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Items: 40

1.

The impact of combinatorial stress on the growth dynamics and metabolome of Burkholderia mesoacidophila demonstrates the complexity of tolerance mechanisms.

Moody SC, Bull JC, Dudley E, Loveridge EJ.

J Appl Microbiol. 2019 Jul 29. doi: 10.1111/jam.14404. [Epub ahead of print]

PMID:
31359569
2.

TCR-induced alteration of primary MHC peptide anchor residue.

Madura F, Rizkallah PJ, Legut M, Holland CJ, Fuller A, Bulek A, Schauenburg AJ, Trimby A, Hopkins JR, Wells SA, Godkin A, Miles JJ, Sami M, Li Y, Liddy N, Jakobsen BK, Loveridge EJ, Cole DK, Sewell AK.

Eur J Immunol. 2019 Jul;49(7):1052-1066. doi: 10.1002/eji.201948085. Epub 2019 May 27.

3.

Chemoenzymatic Assembly of Isotopically Labeled Folates.

Angelastro A, Dawson WM, Luk LYP, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2017 Sep 20;139(37):13047-13054. doi: 10.1021/jacs.7b06358. Epub 2017 Sep 6.

PMID:
28820585
4.

Reclassification of the Specialized Metabolite Producer Pseudomonas mesoacidophila ATCC 31433 as a Member of the Burkholderia cepacia Complex.

Loveridge EJ, Jones C, Bull MJ, Moody SC, Kahl MW, Khan Z, Neilson L, Tomeva M, Adams SE, Wood AC, Rodriguez-Martin D, Pinel I, Parkhill J, Mahenthiralingam E, Crosby J.

J Bacteriol. 2017 Jun 13;199(13). pii: e00125-17. doi: 10.1128/JB.00125-17. Print 2017 Jul 1.

5.

A Rapid Analysis of Variations in Conformational Behavior during Dihydrofolate Reductase Catalysis.

Hughes RL, Johnson LA, Behiry EM, Loveridge EJ, Allemann RK.

Biochemistry. 2017 Apr 18;56(15):2126-2133. doi: 10.1021/acs.biochem.7b00045. Epub 2017 Apr 7.

PMID:
28368101
6.

Reduction of Folate by Dihydrofolate Reductase from Thermotoga maritima.

Loveridge EJ, Hroch L, Hughes RL, Williams T, Davies RL, Angelastro A, Luk LY, Maglia G, Allemann RK.

Biochemistry. 2017 Apr 4;56(13):1879-1886. doi: 10.1021/acs.biochem.6b01268. Epub 2017 Mar 24.

7.

Pinpointing dynamic coupling in enzymes for efficient drug design.

Loveridge EJ, Allemann RK.

Future Sci OA. 2016 Jan 25;2(1):FSO95. doi: 10.4155/fsoa.2015.0017. eCollection 2016 Mar. No abstract available.

8.

Minimization of dynamic effects in the evolution of dihydrofolate reductase.

Ruiz-Pernía JJ, Behiry E, Luk LYP, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Chem Sci. 2016 May 1;7(5):3248-3255. doi: 10.1039/c5sc04209g. Epub 2016 Feb 3.

9.

Chemical Ligation and Isotope Labeling to Locate Dynamic Effects during Catalysis by Dihydrofolate Reductase.

Luk LY, Ruiz-Pernía JJ, Adesina AS, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

Angew Chem Int Ed Engl. 2015 Jul 27;54(31):9016-20. doi: 10.1002/anie.201503968. Epub 2015 Jun 16.

10.

Protein motions and dynamic effects in enzyme catalysis.

Luk LY, Loveridge EJ, Allemann RK.

Phys Chem Chem Phys. 2015 Dec 14;17(46):30817-27. doi: 10.1039/c5cp00794a.

PMID:
25854702
11.

Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept.

Hull CM, Loveridge EJ, Donnison IS, Kelly DE, Kelly SL.

AMB Express. 2014 Sep 1;4:64. doi: 10.1186/s13568-014-0064-5. eCollection 2014.

12.

Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant.

Luk LY, Ruiz-Pernía JJ, Dawson WM, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2014 Dec 10;136(49):17317-23. doi: 10.1021/ja5102536. Epub 2014 Nov 26.

PMID:
25396728
13.

Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock.

Hull CM, Loveridge EJ, Rolley NJ, Donnison IS, Kelly SL, Kelly DE.

Biotechnol Biofuels. 2014 Sep 24;7(1):133. doi: 10.1186/s13068-014-0133-7. eCollection 2014.

14.

CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces.

Moody SC, Loveridge EJ.

J Appl Microbiol. 2014 Dec;117(6):1549-63. doi: 10.1111/jam.12662. Epub 2014 Nov 4. Review.

15.

Role of the occluded conformation in bacterial dihydrofolate reductases.

Behiry EM, Luk LY, Matthews SM, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4761-8. doi: 10.1021/bi500507v. Epub 2014 Jul 18.

16.

Loop interactions during catalysis by dihydrofolate reductase from Moritella profunda.

Behiry EM, Evans RM, Guo J, Loveridge EJ, Allemann RK.

Biochemistry. 2014 Jul 29;53(29):4769-74. doi: 10.1021/bi500508z. Epub 2014 Jul 18.

17.

Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.

Luk LY, Loveridge EJ, Allemann RK.

J Am Chem Soc. 2014 May 14;136(19):6862-5. doi: 10.1021/ja502673h. Epub 2014 May 5.

18.

Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.

Guo J, Luk LY, Loveridge EJ, Allemann RK.

Biochemistry. 2014 May 6;53(17):2855-63. doi: 10.1021/bi500238q. Epub 2014 Apr 22.

19.

Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.

Ruiz-Pernia JJ, Luk LY, García-Meseguer R, Martí S, Loveridge EJ, Tuñón I, Moliner V, Allemann RK.

J Am Chem Soc. 2013 Dec 11;135(49):18689-96. doi: 10.1021/ja410519h. Epub 2013 Nov 26.

20.

Unraveling the role of protein dynamics in dihydrofolate reductase catalysis.

Luk LY, Javier Ruiz-Pernía J, Dawson WM, Roca M, Loveridge EJ, Glowacki DR, Harvey JN, Mulholland AJ, Tuñón I, Moliner V, Allemann RK.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16344-9. doi: 10.1073/pnas.1312437110. Epub 2013 Sep 24.

21.

Effect of dimerization on dihydrofolate reductase catalysis.

Guo J, Loveridge EJ, Luk LY, Allemann RK.

Biochemistry. 2013 Jun 4;52(22):3881-7. doi: 10.1021/bi4005073. Epub 2013 May 22.

PMID:
23672258
22.

¹H, ¹³C and ¹⁵N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide.

Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK.

Biomol NMR Assign. 2013 Oct;7(2):187-91. doi: 10.1007/s12104-012-9407-9. Epub 2012 Jun 30.

PMID:
22744789
23.

NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL.

Wysoczanski P, Mart RJ, Loveridge EJ, Williams C, Whittaker SB, Crump MP, Allemann RK.

J Am Chem Soc. 2012 May 9;134(18):7644-7. doi: 10.1021/ja302390a. Epub 2012 Apr 25.

PMID:
22515821
24.

Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.

Loveridge EJ, Behiry EM, Guo J, Allemann RK.

Nat Chem. 2012 Mar 11;4(4):292-7. doi: 10.1038/nchem.1296.

PMID:
22437714
25.

Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.

Loveridge EJ, Matthews SM, Williams C, Whittaker SB, Günther UL, Evans RM, Dawson WM, Crump MP, Allemann RK.

Biomol NMR Assign. 2013 Apr;7(1):61-4. doi: 10.1007/s12104-012-9378-x. Epub 2012 Mar 14.

PMID:
22415546
26.

The role of large-scale motions in catalysis by dihydrofolate reductase.

Loveridge EJ, Tey LH, Behiry EM, Dawson WM, Evans RM, Whittaker SB, Günther UL, Williams C, Crump MP, Allemann RK.

J Am Chem Soc. 2011 Dec 21;133(50):20561-70. doi: 10.1021/ja208844j. Epub 2011 Nov 22.

27.

Reduced susceptibility of Moritella profunda dihydrofolate reductase to trimethoprim is not due to glutamate 28.

Loveridge EJ, Dawson WM, Evans RM, Sobolewska A, Allemann RK.

Protein J. 2011 Dec;30(8):546-8. doi: 10.1007/s10930-011-9361-x.

PMID:
21968646
28.

Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.

Loveridge EJ, Allemann RK.

Chembiochem. 2011 May 16;12(8):1258-62. doi: 10.1002/cbic.201000794. Epub 2011 Apr 19.

PMID:
21506230
29.

Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda.

Evans RM, Behiry EM, Tey LH, Guo J, Loveridge EJ, Allemann RK.

Chembiochem. 2010 Sep 24;11(14):2010-7. doi: 10.1002/cbic.201000341.

PMID:
20726028
30.
31.

Highly site-selective stability increases by glycosylation of dihydrofolate reductase.

Tey LH, Loveridge EJ, Swanwick RS, Flitsch SL, Allemann RK.

FEBS J. 2010 May;277(9):2171-9. doi: 10.1111/j.1742-4658.2010.07634.x.

32.

Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.

Loveridge EJ, Tey LH, Allemann RK.

J Am Chem Soc. 2010 Jan 27;132(3):1137-43. doi: 10.1021/ja909353c.

PMID:
20047317
33.

The role of arginine 28 in catalysis by dihydrofolate reductase from the hyperthermophile Thermotoga maritima.

Loveridge EJ, Maglia G, Allemann RK.

Chembiochem. 2009 Nov 2;10(16):2624-7. doi: 10.1002/cbic.200900465. No abstract available.

PMID:
19816891
34.

Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?

Hay S, Evans RM, Levy C, Loveridge EJ, Wang X, Leys D, Allemann RK, Scrutton NS.

Chembiochem. 2009 Sep 21;10(14):2348-53. doi: 10.1002/cbic.200900367.

PMID:
19681091
35.

Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima.

Loveridge EJ, Rodriguez RJ, Swanwick RS, Allemann RK.

Biochemistry. 2009 Jun 30;48(25):5922-33. doi: 10.1021/bi900411a.

PMID:
19453185
36.

Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases.

Loveridge EJ, Behiry EM, Swanwick RS, Allemann RK.

J Am Chem Soc. 2009 May 27;131(20):6926-7. doi: 10.1021/ja901441k.

PMID:
19419144
37.

Probing coupled motions in enzymatic hydrogen tunnelling reactions.

Allemann RK, Evans RM, Loveridge EJ.

Biochem Soc Trans. 2009 Apr;37(Pt 2):349-53. doi: 10.1042/BST0370349. Review.

PMID:
19290860
38.

Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL.

Kneissl S, Loveridge EJ, Williams C, Crump MP, Allemann RK.

Chembiochem. 2008 Dec 15;9(18):3046-54. doi: 10.1002/cbic.200800502.

PMID:
19012295
39.

Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima.

Loveridge EJ, Evans RM, Allemann RK.

Chemistry. 2008;14(34):10782-8. doi: 10.1002/chem.200801804.

PMID:
18924193
40.

Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases.

Simm AM, Loveridge EJ, Crosby J, Avison MB, Walsh TR, Bennett PM.

Biochem J. 2005 May 1;387(Pt 3):585-90.

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