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Orientation selective deep brain stimulation of the subthalamic nucleus in rats.

Lehto LJ, Canna A, Wu L, Sierra A, Zhurakovskaya E, Ma J, Pearce C, Shaio M, Filip P, Johnson MD, Low WC, Gröhn O, Tanila H, Mangia S, Michaeli S.

Neuroimage. 2020 Mar 17:116750. doi: 10.1016/j.neuroimage.2020.116750. [Epub ahead of print]


Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease-A Pilot Study.

Sathe AG, Tuite P, Chen C, Ma Y, Chen W, Cloyd J, Low WC, Steer CJ, Lee BY, Zhu XH, Coles LD.

J Clin Pharmacol. 2020 Feb 12. doi: 10.1002/jcph.1575. [Epub ahead of print]


Efficacy of Cell-Based Therapies for Traumatic Brain Injuries.

Chrostek MR, Fellows EG, Guo WL, Swanson WJ, Crane AT, Cheeran MC, Low WC, Grande AW.

Brain Sci. 2019 Oct 10;9(10). pii: E270. doi: 10.3390/brainsci9100270.


Health-seeking behaviour of the elderly living alone in an urbanised low-income community in Singapore.

Lee JMG, Chan CQH, Low WC, Lee KH, Low LL.

Singapore Med J. 2019 Sep 6. doi: 10.11622/smedj.2019104. [Epub ahead of print]


Interspecies Organogenesis for Human Transplantation.

Crane AT, Aravalli RN, Asakura A, Grande AW, Krishna VD, Carlson DF, Cheeran MC, Danczyk G, Dutton JR, Hackett PB, Hu WS, Li L, Lu WC, Miller ZD, O'Brien TD, Panoskaltsis-Mortari A, Parr AM, Pearce C, Ruiz-Estevez M, Shiao M, Sipe CJ, Toman NG, Voth J, Xie H, Steer CJ, Low WC.

Cell Transplant. 2019 Sep-Oct;28(9-10):1091-1105. doi: 10.1177/0963689719845351. Epub 2019 Aug 19.


Efficacy of stem cell-based therapies for stroke.

Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC.

Brain Res. 2019 Nov 1;1722:146362. doi: 10.1016/j.brainres.2019.146362. Epub 2019 Aug 2. Review.


Neural Repair in Stroke.

Toman NG, Grande AW, Low WC.

Cell Transplant. 2019 Sep-Oct;28(9-10):1123-1126. doi: 10.1177/0963689719863784. Epub 2019 Jul 29.


A Proof of Concept for Applying the Radicchi Index (hf) to Compare Academic Productivity and Scientific Impact Among Medical Specialties.

Do TH, Miller C, Low WC, Haines SJ.

Neurosurgery. 2020 Apr 1;86(4):593-603. doi: 10.1093/neuros/nyz207.


SOX2 is required for inner ear growth and cochlear nonsensory formation before sensory development.

Steevens AR, Glatzer JC, Kellogg CC, Low WC, Santi PA, Kiernan AE.

Development. 2019 Jun 21;146(13). pii: dev170522. doi: 10.1242/dev.170522.


Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis.

Shiao ML, Yuan C, Crane AT, Voth JP, Juliano M, Stone LLH, Nan Z, Zhang Y, Kuzmin-Nichols N, Sanberg PR, Grande AW, Low WC.

Cell Transplant. 2019 Jul;28(7):864-873. doi: 10.1177/0963689719836763. Epub 2019 May 8.


Concise Review: Human-Animal Neurological Chimeras: Humanized Animals or Human Cells in an Animal?

Crane AT, Voth JP, Shen FX, Low WC.

Stem Cells. 2019 Apr;37(4):444-452. doi: 10.1002/stem.2971. Epub 2019 Jan 28. Review.


Tuning Neuromodulation Effects by Orientation Selective Deep Brain Stimulation in the Rat Medial Frontal Cortex.

Lehto LJ, Filip P, Laakso H, Sierra A, Slopsema JP, Johnson MD, Eberly LE, Low WC, Gröhn O, Tanila H, Mangia S, Michaeli S.

Front Neurosci. 2018 Dec 13;12:899. doi: 10.3389/fnins.2018.00899. eCollection 2018.


Distinct Patterns of Fiber Type Adaptation in Rat Hindlimb Muscles 4 Weeks After Hemorrhagic Stroke.

Snow LM, Low WC, Thompson LV.

Am J Phys Med Rehabil. 2019 Apr;98(4):266-274. doi: 10.1097/PHM.0000000000001062.


Functional Magnetic Resonance Imaging and Oculomotor Dysfunction in Mild Traumatic Brain Injury.

Rockswold SB, Burton PC, Chang A, McNally N, Grant A, Rockswold GL, Low WC, Eberly LE, Yacoub E, Lenglet C.

J Neurotrauma. 2019 Apr 1;36(7):1099-1105. doi: 10.1089/neu.2018.5796. Epub 2018 Aug 28.


Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells.

Walsh P, Truong V, Hill C, Stoflet ND, Baden J, Low WC, Keirstead SA, Dutton JR, Parr AM.

Cell Transplant. 2017 Dec;26(12):1890-1902. doi: 10.1177/0963689717737074.


Prevention of Neurocognitive Deficiency in Mucopolysaccharidosis Type II Mice by Central Nervous System-Directed, AAV9-Mediated Iduronate Sulfatase Gene Transfer.

Laoharawee K, Podetz-Pedersen KM, Nguyen TT, Evenstar LB, Kitto KF, Nan Z, Fairbanks CA, Low WC, Kozarsky KF, McIvor RS.

Hum Gene Ther. 2017 Aug;28(8):626-638. doi: 10.1089/hum.2016.184. Epub 2017 May 5.


Intranasal Adeno-Associated Virus Mediated Gene Delivery and Expression of Human Iduronidase in the Central Nervous System: A Noninvasive and Effective Approach for Prevention of Neurologic Disease in Mucopolysaccharidosis Type I.

Belur LR, Temme A, Podetz-Pedersen KM, Riedl M, Vulchanova L, Robinson N, Hanson LR, Kozarsky KF, Orchard PJ, Frey WH 2nd, Low WC, McIvor RS.

Hum Gene Ther. 2017 Jul;28(7):576-587. doi: 10.1089/hum.2017.187. Epub 2017 Apr 20.


Immune and viral therapies for malignant primary brain tumors.

Gardeck AM, Sheehan J, Low WC.

Expert Opin Biol Ther. 2017 Apr;17(4):457-474. doi: 10.1080/14712598.2017.1296132. Epub 2017 Mar 5. Review.


Orientation selective deep brain stimulation.

Lehto LJ, Slopsema JP, Johnson MD, Shatillo A, Teplitzky BA, Utecht L, Adriany G, Mangia S, Sierra A, Low WC, Gröhn O, Michaeli S.

J Neural Eng. 2017 Feb;14(1):016016. doi: 10.1088/1741-2552/aa5238. Epub 2017 Jan 9.


Amelioration of Ischemic Brain Injury in Rats With Human Umbilical Cord Blood Stem Cells: Mechanisms of Action.

Hocum Stone LL, Xiao F, Rotschafer J, Nan Z, Juliano M, Sanberg CD, Sanberg PR, Kuzmin-Nichols N, Grande A, Cheeran MC, Low WC.

Cell Transplant. 2016;25(8):1473-88. doi: 10.3727/096368916X691277. Epub 2016 Mar 18.


T cell deficiency in spinal cord injury: altered locomotor recovery and whole-genome transcriptional analysis.

Satzer D, Miller C, Maxon J, Voth J, DiBartolomeo C, Mahoney R, Dutton JR, Low WC, Parr AM.

BMC Neurosci. 2015 Nov 6;16:74. doi: 10.1186/s12868-015-0212-0.


Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development.

Diao HJ, Low WC, Lu QR, Chew SY.

Biomaterials. 2015 Nov;70:105-14. doi: 10.1016/j.biomaterials.2015.08.029. Epub 2015 Aug 18.


Mussel-Inspired Modification of Nanofibers for REST siRNA Delivery: Understanding the Effects of Gene-Silencing and Substrate Topography on Human Mesenchymal Stem Cell Neuronal Commitment.

Low WC, Rujitanaroj PO, Lee DK, Kuang J, Messersmith PB, Chan JK, Chew SY.

Macromol Biosci. 2015 Oct;15(10):1457-68. doi: 10.1002/mabi.201500101. Epub 2015 Jun 19.


Alignment Analyses in the Varus Osteoarthritic Knee Using Computer Navigation.

Tan KG, Sathappan SS, Teo YH, Low WC.

Am J Orthop (Belle Mead NJ). 2015 Jun;44(6):277-83.


Directed Differentiation of Oligodendrocyte Progenitor Cells From Mouse Induced Pluripotent Stem Cells.

Terzic D, Maxon JR, Krevitt L, DiBartolomeo C, Goyal T, Low WC, Dutton JR, Parr AM.

Cell Transplant. 2016;25(2):411-24. doi: 10.3727/096368915X688137. Epub 2015 May 7.


Nanofiber-mediated release of retinoic acid and brain-derived neurotrophic factor for enhanced neuronal differentiation of neural progenitor cells.

Low WC, Rujitanaroj PO, Wang F, Wang J, Chew SY.

Drug Deliv Transl Res. 2015 Apr;5(2):89-100. doi: 10.1007/s13346-013-0131-5.


Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells.

Diao HJ, Low WC, Milbreta U, Lu QR, Chew SY.

J Control Release. 2015 Jun 28;208:85-92. doi: 10.1016/j.jconrel.2015.03.005. Epub 2015 Mar 5.


Assessment of dysmyelination with RAFFn MRI: application to murine MPS I.

Satzer D, DiBartolomeo C, Ritchie MM, Storino C, Liimatainen T, Hakkarainen H, Idiyatullin D, Mangia S, Michaeli S, Parr AM, Low WC.

PLoS One. 2015 Feb 13;10(2):e0116788. doi: 10.1371/journal.pone.0116788. eCollection 2015.


A Novel Preclinical Model of Moderate Primary Blast-Induced Traumatic Brain Injury.

Divani AA, Murphy AJ, Meints J, Sadeghi-Bazargani H, Nordberg J, Monga M, Low WC, Bhatia PM, Beilman GJ, SantaCruz KS.

J Neurotrauma. 2015 Jul 15;32(14):1109-16. doi: 10.1089/neu.2014.3686. Epub 2015 Apr 10.


Gene therapy for neurologic manifestations of mucopolysaccharidoses.

Wolf DA, Banerjee S, Hackett PB, Whitley CB, McIvor RS, Low WC.

Expert Opin Drug Deliv. 2015 Feb;12(2):283-96. doi: 10.1517/17425247.2015.966682. Epub 2014 Dec 16. Review.


Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice.

Heuss ND, Pierson MJ, Montaniel KR, McPherson SW, Lehmann U, Hussong SA, Ferrington DA, Low WC, Gregerson DS.

J Neuroinflammation. 2014 Aug 13;11:143. doi: 10.1186/s12974-014-0143-1.


The Unexpected Uses of Urso- and Tauroursodeoxycholic Acid in the Treatment of Non-liver Diseases.

Vang S, Longley K, Steer CJ, Low WC.

Glob Adv Health Med. 2014 May;3(3):58-69. doi: 10.7453/gahmj.2014.017. Review.


The Structural Basis of Functional Improvement in Response to Human Umbilical Cord Blood Stem Cell Transplantation in Hearts With Postinfarct LV Remodeling.

Chen Y, Ye L, Zhong J, Li X, Yan C, Chandler MP, Calvin S, Xiao F, Negia M, Low WC, Zhang J, Yu X.

Cell Transplant. 2015;24(6):971-83. doi: 10.3727/096368913X675746. Epub 2013 Dec 10.


Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-α-L-Iduronidase for Hurler Disease.

Janson CG, Romanova LG, Leone P, Nan Z, Belur L, McIvor RS, Low WC.

Neurosurgery. 2014 Jan;74(1):99-111. doi: 10.1227/NEU.0000000000000157.


Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.

Wang C, Low WC, Liu A, Wang B.

J Biol Chem. 2013 Oct 11;288(41):29518-29. doi: 10.1074/jbc.M113.492066. Epub 2013 Aug 16.


Modulation of neural stem/progenitor cell proliferation during experimental Herpes Simplex encephalitis is mediated by differential FGF-2 expression in the adult brain.

Rotschafer JH, Hu S, Little M, Erickson M, Low WC, Cheeran MC.

Neurobiol Dis. 2013 Oct;58:144-55. doi: 10.1016/j.nbd.2013.05.018. Epub 2013 Jun 5.


Central calcaneal osteotomy for correction of flexible pes planovalgus deformity.

Klaue K, Kaliyaperumal K, Swanson SA, Low WC.

Foot Ankle Int. 2013 Aug;34(8):1079-89. doi: 10.1177/1071100713483102. Epub 2013 Mar 26.


Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells.

Low WC, Rujitanaroj PO, Lee DK, Messersmith PB, Stanton LW, Goh E, Chew SY.

Biomaterials. 2013 May;34(14):3581-90. doi: 10.1016/j.biomaterials.2013.01.093. Epub 2013 Feb 14.


Neural repair and neuroprotection with stem cells in ischemic stroke.

Stone LL, Grande A, Low WC.

Brain Sci. 2013 Apr 23;3(2):599-614. doi: 10.3390/brainsci3020599.


Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy.

Misra V, Ritchie MM, Stone LL, Low WC, Janardhan V.

Neurology. 2012 Sep 25;79(13 Suppl 1):S207-12. Review.


Parental smoking and childhood refractive error: the STARS study.

Iyer JV, Low WC, Dirani M, Saw SM.

Eye (Lond). 2012 Oct;26(10):1324-8. doi: 10.1038/eye.2012.160. Epub 2012 Aug 31.


Skeletal muscle plasticity after hemorrhagic stroke in rats: influence of spontaneous physical activity.

Snow LM, Low WC, Thompson LV.

Am J Phys Med Rehabil. 2012 Nov;91(11):965-76. doi: 10.1097/PHM.0b013e31825f18e1.


Prognosis of treatment response (pathological complete response) in breast cancer.

Nikas JB, Low WC, Burgio PA.

Biomark Insights. 2012;7:59-70. doi: 10.4137/BMI.S9387. Epub 2012 May 8.


Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I).

Nan Z, Shekels L, Ryabinin O, Evavold C, Nelson MS, Khan SA, Deans RJ, Mays RW, Low WC, Gupta P.

Cell Transplant. 2012;21(7):1577-93.


Lysosomal enzyme can bypass the blood-brain barrier and reach the CNS following intranasal administration.

Wolf DA, Hanson LR, Aronovich EL, Nan Z, Low WC, Frey WH 2nd, McIvor RS.

Mol Genet Metab. 2012 May;106(1):131-4. doi: 10.1016/j.ymgme.2012.02.006. Epub 2012 Feb 10.


Directing neuronal differentiation of primary neural progenitor cells by gene knockdown approach.

Low WC, Yau WW, Stanton LW, Marcy G, Goh E, Chew SY.

DNA Cell Biol. 2012 Jul;31(7):1148-60. doi: 10.1089/dna.2011.1557. Epub 2012 Feb 17.


Linear Discriminant Functions in Connection with the micro-RNA Diagnosis of Colon Cancer.

Nikas JB, Low WC.

Cancer Inform. 2012;11:1-14. doi: 10.4137/CIN.S8779. Epub 2011 Dec 20.


Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I.

Wolf DA, Lenander AW, Nan Z, Braunlin EA, Podetz-Pedersen KM, Whitley CB, Gupta P, Low WC, McIvor RS.

Bone Marrow Transplant. 2012 Sep;47(9):1235-40. doi: 10.1038/bmt.2011.239. Epub 2011 Dec 19.


Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells.

Chun HS, Low WC.

Toxicology. 2012 Feb 26;292(2-3):105-12. doi: 10.1016/j.tox.2011.11.020. Epub 2011 Dec 8.


Mathematical prognostic biomarker models for treatment response and survival in epithelial ovarian cancer.

Nikas JB, Boylan KL, Skubitz AP, Low WC.

Cancer Inform. 2011;10:233-47. doi: 10.4137/CIN.S8104. Epub 2011 Oct 3.

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