Dillon ET, Lowndes NF, Ceredig R.

Front Physiol. 2018 Apr 26;9:439. doi: 10.3389/fphys.2018.00439. eCollection 2018.

3.

Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.

Bueno MTD, Baldascini M, Richard S, Lowndes NF.

Oncotarget. 2018 Mar 23;9(22):15915-15930. doi: 10.18632/oncotarget.24636. eCollection 2018 Mar 23.

4.

Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression.

Connaughton EP, Naicker S, Hanley SA, Slevin SM, Eykelenboom JK, Lowndes NF, O'Brien T, Ceredig R, Griffin MD, Dennedy MC.

Immunol Cell Biol. 2018 Mar 5. doi: 10.1111/imcb.12032. [Epub ahead of print]

PMID:
29505094
5.

Correction for Travesa et al., "Repression of G1/S Transcription Is Mediated via Interaction of the GTB Motifs of Nrm1 and Whi5 with Swi6".

Travesa A, Kalashnikova TI, de Bruin RAM, Cass SR, Chahwan C, Lee DE, Lowndes NF, Wittenberg C.

Mol Cell Biol. 2017 Jul 28;37(16). pii: e00272-17. doi: 10.1128/MCB.00272-17. Print 2017 Aug 15. No abstract available.

6.

Analysis of Biphenyl-Type Inhibitors Targeting the Eg5 α4/α6 Allosteric Pocket.

Gao C, Lowndes NF, Eriksson LA.

ACS Omega. 2017 May 31;2(5):1836-1849. doi: 10.1021/acsomega.6b00467. Epub 2017 May 5.

7.

Differential Response of Mouse Thymic Epithelial Cell Types to Ionizing Radiation-Induced DNA Damage.

Calvo-Asensio I, Barthlott T, von Muenchow L, Lowndes NF, Ceredig R.

Front Immunol. 2017 Apr 13;8:418. doi: 10.3389/fimmu.2017.00418. eCollection 2017.

8.

Correction: The RSF1 Histone-Remodelling Factor Facilitates DNA Double Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins.

Pessina F, Lowndes NF.

PLoS Biol. 2017 Feb 1;15(2):e1002595. doi: 10.1371/journal.pbio.1002595. eCollection 2017 Feb.

9.

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.

Moureau S, Luessing J, Harte EC, Voisin M, Lowndes NF.

Open Biol. 2016 Sep;6(9). pii: 160225.

10.

BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells.

Draga M, Madgett EB, Vandenberg CJ, du Plessis D, Kaufmann A, Werler P, Chakraborty P, Lowndes NF, Hiom K.

Mol Cell Biol. 2015 Nov;35(22):3829-40. doi: 10.1128/MCB.01497-14. Epub 2015 Aug 31.

11.

Rational design and validation of a Tip60 histone acetyltransferase inhibitor.

Gao C, Bourke E, Scobie M, Famme MA, Koolmeister T, Helleday T, Eriksson LA, Lowndes NF, Brown JA.

Sci Rep. 2014 Jun 20;4:5372. doi: 10.1038/srep05372.

12.

The RSF1 histone-remodelling factor facilitates DNA double-strand break repair by recruiting centromeric and Fanconi Anaemia proteins.

Pessina F, Lowndes NF.

PLoS Biol. 2014 May 6;12(5):e1001856. doi: 10.1371/journal.pbio.1001856. eCollection 2014 May. Erratum in: PLoS Biol. 2017 Feb 1;15(2):e1002595.

13.

Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells.

Sugrue T, Lowndes NF, Ceredig R.

Stem Cells. 2014 Aug;32(8):2188-200. doi: 10.1002/stem.1683.

14.

ATR activates the S-M checkpoint during unperturbed growth to ensure sufficient replication prior to mitotic onset.

Eykelenboom JK, Harte EC, Canavan L, Pastor-Peidro A, Calvo-Asensio I, Llorens-Agost M, Lowndes NF.

Cell Rep. 2013 Nov 27;5(4):1095-107. doi: 10.1016/j.celrep.2013.10.027. Epub 2013 Nov 21.

15.

Binding specificity of the G1/S transcriptional regulators in budding yeast.

Harris MR, Lee D, Farmer S, Lowndes NF, de Bruin RA.

PLoS One. 2013 Apr 4;8(4):e61059. doi: 10.1371/journal.pone.0061059. Print 2013.

16.

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.

Abreu CM, Kumar R, Hamilton D, Dawdy AW, Creavin K, Eivers S, Finn K, Balsbaugh JL, O'Connor R, Kiely PA, Shabanowitz J, Hunt DF, Grenon M, Lowndes NF.

PLoS Genet. 2013 Apr;9(4):e1003310. doi: 10.1371/journal.pgen.1003310. Epub 2013 Apr 4.

17.

Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6.

Travesa A, Kalashnikova TI, de Bruin RA, Cass SR, Chahwan C, Lee DE, Lowndes NF, Wittenberg C.

Mol Cell Biol. 2013 Apr;33(8):1476-86. doi: 10.1128/MCB.01333-12. Epub 2013 Feb 4. Erratum in: Mol Cell Biol. 2017 Jul 28;37(16):.

18.

Mesenchymal stromal cells: radio-resistant members of the bone marrow.

Sugrue T, Lowndes NF, Ceredig R.

Immunol Cell Biol. 2013 Jan;91(1):5-11. doi: 10.1038/icb.2012.61. Epub 2012 Nov 20. Review.

PMID:
23165606
19.

Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines.

Sugrue T, Brown JA, Lowndes NF, Ceredig R.

Stem Cells. 2013 Jan;31(1):137-45. doi: 10.1002/stem.1222.

20.

ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.

Shigechi T, Tomida J, Sato K, Kobayashi M, Eykelenboom JK, Pessina F, Zhang Y, Uchida E, Ishiai M, Lowndes NF, Yamamoto K, Kurumizaka H, Maehara Y, Takata M.

Cancer Res. 2012 Mar 1;72(5):1149-56. doi: 10.1158/0008-5472.CAN-11-2904. Epub 2012 Jan 18.

21.

Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity.

Brown JA, Eykelenboom JK, Lowndes NF.

FEBS Open Bio. 2012 Sep 29;2:313-7. doi: 10.1016/j.fob.2012.09.008. Print 2012.

22.

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.

Finn K, Lowndes NF, Grenon M.

Cell Mol Life Sci. 2012 May;69(9):1447-73. doi: 10.1007/s00018-011-0875-3. Epub 2011 Nov 15. Review.

PMID:
22083606
23.

Modification of histones by sugar β-N-acetylglucosamine (GlcNAc) occurs on multiple residues, including histone H3 serine 10, and is cell cycle-regulated.

Zhang S, Roche K, Nasheuer HP, Lowndes NF.

J Biol Chem. 2011 Oct 28;286(43):37483-95. doi: 10.1074/jbc.M111.284885. Epub 2011 Sep 6.

24.

Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor.

FitzGerald J, Moureau S, Drogaris P, O'Connell E, Abshiru N, Verreault A, Thibault P, Grenon M, Lowndes NF.

PLoS One. 2011 Feb 24;6(2):e14714. doi: 10.1371/journal.pone.0014714.

25.

The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer.

Lowndes NF.

DNA Repair (Amst). 2010 Oct 5;9(10):1112-6. doi: 10.1016/j.dnarep.2010.07.012. Epub 2010 Aug 17.

PMID:
20724228
26.

Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity.

Granata M, Lazzaro F, Novarina D, Panigada D, Puddu F, Abreu CM, Kumar R, Grenon M, Lowndes NF, Plevani P, Muzi-Falconi M.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001047. doi: 10.1371/journal.pgen.1001047. Erratum in: PLoS Genet. 2014 Jun; 10(6): e1004535.

27.

Enhanced protein detection using a trapping mode on a hybrid quadrupole linear ion trap (Q-Trap).

Drogaris P, Le Blanc JC, Fitzgerald JE, Lowndes NF, Verreault A, Thibault P.

Anal Chem. 2009 Aug 1;81(15):6300-9. doi: 10.1021/ac9004259.

PMID:
20337398
28.

Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56.

Costelloe T, Lowndes NF.

Subcell Biochem. 2010;50:43-54. doi: 10.1007/978-90-481-3471-7_3. Review.

PMID:
20012576
29.

MRN and the race to the break.

Rupnik A, Lowndes NF, Grenon M.

Chromosoma. 2010 Apr;119(2):115-35. doi: 10.1007/s00412-009-0242-4. Epub 2009 Oct 28. Review.

PMID:
19862546
30.

53BP1: function and mechanisms of focal recruitment.

FitzGerald JE, Grenon M, Lowndes NF.

Biochem Soc Trans. 2009 Aug;37(Pt 4):897-904. doi: 10.1042/BST0370897. Review.

PMID:
19614615
31.

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.

Nakahara M, Sonoda E, Nojima K, Sale JE, Takenaka K, Kikuchi K, Taniguchi Y, Nakamura K, Sumitomo Y, Bree RT, Lowndes NF, Takeda S.

PLoS Genet. 2009 Jan;5(1):e1000356. doi: 10.1371/journal.pgen.1000356. Epub 2009 Jan 30.

32.

Autofluorescent proteins.

Dobbie IM, Lowndes NF, Sullivan KF.

Methods Cell Biol. 2008;85:1-22. Review.

PMID:
18155456
33.

An investigation into 53BP1 complex formation.

Roche KC, Lowndes NF.

Adv Exp Med Biol. 2007;604:47-57.

PMID:
17695720
34.

Transcriptional response of Candida parapsilosis following exposure to farnesol.

Rossignol T, Logue ME, Reynolds K, Grenon M, Lowndes NF, Butler G.

Antimicrob Agents Chemother. 2007 Jul;51(7):2304-12. Erratum in: Antimicrob Agents Chemother. 2008 Jun;52(6):2296.

35.

Comparisons between DT40 wildtype and DT40-Cre1 cells as suitable model systems for studying the DNA damage response.

Bree RT, Lai XY, Canavan LE, Lowndes NF.

Cell Cycle. 2007 Sep 15;6(18):2310-3. Epub 2007 Jul 10. No abstract available.

PMID:
17671434
36.
37.

Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain.

Grenon M, Costelloe T, Jimeno S, O'Shaughnessy A, Fitzgerald J, Zgheib O, Degerth L, Lowndes NF.

Yeast. 2007 Feb;24(2):105-19.

38.

Chromatin modulation and the DNA damage response.

Costelloe T, Fitzgerald J, Murphy NJ, Flaus A, Lowndes NF.

Exp Cell Res. 2006 Aug 15;312(14):2677-86. Epub 2006 Jun 30. Review.

PMID:
16893724
39.

Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation.

Grenon M, Magill CP, Lowndes NF, Jackson SP.

FEMS Yeast Res. 2006 Aug;6(5):836-47.

40.

Multiple approaches to study S. cerevisiae Rad9, a prototypical checkpoint protein.

O'Shaughnessy AM, Grenon M, Gilbert C, Toh GW, Green CM, Lowndes NF.

Methods Enzymol. 2006;409:131-50.

PMID:
16793399
41.

Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.

Toh GW, O'Shaughnessy AM, Jimeno S, Dobbie IM, Grenon M, Maffini S, O'Rorke A, Lowndes NF.

DNA Repair (Amst). 2006 Jun 10;5(6):693-703. Epub 2006 May 2.

PMID:
16650810
42.

Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks.

Nakamura K, Sakai W, Kawamoto T, Bree RT, Lowndes NF, Takeda S, Taniguchi Y.

DNA Repair (Amst). 2006 Jun 10;5(6):741-9. Epub 2006 Apr 27.

PMID:
16644291
43.

DNA repair: the importance of phosphorylating histone H2AX.

Lowndes NF, Toh GW.

Curr Biol. 2005 Feb 8;15(3):R99-R102. Review.

44.

The switch from survival responses to apoptosis after chromosomal breaks.

Bree RT, Neary C, Samali A, Lowndes NF.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):989-95. Review.

PMID:
15279785
45.

Purification and analysis of checkpoint protein complexes from Saccharomyces cerevisiae.

Green CM, Lowndes NF.

Methods Mol Biol. 2004;280:291-306.

PMID:
15187261
46.

Remodelling the Rad9 checkpoint complex: preparing Rad53 for action.

van den Bosch M, Lowndes NF.

Cell Cycle. 2004 Feb;3(2):119-22.

PMID:
14712069
47.

The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function.

Gilbert CS, van den Bosch M, Green CM, Vialard JE, Grenon M, Erdjument-Bromage H, Tempst P, Lowndes NF.

EMBO Rep. 2003 Oct;4(10):953-8. Epub 2003 Sep 5.

48.

The MRN complex: coordinating and mediating the response to broken chromosomes.

van den Bosch M, Bree RT, Lowndes NF.

EMBO Rep. 2003 Sep;4(9):844-9. Review.

49.

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.

Redon C, Pilch DR, Rogakou EP, Orr AH, Lowndes NF, Bonner WM.

EMBO Rep. 2003 Jul;4(7):678-84.

50.

Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage.

Toh GW, Lowndes NF.

Biochem Soc Trans. 2003 Feb;31(Pt 1):242-6. Review.

PMID:
12546694

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