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Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents.

Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13670-13679. doi: 10.1073/pnas.1901795116. Epub 2019 Jun 18.


Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM.

Nature. 2019 Jun;570(7760):E32. doi: 10.1038/s41586-019-1267-3.


Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM.

Nature. 2019 May;569(7755):229-235. doi: 10.1038/s41586-019-1156-9. Epub 2019 May 1. Erratum in: Nature. 2019 Jun;570(7760):E32.


The Neuroscience of Drives for Food, Water, and Salt. Reply.

Lowell BB.

N Engl J Med. 2019 May 2;380(18):e33. doi: 10.1056/NEJMc1902946. No abstract available.


The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits.

Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB.

Neuron. 2019 May 8;102(3):653-667.e6. doi: 10.1016/j.neuron.2019.02.028. Epub 2019 Mar 14.


New Neuroscience of Homeostasis and Drives for Food, Water, and Salt.

Lowell BB.

N Engl J Med. 2019 Jan 31;380(5):459-471. doi: 10.1056/NEJMra1812053.


A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia.

Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB.

Curr Biol. 2018 Jul 23;28(14):2291-2301.e5. doi: 10.1016/j.cub.2018.05.064. Epub 2018 Jul 12.


PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse.

Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM.

Elife. 2018 Jun 15;7. pii: e35960. doi: 10.7554/eLife.35960.


A hypothalamic circuit for the circadian control of aggression.

Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB.

Nat Neurosci. 2018 May;21(5):717-724. doi: 10.1038/s41593-018-0126-0. Epub 2018 Apr 9.


Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.

Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BB.

Neuron. 2017 Sep 27;96(1):190-206.e7. doi: 10.1016/j.neuron.2017.09.014.


Toward a Wiring Diagram Understanding of Appetite Control.

Andermann ML, Lowell BB.

Neuron. 2017 Aug 16;95(4):757-778. doi: 10.1016/j.neuron.2017.06.014. Review.


Corrigendum: A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH.

Fenselau H, Campbell JN, Verstegen AMJ, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB.

Nat Neurosci. 2017 Jul 26;20(8):1189. doi: 10.1038/nn0817-1189b. No abstract available.


Homeostatic circuits selectively gate food cue responses in insular cortex.

Livneh Y, Ramesh RN, Burgess CR, Levandowski KM, Madara JC, Fenselau H, Goldey GJ, Diaz VE, Jikomes N, Resch JM, Lowell BB, Andermann ML.

Nature. 2017 Jun 29;546(7660):611-616. doi: 10.1038/nature22375. Epub 2017 Jun 14.


Identification of spinal circuits involved in touch-evoked dynamic mechanical pain.

Cheng L, Duan B, Huang T, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y, Ma Q.

Nat Neurosci. 2017 Jun;20(6):804-814. doi: 10.1038/nn.4549. Epub 2017 Apr 24.


GABAergic Neurons of the Central Amygdala Promote Cataplexy.

Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE.

J Neurosci. 2017 Apr 12;37(15):3995-4006. doi: 10.1523/JNEUROSCI.4065-15.2017. Epub 2017 Feb 24.


A molecular census of arcuate hypothalamus and median eminence cell types.

Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT.

Nat Neurosci. 2017 Mar;20(3):484-496. doi: 10.1038/nn.4495. Epub 2017 Feb 6.


Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity.

Tejeda HA, Wu J, Kornspun AR, Pignatelli M, Kashtelyan V, Krashes MJ, Lowell BB, Carlezon WA Jr, Bonci A.

Neuron. 2017 Jan 4;93(1):147-163. doi: 10.1016/j.neuron.2016.12.005.


Descending projections from the basal forebrain to the orexin neurons in mice.

Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE.

J Comp Neurol. 2017 May 1;525(7):1668-1684. doi: 10.1002/cne.24158. Epub 2017 Feb 22.


Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons.

Mandelblat-Cerf Y, Kim A, Burgess CR, Subramanian S, Tannous BA, Lowell BB, Andermann ML.

Neuron. 2017 Jan 4;93(1):57-65. doi: 10.1016/j.neuron.2016.11.021. Epub 2016 Dec 15.


A rapidly acting glutamatergic ARC→PVH satiety circuit postsynaptically regulated by α-MSH.

Fenselau H, Campbell JN, Verstegen AM, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB.

Nat Neurosci. 2017 Jan;20(1):42-51. doi: 10.1038/nn.4442. Epub 2016 Nov 21. Erratum in: Nat Neurosci. 2017 Jul 26;20(8):1189.


Dynamic GABAergic afferent modulation of AgRP neurons.

Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG Jr, Andermann ML, Krashes MJ, Lowell BB.

Nat Neurosci. 2016 Dec;19(12):1628-1635. doi: 10.1038/nn.4392. Epub 2016 Sep 19.


A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction.

Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS.

Elife. 2016 Sep 26;5. pii: e15392. doi: 10.7554/eLife.15392.


Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice.

Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB.

Neuroscience. 2016 Nov 12;336:102-113. doi: 10.1016/j.neuroscience.2016.08.046. Epub 2016 Sep 3.


Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala.

Burgess CR, Ramesh RN, Sugden AU, Levandowski KM, Minnig MA, Fenselau H, Lowell BB, Andermann ML.

Neuron. 2016 Sep 7;91(5):1154-1169. doi: 10.1016/j.neuron.2016.07.032. Epub 2016 Aug 11.


A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons.

Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB.

Neuron. 2016 Jul 6;91(1):25-33. doi: 10.1016/j.neuron.2016.05.025. Epub 2016 Jun 16.


Sensory Neurons that Detect Stretch and Nutrients in the Digestive System.

Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD.

Cell. 2016 Jun 30;166(1):209-21. doi: 10.1016/j.cell.2016.05.011. Epub 2016 May 26.


A specific area of olfactory cortex involved in stress hormone responses to predator odours.

Kondoh K, Lu Z, Ye X, Olson DP, Lowell BB, Buck LB.

Nature. 2016 Apr 7;532(7597):103-6. doi: 10.1038/nature17156. Epub 2016 Mar 21.


Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.

Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL.

Cell Rep. 2016 Mar 29;14(12):2774-83. doi: 10.1016/j.celrep.2016.02.069. Epub 2016 Mar 17.


Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.

D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK.

Elife. 2016 Mar 14;5. pii: e12225. doi: 10.7554/eLife.12225.


Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J.

Nat Commun. 2016 Mar 3;7:11019. doi: 10.1038/ncomms11019. No abstract available.


Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.

Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ.

Elife. 2016 Feb 24;5:e10031. doi: 10.7554/eLife.10031.


Melanocortin-4 receptor-regulated energy homeostasis.

Krashes MJ, Lowell BB, Garfield AS.

Nat Neurosci. 2016 Feb;19(2):206-19. doi: 10.1038/nn.4202. Review.


Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake.

Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J.

Nat Commun. 2016 Jan 8;7:10268. doi: 10.1038/ncomms10268. Erratum in: Nat Commun. 2016;7:11019.


Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.

Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E.

J Physiol. 2016 Feb 15;594(4):1069-85. doi: 10.1113/JP271657. Epub 2016 Jan 5.


Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus.

Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE.

Am J Physiol Regul Integr Comp Physiol. 2016 Jan 1;310(1):R41-54. doi: 10.1152/ajpregu.00094.2015. Epub 2015 Oct 21.


Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward.

Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR.

Neuron. 2015 Sep 2;87(5):1063-77. doi: 10.1016/j.neuron.2015.08.019.


Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales.

Mandelblat-Cerf Y, Ramesh RN, Burgess CR, Patella P, Yang Z, Lowell BB, Andermann ML.

Elife. 2015 Jul 10;4. doi: 10.7554/eLife.07122.


A neural basis for melanocortin-4 receptor-regulated appetite.

Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB.

Nat Neurosci. 2015 Jun;18(6):863-71. doi: 10.1038/nn.4011. Epub 2015 Apr 27.


TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons.

Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG Jr, Olson DP.

Mol Metab. 2015 Feb 7;4(4):299-309. doi: 10.1016/j.molmet.2015.01.012. eCollection 2015 Apr.


NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.

Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL.

Nat Neurosci. 2015 Apr;18(4):545-52. doi: 10.1038/nn.3972. Epub 2015 Mar 9.


A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia.

Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG Jr, Heisler LK.

Cell Metab. 2014 Dec 2;20(6):1030-7. doi: 10.1016/j.cmet.2014.11.006.


Identification of spinal circuits transmitting and gating mechanical pain.

Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross S, Lowell BB, Wang Y, Goulding M, Ma Q.

Cell. 2014 Dec 4;159(6):1417-1432. doi: 10.1016/j.cell.2014.11.003. Epub 2014 Nov 20.


The hypothalamus.

Saper CB, Lowell BB.

Curr Biol. 2014 Dec 1;24(23):R1111-6. doi: 10.1016/j.cub.2014.10.023. Epub 2014 Dec 1. No abstract available.


Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE.

Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1438-47. doi: 10.1152/ajpregu.00131.2014. Epub 2014 Oct 22.


MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus.

Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13193-8. doi: 10.1073/pnas.1407843111. Epub 2014 Aug 25.


Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.

Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK.

Nat Neurosci. 2014 Jul;17(7):911-3. doi: 10.1038/nn.3737. Epub 2014 Jun 8.


Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone.

Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB.

J Neurosci. 2014 Apr 23;34(17):6047-56. doi: 10.1523/JNEUROSCI.3003-13.2014.


An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger.

Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB.

Nature. 2014 Mar 13;507(7491):238-42. doi: 10.1038/nature12956. Epub 2014 Feb 2.


Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.

Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q.

Cell Metab. 2013 Dec 3;18(6):860-70. doi: 10.1016/j.cmet.2013.11.003.


Was it something I ate?

Garfield AS, Lowell BB.

Cell Metab. 2013 Dec 3;18(6):769-70. doi: 10.1016/j.cmet.2013.11.010.

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