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Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils.

Mahiddine K, Blaisdell A, Ma S, Créquer-Grandhomme A, Lowell CA, Erlebacher A.

J Clin Invest. 2019 Oct 10. pii: 130952. doi: 10.1172/JCI130952. [Epub ahead of print]


CARD9 mediates dendritic cell-induced development of Lyn deficiency-associated autoimmune and inflammatory diseases.

Ma J, Abram CL, Hu Y, Lowell CA.

Sci Signal. 2019 Oct 8;12(602). pii: eaao3829. doi: 10.1126/scisignal.aao3829.


L-selectin shedding affects bacterial clearance in the lung - a new regulatory pathway for integrin-outside-in signaling.

Cappenberg A, Margraf A, Thomas K, Bardel B, McCreedy DA, Van Marck V, Mellmann A, Lowell CA, Zarbock A.

Blood. 2019 Jul 31. pii: blood.2019000685. doi: 10.1182/blood.2019000685. [Epub ahead of print]


CRAC channel regulation of innate immune cells in health and disease.

Clemens RA, Lowell CA.

Cell Calcium. 2019 Mar;78:56-65. doi: 10.1016/j.ceca.2019.01.003. Epub 2019 Jan 9. Review.


Early Targeting of L-Selectin on Leukocytes Promotes Recovery after Spinal Cord Injury, Implicating Novel Mechanisms of Pathogenesis.

McCreedy DA, Lee S, Sontag CJ, Weinstein P, Olivas AD, Martinez AF, Fandel TM, Trivedi A, Lowell CA, Rosen SD, Noble-Haeusslein LJ.

eNeuro. 2018 Aug 29;5(4). pii: ENEURO.0101-18.2018. doi: 10.1523/ENEURO.0101-18.2018. eCollection 2018 Jul-Aug.


Neutrophils: Their Role in Innate and Adaptive Immunity 2017.

Rosales C, Lowell CA, Schnoor M, Uribe-Querol E.

J Immunol Res. 2017;2017:9748345. doi: 10.1155/2017/9748345. Epub 2017 Nov 7. No abstract available.


PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling.

Herter JM, Margraf A, Volmering S, Correia BE, Bradshaw JM, Bisconte A, Hill RJ, Langrish CL, Lowell CA, Zarbock A.

Br J Pharmacol. 2018 Feb;175(3):429-439. doi: 10.1111/bph.14090. Epub 2017 Dec 22.


B cell autoimmunity at the extremes.

Zikherman J, Lowell CA.

Nat Immunol. 2017 Sep 19;18(10):1065-1066. doi: 10.1038/ni.3840. No abstract available.


STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production.

Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA.

Blood. 2017 Sep 28;130(13):1565-1577. doi: 10.1182/blood-2016-11-751230. Epub 2017 Jul 19.


Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells.

Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P.

J Leukoc Biol. 2017 Sep;102(3):791-803. doi: 10.1189/jlb.3MA0217-054RR. Epub 2017 Jun 22.


Shp1 function in myeloid cells.

Abram CL, Lowell CA.

J Leukoc Biol. 2017 Sep;102(3):657-675. doi: 10.1189/jlb.2MR0317-105R. Epub 2017 Jun 12. Review.


Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL; TRALI Study Group.

Transfusion. 2017 Jul;57(7):1684-1690. doi: 10.1111/trf.14118. Epub 2017 May 3.


SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.

Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A.

Nature. 2017 Apr 27;544(7651):493-497. doi: 10.1038/nature22076. Epub 2017 Apr 19.


Efficiency and Specificity of Gene Deletion in Lung Epithelial Doxycycline-Inducible Cre Mice.

Sinha M, Lowell CA.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):248-257. doi: 10.1165/rcmb.2016-0208OC.


Isolation of Highly Pure Primary Mouse Alveolar Epithelial Type II Cells by Flow Cytometric Cell Sorting.

Sinha M, Lowell CA.

Bio Protoc. 2016 Nov 20;6(22). pii: e2013. doi: 10.21769/BioProtoc.2013.


Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9.

Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL.

PLoS One. 2016 Dec 15;11(12):e0167693. doi: 10.1371/journal.pone.0167693. eCollection 2016.


Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.

Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D.

Immunity. 2016 Oct 18;45(4):788-801. doi: 10.1016/j.immuni.2016.09.012. Epub 2016 Oct 11.


LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.

Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL.

J Clin Invest. 2016 Oct 3;126(10):3758-3771. doi: 10.1172/JCI84440. Epub 2016 Aug 29.


Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis.

Hang L, Blum AM, Kumar S, Urban JF Jr, Mitreva M, Geary TG, Jardim A, Stevenson MM, Lowell CA, Weinstock JV.

J Immunol. 2016 Oct 1;197(7):2948-57. doi: 10.4049/jimmunol.1600063. Epub 2016 Aug 24.


MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M.

PLoS Pathog. 2016 Aug 19;12(8):e1005787. doi: 10.1371/journal.ppat.1005787. eCollection 2016 Aug.


Neutrophils in animal models of autoimmune disease.

Németh T, Mócsai A, Lowell CA.

Semin Immunol. 2016 Apr;28(2):174-86. doi: 10.1016/j.smim.2016.04.001. Epub 2016 Apr 7. Review.


FleA Expression in Aspergillus fumigatus Is Recognized by Fucosylated Structures on Mucins and Macrophages to Prevent Lung Infection.

Kerr SC, Fischer GJ, Sinha M, McCabe O, Palmer JM, Choera T, Lim FY, Wimmerova M, Carrington SD, Yuan S, Lowell CA, Oscarson S, Keller NP, Fahy JV.

PLoS Pathog. 2016 Apr 8;12(4):e1005555. doi: 10.1371/journal.ppat.1005555. eCollection 2016 Apr.


Neutrophils: Their Role in Innate and Adaptive Immunity.

Rosales C, Demaurex N, Lowell CA, Uribe-Querol E.

J Immunol Res. 2016;2016:1469780. doi: 10.1155/2016/1469780. Epub 2016 Feb 24. No abstract available.


Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M.

Nature. 2016 Jun 2;534(7605):138. doi: 10.1038/nature16997. Epub 2016 Mar 9. No abstract available.


The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.

Volmering S, Block H, Boras M, Lowell CA, Zarbock A.

Immunity. 2016 Jan 19;44(1):73-87. doi: 10.1016/j.immuni.2015.11.011. Epub 2016 Jan 5.


Immune Defense Protein Expression in Highly Purified Mouse Lung Epithelial Cells.

Sinha M, Lowell CA.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):802-13. doi: 10.1165/rcmb.2015-0171OC.


LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A.

Elife. 2015 Oct 30;4. pii: e09183. doi: 10.7554/eLife.09183.


Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.

Yi T, Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG.

Immunity. 2015 Oct 20;43(4):764-75. doi: 10.1016/j.immuni.2015.08.021. Epub 2015 Oct 6.


The Src-Family Kinases Hck and Fgr Regulate Early Lipopolysaccharide-Induced Myeloid Cell Recruitment into the Lung and Their Ability To Secrete Chemokines.

Mazzi P, Caveggion E, Lapinet-Vera JA, Lowell CA, Berton G.

J Immunol. 2015 Sep 1;195(5):2383-95. doi: 10.4049/jimmunol.1402011. Epub 2015 Jul 31.


Cross-Talk between Shp1 and PIPKIγ Controls Leukocyte Recruitment.

Stadtmann A, Block H, Volmering S, Abram C, Sohlbach C, Boras M, Lowell CA, Zarbock A.

J Immunol. 2015 Aug 1;195(3):1152-61. doi: 10.4049/jimmunol.1500606. Epub 2015 Jun 22.


Intracellular signalling during neutrophil recruitment.

Mócsai A, Walzog B, Lowell CA.

Cardiovasc Res. 2015 Aug 1;107(3):373-85. doi: 10.1093/cvr/cvv159. Epub 2015 May 21. Review.


Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M.

Nature. 2015 May 21;521(7552):357-61. doi: 10.1038/nature14231. Epub 2015 Mar 23. Erratum in: Nature. 2016 Jun 2;534(7605):138.


Store-operated calcium signaling in neutrophils.

Clemens RA, Lowell CA.

J Leukoc Biol. 2015 Oct;98(4):497-502. doi: 10.1189/jlb.2MR1114-573R. Epub 2015 Feb 24. Review.


Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL; TRALI Study Group.

Transfusion. 2015 Aug;55(8):1838-46. doi: 10.1111/trf.13021. Epub 2015 Feb 23.


Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR.

Transfusion. 2015 May;55(5):947-52. doi: 10.1111/trf.12954. Epub 2014 Dec 8.


The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

Kovács M, Németh T, Jakus Z, Sitaru C, Simon E, Futosi K, Botz B, Helyes Z, Lowell CA, Mócsai A.

J Exp Med. 2014 Sep 22;211(10):1993-2011. doi: 10.1084/jem.20132496. Epub 2014 Sep 15.


Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering.

Jaumouillé V, Farkash Y, Jaqaman K, Das R, Lowell CA, Grinstein S.

Dev Cell. 2014 Jun 9;29(5):534-546. doi: 10.1016/j.devcel.2014.04.031.


Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice.

Abram CL, Roberge GL, Hu Y, Lowell CA.

J Immunol Methods. 2014 Jun;408:89-100. doi: 10.1016/j.jim.2014.05.009. Epub 2014 May 22.


ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.

Acín-Pérez R, Carrascoso I, Baixauli F, Roche-Molina M, Latorre-Pellicer A, Fernández-Silva P, Mittelbrunn M, Sanchez-Madrid F, Pérez-Martos A, Lowell CA, Manfredi G, Enríquez JA.

Cell Metab. 2014 Jun 3;19(6):1020-33. doi: 10.1016/j.cmet.2014.04.015. Epub 2014 May 22.


Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P; Transfusion-Related Acute Lung Injury Study Group.

Crit Care Med. 2014 Jul;42(7):1676-87. doi: 10.1097/CCM.0000000000000323.


Molecular editing of cellular responses by the high-affinity receptor for IgE.

Suzuki R, Leach S, Liu W, Ralston E, Scheffel J, Zhang W, Lowell CA, Rivera J.

Science. 2014 Feb 28;343(6174):1021-5. doi: 10.1126/science.1246976. Epub 2014 Feb 6.


STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.

Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA.

Blood. 2014 Apr 3;123(14):2238-49. doi: 10.1182/blood-2012-08-450403. Epub 2014 Feb 3.


Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice.

Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL.

J Immunol. 2014 Feb 1;192(3):875-85. doi: 10.4049/jimmunol.1300683. Epub 2013 Dec 30.


B cell-specific loss of Lyn kinase leads to autoimmunity.

Lamagna C, Hu Y, DeFranco AL, Lowell CA.

J Immunol. 2014 Feb 1;192(3):919-28. doi: 10.4049/jimmunol.1301979. Epub 2013 Dec 27.


Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma.

Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL.

Clin Cancer Res. 2014 Feb 15;20(4):1029-41. doi: 10.1158/1078-0432.CCR-13-0474. Epub 2013 Nov 4.


Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice.

Graham MT, Abram CL, Hu Y, Lowell CA.

PLoS One. 2013 Oct 8;8(10):e77542. doi: 10.1371/journal.pone.0077542. eCollection 2013.


A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.

Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, Li Z.

Blood. 2013 Dec 12;122(25):4140-9. doi: 10.1182/blood-2013-03-491423. Epub 2013 Oct 9.


The multifaceted functions of neutrophils.

Mayadas TN, Cullere X, Lowell CA.

Annu Rev Pathol. 2014;9:181-218. doi: 10.1146/annurev-pathol-020712-164023. Epub 2013 Sep 16. Review.


Neutrophils mediate antibody-induced antitumor effects in mice.

Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P.

Blood. 2013 Oct 31;122(18):3160-4. doi: 10.1182/blood-2013-04-497446. Epub 2013 Aug 26.


Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation.

Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):E3311-20. doi: 10.1073/pnas.1300617110. Epub 2013 Aug 12.

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