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Uncoupling proteins as a therapeutic target to protect the diabetic heart.

Dludla PV, Nkambule BB, Tiano L, Louw J, Jastroch M, Mazibuko-Mbeje SE.

Pharmacol Res. 2018 Sep 14. pii: S1043-6618(18)31056-9. doi: 10.1016/j.phrs.2018.09.013. [Epub ahead of print] Review.


Aspalathin, a C-glucosyl dihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice.

Dludla PV, Gabuza KB, Muller CJF, Joubert E, Louw J, Johnson R.

Physiol Res. 2018 Jul 25. [Epub ahead of print]


Altered microRNA expression during Impaired Glucose Tolerance and High-fat Diet Feeding.

Pheiffer C, Dias S, Willmer T, Pace R, Aagaard K, Louw J.

Exp Clin Endocrinol Diabetes. 2018 Jun 11. doi: 10.1055/a-0619-4576. [Epub ahead of print]


A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications.

Dludla PV, Dias SC, Obonye N, Johnson R, Louw J, Nkambule BB.

Am J Cardiovasc Drugs. 2018 Aug;18(4):283-298. doi: 10.1007/s40256-018-0275-2. Review.


When There Are Only Minorities: Identity and In-Group / Out-Group Orientations of Emerging Adults in Four South African Ethnocultural Groups.

Adams BG, Naudé L, Nel JA, van de Vijver FJR, Laher S, Louw J, Tadi F.

Emerg Adulthood. 2018 Feb;6(1):7-16. doi: 10.1177/2167696817752755. Epub 2018 Jan 22.


Critical evaluation of causality assessment of herb-drug interactions in patients.

Awortwe C, Makiwane M, Reuter H, Muller C, Louw J, Rosenkranz B.

Br J Clin Pharmacol. 2018 Apr;84(4):679-693. doi: 10.1111/bcp.13490. Epub 2018 Jan 29. Review.


Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings.

Louw JJ, Nunes Bastos R, Chen X, Verdood C, Corveleyn A, Jia Y, Breckpot J, Gewillig M, Peeters H, Santoro MM, Barr F, Devriendt K.

PLoS Genet. 2018 Jan 22;14(1):e1007138. doi: 10.1371/journal.pgen.1007138. eCollection 2018 Jan.


App-Supported Promotion of Child Growth and Development by Community Health Workers in Kenya: Feasibility and Acceptability Study.

van Heerden A, Sen D, Desmond C, Louw J, Richter L.

JMIR Mhealth Uhealth. 2017 Dec 5;5(12):e182. doi: 10.2196/mhealth.6911.


Patient- or person-centred practice in medicine? - A review of concepts.

Louw JM, Marcus TS, Hugo JFM.

Afr J Prim Health Care Fam Med. 2017 Oct 19;9(1):e1-e7. doi: 10.4102/phcfm.v9i1.1455. Review.


Androgen receptor expression on circulating tumor cells in metastatic breast cancer.

Fujii T, Reuben JM, Huo L, Espinosa Fernandez JR, Gong Y, Krupa R, Suraneni MV, Graf RP, Lee J, Greene S, Rodriguez A, Dugan L, Louw J, Lim B, Barcenas CH, Marx AN, Tripathy D, Wang Y, Landers M, Dittamore R, Ueno NT.

PLoS One. 2017 Sep 28;12(9):e0185231. doi: 10.1371/journal.pone.0185231. eCollection 2017.


Polyphenol-Enriched Fractions of Cyclopia intermedia Selectively Affect Lipogenesis and Lipolysis in 3T3-L1 Adipocytes.

Jack BU, Malherbe CJ, Willenburg EL, de Beer D, Huisamen B, Joubert E, Muller CJF, Louw J, Pheiffer C.

Planta Med. 2018 Jan;84(2):100-110. doi: 10.1055/s-0043-119463. Epub 2017 Sep 22.


Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling.

Johnson R, Shabalala S, Louw J, Kappo AP, Muller CJF.

Molecules. 2017 Sep 22;22(10). pii: E1589. doi: 10.3390/molecules22101589.


Phenotypic Heterogeneity of Circulating Tumor Cells Informs Clinical Decisions between AR Signaling Inhibitors and Taxanes in Metastatic Prostate Cancer.

Scher HI, Graf RP, Schreiber NA, McLaughlin B, Jendrisak A, Wang Y, Lee J, Greene S, Krupa R, Lu D, Bamford P, Louw JE, Dugan L, Vargas HA, Fleisher M, Landers M, Heller G, Dittamore R.

Cancer Res. 2017 Oct 15;77(20):5687-5698. doi: 10.1158/0008-5472.CAN-17-1353. Epub 2017 Aug 17.


Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside.

Dludla PV, Joubert E, Muller CJF, Louw J, Johnson R.

Nutr Metab (Lond). 2017 Jul 10;14:45. doi: 10.1186/s12986-017-0200-8. eCollection 2017. Review.


Public Representations of Loss in Death Announcements, 1912 to 2002.

Brusser P, Louw J.

Omega (Westport). 2017 Jan 1:30222817709692. doi: 10.1177/0030222817709692. [Epub ahead of print]


MicroRNA Expression Varies according to Glucose Tolerance, Measurement Platform, and Biological Source.

Dias S, Hemmings S, Muller C, Louw J, Pheiffer C.

Biomed Res Int. 2017;2017:1080157. doi: 10.1155/2017/1080157. Epub 2017 Apr 26.


Polyphenols, autophagy and doxorubicin-induced cardiotoxicity.

Shabalala S, Muller CJF, Louw J, Johnson R.

Life Sci. 2017 Jul 1;180:160-170. doi: 10.1016/j.lfs.2017.05.003. Epub 2017 May 3. Review.


Cellular Expression of PD-L1 in the Peripheral Blood of Lung Cancer Patients is Associated with Worse Survival.

Boffa DJ, Graf RP, Salazar MC, Hoag J, Lu D, Krupa R, Louw J, Dugan L, Wang Y, Landers M, Suraneni M, Greene SB, Magaña M, Makani S, Bazhenova L, Dittamore RV, Nieva J.

Cancer Epidemiol Biomarkers Prev. 2017 Jul;26(7):1139-1145. doi: 10.1158/1055-9965.EPI-17-0120. Epub 2017 Apr 26.


Age-dependent development of left ventricular wall thickness in type 2 diabetic (db/db) mice is associated with elevated low-density lipoprotein and triglyceride serum levels.

Dludla PV, Essop MF, Gabuza KB, Muller CJF, Louw J, Johnson R.

Heart Vessels. 2017 Aug;32(8):1025-1031. doi: 10.1007/s00380-017-0978-3. Epub 2017 Apr 9.


Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.

Bowles S, Joubert E, de Beer D, Louw J, Brunschwig C, Njoroge M, Lawrence N, Wiesner L, Chibale K, Muller C.

Molecules. 2017 Mar 30;22(4). pii: E554. doi: 10.3390/molecules22040554.



Hookey L, Louw J, Wiepjes M, Rubinger N, Van Weyenberg S, Day AG, Paterson W.

Gastrointest Endosc. 2017 Mar;85(3):684-685. doi: 10.1016/j.gie.2016.10.016. No abstract available.


Intestinal transport and absorption of bioactive phenolic compounds from a chemically characterized aqueous extract of Athrixia phylicoides.

Bowles SL, Ntamo Y, Malherbe CJ, Kappo AM, Louw J, Muller CJ.

J Ethnopharmacol. 2017 Mar 22;200:45-50. doi: 10.1016/j.jep.2017.02.019. Epub 2017 Feb 16.


Developing Intervention Strategies to Optimise Body Composition in Early Childhood in South Africa.

Draper CE, Tomaz SA, Stone M, Hinkley T, Jones RA, Louw J, Twine R, Kahn K, Norris SA.

Biomed Res Int. 2017;2017:5283457. doi: 10.1155/2017/5283457. Epub 2017 Jan 16.


Cost effectiveness of clinical associates: A case study for the Mpumalanga province in South Africa.

Hamm J, Bodegraven PV, Bac M, Louw JM.

Afr J Prim Health Care Fam Med. 2016 Nov 15;8(1):e1-e6. doi: 10.4102/phcfm.v8i1.1218.


The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model.

Johnson R, Dludla PV, Muller CJ, Huisamen B, Essop MF, Louw J.

Molecules. 2017 Jan 31;22(2). pii: E219. doi: 10.3390/molecules22020219.


Deceiving proteins! A case of lymphoma and high creatinine.

Metraiah EH, Regan H, Louw J, Kidder D.

BMJ Case Rep. 2017 Jan 23;2017. pii: bcr2016217946. doi: 10.1136/bcr-2016-217946.


Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression.

Dludla PV, Muller CJ, Joubert E, Louw J, Essop MF, Gabuza KB, Ghoor S, Huisamen B, Johnson R.

Molecules. 2017 Jan 14;22(1). pii: E129. doi: 10.3390/molecules22010129.


Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer.

Scher HI, Graf RP, Schreiber NA, McLaughlin B, Lu D, Louw J, Danila DC, Dugan L, Johnson A, Heller G, Fleisher M, Dittamore R.

Eur Urol. 2017 Jun;71(6):874-882. doi: 10.1016/j.eururo.2016.11.024. Epub 2016 Dec 12.


Changes in drinking patterns during and after pregnancy among mothers of children with fetal alcohol syndrome: A study in three districts of South Africa.

Urban MF, Olivier L, Louw JG, Lombard C, Viljoen DL, Scorgie F, Chersich MF.

Drug Alcohol Depend. 2016 Nov 1;168:13-21. doi: 10.1016/j.drugalcdep.2016.08.629. Epub 2016 Sep 1.


Programmed death-ligand 1 (PD-L1) characterization of circulating tumor cells (CTCs) in muscle invasive and metastatic bladder cancer patients.

Anantharaman A, Friedlander T, Lu D, Krupa R, Premasekharan G, Hough J, Edwards M, Paz R, Lindquist K, Graf R, Jendrisak A, Louw J, Dugan L, Baird S, Wang Y, Dittamore R, Paris PL.

BMC Cancer. 2016 Sep 22;16(1):744.


Students' perceptions of the instructional quality of district hospital-based training.

Memon SJ, Louw JM, Bac M, Hugo J, Rauf WU, Sandars JE.

Afr J Prim Health Care Fam Med. 2016 Jul 7;8(1):e1-6. doi: 10.4102/phcfm.v8i1.1028.


Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer.

McDaniel AS, Ferraldeschi R, Krupa R, Landers M, Graf R, Louw J, Jendrisak A, Bales N, Marrinucci D, Zafeiriou Z, Flohr P, Sideris S, Crespo M, Figueiredo I, Mateo J, de Bono JS, Dittamore R, Tomlins SA, Attard G.

BJU Int. 2017 Nov;120(5B):E30-E44. doi: 10.1111/bju.13631. Epub 2016 Sep 18.


Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing.

Sifrim A, Hitz MP, Wilsdon A, Breckpot J, Turki SH, Thienpont B, McRae J, Fitzgerald TW, Singh T, Swaminathan GJ, Prigmore E, Rajan D, Abdul-Khaliq H, Banka S, Bauer UM, Bentham J, Berger F, Bhattacharya S, Bu'Lock F, Canham N, Colgiu IG, Cosgrove C, Cox H, Daehnert I, Daly A, Danesh J, Fryer A, Gewillig M, Hobson E, Hoff K, Homfray T; INTERVAL Study, Kahlert AK, Ketley A, Kramer HH, Lachlan K, Lampe AK, Louw JJ, Manickara AK, Manase D, McCarthy KP, Metcalfe K, Moore C, Newbury-Ecob R, Omer SO, Ouwehand WH, Park SM, Parker MJ, Pickardt T, Pollard MO, Robert L, Roberts DJ, Sambrook J, Setchfield K, Stiller B, Thornborough C, Toka O, Watkins H, Williams D, Wright M, Mital S, Daubeney PE, Keavney B, Goodship J; UK10K Consortium, Abu-Sulaiman RM, Klaassen S, Wright CF, Firth HV, Barrett JC, Devriendt K, FitzPatrick DR, Brook JD; Deciphering Developmental Disorders Study, Hurles ME.

Nat Genet. 2016 Sep;48(9):1060-5. doi: 10.1038/ng.3627. Epub 2016 Aug 1.


Lack of benefit of active preparation compared with a clear fluid-only diet in small-bowel visualization for video capsule endoscopy: results of a randomized, blinded, controlled trial.

Hookey L, Louw J, Wiepjes M, Rubinger N, Van Weyenberg S, Day AG, Paterson W.

Gastrointest Endosc. 2017 Jan;85(1):187-193. doi: 10.1016/j.gie.2016.07.028. Epub 2016 Jul 21.


Phenylpyruvic Acid-2-O-β-D-Glucoside Attenuates High Glucose-Induced Apoptosis in H9c2 Cardiomyocytes.

Dludla PV, Muller CJ, Joubert E, Louw J, Gabuza KB, Huisamen B, Essop MF, Johnson R.

Planta Med. 2016 Nov;82(17):1468-1474. Epub 2016 Jul 12.


Supercritical water gasification of Eucalyptus grandis and related pyrolysis char: Effect of feedstock composition.

Louw J, Schwarz CE, Burger AJ.

Bioresour Technol. 2016 Sep;216:1030-9. doi: 10.1016/j.biortech.2016.06.062. Epub 2016 Jun 18.


Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer.

Scher HI, Lu D, Schreiber NA, Louw J, Graf RP, Vargas HA, Johnson A, Jendrisak A, Bambury R, Danila D, McLaughlin B, Wahl J, Greene SB, Heller G, Marrinucci D, Fleisher M, Dittamore R.

JAMA Oncol. 2016 Nov 1;2(11):1441-1449. doi: 10.1001/jamaoncol.2016.1828. Erratum in: JAMA Oncol. 2016 Nov 1;2(11):1511.


Change in Health-Related Quality of Life among Pulmonary Tuberculosis Patients at Primary Health Care Settings in South Africa: A Prospective Cohort Study.

Louw JS, Mabaso M, Peltzer K.

PLoS One. 2016 May 3;11(5):e0151892. doi: 10.1371/journal.pone.0151892. eCollection 2016.


Optimization of window settings for virtual monoenergetic imaging in dual-energy CT of the liver: A multi-reader evaluation of standard monoenergetic and advanced imaged-based monoenergetic datasets.

De Cecco CN, Caruso D, Schoepf UJ, Wichmann JL, Ter Louw JR, Perry JD, Picard MM, Schaefer AR, Parker LW, Hardie AD.

Eur J Radiol. 2016 Apr;85(4):695-9. doi: 10.1016/j.ejrad.2016.01.007. Epub 2016 Jan 21.


Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans.

Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LCA, Swaminathan GJ, Bentham J, Arndt AK, Louw J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'Lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, FitzPatrick DR; UK10K Consortium, Wilson DI, Mital S, Hurles ME.

Am J Hum Genet. 2016 Mar 3;98(3):592. doi: 10.1016/j.ajhg.2016.02.016. Epub 2016 Mar 3. No abstract available.


Brief school-based interventions and behavioural outcomes for substance-using adolescents.

Carney T, Myers BJ, Louw J, Okwundu CI.

Cochrane Database Syst Rev. 2016 Jan 20;(1):CD008969. doi: 10.1002/14651858.CD008969.pub3. Review.


Aspalathin, a dihydrochalcone C-glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis.

Johnson R, Dludla P, Joubert E, February F, Mazibuko S, Ghoor S, Muller C, Louw J.

Mol Nutr Food Res. 2016 Apr;60(4):922-34. doi: 10.1002/mnfr.201500656. Epub 2016 Feb 12.


The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer.

Beltran H, Jendrisak A, Landers M, Mosquera JM, Kossai M, Louw J, Krupa R, Graf RP, Schreiber NA, Nanus DM, Tagawa ST, Marrinucci D, Dittamore R, Scher HI.

Clin Cancer Res. 2016 Mar 15;22(6):1510-9. doi: 10.1158/1078-0432.CCR-15-0137. Epub 2015 Dec 15.


Catalytic supercritical water gasification of primary paper sludge using a homogeneous and heterogeneous catalyst: Experimental vs thermodynamic equilibrium results.

Louw J, Schwarz CE, Burger AJ.

Bioresour Technol. 2016 Feb;201:111-20. doi: 10.1016/j.biortech.2015.11.043. Epub 2015 Nov 23.


Expression of UCP2 in Wistar rats varies according to age and the severity of obesity.

Pheiffer C, Jacobs C, Patel O, Ghoor S, Muller C, Louw J.

J Physiol Biochem. 2016 Mar;72(1):25-32. doi: 10.1007/s13105-015-0454-4. Epub 2015 Nov 30.


Can a volume challenge pinpoint the limiting factor in a Fontan circulation?

De Mey W, Cools B, Heying R, Budts W, Louw JJ, Boshoff DE, Brown SC, Gewillig M.

Acta Cardiol. 2015 Oct;70(5):536-42. doi: 10.2143/AC.70.5.3110514.


Assessing similarity analysis of chromatographic fingerprints of Cyclopia subternata extracts as potential screening tool for in vitro glucose utilisation.

Schulze AE, De Beer D, Mazibuko SE, Muller CJ, Roux C, Willenburg EL, Nyunaï N, Louw J, Manley M, Joubert E.

Anal Bioanal Chem. 2016 Jan;408(2):639-49. doi: 10.1007/s00216-015-9147-7. Epub 2015 Nov 5.


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