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Items: 20

1.

High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR.

Wang Y, La M, Pham T, Lovrecz GO, Nie G.

FASEB J. 2019 Apr;33(4):5058-5066. doi: 10.1096/fj.201802151RR. Epub 2019 Jan 2.

PMID:
30601675
2.

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase.

Moye AL, Porter KC, Cohen SB, Phan T, Zyner KG, Sasaki N, Lovrecz GO, Beck JL, Bryan TM.

Nat Commun. 2015 Jul 9;6:7643. doi: 10.1038/ncomms8643.

3.

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits.

Ren B, Peat TS, Streltsov VA, Pollard M, Fernley R, Grusovin J, Seabrook S, Pilling P, Phan T, Lu L, Lovrecz GO, Graham LD, Hill RJ.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1954-64. doi: 10.1107/S1399004714009626. Epub 2014 Jun 29.

PMID:
25004972
4.

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.

Davydova N, Streltsov VA, Roufail S, Lovrecz GO, Stacker SA, Adams TE, Achen MG.

Protein Expr Purif. 2012 Mar;82(1):232-9. doi: 10.1016/j.pep.2012.01.001. Epub 2012 Jan 10.

PMID:
22261343
5.

Direct involvement of the TEN domain at the active site of human telomerase.

Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM.

Nucleic Acids Res. 2011 Mar;39(5):1774-88. doi: 10.1093/nar/gkq1083. Epub 2010 Nov 3.

6.

Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors.

Birru W, Fernley RT, Graham LD, Grusovin J, Hill RJ, Hofmann A, Howell L, James PJ, Jarvis KE, Johnson WM, Jones DA, Leitner C, Liepa AJ, Lovrecz GO, Lu L, Nearn RH, O'Driscoll BJ, Phan T, Pollard M, Turner KA, Winkler DA.

Bioorg Med Chem. 2010 Aug 1;18(15):5647-60. doi: 10.1016/j.bmc.2010.06.020. Epub 2010 Jun 15.

PMID:
20619664
7.

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.

J Mol Biol. 2009 Dec 18;394(5):878-92. doi: 10.1016/j.jmb.2009.10.011. Epub 2009 Oct 14.

PMID:
19835884
8.

Protein composition of catalytically active human telomerase from immortal cells.

Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, Reddel RR.

Science. 2007 Mar 30;315(5820):1850-3.

9.

Purification and characterization of recombinant ligand-binding domains from the ecdysone receptors of four pest insects.

Graham LD, Pilling PA, Eaton RE, Gorman JJ, Braybrook C, Hannan GN, Pawlak-Skrzecz A, Noyce L, Lovrecz GO, Lu L, Hill RJ.

Protein Expr Purif. 2007 Jun;53(2):309-24. Epub 2006 Dec 24.

PMID:
17275327
10.

Structure of the insulin receptor ectodomain reveals a folded-over conformation.

McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.

Nature. 2006 Sep 14;443(7108):218-21. Epub 2006 Sep 6.

PMID:
16957736
11.

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.

Lou M, Garrett TP, McKern NM, Hoyne PA, Epa VC, Bentley JD, Lovrecz GO, Cosgrove LJ, Frenkel MJ, Ward CW.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34. Epub 2006 Aug 7.

12.

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.

Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J.

J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25.

13.

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors.

Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Kofler M, Jorissen RN, Nice EC, Burgess AW, Ward CW.

Mol Cell. 2003 Feb;11(2):495-505.

14.

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

Garrett TP, McKern NM, Lou M, Elleman TC, Adams TE, Lovrecz GO, Zhu HJ, Walker F, Frenkel MJ, Hoyne PA, Jorissen RN, Nice EC, Burgess AW, Ward CW.

Cell. 2002 Sep 20;110(6):763-73.

15.

Identification of a determinant of epidermal growth factor receptor ligand-binding specificity using a truncated, high-affinity form of the ectodomain.

Elleman TC, Domagala T, McKern NM, Nerrie M, Lönnqvist B, Adams TE, Lewis J, Lovrecz GO, Hoyne PA, Richards KM, Howlett GJ, Rothacker J, Jorissen RN, Lou M, Garrett TP, Burgess AW, Nice EC, Ward CW.

Biochemistry. 2001 Jul 31;40(30):8930-9.

PMID:
11467954
16.

The three dimensional structure of the type I insulin-like growth factor receptor.

Ward CW, Garrett TP, McKern NM, Lou M, Cosgrove LJ, Sparrow LG, Frenkel MJ, Hoyne PA, Elleman TC, Adams TE, Lovrecz GO, Lawrence LJ, Tulloch PA.

Mol Pathol. 2001 Jun;54(3):125-32. Review.

17.

Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes.

Tulloch PA, Lawrence LJ, McKern NM, Robinson CP, Bentley JD, Cosgrove L, Ivancic N, Lovrecz GO, Siddle K, Ward CW.

J Struct Biol. 1999 Mar;125(1):11-8.

PMID:
10196112
18.

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor.

Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW.

Nature. 1998 Jul 23;394(6691):395-9.

PMID:
9690478
19.

Crystallization of the first three domains of the human insulin-like growth factor-1 receptor.

McKern NM, Lou M, Frenkel MJ, Verkuylen A, Bentley JD, Lovrecz GO, Ivancic N, Elleman TC, Garrett TP, Cosgrove LJ, Ward CW.

Protein Sci. 1997 Dec;6(12):2663-6.

20.

Purification and properties of insulin receptor ectodomain from large-scale mammalian cell culture.

Cosgrove L, Lovrecz GO, Verkuylen A, Cavaleri L, Black LA, Bentley JD, Howlett GJ, Gray PP, Ward CW, McKern NM.

Protein Expr Purif. 1995 Dec;6(6):789-98.

PMID:
8746631

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