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Items: 1 to 50 of 191

1.

The regulation of Sox9 expression in the gonad.

Gonen N, Lovell-Badge R.

Curr Top Dev Biol. 2019;134:223-252. doi: 10.1016/bs.ctdb.2019.01.004. Epub 2019 Feb 13.

PMID:
30999977
2.

CRISPR babies: a view from the centre of the storm.

Lovell-Badge R.

Development. 2019 Feb 6;146(3). pii: dev175778. doi: 10.1242/dev.175778.

3.

After the Storm - A Responsible Path for Genome Editing.

Daley GQ, Lovell-Badge R, Steffann J.

N Engl J Med. 2019 Mar 7;380(10):897-899. doi: 10.1056/NEJMp1900504. Epub 2019 Jan 16. No abstract available.

PMID:
30649993
4.

Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination.

Garcia-Moreno SA, Futtner CR, Salamone IM, Gonen N, Lovell-Badge R, Maatouk DM.

Dev Biol. 2019 Feb 15;446(2):168-179. doi: 10.1016/j.ydbio.2018.12.023. Epub 2018 Dec 27.

5.

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation.

Metzis V, Steinhauser S, Pakanavicius E, Gouti M, Stamataki D, Ivanovitch K, Watson T, Rayon T, Mousavy Gharavy SN, Lovell-Badge R, Luscombe NM, Briscoe J.

Cell. 2018 Nov 1;175(4):1105-1118.e17. doi: 10.1016/j.cell.2018.09.040. Epub 2018 Oct 18.

6.

Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission.

Greenfield A, Braude P, Flinter F, Lovell-Badge R, Ogilvie C, Perry ACF.

Nat Biotechnol. 2018 Jul 6;36(7):660. doi: 10.1038/nbt0718-660b. No abstract available.

PMID:
29979654
7.

Sex reversal following deletion of a single distal enhancer of Sox9.

Gonen N, Futtner CR, Wood S, Garcia-Moreno SA, Salamone IM, Samson SC, Sekido R, Poulat F, Maatouk DM, Lovell-Badge R.

Science. 2018 Jun 29;360(6396):1469-1473. doi: 10.1126/science.aas9408. Epub 2018 Jun 14.

8.

NOTCH activity differentially affects alternative cell fate acquisition and maintenance.

Cheung L, Le Tissier P, Goldsmith SG, Treier M, Lovell-Badge R, Rizzoti K.

Elife. 2018 Mar 26;7. pii: e33318. doi: 10.7554/eLife.33318.

9.

Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission.

Greenfield A, Braude P, Flinter F, Lovell-Badge R, Ogilvie C, Perry ACF.

Nat Biotechnol. 2018 Feb 6;36(2):196. doi: 10.1038/nbt0218-196b. No abstract available.

PMID:
29406506
10.

High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response.

Arrizabalaga O, Moreno-Cugnon L, Auzmendi-Iriarte J, Aldaz P, Ibanez de Caceres I, Garros-Regulez L, Moncho-Amor V, Torres-Bayona S, Pernía O, Pintado-Berninches L, Carrasco-Ramirez P, Cortes-Sempere M, Rosas R, Sanchez-Gomez P, Ruiz I, Caren H, Pollard S, Garcia I, Sacido AA, Lovell-Badge R, Belda-Iniesta C, Sampron N, Perona R, Matheu A.

Oncogenesis. 2017 Dec 14;6(12):401. doi: 10.1038/s41389-017-0003-9.

11.

Erratum: Revisiting the Warnock rule.

Hurlbut JB, Hyun I, Levine AD, Lovell-Badge R, Lunshof JE, Matthews KRW, Mills P, Murdoch A, Pera MF, Scott CT, Tizzard J, Warnock M, Zernicka-Goetz M, Zhou Q, Zoloth L.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211d.

PMID:
29220028
12.

Revisiting the Warnock rule.

Hurlbut JB, Hyun I, Levine AD, Lovell-Badge R, Lunshof JE, Matthews KRW, Mills P, Murdoch A, Pera MF, Scott CT, Tizzard J, Warnock M, Zernicka-Goetz M, Zhou Q, Zoloth L.

Nat Biotechnol. 2017 Nov 9;35(11):1029-1042. doi: 10.1038/nbt.4015. No abstract available. Erratum in: Nat Biotechnol. 2017 Dec 8;35(12 ):1211.

PMID:
29121021
13.

Assisted reproductive technologies to prevent human mitochondrial disease transmission.

Greenfield A, Braude P, Flinter F, Lovell-Badge R, Ogilvie C, Perry ACF.

Nat Biotechnol. 2017 Nov 9;35(11):1059-1068. doi: 10.1038/nbt.3997. [Epub ahead of print] Erratum in: Nat Biotechnol. 2018 Feb 6;36(2):196. Nat Biotechnol. 2018 Jul 6;36(7):660.

PMID:
29121011
14.

Human Embryo Editing: Opportunities and Importance of Transnational Cooperation.

Pei D, Beier DW, Levy-Lahad E, Marchant G, Rossant J, Izpisua Belmonte JC, Lovell-Badge R, Jaenisch R, Charo A, Baltimore D.

Cell Stem Cell. 2017 Oct 5;21(4):423-426. doi: 10.1016/j.stem.2017.09.010.

15.

Perspective on Stem Cells in Developmental Biology, with Special Reference to Neuroendocrine Systems.

Rizzoti K, Pires C, Lovell-Badge R.

In: Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology [Internet]. Cham (CH): Springer; 2016.
2016 Jul 27.

16.

Correction: Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.

Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R.

PLoS Genet. 2017 Feb 1;13(2):e1006584. doi: 10.1371/journal.pgen.1006584. eCollection 2017 Feb.

17.

Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone.

Gonen N, Quinn A, O'Neill HC, Koopman P, Lovell-Badge R.

PLoS Genet. 2017 Jan 3;13(1):e1006520. doi: 10.1371/journal.pgen.1006520. eCollection 2017 Jan. Erratum in: PLoS Genet. 2017 Feb 1;13(2):e1006584.

18.

RNA FISH, DNA FISH and Chromosome Painting of Chicken Oocytes.

Guioli S, Lovell-Badge R.

Methods Mol Biol. 2016;1457:191-208. doi: 10.1007/978-1-4939-3795-0_14.

PMID:
27557582
19.

Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis.

Rizzoti K, Lovell-Badge R.

Mol Cell Endocrinol. 2017 Apr 15;445:7-13. doi: 10.1016/j.mce.2016.08.020. Epub 2016 Aug 13. Review.

20.

Debate on Germline Gene Editing.

Cartier-Lacave N, Ali R, Ylä-Herttuala S, Kato K, Baetschi B, Lovell-Badge R, Naldini L, Thrasher A.

Hum Gene Ther Methods. 2016 Aug;27(4):135-42. doi: 10.1089/hgtb.2016.28999.deb. No abstract available.

PMID:
27529507
21.

SOX2 is sequentially required for progenitor proliferation and lineage specification in the developing pituitary.

Goldsmith S, Lovell-Badge R, Rizzoti K.

Development. 2016 Jul 1;143(13):2376-88. doi: 10.1242/dev.137984. Epub 2016 May 25.

22.

Of sex and determination: marking 25 years of Randy, the sex-reversed mouse.

Koopman P, Sinclair A, Lovell-Badge R.

Development. 2016 May 15;143(10):1633-7. doi: 10.1242/dev.137372.

23.

mTOR inhibition decreases SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance.

Garros-Regulez L, Aldaz P, Arrizabalaga O, Moncho-Amor V, Carrasco-Garcia E, Manterola L, Moreno-Cugnon L, Barrena C, Villanua J, Ruiz I, Pollard S, Lovell-Badge R, Sampron N, Garcia I, Matheu A.

Expert Opin Ther Targets. 2016;20(4):393-405. doi: 10.1517/14728222.2016.1151002.

24.

Genome Editing Technologies and Human Germline Genetic Modification: The Hinxton Group Consensus Statement.

Chan S, Donovan PJ, Douglas T, Gyngell C, Harris J, Lovell-Badge R, Mathews DJ, Regenberg A; Hinxton Group.

Am J Bioeth. 2015;15(12):42-7. doi: 10.1080/15265161.2015.1103814. No abstract available.

PMID:
26632362
25.

CRISPR: A path through the thicket.

Mathews DJ, Chan S, Donovan PJ, Douglas T, Gyngell C, Harris J, Regenberg A, Lovell-Badge R.

Nature. 2015 Nov 12;527(7577):159-61. doi: 10.1038/527159a. No abstract available.

PMID:
26560284
26.

What if stem cells turn into embryos in a dish?

Pera MF, de Wert G, Dondorp W, Lovell-Badge R, Mummery CL, Munsie M, Tam PP.

Nat Methods. 2015 Oct;12(10):917-9. doi: 10.1038/nmeth.3586.

PMID:
26418764
27.

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline.

Carrasco-Garcia E, Arrizabalaga O, Serrano M, Lovell-Badge R, Matheu A.

Aging Cell. 2015 Aug;14(4):710-4. doi: 10.1111/acel.12343. Epub 2015 May 20.

28.

CRISPR germline engineering--the community speaks.

Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q.

Nat Biotechnol. 2015 May;33(5):478-86. doi: 10.1038/nbt.3227. No abstract available.

PMID:
25965754
29.

Coordination of progenitor specification and growth in mouse and chick spinal cord.

Kicheva A, Bollenbach T, Ribeiro A, Valle HP, Lovell-Badge R, Episkopou V, Briscoe J.

Science. 2014 Sep 26;345(6204):1254927. doi: 10.1126/science.1254927.

30.

Guidelines for the use of cell lines in biomedical research.

Geraghty RJ, Capes-Davis A, Davis JM, Downward J, Freshney RI, Knezevic I, Lovell-Badge R, Masters JR, Meredith J, Stacey GN, Thraves P, Vias M; Cancer Research UK.

Br J Cancer. 2014 Sep 9;111(6):1021-46. doi: 10.1038/bjc.2014.166. Epub 2014 Aug 12.

31.

Gonadal asymmetry and sex determination in birds.

Guioli S, Nandi S, Zhao D, Burgess-Shannon J, Lovell-Badge R, Clinton M.

Sex Dev. 2014;8(5):227-42. doi: 10.1159/000358406. Epub 2014 Feb 27. Review.

32.

Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.

Cheng CW, Niu B, Warren M, Pevny LH, Lovell-Badge R, Hwa T, Cheah KS.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2596-601. doi: 10.1073/pnas.1313083111. Epub 2014 Feb 3.

33.

Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast.

Yoshida M, Uchikawa M, Rizzoti K, Lovell-Badge R, Takemoto T, Kondoh H.

Mech Dev. 2014 May;132:59-68. doi: 10.1016/j.mod.2014.01.003. Epub 2014 Feb 6.

34.

Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes.

Hoffmann SA, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S.

Development. 2014 Jan;141(1):39-50. doi: 10.1242/dev.098418. Epub 2013 Nov 20.

35.

Inference of gene-phenotype associations via protein-protein interaction and orthology.

Wang P, Lai WF, Li MJ, Xu F, Yalamanchili HK, Lovell-Badge R, Wang J.

PLoS One. 2013 Oct 23;8(10):e77478. doi: 10.1371/journal.pone.0077478. eCollection 2013.

36.

Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand.

Rizzoti K, Akiyama H, Lovell-Badge R.

Cell Stem Cell. 2013 Oct 3;13(4):419-32. doi: 10.1016/j.stem.2013.07.006.

37.

Looking for the niche: substance delivery into the lateral ventricle of the brain: the osmotic minipump system.

Gómez Gaviro MV, Sánchez Fernández PL, Lovell Badge R, Fernández Avilés F.

Methods Mol Biol. 2013;1035:135-40. doi: 10.1007/978-1-62703-508-8_11.

PMID:
23959987
38.

A microRNA (mmu-miR-124) prevents Sox9 expression in developing mouse ovarian cells.

Real FM, Sekido R, Lupiáñez DG, Lovell-Badge R, Jiménez R, Burgos M.

Biol Reprod. 2013 Oct 4;89(4):78. doi: 10.1095/biolreprod.113.110957. Print 2013 Oct.

PMID:
23946534
39.

Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure.

Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY.

Cell Metab. 2013 Apr 2;17(4):534-48. doi: 10.1016/j.cmet.2013.03.005.

40.

Pituitary phenotypes of mice lacking the notch signalling ligand delta-like 1 homologue.

Cheung LY, Rizzoti K, Lovell-Badge R, Le Tissier PR.

J Neuroendocrinol. 2013 Apr;25(4):391-401. doi: 10.1111/jne.12010.

41.

p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.

Li H, Collado M, Villasante A, Matheu A, Lynch CJ, Cañamero M, Rizzoti K, Carneiro C, Martínez G, Vidal A, Lovell-Badge R, Serrano M.

Cell Stem Cell. 2012 Dec 7;11(6):845-52. doi: 10.1016/j.stem.2012.09.014.

42.

Genetic control of testis development.

Sekido R, Lovell-Badge R.

Sex Dev. 2013;7(1-3):21-32. doi: 10.1159/000342221. Epub 2012 Sep 5. Review.

43.

The vascular stem cell niche.

Gómez-Gaviro MV, Lovell-Badge R, Fernández-Avilés F, Lara-Pezzi E.

J Cardiovasc Transl Res. 2012 Oct;5(5):618-30. Epub 2012 May 30. Review.

PMID:
22644724
44.

Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.

Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ.

Dev Cell. 2012 Mar 13;22(3):585-96. doi: 10.1016/j.devcel.2011.12.023.

45.

Error-prone ZW pairing and no evidence for meiotic sex chromosome inactivation in the chicken germ line.

Guioli S, Lovell-Badge R, Turner JM.

PLoS Genet. 2012;8(3):e1002560. doi: 10.1371/journal.pgen.1002560. Epub 2012 Mar 8.

46.

Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).

Ludbrook LM, Bernard P, Bagheri-Fam S, Ryan J, Sekido R, Wilhelm D, Lovell-Badge R, Harley VR.

Endocrinology. 2012 Apr;153(4):1948-58. doi: 10.1210/en.2011-1428. Epub 2012 Jan 31.

PMID:
22294746
47.

Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice.

Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R, Thomas PQ.

PLoS One. 2012;7(1):e29041. doi: 10.1371/journal.pone.0029041. Epub 2012 Jan 26.

48.

Oncogenicity of the developmental transcription factor Sox9.

Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R.

Cancer Res. 2012 Mar 1;72(5):1301-15. doi: 10.1158/0008-5472.CAN-11-3660. Epub 2012 Jan 13.

49.

Betacellulin promotes cell proliferation in the neural stem cell niche and stimulates neurogenesis.

Gómez-Gaviro MV, Scott CE, Sesay AK, Matheu A, Booth S, Galichet C, Lovell-Badge R.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1317-22. doi: 10.1073/pnas.1016199109. Epub 2012 Jan 9.

50.

Sox9 gene regulation and the loss of the XY/XX sex-determining mechanism in the mole vole Ellobius lutescens.

Bagheri-Fam S, Sreenivasan R, Bernard P, Knower KC, Sekido R, Lovell-Badge R, Just W, Harley VR.

Chromosome Res. 2012 Jan;20(1):191-9. doi: 10.1007/s10577-011-9269-5.

PMID:
22215485

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