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Items: 1 to 50 of 82

1.

Spatial arrangement of LD motif-interacting residues on focal adhesion targeting domain of Focal Adhesion Kinase determine domain-motif interaction affinity and specificity.

Gupta AB, Mukherjee S, Pan CQ, Velazquez-Campoy A, Sivaraman J, Low BC.

Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129450. doi: 10.1016/j.bbagen.2019.129450. Epub 2019 Oct 30.

2.

Hsp90β interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.

He MY, Xu SB, Qu ZH, Guo YM, Liu XC, Cong XX, Wang JF, Low BC, Li L, Wu Q, Lin P, Yan SG, Bao Z, Zhou YT, Zheng LL.

Aging Cell. 2019 Oct;18(5):e13003. doi: 10.1111/acel.13003. Epub 2019 Jul 17.

3.

Large-scale curvature sensing by directional actin flow drives cellular migration mode switching.

Chen T, Callan-Jones A, Fedorov E, Ravasio A, Brugués A, Ong HT, Toyama Y, Low BC, Trepat X, Shemesh T, Voituriez R, Ladoux B.

Nat Phys. 2019 Apr;15:393-402. doi: 10.1038/s41567-018-0383-6. Epub 2019 Jan 21.

4.

Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration.

Fan W, Gao XK, Rao XS, Shi YP, Liu XC, Wang FY, Liu YF, Cong XX, He MY, Xu SB, Shen WL, Shen Y, Yan SG, Luo Y, Low BC, Ouyang H, Bao Z, Zheng LL, Zhou YT.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00211-18. doi: 10.1128/MCB.00211-18. Print 2018 Dec 15.

5.

Mechanobiology of Tumor Growth.

Chaudhuri PK, Low BC, Lim CT.

Chem Rev. 2018 Jul 25;118(14):6499-6515. doi: 10.1021/acs.chemrev.8b00042. Epub 2018 Jun 21. Review.

PMID:
29927236
6.

Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment.

Ashraf S, Kudo H, Rao J, Kikuchi A, Widmeier E, Lawson JA, Tan W, Hermle T, Warejko JK, Shril S, Airik M, Jobst-Schwan T, Lovric S, Braun DA, Gee HY, Schapiro D, Majmundar AJ, Sadowski CE, Pabst WL, Daga A, van der Ven AT, Schmidt JM, Low BC, Gupta AB, Tripathi BK, Wong J, Campbell K, Metcalfe K, Schanze D, Niihori T, Kaito H, Nozu K, Tsukaguchi H, Tanaka R, Hamahira K, Kobayashi Y, Takizawa T, Funayama R, Nakayama K, Aoki Y, Kumagai N, Iijima K, Fehrenbach H, Kari JA, El Desoky S, Jalalah S, Bogdanovic R, Stajić N, Zappel H, Rakhmetova A, Wassmer SR, Jungraithmayr T, Strehlau J, Kumar AS, Bagga A, Soliman NA, Mane SM, Kaufman L, Lowy DR, Jairajpuri MA, Lifton RP, Pei Y, Zenker M, Kure S, Hildebrandt F.

Nat Commun. 2018 May 17;9(1):1960. doi: 10.1038/s41467-018-04193-w.

7.

Activation of AKT-mTOR Signaling Directs Tenogenesis of Mesenchymal Stem Cells.

Cong XX, Rao XS, Lin JX, Liu XC, Zhang GA, Gao XK, He MY, Shen WL, Fan W, Pioletti D, Zheng LL, Liu HH, Yin Z, Low BC, Schweitzer R, Ouyang H, Chen X, Zhou YT.

Stem Cells. 2018 Apr;36(4):527-539. doi: 10.1002/stem.2765. Epub 2018 Jan 5.

8.

Differential Depth Sensing Reduces Cancer Cell Proliferation via Rho-Rac-Regulated Invadopodia.

Chaudhuri PK, Pan CQ, Low BC, Lim CT.

ACS Nano. 2017 Jul 25;11(7):7336-7348. doi: 10.1021/acsnano.7b03452. Epub 2017 Jul 3.

PMID:
28654281
9.

YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.

Qiao Y, Chen J, Lim YB, Finch-Edmondson ML, Seshachalam VP, Qin L, Jiang T, Low BC, Singh H, Lim CT, Sudol M.

Cell Rep. 2017 May 23;19(8):1495-1502. doi: 10.1016/j.celrep.2017.04.075.

10.

Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis.

Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Pawijit P, Zhuo S, Dong CY, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, Yu H.

J Hepatol. 2017 Jun;66(6):1231-1240. doi: 10.1016/j.jhep.2017.01.026. Epub 2017 Feb 9.

PMID:
28189756
11.

BPGAP1 spatially integrates JNK/ERK signaling crosstalk in oncogenesis.

Jiang T, Pan CQ, Low BC.

Oncogene. 2017 Jun 1;36(22):3178-3192. doi: 10.1038/onc.2016.466. Epub 2017 Jan 16.

PMID:
28092672
12.

Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.

Ramachandran S, Pan CQ, Zimmermann SC, Duvall B, Tsukamoto T, Low BC, Sivaraman J.

Oncotarget. 2016 Sep 6;7(36):57943-57954. doi: 10.18632/oncotarget.10791.

13.

NuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection force.

Li C, Xue C, Yang Q, Low BC, Liou YC.

Nat Commun. 2016 Feb 3;7:10597. doi: 10.1038/ncomms10597.

14.

Topography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility.

Chaudhuri PK, Pan CQ, Low BC, Lim CT.

Sci Rep. 2016 Jan 22;6:19672. doi: 10.1038/srep19672.

15.

Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.

Mohanty S, Jobichen C, Chichili VP, Velázquez-Campoy A, Low BC, Hogue CW, Sivaraman J.

J Biol Chem. 2015 Nov 6;290(45):27280-96. doi: 10.1074/jbc.M115.677492. Epub 2015 Sep 14.

16.

BNIP-H Recruits the Cholinergic Machinery to Neurite Terminals to Promote Acetylcholine Signaling and Neuritogenesis.

Sun J, Pan CQ, Chew TW, Liang F, Burmeister M, Low BC.

Dev Cell. 2015 Sep 14;34(5):555-68. doi: 10.1016/j.devcel.2015.08.006. Epub 2015 Sep 3.

17.

Annexin-A1 controls an ERK-RhoA-NFκB activation loop in breast cancer cells.

Bist P, Phua QH, Shu S, Yi Y, Anbalagan D, Lee LH, Sethi G, Low BC, Lim LH.

Biochem Biophys Res Commun. 2015 May 22;461(1):47-53. doi: 10.1016/j.bbrc.2015.03.166. Epub 2015 Apr 9.

PMID:
25866182
18.

Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2A.

Ravi A, Kaushik S, Ravichandran A, Pan CQ, Low BC.

J Biol Chem. 2015 Feb 13;290(7):4149-62. doi: 10.1074/jbc.M114.616839. Epub 2014 Dec 18.

19.

Concerted modulation of paxillin dynamics at focal adhesions by Deleted in Liver Cancer-1 and focal adhesion kinase during early cell spreading.

Kaushik S, Ravi A, Hameed FM, Low BC.

Cytoskeleton (Hoboken). 2014 Dec;71(12):677-94. doi: 10.1002/cm.21201. Epub 2015 Jan 31.

PMID:
25448629
20.

KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.

Yi P, Chew LL, Zhang Z, Ren H, Wang F, Cong X, Zheng L, Luo Y, Ouyang H, Low BC, Zhou YT.

Mol Biol Cell. 2015 Jan 1;26(1):29-42. doi: 10.1091/mbc.E14-03-0797. Epub 2014 Nov 5.

21.

The bi-lobe-associated LRRP1 regulates Ran activity in Trypanosoma brucei.

Brasseur A, Bayat S, Chua XL, Zhang Y, Zhou Q, Low BC, He CY.

J Cell Sci. 2014 Nov 15;127(Pt 22):4846-56. doi: 10.1242/jcs.148015. Epub 2014 Sep 12.

22.

A cooperative jack model of random coil-to-elongation transition of the FH1 domain by profilin binding explains formin motor behavior in actin polymerization.

Zhao C, Liu C, Hogue CW, Low BC.

FEBS Lett. 2014 Jun 27;588(14):2288-93. doi: 10.1016/j.febslet.2014.05.016. Epub 2014 May 23.

23.

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth.

Low BC, Pan CQ, Shivashankar GV, Bershadsky A, Sudol M, Sheetz M.

FEBS Lett. 2014 Aug 19;588(16):2663-70. doi: 10.1016/j.febslet.2014.04.012. Epub 2014 Apr 18. Review.

24.

Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).

Thangavelu K, Chong QY, Low BC, Sivaraman J.

Sci Rep. 2014 Jan 23;4:3827. doi: 10.1038/srep03827.

25.

Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.

Chew TW, Liu XJ, Liu L, Spitsbergen JM, Gong Z, Low BC.

Oncogene. 2014 May 22;33(21):2717-27. doi: 10.1038/onc.2013.240. Epub 2013 Jul 1.

PMID:
23812423
26.

SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation.

Ravichandran A, Low BC.

Mol Biol Cell. 2013 Jan;24(2):145-56. doi: 10.1091/mbc.E12-04-0300. Epub 2012 Nov 14.

27.

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling.

Pan CQ, Sudol M, Sheetz M, Low BC.

Cell Signal. 2012 Nov;24(11):2143-65. doi: 10.1016/j.cellsig.2012.06.002. Epub 2012 Jun 25. Review.

28.

Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics.

Pan CQ, Low BC.

FEBS Lett. 2012 Aug 14;586(17):2674-91. doi: 10.1016/j.febslet.2012.04.023. Epub 2012 Apr 21. Review.

29.

Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism.

Thangavelu K, Pan CQ, Karlberg T, Balaji G, Uttamchandani M, Suresh V, Schüler H, Low BC, Sivaraman J.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7705-10. doi: 10.1073/pnas.1116573109. Epub 2012 Apr 26.

30.

Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily.

Gupta AB, Wee LE, Zhou YT, Hortsch M, Low BC.

PLoS One. 2012;7(3):e33863. doi: 10.1371/journal.pone.0033863. Epub 2012 Mar 27.

31.

Using zebrafish for studying Rho GTPases signaling in vivo.

Zhu S, Low BC.

Methods Mol Biol. 2012;827:321-37. doi: 10.1007/978-1-61779-442-1_21.

PMID:
22144284
32.

Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin.

Huang L, Pan CQ, Li B, Tucker-Kellogg L, Tidor B, Chen Y, Low BC.

PLoS One. 2011;6(8):e22933. doi: 10.1371/journal.pone.0022933. Epub 2011 Aug 1.

33.

An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability.

Wei XN, Han BC, Zhang JX, Liu XH, Tan CY, Jiang YY, Low BC, Tidor B, Chen YZ.

BMC Syst Biol. 2011 Jul 15;5:112. doi: 10.1186/1752-0509-5-112.

34.

Magneto-thermal convection in solar prominences.

Berger T, Testa P, Hillier A, Boerner P, Low BC, Shibata K, Schrijver C, Tarbell T, Title A.

Nature. 2011 Apr 14;472(7342):197-200. doi: 10.1038/nature09925.

PMID:
21490669
35.

Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes.

Li A, Lim TS, Shi H, Yin J, Tan SJ, Li Z, Low BC, Tan KS, Lim CT.

PLoS One. 2011 Mar 17;6(3):e16929. doi: 10.1371/journal.pone.0016929. Erratum in: PLoS One. 2011;6(3). doi: 10.1371/annotation/4aae1ede-d539-40d5-bcc2-5790b1709fde.

36.

Virtual screening of selective multitarget kinase inhibitors by combinatorial support vector machines.

Ma XH, Wang R, Tan CY, Jiang YY, Lu T, Rao HB, Li XY, Go ML, Low BC, Chen YZ.

Mol Pharm. 2010 Oct 4;7(5):1545-60. doi: 10.1021/mp100179t. Epub 2010 Aug 26.

PMID:
20712327
37.

Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.

Scott GB, Bowles PA, Wilson EB, Meade JL, Low BC, Davison A, Blair GE, Cook GP.

Biochem J. 2010 Nov 1;431(3):423-31. doi: 10.1042/BJ20091073.

PMID:
20704564
38.

The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.

Zhou YT, Chew LL, Lin SC, Low BC.

Mol Biol Cell. 2010 Sep 15;21(18):3232-46. doi: 10.1091/mbc.E09-05-0408. Epub 2010 Jul 21.

39.

In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening.

Ma XH, Shi Z, Tan C, Jiang Y, Go ML, Low BC, Chen YZ.

Pharm Res. 2010 May;27(5):739-49. doi: 10.1007/s11095-010-0065-2. Epub 2010 Mar 11. Review.

PMID:
20221898
40.

Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration.

Pan CQ, Liou YC, Low BC.

J Cell Sci. 2010 Mar 15;123(Pt 6):903-16. doi: 10.1242/jcs.064162. Epub 2010 Feb 23.

41.

A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruning.

Kirilly D, Gu Y, Huang Y, Wu Z, Bashirullah A, Low BC, Kolodkin AL, Wang H, Yu F.

Nat Neurosci. 2009 Dec;12(12):1497-505. doi: 10.1038/nn.2415. Epub 2009 Nov 1.

42.

Virtual screening of Abl inhibitors from large compound libraries by support vector machines.

Liu XH, Ma XH, Tan CY, Jiang YY, Go ML, Low BC, Chen YZ.

J Chem Inf Model. 2009 Sep;49(9):2101-10. doi: 10.1021/ci900135u.

PMID:
19689138
44.

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.

Zhong D, Zhang J, Yang S, Soh UJ, Buschdorf JP, Zhou YT, Yang D, Low BC.

J Cell Sci. 2009 Feb 1;122(Pt 3):414-24. doi: 10.1242/jcs.027482.

45.

Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1.

Li H, Ung CY, Ma XH, Li BW, Low BC, Cao ZW, Chen YZ.

Bioinformatics. 2009 Feb 1;25(3):358-64. doi: 10.1093/bioinformatics/btn635. Epub 2008 Dec 11.

PMID:
19074159
46.

K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis.

Liu L, Zhu S, Gong Z, Low BC.

PLoS One. 2008 Aug 6;3(8):e2850. doi: 10.1371/journal.pone.0002850.

47.

A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.

Kang JS, Bae GU, Yi MJ, Yang YJ, Oh JE, Takaesu G, Zhou YT, Low BC, Krauss RS.

J Cell Biol. 2008 Aug 11;182(3):497-507. doi: 10.1083/jcb.200801119. Epub 2008 Aug 4.

48.

Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons.

Buschdorf JP, Chew LL, Soh UJ, Liou YC, Low BC.

PLoS One. 2008 Jul 16;3(7):e2686. doi: 10.1371/journal.pone.0002686.

49.

Evaluation of virtual screening performance of support vector machines trained by sparsely distributed active compounds.

Ma XH, Wang R, Yang SY, Li ZR, Xue Y, Wei YC, Low BC, Chen YZ.

J Chem Inf Model. 2008 Jun;48(6):1227-37. doi: 10.1021/ci800022e. Epub 2008 Jun 6.

PMID:
18533644
50.

Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk.

Ung CY, Li H, Ma XH, Jia J, Li BW, Low BC, Chen YZ.

FEBS Lett. 2008 Jun 25;582(15):2283-90. doi: 10.1016/j.febslet.2008.05.026. Epub 2008 May 27.

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