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Items: 22


Deuteration protects asparagine residues against racemization.

Lowenson JD, Shmanai VV, Shklyaruck D, Clarke SG, Shchepinov MS.

Amino Acids. 2016 Sep;48(9):2189-96. doi: 10.1007/s00726-016-2250-z. Epub 2016 May 12.


Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice.

Yang H, Lowenson JD, Clarke S, Zubarev RA.

J Proteome Res. 2013 Oct 4;12(10):4566-76. doi: 10.1021/pr400688r. Epub 2013 Sep 10.


An Arabidopsis ATP-dependent, DEAD-box RNA helicase loses activity upon IsoAsp formation but is restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE.

Nayak NR, Putnam AA, Addepalli B, Lowenson JD, Chen T, Jankowsky E, Perry SE, Dinkins RD, Limbach PA, Clarke SG, Downie AB.

Plant Cell. 2013 Jul;25(7):2573-86. doi: 10.1105/tpc.113.113456. Epub 2013 Jul 31.


Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.

MacKay KB, Lowenson JD, Clarke SG.

PLoS One. 2012;7(10):e46719. doi: 10.1371/journal.pone.0046719. Epub 2012 Oct 5.


Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping.

Alfaro JF, Gillies LA, Sun HG, Dai S, Zang T, Klaene JJ, Kim BJ, Lowenson JD, Clarke SG, Karger BL, Zhou ZS.

Anal Chem. 2008 May 15;80(10):3882-9. doi: 10.1021/ac800251q. Epub 2008 Apr 18.


Intracellular protein modification associated with altered T cell functions in autoimmunity.

Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ.

J Immunol. 2006 Oct 1;177(7):4541-9. Erratum in: J Immunol. 2006 Dec 15;177(12):8878.


Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme.

Vigneswara V, Lowenson JD, Powell CD, Thakur M, Bailey K, Clarke S, Ray DE, Carter WG.

J Biol Chem. 2006 Oct 27;281(43):32619-29. Epub 2006 Aug 21.


Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.

Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW.

J Biol Chem. 2006 Mar 31;281(13):8389-98. Epub 2006 Jan 27.


A new type of protein methylation activated by tyrphostin A25 and vanadate.

Miranda TB, Lowenson JD, Clarke S.

FEBS Lett. 2004 Nov 5;577(1-2):181-6.


Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice.

Lowenson JD, Kim E, Young SG, Clarke S.

J Biol Chem. 2001 Jun 8;276(23):20695-702. Epub 2001 Mar 7.


Chemical modifications of deposited amyloid-beta peptides.

Lowenson JD, Clarke S, Roher AE.

Methods Enzymol. 1999;309:89-105. No abstract available.


Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase.

Kim E, Lowenson JD, Clarke S, Young SG.

J Biol Chem. 1999 Jul 16;274(29):20671-8.


Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice.

Kim E, Lowenson JD, MacLaren DC, Clarke S, Young SG.

Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6132-7.


D-aspartate content of erythrocyte membrane proteins is decreased in uremia: implications for the repair of damaged proteins.

Perna AF, D'Aniello A, Lowenson JD, Clarke S, De Santo NG, Ingrosso D.

J Am Soc Nephrol. 1997 Jan;8(1):95-104.


Protein aging Extracellular amyloid formation and intracellular repair.

Lowenson JD, Roher AE, Clarke S.

Trends Cardiovasc Med. 1994 Jan-Feb;4(1):3-8. doi: 10.1016/1050-1738(94)90019-1.


beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10836-40.


Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

Roher AE, Lowenson JD, Clarke S, Wolkow C, Wang R, Cotter RJ, Reardon IM, Z├╝rcher-Neely HA, Heinrikson RL, Ball MJ, et al.

J Biol Chem. 1993 Feb 15;268(5):3072-83.

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