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Items: 1 to 50 of 54


Plasma/serum proteomics: depletion strategies for reducing high-abundance proteins for biomarker discovery.

Lee PY, Osman J, Low TY, Jamal R.

Bioanalysis. 2019 Oct 16. doi: 10.4155/bio-2019-0145. [Epub ahead of print]


Changing trends and outcomes associated with the adoption of minimally invasive pancreatic surgeries: A single institution experience with 150 consecutive procedures in Southeast Asia.

Goh BK, Low TY, Koh YX, Lee SY, Teo JY, Kam JH, Jeyaraj PR, Cheow PC, Chow PK, Ooi LL, Chung AY, Chan CY.

J Minim Access Surg. 2019 Oct 1. doi: 10.4103/jmas.JMAS_127_19. [Epub ahead of print]


First experience with robotic pancreatoduodenectomy in Singapore.

Low TY, Koh YX, Goh BK.

Singapore Med J. 2019 Sep 19. doi: 10.11622/smedj.2019119. [Epub ahead of print]


Proteogenomics: From next-generation sequencing (NGS) and mass spectrometry-based proteomics to precision medicine.

Ang MY, Low TY, Lee PY, Wan Mohamad Nazarie WF, Guryev V, Jamal R.

Clin Chim Acta. 2019 Nov;498:38-46. doi: 10.1016/j.cca.2019.08.010. Epub 2019 Aug 14. Review.


Signatures of gene expression, DNA methylation and microRNAs of hepatocellular carcinoma with vascular invasion.

Sulaiman SA, Abu N, Ab-Mutalib NS, Low TY, Jamal R.

Future Oncol. 2019 Aug;15(22):2603-2617. doi: 10.2217/fon-2018-0909. Epub 2019 Jul 24.


Sudden Cardiac Death (SCD) - risk stratification and prediction with molecular biomarkers.

Osman J, Tan SC, Lee PY, Low TY, Jamal R.

J Biomed Sci. 2019 May 22;26(1):39. doi: 10.1186/s12929-019-0535-8. Review.


Initial single institution experience with robotic biliary surgery and bilio-enteric anastomosis in southeast Asia.

Goh BKP, Low TY, Teo JY, Lee SY, Chan CY, Chung AYF, Ooi LLPJ.

ANZ J Surg. 2019 Apr;89(4):E142-E146. doi: 10.1111/ans.15135. Epub 2019 Mar 18.


Initial experience with laparoscopic and robotic surgery for the treatment of periampullary tumours: single institution experience with the first 30 consecutive cases.

Goh BKP, Low TY, Kam JH, Lee SY, Chan CY.

ANZ J Surg. 2019 Apr;89(4):E137-E141. doi: 10.1111/ans.15033. Epub 2019 Feb 25.


Probing the endogenous peptidomes of cancer for biomarkers: A new endeavor.

Lee PY, Low TY, Jamal R.

Adv Clin Chem. 2019;88:67-89. doi: 10.1016/bs.acc.2018.10.004. Epub 2018 Dec 27. Review.


Analyzing the Secretome of Gut Microbiota as the Next Strategy For Early Detection of Colorectal Cancer.

Megat Mohd Azlan PI, Chin SF, Low TY, Neoh HM, Jamal R.

Proteomics. 2019 May;19(10):e1800176. doi: 10.1002/pmic.201800176. Epub 2019 Jan 25. Review.


Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.

Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I.

Nat Struct Mol Biol. 2018 Dec;25(12):1119-1127. doi: 10.1038/s41594-018-0156-z. Epub 2018 Dec 3.


Connecting Proteomics to Next-Generation Sequencing: Proteogenomics and Its Current Applications in Biology.

Low TY, Mohtar MA, Ang MY, Jamal R.

Proteomics. 2019 May;19(10):e1800235. doi: 10.1002/pmic.201800235. Epub 2018 Dec 11. Review.


Corrigendum to "Probing the colorectal cancer proteome for biomarkers: Current status and perspectives" [J Proteomics Vol. 187 (2018) 93-105].

Lee PY, Chin SF, Low TY, Jamal R.

J Proteomics. 2019 Feb 10;192:383. doi: 10.1016/j.jprot.2018.08.017. Epub 2018 Sep 10. No abstract available.


Outcomes After Metabolic Surgery in Asians-a Meta-analysis.

Yeo D, Yeo C, Low TY, Ahmed S, Phua S, Oo AM, Rao J, Koura A, Venkataraman K, Kaushal S.

Obes Surg. 2019 Jan;29(1):114-126. doi: 10.1007/s11695-018-3484-5.


Probing the colorectal cancer proteome for biomarkers: Current status and perspectives.

Lee PY, Chin SF, Low TY, Jamal R.

J Proteomics. 2018 Sep 15;187:93-105. doi: 10.1016/j.jprot.2018.06.014. Epub 2018 Jun 25. Review. Erratum in: J Proteomics. 2019 Feb 10;192:383.


Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1.

Magliozzi R, Carrero ZI, Low TY, Yuniati L, Valdes-Quezada C, Kruiswijk F, van Wijk K, Heck AJR, Jackson CL, Guardavaccaro D.

Cell Rep. 2018 Jun 12;23(11):3381-3391.e4. doi: 10.1016/j.celrep.2018.05.031.


Initial experience with robotic pancreatic surgery in Singapore: single institution experience with 30 consecutive cases.

Goh BKP, Low TY, Lee SY, Chan CY, Chung AYF, Ooi LLPJ.

ANZ J Surg. 2019 Mar;89(3):206-210. doi: 10.1111/ans.14673. Epub 2018 May 24.


TMEM59 potentiates Wnt signaling by promoting signalosome formation.

Gerlach JP, Jordens I, Tauriello DVF, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJR, Egan DA, Maurice MM.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3996-E4005. doi: 10.1073/pnas.1721321115. Epub 2018 Apr 9.


Short-Term Outcomes of Extended Pancreatectomy: A Single-Surgeon Experience.

Low TY, Koh YX, Teo JY, Goh BKP.

Gastrointest Tumors. 2018 Feb;4(3-4):72-83. doi: 10.1159/000484523. Epub 2017 Nov 30.


Emergency hand-assisted laparoscopic haemostasis for post-operative haemorrhage following laparoscopic liver resection.

Low TY, Goh BKP.

J Minim Access Surg. 2018 Apr-Jun;14(2):171-173. doi: 10.4103/jmas.JMAS_50_17.


Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.

Wang SC, Low TYF, Nishimura Y, Gole L, Yu W, Motegi F.

Nat Cell Biol. 2017 Aug;19(8):988-995. doi: 10.1038/ncb3577. Epub 2017 Jul 24.


Forceful patterning in mouse preimplantation embryos.

Ramanujam R, Low TYF, Lim YW, Motegi F.

Semin Cell Dev Biol. 2017 Nov;71:129-136. doi: 10.1016/j.semcdb.2017.05.011. Epub 2017 May 31. Review.


A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.

Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B, van den Heuvel S, Heck AJ, Boxem M.

BMC Biol. 2016 Aug 9;14:66. doi: 10.1186/s12915-016-0286-x.


Six alternative proteases for mass spectrometry-based proteomics beyond trypsin.

Giansanti P, Tsiatsiani L, Low TY, Heck AJ.

Nat Protoc. 2016 May;11(5):993-1006. doi: 10.1038/nprot.2016.057. Epub 2016 Apr 28.


Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.

Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM.

Nat Struct Mol Biol. 2016 Apr;23(4):324-32. doi: 10.1038/nsmb.3191. Epub 2016 Mar 14.


Reconciling proteomics with next generation sequencing.

Low TY, Heck AJ.

Curr Opin Chem Biol. 2016 Feb;30:14-20. doi: 10.1016/j.cbpa.2015.10.023. Epub 2015 Nov 17. Review.


Datasets from an interaction proteomics screen for substrates of the SCF(βTrCP) ubiquitin ligase.

Magliozzi R, Peng M, Mohammed S, Guardavaccaro D, Heck AJ, Low TY.

Data Brief. 2015 Jun 10;4:229-34. doi: 10.1016/j.dib.2015.05.003. eCollection 2015 Sep.


A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

Low TY, Peng M, Magliozzi R, Mohammed S, Guardavaccaro D, Heck AJ.

Sci Signal. 2014 Dec 16;7(356):rs8. doi: 10.1126/scisignal.2005882.


USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

Kim J, D'Annibale S, Magliozzi R, Low TY, Jansen P, Shaltiel IA, Mohammed S, Heck AJ, Medema RH, Guardavaccaro D.

Mol Cell Biol. 2014 Nov 15;34(22):4177-85. doi: 10.1128/MCB.00530-14. Epub 2014 Sep 8.


Degradation of Tiam1 by casein kinase 1 and the SCFβTrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.

Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D.

J Biol Chem. 2014 Oct 3;289(40):27400-9. doi: 10.1074/jbc.M114.575571. Epub 2014 Aug 14.


Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.

D'Annibale S, Kim J, Magliozzi R, Low TY, Mohammed S, Heck AJ, Guardavaccaro D.

J Biol Chem. 2014 Mar 14;289(11):7730-7. doi: 10.1074/jbc.M114.549535. Epub 2014 Feb 5.


Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D.

Dev Cell. 2013 Dec 9;27(5):574-85. doi: 10.1016/j.devcel.2013.10.023. Epub 2013 Nov 27.


Quantitative and qualitative proteome characteristics extracted from in-depth integrated genomics and proteomics analysis.

Low TY, van Heesch S, van den Toorn H, Giansanti P, Cristobal A, Toonen P, Schafer S, Hübner N, van Breukelen B, Mohammed S, Cuppen E, Heck AJ, Guryev V.

Cell Rep. 2013 Dec 12;5(5):1469-78. doi: 10.1016/j.celrep.2013.10.041. Epub 2013 Nov 27.


The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.


Unraveling the ubiquitin-regulated signaling networks by mass spectrometry-based proteomics.

Low TY, Magliozzi R, Guardavaccaro D, Heck AJ.

Proteomics. 2013 Feb;13(3-4):526-37. doi: 10.1002/pmic.201200244. Epub 2012 Nov 26. Review.


Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.

Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H.

Nature. 2012 Aug 30;488(7413):665-9. doi: 10.1038/nature11308.


Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H.

Cell. 2012 Jun 8;149(6):1245-56. doi: 10.1016/j.cell.2012.05.002.


Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

Kruiswijk F, Yuniati L, Magliozzi R, Low TY, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJ, Pagano M, Guardavaccaro D.

Sci Signal. 2012 Jun 5;5(227):ra40. doi: 10.1126/scisignal.2002718.


Use of stable isotope dimethyl labeling coupled to selected reaction monitoring to enhance throughput by multiplexing relative quantitation of targeted proteins.

Aye TT, Low TY, Bjørlykke Y, Barsnes H, Heck AJ, Berven FS.

Anal Chem. 2012 Jun 5;84(11):4999-5006. doi: 10.1021/ac300596r. Epub 2012 May 15.


The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells.

Munoz J, Low TY, Kok YJ, Chin A, Frese CK, Ding V, Choo A, Heck AJ.

Mol Syst Biol. 2011 Nov 22;7:550. doi: 10.1038/msb.2011.84.


Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.

de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, Nishimori K, Mohammed S, Heck AJ, Clevers H.

Nature. 2011 Jul 4;476(7360):293-7. doi: 10.1038/nature10337.


Enhancing the identification of phosphopeptides from putative basophilic kinase substrates using Ti (IV) based IMAC enrichment.

Zhou H, Low TY, Hennrich ML, van der Toorn H, Schwend T, Zou H, Mohammed S, Heck AJ.

Mol Cell Proteomics. 2011 Oct;10(10):M110.006452. doi: 10.1074/mcp.M110.006452. Epub 2011 Jun 29. Erratum in: Mol Cell Proteomics. 2013 Sep;12(9):2673. Mohammed, Shabaz [added].


In-depth quantitative cardiac proteomics combining electron transfer dissociation and the metalloendopeptidase Lys-N with the SILAC mouse.

Scholten A, Mohammed S, Low TY, Zanivan S, van Veen TA, Delanghe B, Heck AJ.

Mol Cell Proteomics. 2011 Oct;10(10):O111.008474. doi: 10.1074/mcp.O111.008474. Epub 2011 Jun 24.


Deconvolution of overlapping isotopic clusters improves quantification of stable isotope-labeled peptides.

Cappadona S, Muñoz J, Spee WP, Low TY, Mohammed S, van Breukelen B, Heck AJ.

J Proteomics. 2011 Sep 6;74(10):2204-9. doi: 10.1016/j.jprot.2011.04.022. Epub 2011 May 15.


Novel polymer composite to eliminate background matrix ions in matrix assisted laser desorption/ionization-mass spectrometry.

Hua L, Low TY, Meng W, Chan-Park MB, Sze SK.

Analyst. 2007 Dec;132(12):1223-30.


Increase in local protein concentration by field-inversion gel electrophoresis.

Tsai H, Low TY, Freeby S, Paulus A, Ramnarayanan K, Cheng CP, Leung HC.

Proteome Sci. 2007 Sep 26;5:18.


Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.

Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP.

Proteomics. 2007 Jul;7(14):2384-97.


Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells.

Sze SK, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK.

Mol Cell Proteomics. 2007 Oct;6(10):1680-9. Epub 2007 Jun 11.


Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells.

Wu Q, Chen X, Zhang J, Loh YH, Low TY, Zhang W, Zhang W, Sze SK, Lim B, Ng HH.

J Biol Chem. 2006 Aug 25;281(34):24090-4. Epub 2006 Jul 13.

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