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Intra-operative ureter visualization using a novel near infrared fluorescent dye.

Mahalingam SM, Dip F, Castillo M, Roy M, Wexner SD, Rosenthal RJ, Low PS.

Mol Pharm. 2018 Jul 6. doi: 10.1021/acs.molpharmaceut.8b00427. [Epub ahead of print]


Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.

Silvola JMU, Li XG, Virta J, Marjamäki P, Liljenbäck H, Hytönen JP, Tarkia M, Saunavaara V, Hurme S, Palani S, Hakovirta H, Ylä-Herttuala S, Saukko P, Chen Q, Low PS, Knuuti J, Saraste A, Roivainen A.

Sci Rep. 2018 Jun 26;8(1):9720. doi: 10.1038/s41598-018-27618-4.


Targeted Tubulysin B Hydrazide Conjugate for the Treatment of Luteinizing Hormone-Releasing Hormone Receptor-Positive Cancers.

Roy J, Kaake M, Srinivasarao M, Low PS.

Bioconjug Chem. 2018 Jun 13. doi: 10.1021/acs.bioconjchem.8b00164. [Epub ahead of print]


Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate.

Chandrupatla DMSH, Molthoff CFM, Ritsema WIGR, Vos R, Elshof E, Matsuyama T, Low PS, Musters RJP, Hammond A, Windhorst AD, Lammertsma AA, van der Laken CJ, Brands R, Jansen G.

Transl Res. 2018 May 17. pii: S1931-5244(18)30055-0. doi: 10.1016/j.trsl.2018.04.001. [Epub ahead of print]


Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.

Marks IS, Gardeen SS, Kurdziel SJ, Nicolaou ST, Woods JE, Kularatne SA, Low PS.

Mol Pharm. 2018 Jun 4;15(6):2289-2296. doi: 10.1021/acs.molpharmaceut.8b00139. Epub 2018 May 1.


Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [18F]Fluoro-PEG-Folate.

Chandrupatla DMSH, Jansen G, Mantel E, Low PS, Matsuyama T, Musters RP, Windhorst AD, Lammertsma AA, Molthoff CFM, van der Laken CJ.

Contrast Media Mol Imaging. 2018 Feb 21;2018:8092781. doi: 10.1155/2018/8092781. eCollection 2018.


Localization of Pulmonary Ground-Glass Opacities with Folate Receptor-Targeted Intraoperative Molecular Imaging.

Predina JD, Newton A, Corbett C, Xia L, Sulyok LF, Shin M, Deshpande C, Litzky L, Barbosa E, Low PS, Kucharczuk JC, Singhal S.

J Thorac Oncol. 2018 Jul;13(7):1028-1036. doi: 10.1016/j.jtho.2018.03.023. Epub 2018 Apr 4.


Expression of functional folate receptors in multiple myeloma.

Zhou Y, Unno K, Hyjek E, Liu H, Zimmerman T, Karmakar S, Putt KS, Shen J, Low PS, Wickrema A.

Leuk Lymphoma. 2018 Apr 4:1-8. doi: 10.1080/10428194.2018.1453066. [Epub ahead of print]


Fluorescence-guided surgery of cancer: applications, tools and perspectives.

Low PS, Singhal S, Srinivasarao M.

Curr Opin Chem Biol. 2018 Mar 23;45:64-72. doi: 10.1016/j.cbpa.2018.03.002. [Epub ahead of print] Review.


An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas.

Predina JD, Newton AD, Xia L, Corbett C, Connolly C, Shin M, Sulyok LF, Litzky L, Deshpande C, Nie S, Kularatne SA, Low PS, Singhal S.

Oncotarget. 2018 Feb 5;9(17):13517-13529. doi: 10.18632/oncotarget.24399. eCollection 2018 Mar 2.


Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts.

Zhang H, Kanduluru AK, Desai P, Ahad A, Carlin S, Tandon N, Weber WA, Low PS.

Bioconjug Chem. 2018 Apr 18;29(4):1319-1326. doi: 10.1021/acs.bioconjchem.8b00063. Epub 2018 Feb 27.


New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange.

Rangasamy L, Chelvam V, Kanduluru AK, Srinivasarao M, Bandara NA, You F, Orellana EA, Kasinski AL, Low PS.

Bioconjug Chem. 2018 Apr 18;29(4):1047-1059. doi: 10.1021/acs.bioconjchem.7b00714. Epub 2018 Mar 2.


Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies.

Shen J, Hu Y, Putt KS, Singhal S, Han H, Visscher DW, Murphy LM, Low PS.

Oncotarget. 2017 Dec 15;9(4):4485-4495. doi: 10.18632/oncotarget.23321. eCollection 2018 Jan 12.


Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study.

Boogerd LSF, Hoogstins CES, Gaarenstroom KN, de Kroon CD, Beltman JJ, Bosse T, Stelloo E, Vuyk J, Low PS, Burggraaf J, Vahrmeijer AL.

Oncotarget. 2017 Dec 11;9(1):791-801. doi: 10.18632/oncotarget.23155. eCollection 2018 Jan 2.


Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases.

Poh S, Chelvam V, Ayala-López W, Putt KS, Low PS.

Nanomedicine. 2018 Apr;14(3):1033-1043. doi: 10.1016/j.nano.2018.01.009. Epub 2018 Feb 1.


A Phase I Clinical Trial of Targeted Intraoperative Molecular Imaging for Pulmonary Adenocarcinomas.

Predina JD, Newton AD, Keating J, Dunbar A, Connolly C, Baldassari M, Mizelle J, Xia L, Deshpande C, Kucharczuk J, Low PS, Singhal S.

Ann Thorac Surg. 2018 Mar;105(3):901-908. doi: 10.1016/j.athoracsur.2017.08.062. Epub 2018 Feb 15.


Identification of a Folate Receptor-Targeted Near-Infrared Molecular Contrast Agent to Localize Pulmonary Adenocarcinomas.

Predina JD, Newton AD, Connolly C, Dunbar A, Baldassari M, Deshpande C, Cantu E 3rd, Stadanlick J, Kularatne SA, Low PS, Singhal S.

Mol Ther. 2018 Feb 7;26(2):390-403. doi: 10.1016/j.ymthe.2017.10.016. Epub 2017 Oct 26.


Folate-PEG-NOTA-Al18F: A New Folate Based Radiotracer for PET Imaging of Folate Receptor-Positive Tumors.

Chen Q, Meng X, McQuade P, Rubins D, Lin SA, Zeng Z, Haley H, Miller P, González Trotter D, Low PS.

Mol Pharm. 2017 Dec 4;14(12):4353-4361. doi: 10.1021/acs.molpharmaceut.7b00415. Epub 2017 Nov 1.


Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis.

Poh S, Chelvam V, Kelderhouse LE, Ayala-López W, Vaitilingam B, Putt KS, Low PS.

Nanomedicine (Lond). 2017 Oct;12(20):2441-2451. doi: 10.2217/nnm-2017-0166. Epub 2017 Sep 20.


Development of a Ligand-Targeted Therapeutic Agent for Neurokinin-1 Receptor Expressing Cancers.

Kanduluru AK, Low PS.

Mol Pharm. 2017 Nov 6;14(11):3859-3865. doi: 10.1021/acs.molpharmaceut.7b00583. Epub 2017 Oct 17.


Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.

Mahalingam SM, Dudkin VY, Goldberg S, Klein D, Yi F, Singhal S, O'Neil KT, Low PS.

Bioconjug Chem. 2017 Nov 15;28(11):2865-2873. doi: 10.1021/acs.bioconjchem.7b00566. Epub 2017 Oct 17.


Ligand-Targeted Drug Delivery.

Srinivasarao M, Low PS.

Chem Rev. 2017 Oct 11;117(19):12133-12164. doi: 10.1021/acs.chemrev.7b00013. Epub 2017 Sep 12. Review.


Folate-Targeted Dendrimers Selectively Accumulate at Sites of Inflammation in Mouse Models of Ulcerative Colitis and Atherosclerosis.

Poh S, Putt KS, Low PS.

Biomacromolecules. 2017 Oct 9;18(10):3082-3088. doi: 10.1021/acs.biomac.7b00728. Epub 2017 Sep 14.


Folate receptor overexpression can be visualized in real time during pituitary adenoma endoscopic transsphenoidal surgery with near-infrared imaging.

Lee JYK, Cho SS, Zeh R, Pierce JT, Martinez-Lage M, Adappa ND, Palmer JN, Newman JG, Learned KO, White C, Kharlip J, Snyder P, Low PS, Singhal S, Grady MS.

J Neurosurg. 2017 Aug 25:1-14. doi: 10.3171/2017.2.JNS163191. [Epub ahead of print]


FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer.

Orellana EA, Tenneti S, Rangasamy L, Lyle LT, Low PS, Kasinski AL.

Sci Transl Med. 2017 Aug 2;9(401). pii: eaam9327. doi: 10.1126/scitranslmed.aam9327.


Conjugation Dependent Interaction of Folic Acid with Folate Binding Protein.

Merzel RL, Frey C, Chen J, Garn R, van Dongen M, Dougherty CA, Kandaluru AK, Low PS, Marsh ENG, Banaszak Holl MM.

Bioconjug Chem. 2017 Sep 20;28(9):2350-2360. doi: 10.1021/acs.bioconjchem.7b00373. Epub 2017 Aug 9.


Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress.

Pantaleo A, Kesely KR, Pau MC, Tsamesidis I, Schwarzer E, Skorokhod OA, Chien HD, Ponzi M, Bertuccini L, Low PS, Turrini FM.

Blood. 2017 Aug 24;130(8):1031-1040. doi: 10.1182/blood-2016-11-748053. Epub 2017 Jun 20.


In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography.

Chandrupatla DMSH, Jansen G, Vos R, Verlaan M, Chen Q, Low PS, Windhorst AD, Lammertsma AA, van der Laken CJ, Molthoff CFM.

Arthritis Res Ther. 2017 May 31;19(1):114. doi: 10.1186/s13075-017-1325-x.


Synthesis and evaluation of a ligand targeting the μ and δ opioid receptors for drug delivery to lung cancer.

Li G, Low PS.

Bioorg Med Chem Lett. 2017 May 1;27(9):2074-2078. doi: 10.1016/j.bmcl.2016.06.067. Epub 2016 Jun 28.


Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model.

Keating JJ, Runge JJ, Singhal S, Nims S, Venegas O, Durham AC, Swain G, Nie S, Low PS, Holt DE.

Cancer. 2017 May 15;123(6):1051-1060. doi: 10.1002/cncr.30419. Epub 2016 Nov 7.


Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair.

Low SA, Galliford CV, Jones-Hall YL, Roy J, Yang J, Low PS, Kopeček J.

Nanomedicine (Lond). 2017 Feb;12(3):185-193. doi: 10.2217/nnm-2016-0340. Epub 2017 Jan 17.


Intraoperative molecular imaging to identify lung adenocarcinomas.

Newton AD, Kennedy GT, Predina JD, Low PS, Singhal S.

J Thorac Dis. 2016 Oct;8(Suppl 9):S697-S704. doi: 10.21037/jtd.2016.09.50. Review.


Separation and dual detection of prostate cancer cells and protein biomarkers using a microchip device.

Huang W, Chang CL, Brault ND, Gur O, Wang Z, Jalal SI, Low PS, Ratliff TL, Pili R, Savran CA.

Lab Chip. 2017 Jan 31;17(3):415-428. doi: 10.1039/c6lc01279e.


Folate-Hapten-Mediated Immunotherapy Synergizes with Vascular Endothelial Growth Factor Receptor Inhibitors in Treating Murine Models of Cancer.

Bandara NA, Bates CD, Lu Y, Hoylman EK, Low PS.

Mol Cancer Ther. 2017 Mar;16(3):461-468. doi: 10.1158/1535-7163.MCT-16-0569. Epub 2016 Dec 15.


Evaluation of Nonpeptidic Ligand Conjugates for the Treatment of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers.

Lv PC, Roy J, Putt KS, Low PS.

Mol Cancer Ther. 2017 Mar;16(3):453-460. doi: 10.1158/1535-7163.MCT-16-0537. Epub 2016 Dec 15.


Novel Use of Folate-Targeted Intraoperative Fluorescence, OTL38, in Robot-Assisted Laparoscopic Partial Nephrectomy: Report of the First Three Cases.

Shum CF, Bahler CD, Low PS, Ratliff TL, Kheyfets SV, Natarajan JP, Sandusky GE, Sundaram CP.

J Endourol Case Rep. 2016 Nov 1;2(1):189-197. eCollection 2016.


Global transformation of erythrocyte properties via engagement of an SH2-like sequence in band 3.

Puchulu-Campanella E, Turrini FM, Li YH, Low PS.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13732-13737. Epub 2016 Nov 15.


Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia.

Kesely KR, Pantaleo A, Turrini FM, Olupot-Olupot P, Low PS.

PLoS One. 2016 Oct 21;11(10):e0164895. doi: 10.1371/journal.pone.0164895. eCollection 2016.


Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties.

Chu H, McKenna MM, Krump NA, Zheng S, Mendelsohn L, Thein SL, Garrett LJ, Bodine DM, Low PS.

Blood. 2016 Dec 8;128(23):2708-2716. Epub 2016 Sep 29.


Single Molecule Studies of the Diffusion of Band 3 in Sickle Cell Erythrocytes.

Spector J, Kodippili GC, Ritchie K, Low PS.

PLoS One. 2016 Sep 6;11(9):e0162514. doi: 10.1371/journal.pone.0162514. eCollection 2016.


Diffusion of glycophorin A in human erythrocytes.

Giger K, Habib I, Ritchie K, Low PS.

Biochim Biophys Acta. 2016 Nov;1858(11):2839-2845. doi: 10.1016/j.bbamem.2016.08.012. Epub 2016 Aug 28.


Design, Synthesis, and Evaluation of a Neurokinin-1 Receptor-Targeted Near-IR Dye for Fluorescence-Guided Surgery of Neuroendocrine Cancers.

Kanduluru AK, Srinivasarao M, Low PS.

Bioconjug Chem. 2016 Sep 21;27(9):2157-65. doi: 10.1021/acs.bioconjchem.6b00374. Epub 2016 Sep 2.


Identification of adducin-binding residues on the cytoplasmic domain of erythrocyte membrane protein, band 3.

Franco T, Chu H, Low PS.

Biochem J. 2016 Oct 1;473(19):3147-58. doi: 10.1042/BCJ20160328. Epub 2016 Jul 19.


Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers.

Lv PC, Putt KS, Low PS.

Bioconjug Chem. 2016 Jul 20;27(7):1762-9. doi: 10.1021/acs.bioconjchem.6b00271. Epub 2016 Jul 7.


A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer.

Hoogstins CE, Tummers QR, Gaarenstroom KN, de Kroon CD, Trimbos JB, Bosse T, Smit VT, Vuyk J, van de Velde CJ, Cohen AF, Low PS, Burggraaf J, Vahrmeijer AL.

Clin Cancer Res. 2016 Jun 15;22(12):2929-38. doi: 10.1158/1078-0432.CCR-15-2640.


Optimization of Folate-Targeted Immunotherapy for the Treatment of Experimental Arthritis.

Varghese B, Paulos C, Low PS.

Inflammation. 2016 Aug;39(4):1345-53. doi: 10.1007/s10753-016-0366-7.


Direct in vivo evidence of activated macrophages in human osteoarthritis.

Kraus VB, McDaniel G, Huebner JL, Stabler TV, Pieper CF, Shipes SW, Petry NA, Low PS, Shen J, McNearney TA, Mitchell P.

Osteoarthritis Cartilage. 2016 Sep;24(9):1613-21. doi: 10.1016/j.joca.2016.04.010. Epub 2016 Apr 12.


Synthesis and Evaluation of Folate-Conjugated Phenanthraquinones for Tumor-Targeted Oxidative Chemotherapy.

Kumar A, Chelvam V, Sakkarapalayam M, Li G, Sanchez-Cruz P, Piñero NS, Low PS, Alegria AE.

Open J Med Chem. 2016 Mar;6(1):1-17. Epub 2016 Mar 11.


Synthesis and Preclinical Evaluation of Folate-NOTA-Al(18)F for PET Imaging of Folate-Receptor-Positive Tumors.

Chen Q, Meng X, McQuade P, Rubins D, Lin SA, Zeng Z, Haley H, Miller P, González Trotter D, Low PS.

Mol Pharm. 2016 May 2;13(5):1520-7. doi: 10.1021/acs.molpharmaceut.5b00989. Epub 2016 Apr 18.


Evaluation of a Carbonic Anhydrase IX-Targeted Near-Infrared Dye for Fluorescence-Guided Surgery of Hypoxic Tumors.

Lv PC, Roy J, Putt KS, Low PS.

Mol Pharm. 2016 May 2;13(5):1618-25. doi: 10.1021/acs.molpharmaceut.6b00065. Epub 2016 Apr 4.

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