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Items: 30

1.

Successful treatment of hepatitis C, genotype 3, with sofosbuvir/ledipasvir in decompensated cirrhosis complicated by mixed cryoglobulinaemia.

Flemming JA, Lowe CE.

BMJ Case Rep. 2016 Jun 9;2016. pii: bcr2016215293. doi: 10.1136/bcr-2016-215293.

2.

A Medium-Throughput Single Cell CRISPR-Cas9 Assay to Assess Gene Essentiality.

Grassian AR, Scales TME, Knutson SK, Kuntz KW, McCarthy NJ, Lowe CE, Moore JD, Copeland RA, Keilhack H, Smith JJ, Wickenden JA, Ribich S.

Biol Proced Online. 2015 Nov 14;17:15. doi: 10.1186/s12575-015-0028-4. eCollection 2015.

3.

Knockdown of diacylglycerol kinase delta inhibits adipocyte differentiation and alters lipid synthesis.

Lowe CE, Zhang Q, Dennis RJ, Aubry EM, O'Rahilly S, Wakelam MJ, Rochford JJ.

Obesity (Silver Spring). 2013 Sep;21(9):1823-9. doi: 10.1002/oby.20297. Epub 2013 May 23.

4.

Mapping cis- and trans-regulatory effects across multiple tissues in twins.

Grundberg E, Small KS, Hedman ÅK, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, Shin SY, Glass D, Travers M, Min JL, Ring S, Ho K, Thorleifsson G, Kong A, Thorsteindottir U, Ainali C, Dimas AS, Hassanali N, Ingle C, Knowles D, Krestyaninova M, Lowe CE, Di Meglio P, Montgomery SB, Parts L, Potter S, Surdulescu G, Tsaprouni L, Tsoka S, Bataille V, Durbin R, Nestle FO, O'Rahilly S, Soranzo N, Lindgren CM, Zondervan KT, Ahmadi KR, Schadt EE, Stefansson K, Smith GD, McCarthy MI, Deloukas P, Dermitzakis ET, Spector TD; Multiple Tissue Human Expression Resource (MuTHER) Consortium.

Nat Genet. 2012 Oct;44(10):1084-9. doi: 10.1038/ng.2394. Epub 2012 Sep 2.

5.

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.

Lowe CE, Dennis RJ, Obi U, O'Rahilly S, Rochford JJ.

Int J Obes (Lond). 2012 Sep;36(9):1248-51. doi: 10.1038/ijo.2011.233. Epub 2011 Nov 29.

6.

Adipogenesis at a glance.

Lowe CE, O'Rahilly S, Rochford JJ.

J Cell Sci. 2011 Aug 15;124(Pt 16):2681-6. doi: 10.1242/jcs.079699. Review. No abstract available. Erratum in: J Cell Sci. 2011 Nov 1;124(Pt 21):3726.

7.

Opportunity costs of gastrointestinal endoscopic training in Canada.

Depew WT, Hookey LC, Vanner SJ, Louw JA, Lowe CE, Ropeleski MJ, Beyak MJ, Lazarescu A, Paterson WG.

Can J Gastroenterol. 2010 Dec;24(12):733-8.

8.

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis.

Payne VA, Au WS, Lowe CE, Rahman SM, Friedman JE, O'Rahilly S, Rochford JJ.

Biochem J. 2009 Dec 14;425(1):215-23. doi: 10.1042/BJ20091112.

9.

Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.

Carr EJ, Clatworthy MR, Lowe CE, Todd JA, Wong A, Vyse TJ, Kamesh L, Watts RA, Lyons PA, Smith KG.

BMC Med Genet. 2009 Mar 5;10:22. doi: 10.1186/1471-2350-10-22.

10.

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S; International Multiple Sclerosis Genetics Consortium, De Jager PL, Wicker LS, Todd JA, Hafler DA.

PLoS Genet. 2009 Jan;5(1):e1000322. doi: 10.1371/journal.pgen.1000322. Epub 2009 Jan 2.

11.

Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes.

Vella A, Bouatia-Naji N, Heude B, Cooper JD, Lowe CE, Petry C, Ring SM, Dunger DB, Todd JA, Ong KK.

Diabetologia. 2008 May;51(5):811-5. doi: 10.1007/s00125-008-0970-7. Epub 2008 Mar 4.

12.

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA.

Nat Genet. 2007 Sep;39(9):1074-82. Epub 2007 Aug 5.

PMID:
17676041
13.

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C; Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC; Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG.

Nat Genet. 2007 Jul;39(7):857-64. Epub 2007 Jun 6.

14.

Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11.

Nejentsev S, Smink LJ, Smyth D, Bailey R, Lowe CE, Payne F, Masters J, Godfrey L, Lam A, Burren O, Stevens H, Nutland S, Walker NM, Smith A, Twells R, Barratt BJ, Wright C, French L, Chen Y, Deloukas P, Rogers J, Dunham I, Todd JA.

BMC Genet. 2007 May 17;8:24.

15.

Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.

Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC.

Clin Endocrinol (Oxf). 2007 Apr;66(4):508-12.

PMID:
17371467
16.

Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.

Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP.

J Allergy Clin Immunol. 2006 Jun;117(6):1306-13. Epub 2006 Apr 3.

PMID:
16750991
17.

No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases.

Smyth DJ, Cooper JD, Lowe CE, Nutland S, Walker NM, Clayton DG, Todd JA.

Diabetes. 2006 May;55(5):1525-8.

18.

Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.

Taniguchi H, Lowe CE, Cooper JD, Smyth DJ, Bailey R, Nutland S, Healy BC, Lam AC, Burren O, Walker NM, Smink LJ, Wicker LS, Todd JA.

BMC Genet. 2006 Apr 20;7:22.

19.

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

Smyth DJ, Howson JM, Payne F, Maier LM, Bailey R, Holland K, Lowe CE, Cooper JD, Hulme JS, Vella A, Dahlman I, Lam AC, Nutland S, Walker NM, Twells RC, Todd JA.

BMC Med Genet. 2006 Mar 6;7:20.

20.

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.

Morris GA, Lowe CE, Cooper JD, Payne F, Vella A, Godfrey L, Hulme JS, Walker NM, Healy BC, Lam AC, Lyons PA, Todd JA.

BMC Genet. 2006 Feb 22;7:12.

21.

The outcome of cardiac surgery in dialysis-dependent patients.

Zimmet AD, Almeida A, Goldstein J, Shardey GC, Pick AW, Lowe CE, Jolley DJ, Smith JA.

Heart Lung Circ. 2005 Sep;14(3):187-90. Epub 2005 Jul 25.

PMID:
16352275
22.

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.

Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, Jones R, Ring SM, McArdle W, Pembrey ME, Strachan DP, Dunger DB, Twells RC, Clayton DG, Todd JA.

Am J Hum Genet. 2005 May;76(5):773-9. Epub 2005 Mar 17.

23.

The effects of ligand exchange and mobility on the peroxidase activity of a bacterial cytochrome c upon unfolding.

Worrall JA, Diederix RE, Prudêncio M, Lowe CE, Ciofi-Baffoni S, Ubbink M, Canters GW.

Chembiochem. 2005 Apr;6(4):747-58.

PMID:
15744766
24.

Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.

Nat Genet. 2005 Feb;37(2):110-1; author reply 112-3. No abstract available. Erratum in: Nat Genet. 2005 Mar;37(3):328.

PMID:
15678134
25.

Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetes.

Hulme JS, Barratt BJ, Twells RC, Cooper JD, Lowe CE, Howson JM, Lam AC, Smink LJ, Savage DA, Undlien DE, Guja C, Ionescu-Tîirgoviste C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA.

Diabetes. 2004 Sep;53(9):2479-82.

26.

Functional characterization of the evolutionarily divergent fern plastocyanin.

Navarro JA, Lowe CE, Amons R, Kohzuma T, Canters GW, De la Rosa MA, Ubbink M, Hervás M.

Eur J Biochem. 2004 Aug;271(16):3449-56.

27.

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA.

Diabetes. 2004 Jul;53(7):1884-9.

28.

Cost-effective analysis of candidate genes using htSNPs: a staged approach.

Lowe CE, Cooper JD, Chapman JM, Barratt BJ, Twells RC, Green EA, Savage DA, Guja C, Ionescu-Tîrgovişte C, Tuomilehto-Wolf E, Tuomilehto J, Todd JA, Clayton DG.

Genes Immun. 2004 Jun;5(4):301-5.

PMID:
15029236
29.

Upper gastrointestinal toxicity of alendronate.

Lowe CE, Depew WT, Vanner SJ, Paterson WG, Meddings JB.

Am J Gastroenterol. 2000 Mar;95(3):634-40.

PMID:
10710050
30.

Hypercalcemia in myxedema.

LOWE CE, BIRD ED, THOMAS WC Jr.

J Clin Endocrinol Metab. 1962 Mar;22:261-7. No abstract available.

PMID:
14466928

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