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Items: 1 to 50 of 53

1.

Versatile and on-demand biologics co-production in yeast.

Cao J, Perez-Pinera P, Lowenhaupt K, Wu MR, Purcell O, de la Fuente-Nunez C, Lu TK.

Nat Commun. 2018 Jan 8;9(1):77. doi: 10.1038/s41467-017-02587-w.

2.

Production of Functional Anti-Ebola Antibodies in Pichia pastoris.

Purcell O, Opdensteinen P, Chen W, Lowenhaupt K, Brown A, Hermann M, Cao J, Tenhaef N, Kallweit E, Kastilan R, Sinskey AJ, Perez-Pinera P, Buyel JF, Lu TK.

ACS Synth Biol. 2017 Dec 15;6(12):2183-2190. doi: 10.1021/acssynbio.7b00234. Epub 2017 Aug 17.

PMID:
28786662
3.

Incorporation of CC steps into Z-DNA: interplay between B-Z junction and Z-DNA helical formation.

Bothe JR, Lowenhaupt K, Al-Hashimi HM.

Biochemistry. 2012 Aug 28;51(34):6871-9. Epub 2012 Aug 17.

4.

Sequence-specific B-DNA flexibility modulates Z-DNA formation.

Bothe JR, Lowenhaupt K, Al-Hashimi HM.

J Am Chem Soc. 2011 Feb 23;133(7):2016-8. doi: 10.1021/ja1073068. Epub 2011 Jan 28.

5.

Alternate rRNA secondary structures as regulators of translation.

Feng S, Li H, Zhao J, Pervushin K, Lowenhaupt K, Schwartz TU, Dröge P.

Nat Struct Mol Biol. 2011 Feb;18(2):169-76. doi: 10.1038/nsmb.1962. Epub 2011 Jan 9.

PMID:
21217697
6.

Characterization of DNA-binding activity of Z alpha domains from poxviruses and the importance of the beta-wing regions in converting B-DNA to Z-DNA.

Quyen DV, Ha SC, Lowenhaupt K, Rich A, Kim KK, Kim YG.

Nucleic Acids Res. 2007;35(22):7714-20. Epub 2007 Nov 5.

7.

A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1.

Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A.

Structure. 2007 Apr;15(4):395-404.

8.

A peptide with alternating lysines can act as a highly specific Z-DNA binding domain.

Kim YG, Park HJ, Kim KK, Lowenhaupt K, Rich A.

Nucleic Acids Res. 2006;34(17):4937-42. Epub 2006 Sep 18.

9.

Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases.

Ha SC, Lowenhaupt K, Rich A, Kim YG, Kim KK.

Nature. 2005 Oct 20;437(7062):1183-6.

PMID:
16237447
10.

The crystal structure of the Zbeta domain of the RNA-editing enzyme ADAR1 reveals distinct conserved surfaces among Z-domains.

Athanasiadis A, Placido D, Maas S, Brown BA 2nd, Lowenhaupt K, Rich A.

J Mol Biol. 2005 Aug 19;351(3):496-507.

PMID:
16023667
11.

A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.

Rothenburg S, Deigendesch N, Dittmar K, Koch-Nolte F, Haag F, Lowenhaupt K, Rich A.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1602-7. Epub 2005 Jan 19.

12.

A poxvirus protein forms a complex with left-handed Z-DNA: crystal structure of a Yatapoxvirus Zalpha bound to DNA.

Ha SC, Lokanath NK, Van Quyen D, Wu CA, Lowenhaupt K, Rich A, Kim YG, Kim KK.

Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14367-72. Epub 2004 Sep 24.

13.

The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.

Kahmann JD, Wecking DA, Putter V, Lowenhaupt K, Kim YG, Schmieder P, Oschkinat H, Rich A, Schade M.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2712-7. Epub 2004 Feb 23.

14.

Evidence that vaccinia virulence factor E3L binds to Z-DNA in vivo: Implications for development of a therapy for poxvirus infection.

Kim YG, Lowenhaupt K, Oh DB, Kim KK, Rich A.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1514-8. Epub 2004 Feb 2.

15.

Parsing the effects of binding, signaling, and trafficking on the mitogenic potencies of granulocyte colony-stimulating factor analogues.

Sarkar CA, Lowenhaupt K, Wang PJ, Horan T, Lauffenburger DA.

Biotechnol Prog. 2003 May-Jun;19(3):955-64.

PMID:
12790662
16.

A role for Z-DNA binding in vaccinia virus pathogenesis.

Kim YG, Muralinath M, Brandt T, Pearcy M, Hauns K, Lowenhaupt K, Jacobs BL, Rich A.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6974-9. Epub 2003 May 30.

17.

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching".

Sarkar CA, Lowenhaupt K, Horan T, Boone TC, Tidor B, Lauffenburger DA.

Nat Biotechnol. 2002 Sep;20(9):908-13. Epub 2002 Aug 5.

PMID:
12161759
18.

Crystallization of the Zalpha domain of the human editing enzyme ADAR1 complexed with a DNA-RNA chimeric oligonucleotide in the left-handed Z-conformation.

Brown BA 2nd, Athanasiadis A, Hanlon EB, Lowenhaupt K, Wilbert CM, Rich A.

Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):120-3. Epub 2001 Dec 21.

PMID:
11752786
19.

Another protozoan contributes to understanding telomeres and transposable elements.

Pardue ML, DeBaryshe PG, Lowenhaupt K.

Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14195-7. Review. No abstract available.

20.

Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.

Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A.

Nat Struct Biol. 2001 Sep;8(9):761-5.

PMID:
11524677
21.

The zalpha domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA.

Brown BA 2nd, Lowenhaupt K, Wilbert CM, Hanlon EB, Rich A.

Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13532-6.

22.

The zab domain of the human RNA editing enzyme ADAR1 recognizes Z-DNA when surrounded by B-DNA.

Kim YG, Lowenhaupt K, Maas S, Herbert A, Schwartz T, Rich A.

J Biol Chem. 2000 Sep 1;275(35):26828-33.

23.

The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.

Schade M, Turner CJ, Kühne R, Schmieder P, Lowenhaupt K, Herbert A, Rich A, Oschkinat H.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12465-70.

24.

A 6 bp Z-DNA hairpin binds two Z alpha domains from the human RNA editing enzyme ADAR1.

Schade M, Behlke J, Lowenhaupt K, Herbert A, Rich A, Oschkinat H.

FEBS Lett. 1999 Sep 10;458(1):27-31.

25.

Crystallization and preliminary studies of the DNA-binding domain Za from ADAR1 complexed to left-handed DNA.

Schwartz T, Shafer K, Lowenhaupt K, Hanlon E, Herbert A, Rich A.

Acta Crystallogr D Biol Crystallogr. 1999 Jul;55(Pt 7):1362-4.

PMID:
10393308
26.
27.

Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.

Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A.

Science. 1999 Jun 11;284(5421):1841-5.

28.

Proteolytic dissection of Zab, the Z-DNA-binding domain of human ADAR1.

Schwartz T, Lowenhaupt K, Kim YG, Li L, Brown BA 2nd, Herbert A, Rich A.

J Biol Chem. 1999 Jan 29;274(5):2899-906.

30.

Spectroscopic characterization of a DNA-binding domain, Z alpha, from the editing enzyme, dsRNA adenosine deaminase: evidence for left-handed Z-DNA in the Z alpha-DNA complex.

Berger I, Winston W, Manoharan R, Schwartz T, Alfken J, Kim YG, Lowenhaupt K, Herbert A, Rich A.

Biochemistry. 1998 Sep 22;37(38):13313-21.

PMID:
9748339
31.

The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences.

Herbert A, Schade M, Lowenhaupt K, Alfken J, Schwartz T, Shlyakhtenko LS, Lyubchenko YL, Rich A.

Nucleic Acids Res. 1998 Aug 1;26(15):3486-93.

32.

Conserved subfamilies of the Drosophila HeT-A telomere-specific retrotransposon.

Danilevskaya ON, Lowenhaupt K, Pardue ML.

Genetics. 1998 Jan;148(1):233-42.

33.

Evolutionary links between telomeres and transposable elements.

Pardue ML, Danilevskaya ON, Traverse KL, Lowenhaupt K.

Genetica. 1997;100(1-3):73-84. Review.

PMID:
9440260
34.

The gag coding region of the Drosophila telomeric retrotransposon, HeT-A, has an internal frame shift and a length polymorphic region.

Pardue ML, Danilevskaya ON, Lowenhaupt K, Wong J, Erby K.

J Mol Evol. 1996 Dec;43(6):572-83.

PMID:
8995054
35.

Drosophila telomeres: new views on chromosome evolution.

Pardue ML, Danilevskaya ON, Lowenhaupt K, Slot F, Traverse KL.

Trends Genet. 1996 Feb;12(2):48-52. Review.

PMID:
8851970
36.

Chicken double-stranded RNA adenosine deaminase has apparent specificity for Z-DNA.

Herbert A, Lowenhaupt K, Spitzner J, Rich A.

Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7550-4.

37.

Double-stranded RNA adenosine deaminase binds Z-DNA in vitro.

Herbert A, Lowenhaupt K, Spitzner J, Rich A.

Nucleic Acids Symp Ser. 1995;(33):16-9.

PMID:
8643357
38.

Z-DNA binding protein from chicken blood nuclei.

Herbert AG, Spitzner JR, Lowenhaupt K, Rich A.

Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3339-42.

39.
40.

Drosophila Rrp1 protein: an apurinic endonuclease with homologous recombination activities.

Sander M, Lowenhaupt K, Rich A.

Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6780-4.

41.
45.

Analysis of Z-DNA in fixed polytene chromosomes with monoclonal antibodies that show base sequence-dependent selectivity in reactions with supercoiled plasmids and polynucleotides.

Nordheim A, Pardue ML, Weiner LM, Lowenhaupt K, Scholten P, Möller A, Rich A, Stollar BD.

J Biol Chem. 1986 Jan 5;261(1):468-76.

46.

Chromatin structure in pre- and postblastula embryos of Drosophila.

Lowenhaupt K, Cartwright IL, Keene MA, Zimmerman JL, Elgin SC.

Dev Biol. 1983 Sep;99(1):194-201.

PMID:
6413275
47.

Cleavage reagents as probes of DNA sequence organization and chromatin structure: Drosophila melanogaster locus 67B1.

Elgin SC, Cartwright IL, Fleischmann G, Lowenhaupt K, Keene MA.

Cold Spring Harb Symp Quant Biol. 1983;47 Pt 1:529-38. No abstract available.

PMID:
6305565
48.

Nucleosome repeat structure is present in native salivary chromosomes of Drosophila melanogaster.

Hill RJ, Mott MR, Burnett EJ, Abmayr SM, Lowenhaupt K, Elgin SC.

J Cell Biol. 1982 Oct;95(1):262-6.

49.

Chromatin structure and gene activity: the role of nonhistone chromosomal proteins.

Cartwright IL, Abmayr SM, Fleischmann G, Lowenhaupt K, Elgin SC, Keene MA, Howard GC.

CRC Crit Rev Biochem. 1982;13(1):1-86. Review. No abstract available.

PMID:
6751690
50.

DNase I hypersensitive sites in Drosophila chromatin occur at the 5' ends of regions of transcription.

Keene MA, Corces V, Lowenhaupt K, Elgin SC.

Proc Natl Acad Sci U S A. 1981 Jan;78(1):143-6.

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