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Dysregulation of M segment gene expression contributes to influenza A virus host restriction.

Calderon BM, Danzy S, Delima GK, Jacobs NT, Ganti K, Hockman MR, Conn GL, Lowen AC, Steel J.

PLoS Pathog. 2019 Aug 15;15(8):e1007892. doi: 10.1371/journal.ppat.1007892. eCollection 2019 Aug.


Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread.

Jacobs NT, Onuoha NO, Antia A, Steel J, Antia R, Lowen AC.

Nat Commun. 2019 Aug 6;10(1):3526. doi: 10.1038/s41467-019-11428-x.


H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus.

White MC, Tao H, Steel J, Lowen AC.

Proc Natl Acad Sci U S A. 2019 Feb 13. pii: 201818494. doi: 10.1073/pnas.1818494116. [Epub ahead of print]


Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

Li ZT, Zarnitsyna VI, Lowen AC, Weissman D, Koelle K, Kohlmeier JE, Antia R.

J Virol. 2019 Mar 5;93(6). pii: e01534-18. doi: 10.1128/JVI.01534-18. Print 2019 Mar 15.


It's in the mix: Reassortment of segmented viral genomes.

Lowen AC.

PLoS Pathog. 2018 Sep 13;14(9):e1007200. doi: 10.1371/journal.ppat.1007200. eCollection 2018 Sep. Review. No abstract available.


Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00766-18. doi: 10.1128/AAC.00766-18. Print 2018 Aug.


Implications of segment mismatch for influenza A virus evolution.

White MC, Lowen AC.

J Gen Virol. 2018 Jan;99(1):3-16. doi: 10.1099/jgv.0.000989. Epub 2017 Dec 15. Review.


Influenza A Virus Reassortment Is Limited by Anatomical Compartmentalization following Coinfection via Distinct Routes.

Richard M, Herfst S, Tao H, Jacobs NT, Lowen AC.

J Virol. 2018 Feb 12;92(5). pii: e02063-17. doi: 10.1128/JVI.02063-17. Print 2018 Mar 1.


Seasonal H3N2 and 2009 Pandemic H1N1 Influenza A Viruses Reassort Efficiently but Produce Attenuated Progeny.

Phipps KL, Marshall N, Tao H, Danzy S, Onuoha N, Steel J, Lowen AC.

J Virol. 2017 Aug 10;91(17). pii: e00830-17. doi: 10.1128/JVI.00830-17. Print 2017 Sep 1.


Constraints, Drivers, and Implications of Influenza A Virus Reassortment.

Lowen AC.

Annu Rev Virol. 2017 Sep 29;4(1):105-121. doi: 10.1146/annurev-virology-101416-041726. Epub 2017 May 26. Review.


An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses.

Holthausen DJ, Lee SH, Kumar VT, Bouvier NM, Krammer F, Ellebedy AH, Wrammert J, Lowen AC, George S, Pillai MR, Jacob J.

Immunity. 2017 Apr 18;46(4):587-595. doi: 10.1016/j.immuni.2017.03.018.


Heterologous Packaging Signals on Segment 4, but Not Segment 6 or Segment 8, Limit Influenza A Virus Reassortment.

White MC, Steel J, Lowen AC.

J Virol. 2017 May 12;91(11). pii: e00195-17. doi: 10.1128/JVI.00195-17. Print 2017 Jun 1.


Droplet digital PCR: A novel method for detection of influenza virus defective interfering particles.

Schwartz SL, Lowen AC.

J Virol Methods. 2016 Nov;237:159-165. doi: 10.1016/j.jviromet.2016.08.023. Epub 2016 Aug 31.


Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening.

Weisshaar M, Cox R, Morehouse Z, Kumar Kyasa S, Yan D, Oberacker P, Mao S, Golden JE, Lowen AC, Natchus MG, Plemper RK.

J Virol. 2016 Jul 27;90(16):7368-7387. doi: 10.1128/JVI.00898-16. Print 2016 Aug 15.


Virology: Host protein clips bird flu's wings in mammals.

Lowen AC.

Nature. 2016 Jan 7;529(7584):30-1. doi: 10.1038/529030a. No abstract available.


Influenza Virus Reassortment Is Enhanced by Semi-infectious Particles but Can Be Suppressed by Defective Interfering Particles.

Fonville JM, Marshall N, Tao H, Steel J, Lowen AC.

PLoS Pathog. 2015 Oct 6;11(10):e1005204. doi: 10.1371/journal.ppat.1005204. eCollection 2015 Oct.


In memoriam--Richard M. Elliott (1954-2015).

Brennan B, Weber F, Kormelink R, Schnettler E, Bouloy M, Failloux AB, Weaver SC, Fazakerley JK, Fragkoudis R, Harris M, Barr JN, Palese P, García-Sastre A, Dalziel RG, Dutia BM, Lowen AC, Steel J, Randall RE, Paul Duprex W, Rice CM, Tesh RB, Murphy FA, Ebihara H, Vasconcelos PF, Nunes MR, Fooks AR, Smith GL, Goodfellow I, Pappu HR, Lamb RA, Paterson RG, Higgs S, Vanlandingham DL, Dietzgen RG, Stephen Lodmell J, Nichol ST, Daly J, Ullman DE, Plyusnin A, Plyusnina A, Efstathiou S, Hewson R, Tordo N, Cherry S, Boutell C, Hosie MJ, Murcia PR, Neil JC, Palmarini M, Patel AH, Willett BJ, Kohl A, McLauchlan J.

J Gen Virol. 2015 Aug;96(8):1975-8. doi: 10.1099/jgv.0.000241. No abstract available.


Influenza A Virus Coinfection through Transmission Can Support High Levels of Reassortment.

Tao H, Li L, White MC, Steel J, Lowen AC.

J Virol. 2015 Aug;89(16):8453-61. doi: 10.1128/JVI.01162-15. Epub 2015 Jun 3.


Competitive fitness of influenza B viruses with neuraminidase inhibitor-resistant substitutions in a coinfection model of the human airway epithelium.

Burnham AJ, Armstrong J, Lowen AC, Webster RG, Govorkova EA.

J Virol. 2015 Apr;89(8):4575-87. doi: 10.1128/JVI.02473-14. Epub 2015 Feb 11.


Filament-producing mutants of influenza A/Puerto Rico/8/1934 (H1N1) virus have higher neuraminidase activities than the spherical wild-type.

Seladi-Schulman J, Campbell PJ, Suppiah S, Steel J, Lowen AC.

PLoS One. 2014 Nov 10;9(11):e112462. doi: 10.1371/journal.pone.0112462. eCollection 2014.


Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.

Danzy S, Studdard LR, Manicassamy B, Solorzano A, Marshall N, García-Sastre A, Steel J, Lowen AC.

J Virol. 2014 Nov;88(22):13436-46. doi: 10.1128/JVI.01093-14. Epub 2014 Sep 10.


Influenza A virus reassortment.

Steel J, Lowen AC.

Curr Top Microbiol Immunol. 2014;385:377-401. doi: 10.1007/82_2014_395. Review.


Transmission in the guinea pig model.

Lowen AC, Bouvier NM, Steel J.

Curr Top Microbiol Immunol. 2014;385:157-83. doi: 10.1007/82_2014_390. Review.


Roles of humidity and temperature in shaping influenza seasonality.

Lowen AC, Steel J.

J Virol. 2014 Jul;88(14):7692-5. doi: 10.1128/JVI.03544-13. Epub 2014 Apr 30.


Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission.

Campbell PJ, Kyriakis CS, Marshall N, Suppiah S, Seladi-Schulman J, Danzy S, Lowen AC, Steel J.

J Virol. 2014 Jul;88(13):7569-77. doi: 10.1128/JVI.00119-14. Epub 2014 Apr 23.


Intrahost dynamics of influenza virus reassortment.

Tao H, Steel J, Lowen AC.

J Virol. 2014 Jul;88(13):7485-92. doi: 10.1128/JVI.00715-14. Epub 2014 Apr 16.


Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models.

Siegers JY, Short KR, Leijten LM, de Graaf M, Spronken MI, Schrauwen EJ, Marshall N, Lowen AC, Gabriel G, Osterhaus AD, Kuiken T, van Riel D.

J Virol. 2014 Apr;88(8):4595-9. doi: 10.1128/JVI.03190-13. Epub 2014 Jan 29.


Novel H7N9 influenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model.

Gabbard JD, Dlugolenski D, Van Riel D, Marshall N, Galloway SE, Howerth EW, Campbell PJ, Jones C, Johnson S, Byrd-Leotis L, Steinhauer DA, Kuiken T, Tompkins SM, Tripp R, Lowen AC, Steel J.

J Virol. 2014 Feb;88(3):1502-12. doi: 10.1128/JVI.02959-13. Epub 2013 Nov 13.


Spherical influenza viruses have a fitness advantage in embryonated eggs, while filament-producing strains are selected in vivo.

Seladi-Schulman J, Steel J, Lowen AC.

J Virol. 2013 Dec;87(24):13343-53. doi: 10.1128/JVI.02004-13. Epub 2013 Oct 2.


Influenza virus reassortment occurs with high frequency in the absence of segment mismatch.

Marshall N, Priyamvada L, Ende Z, Steel J, Lowen AC.

PLoS Pathog. 2013;9(6):e1003421. doi: 10.1371/journal.ppat.1003421. Epub 2013 Jun 13.


The small genome segment of Bunyamwera orthobunyavirus harbours a single transcription-termination signal.

Blakqori G, Lowen AC, Elliott RM.

J Gen Virol. 2012 Jul;93(Pt 7):1449-55. doi: 10.1099/vir.0.042390-0. Epub 2012 Apr 18.


The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses.

Pica N, Iyer A, Ramos I, Bouvier NM, Fernandez-Sesma A, García-Sastre A, Lowen AC, Palese P, Steel J.

J Virol. 2011 Dec;85(23):12825-9. doi: 10.1128/JVI.05930-11. Epub 2011 Sep 14.


The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model.

Chou YY, Albrecht RA, Pica N, Lowen AC, Richt JA, García-Sastre A, Palese P, Hai R.

J Virol. 2011 Nov;85(21):11235-41. doi: 10.1128/JVI.05794-11. Epub 2011 Aug 31.


Effects of receptor binding specificity of avian influenza virus on the human innate immune response.

Ramos I, Bernal-Rubio D, Durham N, Belicha-Villanueva A, Lowen AC, Steel J, Fernandez-Sesma A.

J Virol. 2011 May;85(9):4421-31. doi: 10.1128/JVI.02356-10. Epub 2011 Feb 23.


Transmission of a 2009 pandemic influenza virus shows a sensitivity to temperature and humidity similar to that of an H3N2 seasonal strain.

Steel J, Palese P, Lowen AC.

J Virol. 2011 Feb;85(3):1400-2. doi: 10.1128/JVI.02186-10. Epub 2010 Nov 17.


Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding.

Chutinimitkul S, Herfst S, Steel J, Lowen AC, Ye J, van Riel D, Schrauwen EJ, Bestebroer TM, Koel B, Burke DF, Sutherland-Cash KH, Whittleston CS, Russell CA, Wales DJ, Smith DJ, Jonges M, Meijer A, Koopmans M, Rimmelzwaan GF, Kuiken T, Osterhaus AD, García-Sastre A, Perez DR, Fouchier RA.

J Virol. 2010 Nov;84(22):11802-13. doi: 10.1128/JVI.01136-10. Epub 2010 Sep 15.


Influenza virus vaccine based on the conserved hemagglutinin stalk domain.

Steel J, Lowen AC, Wang TT, Yondola M, Gao Q, Haye K, García-Sastre A, Palese P.

MBio. 2010 May 18;1(1). pii: e00018-10. doi: 10.1128/mBio.00018-10.


A nine-segment influenza a virus carrying subtype H1 and H3 hemagglutinins.

Gao Q, Lowen AC, Wang TT, Palese P.

J Virol. 2010 Aug;84(16):8062-71. doi: 10.1128/JVI.00722-10. Epub 2010 Jun 2.


Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein.

Hale BG, Steel J, Medina RA, Manicassamy B, Ye J, Hickman D, Hai R, Schmolke M, Lowen AC, Perez DR, García-Sastre A.

J Virol. 2010 Jul;84(14):6909-22. doi: 10.1128/JVI.00081-10. Epub 2010 May 5.


Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus.

Hale BG, Steel J, Manicassamy B, Medina RA, Ye J, Hickman D, Lowen AC, Perez DR, García-Sastre A.

J Gen Virol. 2010 Jul;91(Pt 7):1737-42. doi: 10.1099/vir.0.020925-0. Epub 2010 Mar 17.


Animal Models for Influenza Virus Pathogenesis and Transmission.

Bouvier NM, Lowen AC.

Viruses. 2010;2(8):1530-1563.


Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment.

Steel J, Staeheli P, Mubareka S, García-Sastre A, Palese P, Lowen AC.

J Virol. 2010 Jan;84(1):21-6. doi: 10.1128/JVI.01732-09.


Transmission of influenza virus via aerosols and fomites in the guinea pig model.

Mubareka S, Lowen AC, Steel J, Coates AL, García-Sastre A, Palese P.

J Infect Dis. 2009 Mar 15;199(6):858-65.


Blocking interhost transmission of influenza virus by vaccination in the guinea pig model.

Lowen AC, Steel J, Mubareka S, Carnero E, García-Sastre A, Palese P.

J Virol. 2009 Apr;83(7):2803-18. doi: 10.1128/JVI.02424-08. Epub 2009 Jan 19.


Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N.

Steel J, Lowen AC, Mubareka S, Palese P.

PLoS Pathog. 2009 Jan;5(1):e1000252. doi: 10.1371/journal.ppat.1000252. Epub 2009 Jan 2.


Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza.

Steel J, Lowen AC, Pena L, Angel M, Solórzano A, Albrecht R, Perez DR, García-Sastre A, Palese P.

J Virol. 2009 Feb;83(4):1742-53. doi: 10.1128/JVI.01920-08. Epub 2008 Dec 10.


Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol.

Bouvier NM, Lowen AC, Palese P.

J Virol. 2008 Oct;82(20):10052-8. doi: 10.1128/JVI.01226-08. Epub 2008 Aug 6.


High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus.

Lowen AC, Steel J, Mubareka S, Palese P.

J Virol. 2008 Jun;82(11):5650-2. doi: 10.1128/JVI.00325-08. Epub 2008 Mar 26.


Influenza virus transmission: basic science and implications for the use of antiviral drugs during a pandemic.

Lowen AC, Palese P.

Infect Disord Drug Targets. 2007 Dec;7(4):318-28. Review.


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