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Items: 47


Phlda3 regulates beta cell survival during stress.

Bensellam M, Chan JY, Lee K, Joglekar MV, Hardikar AA, Loudovaris T, Thomas HE, Jonas JC, Laybutt DR.

Sci Rep. 2019 Sep 6;9(1):12827. doi: 10.1038/s41598-019-49289-5.


Australia and New Zealand Islet and Pancreas Transplant Registry Annual Report 2018-Islet Donations, Islet Isolations, and Islet Transplants.

Webster AC, Hedley JA, Anderson PF, Hawthorne WJ, Radford T, Drogemuller C, Rogers N, Goodman D, Lee MH, Loudovaris T, Kelly PJ.

Transplant Direct. 2019 Jan 7;5(2):e421. doi: 10.1097/TXD.0000000000000851. eCollection 2019 Feb.


Divergent SATB1 expression across human life span and tissue compartments.

Nüssing S, Koay HF, Sant S, Loudovaris T, Mannering SI, Lappas M, D Udekem Y, Konstantinov IE, Berzins SP, Rimmelzwaan GF, Turner SJ, Clemens EB, Godfrey DI, Nguyen TH, Kedzierska K.

Immunol Cell Biol. 2019 May;97(5):498-511. doi: 10.1111/imcb.12233. Epub 2019 Feb 25.


Human CD8+ T cell cross-reactivity across influenza A, B and C viruses.

Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, Eltahla AA, Clemens EB, Sant S, Chua BY, Wong CY, Allen EK, Teng D, Dash P, Boyd DF, Grzelak L, Zeng W, Hurt AC, Barr I, Rockman S, Jackson DC, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Wakim LM, Rossjohn J, Vijaykrishna D, Luciani F, Thomas PG, Gras S, Purcell AW, Kedzierska K.

Nat Immunol. 2019 May;20(5):613-625. doi: 10.1038/s41590-019-0320-6. Epub 2019 Feb 18.


Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets.

Burzava ALS, Forget A, Harding FJ, Cockshell MP, Penko D, Rouzaud C, Ahmadi V, Marina PF, Rojas-Canales D, Bonder CS, Coates PTH, Waibel M, Thomas HE, Kay TW, Loudovaris T, Blencowe A, Voelcker NH.

Biointerphases. 2019 Jan 30;14(1):011002. doi: 10.1116/1.5087737.


Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling.

Kelly AC, Smith KE, Purvis WG, Min CG, Weber CS, Cooksey AM, Hasilo C, Paraskevas S, Suszynski TM, Weegman BP, Anderson MJ, Camacho LE, Harland RC, Loudovaris T, Jandova J, Molano DS, Price ND, Georgiev IG, Scott WE 3rd, Manas DMD, Shaw JAM, OʼGorman D, Kin T, McCarthy FM, Szot GL, Posselt AM, Stock PG, Karatzas T, Shapiro AMJ, Lynch RM, Limesand SW, Papas KK.

Transplantation. 2019 Jan;103(1):160-167. doi: 10.1097/TP.0000000000002400.


Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection.

Sant S, Grzelak L, Wang Z, Pizzolla A, Koutsakos M, Crowe J, Loudovaris T, Mannering SI, Westall GP, Wakim LM, Rossjohn J, Gras S, Richards M, Xu J, Thomas PG, Loh L, Nguyen THO, Kedzierska K.

Front Immunol. 2018 Jun 27;9:1453. doi: 10.3389/fimmu.2018.01453. eCollection 2018.


Expression of miR-206 in human islets and its role in glucokinase regulation.

Joglekar MV, Wong WKM, Maynard CL, Umrani MR, Martin D, Loudovaris T, Thomas HE, Dalgaard LT, Hardikar AA.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E634-E637. doi: 10.1152/ajpendo.00152.2018. Epub 2018 Jul 10.


Oxygen-permeable microwell device maintains islet mass and integrity during shipping.

Rojas-Canales DM, Waibel M, Forget A, Penko D, Nitschke J, Harding FJ, Delalat B, Blencowe A, Loudovaris T, Grey ST, Thomas HE, Kay TWH, Drogemuller CJ, Voelcker NH, Coates PT.

Endocr Connect. 2018 Mar;7(3):490-503. doi: 10.1530/EC-17-0349. Epub 2018 Feb 26.


Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

Koutsakos M, Wheatley AK, Loh L, Clemens EB, Sant S, Nüssing S, Fox A, Chung AW, Laurie KL, Hurt AC, Rockman S, Lappas M, Loudovaris T, Mannering SI, Westall GP, Elliot M, Tangye SG, Wakim LM, Kent SJ, Nguyen THO, Kedzierska K.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan8405. doi: 10.1126/scitranslmed.aan8405.


Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR.

PLoS One. 2018 Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.


Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.

Pizzolla A, Nguyen TH, Sant S, Jaffar J, Loudovaris T, Mannering SI, Thomas PG, Westall GP, Kedzierska K, Wakim LM.

J Clin Invest. 2018 Feb 1;128(2):721-733. doi: 10.1172/JCI96957. Epub 2018 Jan 8.


Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells.

Augstein P, Loudovaris T, Bandala-Sanchez E, Heinke P, Naselli G, Lee L, Hawthorne WJ, Góñez LJ, Neale AM, Vaillant F, Thomas HE, Kay TW, Banakh I, Harrison LC.

Pancreas. 2018 Jan;47(1):25-34. doi: 10.1097/MPA.0000000000000950.


Transplantation sites for human and murine islets.

Stokes RA, Cheng K, Lalwani A, Swarbrick MM, Thomas HE, Loudovaris T, Kay TW, Hawthorne WJ, O'Connell PJ, Gunton JE.

Diabetologia. 2017 Oct;60(10):1961-1971. doi: 10.1007/s00125-017-4362-8. Epub 2017 Jul 22.


First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia.

Geyer MC, Coates PT, Khurana S, Chen JW, Kay TW, Balamurugan AN, Couper JJ, Radford T, Drogemuller CJ, Loudovaris T, Pathi R, Wilks MJ, Couper RT.

Pancreas. 2017 Mar;46(3):e18-e20. doi: 10.1097/MPA.0000000000000769. No abstract available.


Non-invasive, in vitro analysis of islet insulin production enabled by an optical porous silicon biosensor.

Chhasatia R, Sweetman MJ, Harding FJ, Waibel M, Kay T, Thomas H, Loudovaris T, Voelcker NH.

Biosens Bioelectron. 2017 May 15;91:515-522. doi: 10.1016/j.bios.2017.01.004. Epub 2017 Jan 4.


A Combinatorial Protein Microarray for Probing Materials Interaction with Pancreatic Islet Cell Populations.

Delalat B, Rojas-Canales DM, Rasi Ghaemi S, Waibel M, Harding FJ, Penko D, Drogemuller CJ, Loudovaris T, Coates PT, Voelcker NH.

Microarrays (Basel). 2016 Aug 10;5(3). pii: E21. doi: 10.3390/microarrays5030021.


Islet Transplantation Provides Superior Glycemic Control With Less Hypoglycemia Compared With Continuous Subcutaneous Insulin Infusion or Multiple Daily Insulin Injections.

Holmes-Walker DJ, Gunton JE, Hawthorne W, Payk M, Anderson P, Donath S, Loudovaris T, Ward GM, Kay TW, OʼConnell PJ.

Transplantation. 2017 Jun;101(6):1268-1275. doi: 10.1097/TP.0000000000001381.


Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells.

Augstein P, Naselli G, Loudovaris T, Hawthorne WJ, Campbell P, Bandala-Sanchez E, Rogers K, Heinke P, Thomas HE, Kay TW, Harrison LC.

Diabetes Res Clin Pract. 2015 Dec;110(3):291-300. doi: 10.1016/j.diabres.2015.10.010. Epub 2015 Oct 26.


Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST.

J Exp Med. 2015 Jul 27;212(8):1239-54. doi: 10.1084/jem.20150218. Epub 2015 Jun 29.


A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.

Farr RJ, Januszewski AS, Joglekar MV, Liang H, McAulley AK, Hewitt AW, Thomas HE, Loudovaris T, Kay TW, Jenkins A, Hardikar AA.

Sci Rep. 2015 Jun 2;5:10375. doi: 10.1038/srep10375.


Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.

Zhao Y, Scott NA, Quah HS, Krishnamurthy B, Bond F, Loudovaris T, Mannering SI, Kay TW, Thomas HE.

Eur J Immunol. 2015 Sep;45(9):2494-503. doi: 10.1002/eji.201445378. Epub 2015 May 28.


Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.

Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, Kay TW, Thomas HE, Whitehead JP, Forbes JM, Prins JB, McGuckin MA.

Nat Med. 2014 Dec;20(12):1417-26. doi: 10.1038/nm.3705. Epub 2014 Nov 2.


Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.

Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI.

Diabetes. 2015 Jan;64(1):172-82. doi: 10.2337/db14-0858. Epub 2014 Aug 25.


Multicenter Australian trial of islet transplantation: improving accessibility and outcomes.

O'Connell PJ, Holmes-Walker DJ, Goodman D, Hawthorne WJ, Loudovaris T, Gunton JE, Thomas HE, Grey ST, Drogemuller CJ, Ward GM, Torpy DJ, Coates PT, Kay TW; Australian Islet Transplant Consortium.

Am J Transplant. 2013 Jul;13(7):1850-8. doi: 10.1111/ajt.12250. Epub 2013 May 13.


Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets.

Stokes RA, Cheng K, Deters N, Lau SM, Hawthorne WJ, O'Connell PJ, Stolp J, Grey S, Loudovaris T, Kay TW, Thomas HE, Gonzalez FJ, Gunton JE.

Cell Transplant. 2013;22(2):253-66. doi: 10.3727/096368912X647180. Epub 2012 Jun 15.


Human islets express a marked proinflammatory molecular signature prior to transplantation.

Cowley MJ, Weinberg A, Zammit NW, Walters SN, Hawthorne WJ, Loudovaris T, Thomas H, Kay T, Gunton JE, Alexander SI, Kaplan W, Chapman J, O'Connell PJ, Grey ST.

Cell Transplant. 2012;21(9):2063-78. doi: 10.3727/096368911X627372. Epub 2012 Mar 8.


Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors.

Joffe M, Necula AS, Chand R, McWhinney BC, Krishnamurthy B, Loudovaris T, Goodman D, Thomas HE, Kay TW, Mannering SI.

Int Immunol. 2012 Jul;24(7):447-53. doi: 10.1093/intimm/dxs042. Epub 2012 Feb 29.


Expression of pro- and antiapoptotic molecules of the Bcl-2 family in human islets postisolation.

Campbell PD, Weinberg A, Chee J, Mariana L, Ayala R, Hawthorne WJ, O'Connell PJ, Loudovaris T, Cowley MJ, Kay TW, Grey ST, Thomas HE.

Cell Transplant. 2012;21(1):49-60. doi: 10.3727/096368911X566262. Epub 2011 Apr 29.


Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

Mittag D, Proietto AI, Loudovaris T, Mannering SI, Vremec D, Shortman K, Wu L, Harrison LC.

J Immunol. 2011 Jun 1;186(11):6207-17. doi: 10.4049/jimmunol.1002632. Epub 2011 Apr 22.


Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE.

J Clin Invest. 2010 Jun;120(6):2171-83. doi: 10.1172/JCI35846. Epub 2010 May 3.


Survival of macroencapsulated allogeneic parathyroid tissue one year after transplantation in nonimmunosuppressed humans.

Tibell A, Rafael E, Wennberg L, Nordenström J, Bergström M, Geller RL, Loudovaris T, Johnson RC, Brauker JH, Neuenfeldt S, Wernerson A.

Cell Transplant. 2001;10(7):591-9.


Correction of diabetic nod mice with insulinomas implanted within Baxter immunoisolation devices.

Loudovaris T, Jacobs S, Young S, Maryanov D, Brauker J, Johnson RC.

J Mol Med (Berl). 1999 Jan;77(1):219-22.


In vivo delivery of recombinant human growth hormone from genetically engineered human fibroblasts implanted within Baxter immunoisolation devices.

Josephs SF, Loudovaris T, Dixit A, Young SK, Johnson RC.

J Mol Med (Berl). 1999 Jan;77(1):211-4.


Use of an immunoisolation device for cell transplantation and tumor immunotherapy.

Geller RL, Loudovaris T, Neuenfeldt S, Johnson RC, Brauker JH.

Ann N Y Acad Sci. 1997 Dec 31;831:438-51. Review. No abstract available.


CD4+ T cell mediated destruction of xenografts within cell-impermeable membranes in the absence of CD8+ T cells and B cells.

Loudovaris T, Mandel TE, Charlton B.

Transplantation. 1996 Jun 27;61(12):1678-84.


The role of T cells in the destruction of xenografts within cell-impermeable membranes.

Loudovaris T, Charlton B, Mandel T.

Transplant Proc. 1992 Dec;24(6):2938. No abstract available.


Destruction of transplanted beta cells into diabetic NOD mice is not mediated by antibody alone.

Hodgson RJ, Loudovaris T, Charlton B, Mandel TE.

Transplant Proc. 1992 Oct;24(5):2300. No abstract available.


Destruction of xenografts but not allografts within cell impermeable membranes.

Loudovaris T, Charlton B, Hodgson RJ, Mandel TE.

Transplant Proc. 1992 Oct;24(5):2291-2. No abstract available.


Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes.

Harrison LC, De Aizpurua H, Loudovaris T, Campbell IL, Cebon JS, Tait BD, Colman PG.

Diabetes. 1991 Sep;40(9):1128-33.


Genetic resistance to infectious laryngotracheitis in inbred lines of White Leghorn chickens.

Loudovaris T, Yoo BH, Fahey KJ.

Avian Pathol. 1991 Jun;20(2):357-61.


Genetic susceptibility of chicken macrophages to in vitro infection with infectious laryngotracheitis virus.

Loudovaris T, Calnek BW, Yoo BH, Fahey KJ.

Avian Pathol. 1991 Jun;20(2):291-302.


Xenografts of organ-cultured fetal pig pancreas in NOD mice: a comparison with allografts and isografts in transiently immunosuppressed recipients.

Mandel TE, Koulmanda M, Loudovaris T.

Transplant Proc. 1990 Apr;22(2):816-8. No abstract available.


The major histocompatibility complex and genetic control of antibody response to synthetic antigens in chickens.

Loudovaris T, Brandon MR, Fahey KJ.

Avian Pathol. 1990 Jan;19(1):101-17.


The chicken major histocompatibility complex and resistance to Rous sarcoma virus tumours.

Loudovaris T, Ignjatovic J, Fahey KJ.

Avian Pathol. 1989 Oct;18(4):751-5.


Islet grafts in NOD mice: a comparison of iso-, allo-, and pig xenografts.

Mandel TE, Koulmanda M, Loudovaris T, Bacelj A.

Transplant Proc. 1989 Oct;21(5):3813-4. No abstract available.


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