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Items: 40


Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.

Vousden KA, Lundqvist T, Popovic B, Naiman B, Carruthers AM, Newton P, Johnson DJD, Pomowski A, Wilkinson T, Dufner P, de Mendez I, Mallinder PR, Murray C, Strain M, Connor J, Murray LA, Sleeman MA, Lowe DC, Huntington JA, Vaughan TJ.

Sci Rep. 2019 Feb 7;9(1):1605. doi: 10.1038/s41598-019-38842-x.


Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS.

Devine PWA, Fisher HC, Calabrese AN, Whelan F, Higazi DR, Potts JR, Lowe DC, Radford SE, Ashcroft AE.

J Am Soc Mass Spectrom. 2017 Sep;28(9):1855-1862. doi: 10.1007/s13361-017-1689-9. Epub 2017 May 8.


Inducing protein aggregation by extensional flow.

Dobson J, Kumar A, Willis LF, Tuma R, Higazi DR, Turner R, Lowe DC, Ashcroft AE, Radford SE, Kapur N, Brockwell DJ.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4673-4678. doi: 10.1073/pnas.1702724114. Epub 2017 Apr 17.


Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.

Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC.

Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644.


A 21st-century shift from fossil-fuel to biogenic methane emissions indicated by ¹³CH₄.

Schaefer H, Mikaloff Fletcher SE, Veidt C, Lassey KR, Brailsford GW, Bromley TM, Dlugokencky EJ, Michel SE, Miller JB, Levin I, Lowe DC, Martin RJ, Vaughn BH, White JW.

Science. 2016 Apr 1;352(6281):80-4. doi: 10.1126/science.aad2705. Epub 2016 Mar 10.


A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.

Webster CI, Bryson CJ, Cloake EA, Jones TD, Austin MJ, Karle AC, Spindeldreher S, Lowe DC, Baker MP.

MAbs. 2016;8(2):253-63. doi: 10.1080/19420862.2015.1128605. Epub 2016 Jan 29.


The INNs and outs of antibody nonproprietary names.

Jones TD, Carter PJ, Plückthun A, Vásquez M, Holgate RG, Hötzel I, Popplewell AG, Parren PW, Enzelberger M, Rademaker HJ, Clark MR, Lowe DC, Dahiyat BI, Smith V, Lambert JM, Wu H, Reilly M, Haurum JS, Dübel S, Huston JS, Schirrmann T, Janssen RA, Steegmaier M, Gross JA, Bradbury AR, Burton DR, Dimitrov DS, Chester KA, Glennie MJ, Davies J, Walker A, Martin S, McCafferty J, Baker MP.

MAbs. 2016;8(1):1-9. doi: 10.1080/19420862.2015.1114320.


Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability.

Edgeworth MJ, Phillips JJ, Lowe DC, Kippen AD, Higazi DR, Scrivens JH.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15156-9. doi: 10.1002/anie.201507223. Epub 2015 Oct 20.


Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.

Cohen ES, Scott IC, Majithiya JB, Rapley L, Kemp BP, England E, Rees DG, Overed-Sayer CL, Woods J, Bond NJ, Veyssier CS, Embrey KJ, Sims DA, Snaith MR, Vousden KA, Strain MD, Chan DT, Carmen S, Huntington CE, Flavell L, Xu J, Popovic B, Brightling CE, Vaughan TJ, Butler R, Lowe DC, Higazi DR, Corkill DJ, May RD, Sleeman MA, Mustelin T.

Nat Commun. 2015 Sep 14;6:8327. doi: 10.1038/ncomms9327.


Rheumatology: a force for change in monoclonal antibodies.

Lowe DC, Vaughan TJ.

Curr Pharm Des. 2015;21(17):2179-86. Review.


Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1.

Douthwaite JA, Sridharan S, Huntington C, Hammersley J, Marwood R, Hakulinen JK, Ek M, Sjögren T, Rider D, Privezentzev C, Seaman JC, Cariuk P, Knights V, Young J, Wilkinson T, Sleeman M, Finch DK, Lowe DC, Vaughan TJ.

MAbs. 2015;7(1):152-66. doi: 10.4161/19420862.2014.985158.


Differential induction of isolated lymphoid follicles in the gut by 18β-glycyrrhetinic acid.

Hendricks JM, Lowe DC, Hardy ME.

PLoS One. 2014 Jul 3;9(7):e100878. doi: 10.1371/journal.pone.0100878. eCollection 2014.


Current approaches to fine mapping of antigen-antibody interactions.

Abbott WM, Damschroder MM, Lowe DC.

Immunology. 2014 Aug;142(4):526-35. doi: 10.1111/imm.12284. Review.


Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicity.

Rudnicka D, Oszmiana A, Finch DK, Strickland I, Schofield DJ, Lowe DC, Sleeman MA, Davis DM.

Blood. 2013 Jun 6;121(23):4694-702. doi: 10.1182/blood-2013-02-482570. Epub 2013 Apr 23.


Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure.

Wilkinson IC, Fowler SB, Machiesky L, Miller K, Hayes DB, Adib M, Her C, Borrok MJ, Tsui P, Burrell M, Corkill DJ, Witt S, Lowe DC, Webster CI.

MAbs. 2013 May-Jun;5(3):406-17. doi: 10.4161/mabs.23941. Epub 2013 Apr 8.


Engineering approaches to develop the next generation of antibodies to respiratory targets.

Vousden KA, Clarke DL, Lowe DC.

Inflamm Allergy Drug Targets. 2013 Apr;12(2):99-108. Review.


Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection.

Newton P, O'Shea D, Wells E, Moakes K, Dunmore R, Butler RJ, Wilkinson T, Ward A, Casson N, Strain M, Vousden K, Lowe DC, Pattison DV, Carruthers AM, Sleeman MA, Vaughan TJ, Harrison P.

J Biomol Screen. 2013 Mar;18(3):237-46. doi: 10.1177/1087057112469047. Epub 2012 Dec 3.


Whole-molecule antibody engineering: generation of a high-affinity anti-IL-6 antibody with extended pharmacokinetics.

Finch DK, Sleeman MA, Moisan J, Ferraro F, Botterell S, Campbell J, Cochrane D, Cruwys S, England E, Lane S, Rendall E, Sinha M, Walker C, Rees G, Bowen MA, Schneider A, Liang M, Faggioni R, Fung M, Mallinder PR, Wilkinson T, Kolbeck R, Vaughan T, Lowe DC.

J Mol Biol. 2011 Aug 26;411(4):791-807. doi: 10.1016/j.jmb.2011.06.031. Epub 2011 Jun 23.


Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.

Lowe DC, Gerhardt S, Ward A, Hargreaves D, Anderson M, Ferraro F, Pauptit RA, Pattison DV, Buchanan C, Popovic B, Finch DK, Wilkinson T, Sleeman M, Vaughan TJ, Mallinder PR.

J Mol Biol. 2011 Feb 11;406(1):160-75. doi: 10.1016/j.jmb.2010.12.017. Epub 2010 Dec 16.


Identification of a potent anti-IL-15 antibody with opposing mechanisms of action in vitro and in vivo.

Finch DK, Midha A, Buchanan CL, Cochrane D, Craggs RI, Cruwys S, Grahames C, Kolbeck R, Lowe DC, Maltby J, Pattison DV, Vousden KA, Ward A, Sleeman MA, Mallinder PR.

Br J Pharmacol. 2011 Jan;162(2):480-90. doi: 10.1111/j.1476-5381.2010.01061.x.


Complete hunting cycle of Dionaea muscipula: consecutive steps and their electrical properties.

Volkov AG, Pinnock MR, Lowe DC, Gay MS, Markin VS.

J Plant Physiol. 2011 Jan 15;168(2):109-20. doi: 10.1016/j.jplph.2010.06.007. Epub 2010 Jul 27.


Global change: a green source of surprise.

Lowe DC.

Nature. 2006 Jan 12;439(7073):148-9. No abstract available.


Unexpected changes to the global methane budget over the past 2000 years.

Ferretti DF, Miller JB, White JW, Etheridge DM, Lassey KR, Lowe DC, Macfarling Meure CM, Dreier MF, Trudinger CM, van Ommen TD, Langenfelds RL.

Science. 2005 Sep 9;309(5741):1714-7.


Short-term variations in the oxidizing power of the atmosphere.

Manning MR, Lowe DC, Moss RC, Bodeker GE, Allan W.

Nature. 2005 Aug 18;436(7053):1001-4.


The surgery of 'inguino-femoral' lymph nodes: is it adequate or excessive?

Hudson CN, Shulver H, Lowe DC.

Int J Gynecol Cancer. 2004 Sep-Oct;14(5):841-5.


A confidential study of deaths after emergency medical admission: issues relating to quality of care.

Seward E, Greig E, Preston S, Harris RA, Borrill Z, Wardle TD, Burnham R, Driscoll P, Harrison BD, Lowe DC, Pearson MG.

Clin Med (Lond). 2003 Sep-Oct;3(5):425-34.


Characterization of candidate live oral Salmonella typhi vaccine strains harboring defined mutations in aroA, aroC, and htrA.

Lowe DC, Savidge TC, Pickard D, Eckmann L, Kagnoff MF, Dougan G, Chatfield SN.

Infect Immun. 1999 Feb;67(2):700-7.


Apoptosis of human intestinal epithelial cells after bacterial invasion.

Kim JM, Eckmann L, Savidge TC, Lowe DC, Witthöft T, Kagnoff MF.

J Clin Invest. 1998 Nov 15;102(10):1815-23.


Improved needle placement technique in periurethral collagen injection.

Neal DE Jr, Lahaye ME, Lowe DC.

Urology. 1995 May;45(5):865-6.


Flow cytometry.

van Dam PA, Lowe DC.

Br J Obstet Gynaecol. 1992 Jul;99(7):545-6. No abstract available.


Narcolepsy in the elderly: a forgotten diagnosis.

Kelly JF, Lowe DC, Taggart HM.

Age Ageing. 1987 Nov;16(6):405-8.


Long term follow up of patients treated for hyperthyroidism with low dose radioactive iodine.

Blair AL, Lowe DC, Hadden DR, Weaver JA, Montgomery DA.

Ulster Med J. 1980;49(1):71-8. No abstract available.


Studies on sweating in clinical and experimental thyrotoxicosis.

Allen JA, Lowe DC, Roddie IC, Wallace WF.

Clin Sci Mol Med. 1973 Dec;45(6):765-73. No abstract available.


Comparison of the effects of propranolol and MJ 1999 on cardiac beta-adrenoceptors in man.

Kofi Ekue JM, Lowe DC, Shanks RG.

Br J Pharmacol. 1970 May;38(3):546-53.


Propranolol and radioactive iodine in the treatment of thyrotoxicosis.

Hadden DR, Lowe DC, Montgomery DA, Shanks RG, Weaver JA.

Br J Pharmacol. 1970 May;39(1):198P. No abstract available.


Drug treatment of thyrotoxicosis.

Montgomery DA, Lowe DC, Shanks RG, Weaver JA.

Br Med J. 1969 Jul 5;3(5661):55. No abstract available.


Controlled trial of propranolol in thyrotoxicosis.

Shanks RG, Hadden DR, Lowe DC, McDevitt DG, Montgomery DA.

Lancet. 1969 May 17;1(7603):993-4. No abstract available.


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