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The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.

Kitchen GB, Cunningham PS, Poolman TM, Iqbal M, Maidstone R, Baxter M, Bagnall J, Begley N, Saer B, Hussell T, Matthews LC, Dockrell DH, Durrington HJ, Gibbs JE, Blaikley JF, Loudon AS, Ray DW.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1543-1551. doi: 10.1073/pnas.1915932117. Epub 2020 Jan 3.


The circadian clock protein REVERBα inhibits pulmonary fibrosis development.

Cunningham PS, Meijer P, Nazgiewicz A, Anderson SG, Borthwick LA, Bagnall J, Kitchen GB, Lodyga M, Begley N, Venkateswaran RV, Shah R, Mercer PF, Durrington HJ, Henderson NC, Piper-Hanley K, Fisher AJ, Chambers RC, Bechtold DA, Gibbs JE, Loudon AS, Rutter MK, Hinz B, Ray DW, Blaikley JF.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1139-1147. doi: 10.1073/pnas.1912109117. Epub 2019 Dec 26.


Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R.

Nat Commun. 2019 Aug 13;10(1):3503. doi: 10.1038/s41467-019-11456-7.


Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.

Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Commun. 2019 Mar 7;10(1):1100. doi: 10.1038/s41467-019-08917-4.


Biological and clinical insights from genetics of insomnia symptoms.

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J; HUNT All In Sleep, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R.

Nat Genet. 2019 Mar;51(3):387-393. doi: 10.1038/s41588-019-0361-7. Epub 2019 Feb 25.


Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.

Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, Fife M, Hopwood T, Begley N, Saer B, Wang P, Cunningham P, Baxter M, Durrington H, Blaikley JF, Hussell T, Rattray M, Hogenesch JB, Gibbs J, Ray DW, Loudon ASI.

FASEB J. 2019 May;33(5):6226-6238. doi: 10.1096/fj.201801682R. Epub 2019 Feb 22.


Reply to Moitra et al.: Individual Chronotype May Confound Asthma Symptoms and Therapy.

Durrington HJ, Loudon ASI, Ray DW.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):392-394. doi: 10.1164/rccm.201809-1712LE. No abstract available.


Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation.

Cunningham PS, Maidstone R, Durrington HJ, Venkateswaran RV, Cypel M, Keshavjee S, Gibbs JE, Loudon AS, Chow CW, Ray DW, Blaikley JF.

Thorax. 2019 Apr;74(4):413-416. doi: 10.1136/thoraxjnl-2018-212021. Epub 2018 Oct 9.


REVERBa couples the circadian clock to hepatic glucocorticoid action.

Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW.

J Clin Invest. 2018 Oct 1;128(10):4454-4471. doi: 10.1172/JCI96138. Epub 2018 Sep 4.


Time of Day Affects Eosinophil Biomarkers in Asthma: Implications for Diagnosis and treatment.

Durrington HJ, Gioan-Tavernier GO, Maidstone RJ, Krakowiak K, Loudon ASI, Blaikley JF, Fowler SJ, Singh D, Simpson A, Ray DW.

Am J Respir Crit Care Med. 2018 Aug 29. doi: 10.1164/rccm.201807-1289LE. [Epub ahead of print] No abstract available.


Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells.

Ince LM, Zhang Z, Beesley S, Vonslow RM, Saer BR, Matthews LC, Begley N, Gibbs JE, Ray DW, Loudon ASI.

FASEB J. 2019 Jan;33(1):126-139. doi: 10.1096/fj.201800026RR. Epub 2018 Jul 2.


Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW.

J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.


The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

Hopwood TW, Hall S, Begley N, Forman R, Brown S, Vonslow R, Saer B, Little MC, Murphy EA, Hurst RJ, Ray DW, MacDonald AS, Brass A, Bechtold DA, Gibbs JE, Loudon AS, Else KJ.

Sci Rep. 2018 Feb 28;8(1):3782. doi: 10.1038/s41598-018-22021-5.


Misalignment with the external light environment drives metabolic and cardiac dysfunction.

West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA.

Nat Commun. 2017 Sep 12;8(1):417. doi: 10.1038/s41467-017-00462-2.


The circadian clock regulates inflammatory arthritis.

Hand LE, Hopwood TW, Dickson SH, Walker AL, Loudon AS, Ray DW, Bechtold DA, Gibbs JE.

FASEB J. 2016 Nov;30(11):3759-3770. Epub 2016 Aug 3.


Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2.

Smyllie NJ, Pilorz V, Boyd J, Meng QJ, Saer B, Chesham JE, Maywood ES, Krogager TP, Spiller DG, Boot-Handford R, White MR, Hastings MH, Loudon AS.

Curr Biol. 2016 Jul 25;26(14):1880-6. doi: 10.1016/j.cub.2016.05.018. Epub 2016 Jun 30.


A matter of time: study of circadian clocks and their role in inflammation.

Carter SJ, Durrington HJ, Gibbs JE, Blaikley J, Loudon AS, Ray DW, Sabroe I.

J Leukoc Biol. 2016 Apr;99(4):549-60. doi: 10.1189/jlb.3RU1015-451R. Epub 2016 Feb 8. Review.


Natural selection against a circadian clock gene mutation in mice.

Spoelstra K, Wikelski M, Daan S, Loudon AS, Hau M.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):686-91. doi: 10.1073/pnas.1516442113. Epub 2015 Dec 29.


Binary Switching of Calendar Cells in the Pituitary Defines the Phase of the Circannual Cycle in Mammals.

Wood SH, Christian HC, Miedzinska K, Saer BR, Johnson M, Paton B, Yu L, McNeilly J, Davis JR, McNeilly AS, Burt DW, Loudon AS.

Curr Biol. 2015 Oct 19;25(20):2651-62. doi: 10.1016/j.cub.2015.09.014. Epub 2015 Sep 24.


Adiponectin induces A20 expression in adipose tissue to confer metabolic benefit.

Hand LE, Usan P, Cooper GJ, Xu LY, Ammori B, Cunningham PS, Aghamohammadzadeh R, Soran H, Greenstein A, Loudon AS, Bechtold DA, Ray DW.

Diabetes. 2015 Jan;64(1):128-36. doi: 10.2337/db13-1835. Epub 2014 Sep 4.


A novel mechanism controlling resetting speed of the circadian clock to environmental stimuli.

Pilorz V, Cunningham PS, Jackson A, West AC, Wager TT, Loudon AS, Bechtold DA.

Curr Biol. 2014 Mar 31;24(7):766-73. doi: 10.1016/j.cub.2014.02.027. Epub 2014 Mar 20.


Hearing damage and deafness: a role for the circadian clock.

Loudon AS.

Curr Biol. 2014 Mar 17;24(6):R232-4. doi: 10.1016/j.cub.2014.01.054.


Pin1 promotes GR transactivation by enhancing recruitment to target genes.

Poolman TM, Farrow SN, Matthews L, Loudon AS, Ray DW.

Nucleic Acids Res. 2013 Oct;41(18):8515-25. doi: 10.1093/nar/gkt624. Epub 2013 Jul 25.


The circadian clock and asthma.

Durrington HJ, Farrow SN, Loudon AS, Ray DW.

Thorax. 2014 Jan;69(1):90-2. doi: 10.1136/thoraxjnl-2013-203482. Epub 2013 May 23.


A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus.

Brancaccio M, Maywood ES, Chesham JE, Loudon AS, Hastings MH.

Neuron. 2013 May 22;78(4):714-28. doi: 10.1016/j.neuron.2013.03.011. Epub 2013 Apr 25.


Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis.

West A, Dupré SM, Yu L, Paton IR, Miedzinska K, McNeilly AS, Davis JR, Burt DW, Loudon AS.

Mol Endocrinol. 2013 Jun;27(6):979-89. doi: 10.1210/me.2012-1366. Epub 2013 Apr 18.


Induction of the metabolic regulator Txnip in fasting-induced and natural torpor.

Hand LE, Saer BR, Hui ST, Jinnah HA, Steinlechner S, Loudon AS, Bechtold DA.

Endocrinology. 2013 Jun;154(6):2081-91. doi: 10.1210/en.2012-2051. Epub 2013 Apr 12.


Hypothalamic clocks and rhythms in feeding behaviour.

Bechtold DA, Loudon AS.

Trends Neurosci. 2013 Feb;36(2):74-82. doi: 10.1016/j.tins.2012.12.007. Epub 2013 Jan 18. Review.


Circadian biology: a 2.5 billion year old clock.

Loudon AS.

Curr Biol. 2012 Jul 24;22(14):R570-1. doi: 10.1016/j.cub.2012.06.023.


Lithium impacts on the amplitude and period of the molecular circadian clockwork.

Li J, Lu WQ, Beesley S, Loudon AS, Meng QJ.

PLoS One. 2012;7(3):e33292. doi: 10.1371/journal.pone.0033292. Epub 2012 Mar 12.


A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor.

Bechtold DA, Sidibe A, Saer BR, Li J, Hand LE, Ivanova EA, Darras VM, Dam J, Jockers R, Luckman SM, Loudon AS.

Curr Biol. 2012 Jan 10;22(1):70-7. doi: 10.1016/j.cub.2011.11.043. Epub 2011 Dec 22.


The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.

Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):582-7. doi: 10.1073/pnas.1106750109. Epub 2011 Dec 19.


Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.

Bryant CD, Parker CC, Zhou L, Olker C, Chandrasekaran RY, Wager TT, Bolivar VJ, Loudon AS, Vitaterna MH, Turek FW, Palmer AA.

Neuropsychopharmacology. 2012 Mar;37(4):1026-35. doi: 10.1038/npp.2011.287. Epub 2011 Nov 16.


GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.

Li J, Hand LE, Meng QJ, Loudon AS, Bechtold DA.

PLoS One. 2011;6(8):e23725. doi: 10.1371/journal.pone.0023725. Epub 2011 Aug 17.


Evidence for RGS4 modulation of melatonin and thyrotrophin signalling pathways in the pars tuberalis.

Dupré SM, Dardente H, Birnie MJ, Loudon AS, Lincoln GA, Hazlerigg DG.

J Neuroendocrinol. 2011 Aug;23(8):725-32. doi: 10.1111/j.1365-2826.2011.02168.x.


Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.

Maywood ES, Chesham JE, Meng QJ, Nolan PM, Loudon AS, Hastings MH.

J Neurosci. 2011 Jan 26;31(4):1539-44. doi: 10.1523/JNEUROSCI.4107-10.2011.


A molecular switch for photoperiod responsiveness in mammals.

Dardente H, Wyse CA, Birnie MJ, Dupré SM, Loudon AS, Lincoln GA, Hazlerigg DG.

Curr Biol. 2010 Dec 21;20(24):2193-8. doi: 10.1016/j.cub.2010.10.048. Epub 2010 Dec 2.


Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

Meng QJ, Maywood ES, Bechtold DA, Lu WQ, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15240-5. doi: 10.1073/pnas.1005101107. Epub 2010 Aug 9.


Identification of Eya3 and TAC1 as long-day signals in the sheep pituitary.

Dupré SM, Miedzinska K, Duval CV, Yu L, Goodman RL, Lincoln GA, Davis JR, McNeilly AS, Burt DD, Loudon AS.

Curr Biol. 2010 May 11;20(9):829-35. doi: 10.1016/j.cub.2010.02.066. Epub 2010 Apr 29.


A circadian clock is not required in an arctic mammal.

Lu W, Meng QJ, Tyler NJ, Stokkan KA, Loudon AS.

Curr Biol. 2010 Mar 23;20(6):533-7. doi: 10.1016/j.cub.2010.01.042. Epub 2010 Mar 11.


Circadian dysfunction in disease.

Bechtold DA, Gibbs JE, Loudon AS.

Trends Pharmacol Sci. 2010 May;31(5):191-8. doi: 10.1016/ Epub 2010 Feb 18. Review.


Circadian timing in the lung; a specific role for bronchiolar epithelial cells.

Gibbs JE, Beesley S, Plumb J, Singh D, Farrow S, Ray DW, Loudon AS.

Endocrinology. 2009 Jan;150(1):268-76. doi: 10.1210/en.2008-0638. Epub 2008 Sep 11.


Identification of melatonin-regulated genes in the ovine pituitary pars tuberalis, a target site for seasonal hormone control.

Dupré SM, Burt DW, Talbot R, Downing A, Mouzaki D, Waddington D, Malpaux B, Davis JR, Lincoln GA, Loudon AS.

Endocrinology. 2008 Nov;149(11):5527-39. doi: 10.1210/en.2008-0834. Epub 2008 Jul 31.


The biology of the circadian Ck1epsilon tau mutation in mice and Syrian hamsters: a tale of two species.

Loudon AS, Meng QJ, Maywood ES, Bechtold DA, Boot-Handford RP, Hastings MH.

Cold Spring Harb Symp Quant Biol. 2007;72:261-71. doi: 10.1101/sqb.2007.72.073. Review.


Real-time analysis of gene regulation by glucocorticoid hormones.

McMaster A, Chambers T, Meng QJ, Grundy S, Loudon AS, Donn R, Ray DW.

J Endocrinol. 2008 May;197(2):205-11. doi: 10.1677/JOE-07-0639.


Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.

Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NRJ, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, Boot-Handford RP, Hastings MH, Loudon ASI.

Neuron. 2008 Apr 10;58(1):78-88. doi: 10.1016/j.neuron.2008.01.019.


Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus).

Herwig A, Ivanova EA, Lydon H, Barrett P, Steinlechner S, Loudon AS.

J Neuroendocrinol. 2007 Dec;19(12):1001-7.


Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse.

Ivanova EA, Bechtold DA, Dupré SM, Brennand J, Barrett P, Luckman SM, Loudon AS.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E176-82. Epub 2007 Oct 23.


Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus).

Crawford FI, Hodgkinson CL, Ivanova E, Logunova LB, Evans GJ, Steinlechner S, Loudon AS.

Physiol Genomics. 2007 Nov 14;31(3):521-30. Epub 2007 Sep 11.


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