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Items: 31


Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.

Zhou H, Deng M, Liu Y, Yang C, Hoffman R, Zhou J, Loughran PA, Scott MJ, Neal MD, Billiar TR.

Blood Adv. 2018 Mar 27;2(6):638-648. doi: 10.1182/bloodadvances.2017011817.


cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.

Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, Scott MJ, Huang F, Billiar TR.

Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G655-G667. doi: 10.1152/ajpgi.00326.2017. Epub 2018 Feb 15.


Basics of Digital Microscopy.

Wallace CT, Jessup M, Bernas T, Peña KA, Calderon MJ, Loughran PA.

Curr Protoc Cytom. 2018 Jan 18;83:12.2.1-12.2.14. doi: 10.1002/cpcy.31. Review.


Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice.

Zettel K, Korff S, Zamora R, Morelli AE, Darwiche S, Loughran PA, Elson G, Shang L, Salgado-Pires S, Scott MJ, Vodovotz Y, Billiar TR.

Front Immunol. 2017 Nov 28;8:1672. doi: 10.3389/fimmu.2017.01672. eCollection 2017.


Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest.

Li L, Poloyac SM, Watkins SC, St Croix CM, Alexander H, Gibson GA, Loughran PA, Kirisci L, Clark RS, Kochanek PM, Vazquez AL, Manole MD.

J Cereb Blood Flow Metab. 2019 May;39(5):913-925. doi: 10.1177/0271678X17744717. Epub 2017 Dec 1.


Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Jiao Y, Li Z, Loughran PA, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Shi X, Fan J.

J Leukoc Biol. 2018 Feb;103(2):175-183. doi: 10.1189/jlb.3HI0517-173R. Epub 2017 Dec 28.


Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein.

Zhang L, Xiang W, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR.

J Biol Chem. 2016 Jul 15;291(29):15093-107. doi: 10.1074/jbc.M116.717942. Epub 2016 May 17.


Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling.

Deng M, Loughran PA, Zhang L, Scott MJ, Billiar TR.

Sci Signal. 2015 Jan 27;8(361):ra11. doi: 10.1126/scisignal.2005548.


CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.

Zhang X, Howell GM, Guo L, Collage RD, Loughran PA, Zuckerbraun BS, Rosengart MR.

J Immunol. 2014 Sep 1;193(5):2405-15. doi: 10.4049/jimmunol.1302798. Epub 2014 Jul 28.


Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.

Ding N, Chen G, Hoffman R, Loughran PA, Sodhi CP, Hackam DJ, Billiar TR, Neal MD.

Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.


TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release.

Ding N, Zhang Y, Loughran PA, Wang Q, Tsung A, Billiar TR.

Free Radic Biol Med. 2013 Oct;63:361-7. doi: 10.1016/j.freeradbiomed.2013.05.029. Epub 2013 May 28.


CD14 contributes to warm hepatic ischemia-reperfusion injury in mice.

Cai C, Shi X, Korff S, Zhang J, Loughran PA, Ruan X, Zhang Y, Liu L, Billiar TR.

Shock. 2013 Aug;40(2):115-21. doi: 10.1097/SHK.0b013e318299d1a7.


PEX7 and EBP50 target iNOS to the peroxisome in hepatocytes.

Loughran PA, Stolz DB, Barrick SR, Wheeler DS, Friedman PA, Rachubinski RA, Watkins SC, Billiar TR.

Nitric Oxide. 2013 May 31;31:9-19. doi: 10.1016/j.niox.2013.02.084. Epub 2013 Mar 5.


A role for cGMP in inducible nitric-oxide synthase (iNOS)-induced tumor necrosis factor (TNF) α-converting enzyme (TACE/ADAM17) activation, translocation, and TNF receptor 1 (TNFR1) shedding in hepatocytes.

Chanthaphavong RS, Loughran PA, Lee TY, Scott MJ, Billiar TR.

J Biol Chem. 2012 Oct 19;287(43):35887-98. doi: 10.1074/jbc.M112.365171. Epub 2012 Aug 16.


Mast cells play a critical role in the systemic inflammatory response and end-organ injury resulting from trauma.

Cai C, Cao Z, Loughran PA, Kim S, Darwiche S, Korff S, Billiar TR.

J Am Coll Surg. 2011 Nov;213(5):604-15. doi: 10.1016/j.jamcollsurg.2011.08.009. Epub 2011 Sep 14.


Characterization of DISC formation and TNFR1 translocation to mitochondria in TNF-α-treated hepatocytes.

Eum HA, Vallabhaneni R, Wang Y, Loughran PA, Stolz DB, Billiar TR.

Am J Pathol. 2011 Sep;179(3):1221-9. doi: 10.1016/j.ajpath.2011.05.046. Epub 2011 Jul 8.


Caspase-1 is hepatoprotective during trauma and hemorrhagic shock by reducing liver injury and inflammation.

Menzel CL, Sun Q, Loughran PA, Pape HC, Billiar TR, Scott MJ.

Mol Med. 2011 Sep-Oct;17(9-10):1031-8. doi: 10.2119/molmed.2011.00015. Epub 2011 Jun 7.


Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice.

Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS.

Hepatology. 2011 Jun;53(6):2053-62. doi: 10.1002/hep.24324. Epub 2011 May 2.


Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome.

Cai C, Gill R, Eum HA, Cao Z, Loughran PA, Darwiche S, Edmonds RD, Menzel CL, Billiar TR.

Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1175-82. doi: 10.1152/ajpregu.00282.2010. Epub 2010 Aug 11.


Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis.

Tyagi P, Tyagi V, Yoshimura N, Witteemer E, Barclay D, Loughran PA, Zamora R, Vodovotz Y.

J Inflamm (Lond). 2009 Aug 19;6:23. doi: 10.1186/1476-9255-6-23.


Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.

Metukuri MR, Beer-Stolz D, Namas RA, Dhupar R, Torres A, Loughran PA, Jefferson BS, Tsung A, Billiar TR, Vodovotz Y, Zamora R.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G499-509. doi: 10.1152/ajpgi.90526.2008. Epub 2009 Jan 15.


Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent.

Zhang X, Vallabhaneni R, Loughran PA, Shapiro R, Yin XM, Yuan Y, Billiar TR.

Apoptosis. 2008 Aug;13(8):983-92. doi: 10.1007/s10495-008-0228-3.


Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.

Kim HS, Loughran PA, Rao J, Billiar TR, Zuckerbraun BS.

Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G146-G152. doi: 10.1152/ajpgi.00105.2007. Epub 2008 May 22.


Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.

Kim HS, Loughran PA, Billiar TR.

Nitric Oxide. 2008 Jun;18(4):256-65. doi: 10.1016/j.niox.2008.02.002. Epub 2008 Feb 15.


Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway.

Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.

Biochem Biophys Res Commun. 2006 Jun 16;344(4):1172-8. Epub 2006 Apr 6.


Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes.

Loughran PA, Stolz DB, Vodovotz Y, Watkins SC, Simmons RL, Billiar TR.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13837-42. Epub 2005 Sep 19.


Peroxisomal localization of inducible nitric oxide synthase in hepatocytes.

Stolz DB, Zamora R, Vodovotz Y, Loughran PA, Billiar TR, Kim YM, Simmons RL, Watkins SC.

Hepatology. 2002 Jul;36(1):81-93.


Expressed CYP4A4 metabolism of prostaglandin E(1) and arachidonic acid.

Aitken AE, Roman LJ, Loughran PA, de la Garza M, Masters BS.

Arch Biochem Biophys. 2001 Sep 15;393(2):329-38.


Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.

Zamora R, Vodovotz Y, Alarcon L, Betten B, Loughran PA, Aulak KS, Stuehr DJ, Gibson KF, Billiar TR.

Arch Biochem Biophys. 2001 Jun 15;390(2):287-94.


The kinetic and spectral characterization of the E. coli-expressed mammalian CYP4A7: cytochrome b5 effects vary with substrate.

Loughran PA, Roman LJ, Miller RT, Masters BS.

Arch Biochem Biophys. 2001 Jan 15;385(2):311-21.


Identification of unique amino acids that modulate CYP4A7 activity.

Loughran PA, Roman LJ, Aitken AE, Miller RT, Masters BS.

Biochemistry. 2000 Dec 12;39(49):15110-20.


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