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First in man study of [18F]fluoro-PEG-folate PET: a novel macrophage imaging technique to visualize rheumatoid arthritis.

Verweij NJF, Yaqub M, Bruijnen STG, Pieplenbosch S, Ter Wee MM, Jansen G, Chen Q, Low PS, Windhorst AD, Lammertsma AA, Hoekstra OS, Voskuyl AE, van der Laken CJ.

Sci Rep. 2020 Jan 23;10(1):1047. doi: 10.1038/s41598-020-57841-x.


Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging.

Corbett CJ, Frenzel Sulyok LG, Predina JD, Newton AD, Bryski MG, Xia L, Stadanlick J, Shin MH, Mahalingam SM, Low PS, Singhal S.

Mol Imaging Biol. 2019 Dec 11. doi: 10.1007/s11307-019-01434-2. [Epub ahead of print]


Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.

Elo P, Li XG, Liljenbäck H, Helin S, Teuho J, Koskensalo K, Saunavaara V, Marjamäki P, Oikonen V, Virta J, Chen Q, Low PS, Knuuti J, Jalkanen S, Airas L, Roivainen A.

J Neuroinflammation. 2019 Dec 3;16(1):252. doi: 10.1186/s12974-019-1612-3.


The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.

Lu DC, Hannemann A, Wadud R, Rees DC, Brewin JN, Low PS, Gibson JS.

Pflugers Arch. 2019 Dec;471(11-12):1539-1549. doi: 10.1007/s00424-019-02327-7. Epub 2019 Nov 15.


A phase II, multicenter, open-label trial of OTL38 injection for the intra-operative imaging of folate receptor-alpha positive ovarian cancer.

Randall LM, Wenham RM, Low PS, Dowdy SC, Tanyi JL.

Gynecol Oncol. 2019 Oct;155(1):63-68. doi: 10.1016/j.ygyno.2019.07.010. Epub 2019 Jul 27.


Dysfunctional stem and progenitor cells impair fracture healing with age.

Wagner DR, Karnik S, Gunderson ZJ, Nielsen JJ, Fennimore A, Promer HJ, Lowery JW, Loghmani MT, Low PS, McKinley TO, Kacena MA, Clauss M, Li J.

World J Stem Cells. 2019 Jun 26;11(6):281-296. doi: 10.4252/wjsc.v11.i6.281. Review.


Evaluation of a Neurokinin-1 Receptor-Targeted Technetium-99m Conjugate for Neuroendocrine Cancer Imaging.

Kanduluru AK, Srinivasarao M, Wayua C, Low PS.

Mol Imaging Biol. 2019 Jul 10. doi: 10.1007/s11307-019-01391-w. [Epub ahead of print]


Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters.

Lee YG, Chu H, Lu Y, Leamon CP, Srinivasarao M, Putt KS, Low PS.

Nat Commun. 2019 Jun 18;10(1):2681. doi: 10.1038/s41467-019-10565-7.


Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis.

Hu Y, Wang B, Shen J, Low SA, Putt KS, Niessen HWM, Matteson EL, Murphy L, Ruppert C, Jansen G, Oliver SJ, Feng Y, Dimitrov DS, Nickerson-Nutter C, Low PS.

Arthritis Res Ther. 2019 Jun 7;21(1):143. doi: 10.1186/s13075-019-1912-0.


Oxygen tension-mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia.

Zhou S, Giannetto M, DeCourcey J, Kang H, Kang N, Li Y, Zheng S, Zhao H, Simmons WR, Wei HS, Bodine DM, Low PS, Nedergaard M, Wan J.

Sci Adv. 2019 May 29;5(5):eaaw4466. doi: 10.1126/sciadv.aaw4466. eCollection 2019 May.


Mutational spectrum of dystrophinopathies in Singapore: Insights for genetic diagnosis and precision therapy.

Tomar S, Moorthy V, Sethi R, Chai J, Low PS, Hong STK, Lai PS.

Am J Med Genet C Semin Med Genet. 2019 Jun;181(2):230-244. doi: 10.1002/ajmg.c.31704. Epub 2019 May 13.


Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin.

Orellana EA, Abdelaal AM, Rangasamy L, Tenneti S, Myoung S, Low PS, Kasinski AL.

Mol Ther Nucleic Acids. 2019 Jun 7;16:505-518. doi: 10.1016/j.omtn.2019.04.003. Epub 2019 Apr 11.


Evidence for three populations of the glucose transporter in the human erythrocyte membrane.

Kodippili GC, Putt KS, Low PS.

Blood Cells Mol Dis. 2019 Jul;77:61-66. doi: 10.1016/j.bcmd.2019.03.005. Epub 2019 Mar 29.


Preclinical Evaluation of Bispecific Adaptor Molecule Controlled Folate Receptor CAR-T Cell Therapy With Special Focus on Pediatric Malignancies.

Lu YJ, Chu H, Wheeler LW, Nelson M, Westrick E, Matthaei JF, Cardle II, Johnson A, Gustafson J, Parker N, Vetzel M, Xu LC, Wang EZ, Jensen MC, Klein PJ, Low PS, Leamon CP.

Front Oncol. 2019 Mar 19;9:151. doi: 10.3389/fonc.2019.00151. eCollection 2019.


Clinical impact of the two ART resistance markers, K13 gene mutations and DPC3 in Vietnam.

Pau MC, Pantaleo A, Tsamesidis I, Hoang H, Tuan Tran A, Hanh Nguyen TL, Giang Phan TH, Ton Nu PA, Chau Ngo TM, Marchetti G, Schwarzer E, Fiori PL, Low PS, Dinh Huynh C, Turrini FM.

PLoS One. 2019 Apr 2;14(4):e0214667. doi: 10.1371/journal.pone.0214667. eCollection 2019.


Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases.

Frigerio B, Bizzoni C, Jansen G, Leamon CP, Peters GJ, Low PS, Matherly LH, Figini M.

J Exp Clin Cancer Res. 2019 Mar 12;38(1):125. doi: 10.1186/s13046-019-1123-1.


Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Lake AD, Hardwick RN, Leamon CP, Low PS, Cherrington NJ.

Toxicol Appl Pharmacol. 2019 Apr 1;368:49-54. doi: 10.1016/j.taap.2019.02.009. Epub 2019 Feb 19.


Small molecule targeted NIR dye conjugate for imaging LHRH receptor positive cancers.

Roy J, Kaake M, Low PS.

Oncotarget. 2019 Jan 4;10(2):152-160. doi: 10.18632/oncotarget.26520. eCollection 2019 Jan 4.


Phase I/II clinical trial of the targeted chemotherapeutic drug, folate-tubulysin, in dogs with naturally-occurring invasive urothelial carcinoma.

Szigetvari NM, Dhawan D, Ramos-Vara JA, Leamon CP, Klein PJ, Ruple AA, Heng HG, Pugh MR, Rao S, Vlahov IR, Deshuillers PL, Low PS, Fourez LM, Cournoyer AM, Knapp DW.

Oncotarget. 2018 Dec 11;9(97):37042-37053. doi: 10.18632/oncotarget.26455. eCollection 2018 Dec 11.


Regulation of erythrocyte Na+/K+/2Cl- cotransport by an oxygen-switched kinase cascade.

Zheng S, Krump NA, McKenna MM, Li YH, Hannemann A, Garrett LJ, Gibson JS, Bodine DM, Low PS.

J Biol Chem. 2019 Feb 15;294(7):2519-2528. doi: 10.1074/jbc.RA118.006393. Epub 2018 Dec 18.


Intraoperative near-infrared imaging with receptor-specific versus passive delivery of fluorescent agents in pituitary adenomas.

Cho SS, Jeon J, Buch L, Nag S, Nasrallah M, Low PS, Grady MS, Singhal S, Lee JYK.

J Neurosurg. 2018 Dec 1:1-11. doi: 10.3171/2018.7.JNS181642. [Epub ahead of print]


Use of a Single CAR T Cell and Several Bispecific Adapters Facilitates Eradication of Multiple Antigenically Different Solid Tumors.

Lee YG, Marks I, Srinivasarao M, Kanduluru AK, Mahalingam SM, Liu X, Chu H, Low PS.

Cancer Res. 2019 Jan 15;79(2):387-396. doi: 10.1158/0008-5472.CAN-18-1834. Epub 2018 Nov 27.


Application of Sequential Palladium Catalysis for the Discovery of Janus Kinase Inhibitors in the Benzo[ c]pyrrolo[2,3- h][1,6]naphthyridin-5-one (BPN) Series.

Elsayed MSA, Nielsen JJ, Park S, Park J, Liu Q, Kim CH, Pommier Y, Agama K, Low PS, Cushman M.

J Med Chem. 2018 Dec 13;61(23):10440-10462. doi: 10.1021/acs.jmedchem.8b00510. Epub 2018 Nov 21.


Bone-Fracture-Targeted Dasatinib-Oligoaspartic Acid Conjugate Potently Accelerates Fracture Repair.

Wang M, Park S, Nam Y, Nielsen J, Low SA, Srinivasarao M, Low PS.

Bioconjug Chem. 2018 Nov 21;29(11):3800-3809. doi: 10.1021/acs.bioconjchem.8b00660. Epub 2018 Nov 9.


Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer.

Mahalingam SM, Kularatne SA, Myers CH, Gagare P, Norshi M, Liu X, Singhal S, Low PS.

J Med Chem. 2018 Nov 8;61(21):9637-9646. doi: 10.1021/acs.jmedchem.8b01115. Epub 2018 Oct 19.


Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence Imaging of Hypoxic Tumors.

Mahalingam SM, Chu H, Liu X, Leamon CP, Low PS.

Bioconjug Chem. 2018 Oct 17;29(10):3320-3331. doi: 10.1021/acs.bioconjchem.8b00509. Epub 2018 Sep 20.


Intraoperative fluorescence imaging in thoracic surgery.

Newton AD, Predina JD, Nie S, Low PS, Singhal S.

J Surg Oncol. 2018 Aug;118(2):344-355. doi: 10.1002/jso.25149. Epub 2018 Aug 11. Review.


Targeting of a Photosensitizer to the Mitochondrion Enhances the Potency of Photodynamic Therapy.

Mahalingam SM, Ordaz JD, Low PS.

ACS Omega. 2018 Jun 30;3(6):6066-6074. doi: 10.1021/acsomega.8b00692. Epub 2018 Jun 5.


Intraoperative Ureter Visualization Using a Novel Near-Infrared Fluorescent Dye.

Mahalingam SM, Dip F, Castillo M, Roy M, Wexner SD, Rosenthal RJ, Low PS.

Mol Pharm. 2018 Aug 6;15(8):3442-3447. doi: 10.1021/acs.molpharmaceut.8b00427. Epub 2018 Jul 18.


Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

Silvola JMU, Li XG, Virta J, Marjamäki P, Liljenbäck H, Hytönen JP, Tarkia M, Saunavaara V, Hurme S, Palani S, Hakovirta H, Ylä-Herttuala S, Saukko P, Chen Q, Low PS, Knuuti J, Saraste A, Roivainen A.

Sci Rep. 2018 Jun 26;8(1):9720. doi: 10.1038/s41598-018-27618-4.


Targeted Tubulysin B Hydrazide Conjugate for the Treatment of Luteinizing Hormone-Releasing Hormone Receptor-Positive Cancers.

Roy J, Kaake M, Srinivasarao M, Low PS.

Bioconjug Chem. 2018 Jul 18;29(7):2208-2214. doi: 10.1021/acs.bioconjchem.8b00164. Epub 2018 Jun 13.


Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate.

Chandrupatla DMSH, Molthoff CFM, Ritsema WIGR, Vos R, Elshof E, Matsuyama T, Low PS, Musters RJP, Hammond A, Windhorst AD, Lammertsma AA, van der Laken CJ, Brands R, Jansen G.

Transl Res. 2018 Sep;199:24-38. doi: 10.1016/j.trsl.2018.04.001. Epub 2018 May 17.


Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.

Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS.

Mol Pharm. 2018 Jun 4;15(6):2289-2296. doi: 10.1021/acs.molpharmaceut.8b00139. Epub 2018 May 1.


Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate.

Chandrupatla DMSH, Jansen G, Mantel E, Low PS, Matsuyama T, Musters RP, Windhorst AD, Lammertsma AA, Molthoff CFM, van der Laken CJ.

Contrast Media Mol Imaging. 2018 Feb 21;2018:8092781. doi: 10.1155/2018/8092781. eCollection 2018.


Localization of Pulmonary Ground-Glass Opacities with Folate Receptor-Targeted Intraoperative Molecular Imaging.

Predina JD, Newton A, Corbett C, Xia L, Sulyok LF, Shin M, Deshpande C, Litzky L, Barbosa E, Low PS, Kucharczuk JC, Singhal S.

J Thorac Oncol. 2018 Jul;13(7):1028-1036. doi: 10.1016/j.jtho.2018.03.023. Epub 2018 Apr 4.


Expression of functional folate receptors in multiple myeloma.

Zhou Y, Unno K, Hyjek E, Liu H, Zimmerman T, Karmakar S, Putt KS, Shen J, Low PS, Wickrema A.

Leuk Lymphoma. 2018 Dec;59(12):2982-2989. doi: 10.1080/10428194.2018.1453066. Epub 2018 Apr 4.


Fluorescence-guided surgery of cancer: applications, tools and perspectives.

Low PS, Singhal S, Srinivasarao M.

Curr Opin Chem Biol. 2018 Aug;45:64-72. doi: 10.1016/j.cbpa.2018.03.002. Epub 2018 Mar 23. Review.


An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas.

Predina JD, Newton AD, Xia L, Corbett C, Connolly C, Shin M, Sulyok LF, Litzky L, Deshpande C, Nie S, Kularatne SA, Low PS, Singhal S.

Oncotarget. 2018 Feb 5;9(17):13517-13529. doi: 10.18632/oncotarget.24399. eCollection 2018 Mar 2.


Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts.

Zhang H, Kanduluru AK, Desai P, Ahad A, Carlin S, Tandon N, Weber WA, Low PS.

Bioconjug Chem. 2018 Apr 18;29(4):1319-1326. doi: 10.1021/acs.bioconjchem.8b00063. Epub 2018 Feb 27.


New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange.

Rangasamy L, Chelvam V, Kanduluru AK, Srinivasarao M, Bandara NA, You F, Orellana EA, Kasinski AL, Low PS.

Bioconjug Chem. 2018 Apr 18;29(4):1047-1059. doi: 10.1021/acs.bioconjchem.7b00714. Epub 2018 Mar 2.


Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies.

Shen J, Hu Y, Putt KS, Singhal S, Han H, Visscher DW, Murphy LM, Low PS.

Oncotarget. 2017 Dec 15;9(4):4485-4495. doi: 10.18632/oncotarget.23321. eCollection 2018 Jan 12.


Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study.

Boogerd LSF, Hoogstins CES, Gaarenstroom KN, de Kroon CD, Beltman JJ, Bosse T, Stelloo E, Vuyk J, Low PS, Burggraaf J, Vahrmeijer AL.

Oncotarget. 2017 Dec 11;9(1):791-801. doi: 10.18632/oncotarget.23155. eCollection 2018 Jan 2.


Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases.

Poh S, Chelvam V, Ayala-López W, Putt KS, Low PS.

Nanomedicine. 2018 Apr;14(3):1033-1043. doi: 10.1016/j.nano.2018.01.009. Epub 2018 Feb 1.


A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas.

Predina JD, Newton AD, Keating J, Dunbar A, Connolly C, Baldassari M, Mizelle J, Xia L, Deshpande C, Kucharczuk J, Low PS, Singhal S.

Ann Thorac Surg. 2018 Mar;105(3):901-908. doi: 10.1016/j.athoracsur.2017.08.062. Epub 2018 Feb 15.


Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas.

Predina JD, Newton AD, Connolly C, Dunbar A, Baldassari M, Deshpande C, Cantu E 3rd, Stadanlick J, Kularatne SA, Low PS, Singhal S.

Mol Ther. 2018 Feb 7;26(2):390-403. doi: 10.1016/j.ymthe.2017.10.016. Epub 2017 Oct 26.


Folate-PEG-NOTA-Al18F: A New Folate Based Radiotracer for PET Imaging of Folate Receptor-Positive Tumors.

Chen Q, Meng X, McQuade P, Rubins D, Lin SA, Zeng Z, Haley H, Miller P, González Trotter D, Low PS.

Mol Pharm. 2017 Dec 4;14(12):4353-4361. doi: 10.1021/acs.molpharmaceut.7b00415. Epub 2017 Nov 1.


Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis.

Poh S, Chelvam V, Kelderhouse LE, Ayala-López W, Vaitilingam B, Putt KS, Low PS.

Nanomedicine (Lond). 2017 Oct;12(20):2441-2451. doi: 10.2217/nnm-2017-0166. Epub 2017 Sep 20.


Development of a Ligand-Targeted Therapeutic Agent for Neurokinin-1 Receptor Expressing Cancers.

Kanduluru AK, Low PS.

Mol Pharm. 2017 Nov 6;14(11):3859-3865. doi: 10.1021/acs.molpharmaceut.7b00583. Epub 2017 Oct 17.


Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.

Mahalingam SM, Dudkin VY, Goldberg S, Klein D, Yi F, Singhal S, O'Neil KT, Low PS.

Bioconjug Chem. 2017 Nov 15;28(11):2865-2873. doi: 10.1021/acs.bioconjchem.7b00566. Epub 2017 Oct 17.


Ligand-Targeted Drug Delivery.

Srinivasarao M, Low PS.

Chem Rev. 2017 Oct 11;117(19):12133-12164. doi: 10.1021/acs.chemrev.7b00013. Epub 2017 Sep 12. Review.


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