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Items: 50

1.

High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application.

Grime GW, Zeldin OB, Snell ME, Lowe ED, Hunt JF, Montelione GT, Tong L, Snell EH, Garman EF.

J Am Chem Soc. 2020 Jan 8;142(1):185-197. doi: 10.1021/jacs.9b09186. Epub 2019 Dec 20.

PMID:
31794207
2.

"Whatever I Have to Do That's Right:" Culture and the Precariousness of Personhood in a Poor Urban Neighborhood.

Lowe ED.

Ethos. 2018 Sep;46(3):311-329. doi: 10.1111/etho.12205. Epub 2018 Sep 4.

3.

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.

Jackson VA, Meijer DH, Carrasquero M, van Bezouwen LS, Lowe ED, Kleanthous C, Janssen BJC, Seiradake E.

Nat Commun. 2018 Mar 14;9(1):1079. doi: 10.1038/s41467-018-03460-0.

4.

The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.

Robertson IB, Dias HF, Osuch IH, Lowe ED, Jensen SA, Redfield C, Handford PA.

Structure. 2017 Aug 1;25(8):1208-1221.e5. doi: 10.1016/j.str.2017.06.003. Epub 2017 Jun 29.

5.

Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.

Ryan A, Polycarpou E, Lack NA, Evangelopoulos D, Sieg C, Halman A, Bhakta S, Eleftheriadou O, McHugh TD, Keany S, Lowe ED, Ballet R, Abuhammad A, Jacobs WR Jr, Ciulli A, Sim E.

Br J Pharmacol. 2017 Jul;174(14):2209-2224. doi: 10.1111/bph.13810. Epub 2017 May 9.

6.

Development of tools to automate quantitative analysis of radiation damage in SAXS experiments.

Brooks-Bartlett JC, Batters RA, Bury CS, Lowe ED, Ginn HM, Round A, Garman EF.

J Synchrotron Radiat. 2017 Jan 1;24(Pt 1):63-72. doi: 10.1107/S1600577516015083. Epub 2017 Jan 1.

7.

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals.

Caputo AT, Alonzi DS, Marti L, Reca IB, Kiappes JL, Struwe WB, Cross A, Basu S, Lowe ED, Darlot B, Santino A, Roversi P, Zitzmann N.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4630-8. doi: 10.1073/pnas.1604463113. Epub 2016 Jul 26.

8.

Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa.

Joshi A, Grinter R, Josts I, Chen S, Wojdyla JA, Lowe ED, Kaminska R, Sharp C, McCaughey L, Roszak AW, Cogdell RJ, Byron O, Walker D, Kleanthous C.

J Mol Biol. 2015 Aug 28;427(17):2852-66. doi: 10.1016/j.jmb.2015.07.014. Epub 2015 Jul 26.

9.

Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.

Lane-Serff H, MacGregor P, Lowe ED, Carrington M, Higgins MK.

Elife. 2014 Dec 12;3:e05553. doi: 10.7554/eLife.05553.

10.

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria.

Lau CK, Turner L, Jespersen JS, Lowe ED, Petersen B, Wang CW, Petersen JE, Lusingu J, Theander TG, Lavstsen T, Higgins MK.

Cell Host Microbe. 2015 Jan 14;17(1):118-29. doi: 10.1016/j.chom.2014.11.007. Epub 2014 Dec 4.

11.

Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction.

Fairhead M, Shen D, Chan LK, Lowe ED, Donohoe TJ, Howarth M.

Bioorg Med Chem. 2014 Oct 1;22(19):5476-86. doi: 10.1016/j.bmc.2014.07.029. Epub 2014 Jul 24.

PMID:
25128469
12.

Plug-and-play pairing via defined divalent streptavidins.

Fairhead M, Krndija D, Lowe ED, Howarth M.

J Mol Biol. 2014 Jan 9;426(1):199-214. doi: 10.1016/j.jmb.2013.09.016. Epub 2013 Sep 19.

13.

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.

Abuhammad A, Lowe ED, McDonough MA, Shaw Stewart PD, Kolek SA, Sim E, Garman EF.

Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1433-46. doi: 10.1107/S0907444913015126. Epub 2013 Jul 17.

PMID:
23897467
14.

Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.

Hilbert M, Erat MC, Hachet V, Guichard P, Blank ID, Flückiger I, Slater L, Lowe ED, Hatzopoulos GN, Steinmetz MO, Gönczy P, Vakonakis I.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11373-8. doi: 10.1073/pnas.1302721110. Epub 2013 Jun 24.

15.

Structural basis for duplex RNA recognition and cleavage by Archaeoglobus fulgidus C3PO.

Parizotto EA, Lowe ED, Parker JS.

Nat Struct Mol Biol. 2013 Mar;20(3):380-6. doi: 10.1038/nsmb.2487. Epub 2013 Jan 27.

16.

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.

Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E.

PLoS One. 2012;7(12):e52790. doi: 10.1371/journal.pone.0052790. Epub 2012 Dec 28.

17.

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation.

Boehringer J, Riedinger C, Paraskevopoulos K, Johnson EO, Lowe ED, Khoudian C, Smith D, Noble ME, Gordon C, Endicott JA.

Biochem J. 2012 Nov 15;448(1):55-65. doi: 10.1042/BJ20120542.

18.

Bilirubin oxidase from Myrothecium verrucaria: X-ray determination of the complete crystal structure and a rational surface modification for enhanced electrocatalytic O2 reduction.

Cracknell JA, McNamara TP, Lowe ED, Blanford CF.

Dalton Trans. 2011 Jul 7;40(25):6668-75. doi: 10.1039/c0dt01403f. Epub 2011 May 5.

PMID:
21544308
19.

How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer.

Chivers CE, Koner AL, Lowe ED, Howarth M.

Biochem J. 2011 Apr 1;435(1):55-63. doi: 10.1042/BJ20101593.

20.

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.

Abuhammad AM, Lowe ED, Fullam E, Noble M, Garman EF, Sim E.

Protein Cell. 2010 Apr;1(4):384-392. doi: 10.1007/s13238-010-0037-7. Epub 2010 May 8.

21.

Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.

Riedinger C, Boehringer J, Trempe JF, Lowe ED, Brown NR, Gehring K, Noble ME, Gordon C, Endicott JA.

J Biol Chem. 2010 Oct 29;285(44):33992-4003. doi: 10.1074/jbc.M110.134510. Epub 2010 Aug 24.

22.

Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.

Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD.

J Biol Chem. 2010 Jan 1;285(1):434-43. doi: 10.1074/jbc.M109.058081. Epub 2009 Oct 29.

23.

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction.

Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID.

EMBO J. 2009 Nov 18;28(22):3623-32. doi: 10.1038/emboj.2009.287. Epub 2009 Oct 1.

24.

Structure and interdomain interactions of a hybrid domain: a disulphide-rich module of the fibrillin/LTBP superfamily of matrix proteins.

Jensen SA, Iqbal S, Lowe ED, Redfield C, Handford PA.

Structure. 2009 May 13;17(5):759-68. doi: 10.1016/j.str.2009.03.014.

25.

Identification and structural analysis of type I collagen sites in complex with fibronectin fragments.

Erat MC, Slatter DA, Lowe ED, Millard CJ, Farndale RW, Campbell ID, Vakonakis I.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4195-200. doi: 10.1073/pnas.0812516106. Epub 2009 Feb 27.

26.

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.

Russell AJ, Westwood IM, Crawford MH, Robinson J, Kawamura A, Redfield C, Laurieri N, Lowe ED, Davies SG, Sim E.

Bioorg Med Chem. 2009 Jan 15;17(2):905-18. doi: 10.1016/j.bmc.2008.11.032. Epub 2008 Nov 19.

PMID:
19059786
27.

The HupR receiver domain crystal structure in its nonphospho and inhibitory phospho states.

Davies KM, Lowe ED, Vénien-Bryan C, Johnson LN.

J Mol Biol. 2009 Jan 9;385(1):51-64. doi: 10.1016/j.jmb.2008.10.027. Epub 2008 Oct 19.

PMID:
18977359
28.

Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.

Lorenz S, Vakonakis I, Lowe ED, Campbell ID, Noble ME, Hoellerer MK.

Structure. 2008 Oct 8;16(10):1521-31. doi: 10.1016/j.str.2008.08.007.

29.

Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase.

Lowe ED, Gao GY, Johnson LN, Keung WM.

J Med Chem. 2008 Aug 14;51(15):4482-7. doi: 10.1021/jm800488j. Epub 2008 Jul 10.

PMID:
18613661
30.

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN.

EMBO J. 2008 Jul 9;27(13):1907-18. doi: 10.1038/emboj.2008.121. Epub 2008 Jun 19.

31.

An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.

Oxley CL, Anthis NJ, Lowe ED, Vakonakis I, Campbell ID, Wegener KL.

J Biol Chem. 2008 Feb 29;283(9):5420-6. Epub 2007 Dec 21.

32.

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis.

Lack N, Lowe ED, Liu J, Eltis LD, Noble ME, Sim E, Westwood IM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jan 1;64(Pt 1):2-7. Epub 2007 Dec 20.

33.

Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase.

Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble ME.

J Mol Biol. 2008 Jan 4;375(1):178-91. Epub 2007 Oct 13.

PMID:
18005984
34.

Cyclin B and cyclin A confer different substrate recognition properties on CDK2.

Brown NR, Lowe ED, Petri E, Skamnaki V, Antrobus R, Johnson LN.

Cell Cycle. 2007 Jun 1;6(11):1350-9. Epub 2007 Jun 11.

PMID:
17495531
35.

The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.

Cheng KY, Noble ME, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi G, Johnson LN.

J Biol Chem. 2006 Aug 11;281(32):23167-79. Epub 2006 May 17.

36.

Structures of the Dsk2 UBL and UBA domains and their complex.

Lowe ED, Hasan N, Trempe JF, Fonso L, Noble ME, Endicott JA, Johnson LN, Brown NR.

Acta Crystallogr D Biol Crystallogr. 2006 Feb;62(Pt 2):177-88. Epub 2006 Jan 18.

PMID:
16421449
37.

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain.

Trempe JF, Brown NR, Lowe ED, Gordon C, Campbell ID, Noble ME, Endicott JA.

EMBO J. 2005 Sep 21;24(18):3178-89. Epub 2005 Sep 1.

38.

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.

Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR, Johnson LN.

EMBO J. 2005 Feb 9;24(3):452-63. Epub 2005 Jan 20.

39.

The crystal structure of human CDK7 and its protein recognition properties.

Lolli G, Lowe ED, Brown NR, Johnson LN.

Structure. 2004 Nov;12(11):2067-79.

40.

Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi.

Cordes FS, Kraiczy P, Roversi P, Skerka C, Kirschfink M, Simon MM, Brade V, Lowe ED, Zipfel P, Wallich R, Lea SM.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):929-32. Epub 2004 Apr 21.

PMID:
15103142
41.

The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex.

Cheng KY, Lowe ED, Sinclair J, Nigg EA, Johnson LN.

EMBO J. 2003 Nov 3;22(21):5757-68.

42.

Impacts of children with troubles on working poor families: mixed-method and experimental evidence.

Bernheimer LP, Weisner TS, Lowe ED.

Ment Retard. 2003 Dec;41(6):403-19.

PMID:
14588061
43.
44.

Crystal structure of the potassium channel KirBac1.1 in the closed state.

Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA.

Science. 2003 Jun 20;300(5627):1922-6. Epub 2003 May 8.

45.

Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.

Lowe ED, Tews I, Cheng KY, Brown NR, Gul S, Noble ME, Gamblin SJ, Johnson LN.

Biochemistry. 2002 Dec 31;41(52):15625-34.

PMID:
12501191
46.

Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism.

Cook A, Lowe ED, Chrysina ED, Skamnaki VT, Oikonomakos NG, Johnson LN.

Biochemistry. 2002 Jun 11;41(23):7301-11.

PMID:
12044161
47.

Catalytic mechanism of phosphorylase kinase probed by mutational studies.

Skamnaki VT, Owen DJ, Noble ME, Lowe ED, Lowe G, Oikonomakos NG, Johnson LN.

Biochemistry. 1999 Nov 2;38(44):14718-30.

PMID:
10545198
48.

The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases.

Johnson LN, Lowe ED, Noble ME, Owen DJ.

FEBS Lett. 1998 Jun 23;430(1-2):1-11. Review.

49.

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

Lowe ED, Noble ME, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN.

EMBO J. 1997 Nov 17;16(22):6646-58.

50.

Cloning and expression of Vibrio cholerae dsbA, a gene encoding a periplasmic protein disulphide isomerase.

Lowe ED, Freedman RB, Hirst TR, Barth PT.

Biochem Soc Trans. 1995 Feb;23(1):64S. No abstract available.

PMID:
7758780

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