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Items: 25


Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism.

Bertrand C, Pradère JP, Geoffre N, Deleruyelle S, Masri B, Personnaz J, Le Gonidec S, Batut A, Louche K, Moro C, Valet P, Castan-Laurell I.

Endocrine. 2018 Apr;60(1):112-121. doi: 10.1007/s12020-018-1536-1. Epub 2018 Feb 1.


Natriuretic peptides promote glucose uptake in a cGMP-dependent manner in human adipocytes.

Coué M, Barquissau V, Morigny P, Louche K, Lefort C, Mairal A, Carpéné C, Viguerie N, Arner P, Langin D, Rydén M, Moro C.

Sci Rep. 2018 Jan 18;8(1):1097. doi: 10.1038/s41598-018-19619-0.


Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity.

Le Bacquer O, Combe K, Montaurier C, Salles J, Giraudet C, Patrac V, Domingues-Faria C, Guillet C, Louche K, Boirie Y, Sonenberg N, Moro C, Walrand S.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700128. Epub 2017 Jul 3.


Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle.

Laurens C, Bourlier V, Mairal A, Louche K, Badin PM, Mouisel E, Montagner A, Marette A, Tremblay A, Weisnagel JS, Guillou H, Langin D, Joanisse DR, Moro C.

Sci Rep. 2016 Dec 6;6:38310. doi: 10.1038/srep38310.


Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.

Chrétien C, Fenech C, Liénard F, Grall S, Chevalier C, Chaudy S, Brenachot X, Berges R, Louche K, Stark R, Nédélec E, Laderrière A, Andrews ZB, Benani A, Flockerzi V, Gascuel J, Hartmann J, Moro C, Birnbaumer L, Leloup C, Pénicaud L, Fioramonti X.

Diabetes. 2017 Feb;66(2):314-324. doi: 10.2337/db16-1114. Epub 2016 Nov 29.


Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C.

Sci Rep. 2016 Aug 23;6:31849. doi: 10.1038/srep31849.


G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle.

Laurens C, Badin PM, Louche K, Mairal A, Tavernier G, Marette A, Tremblay A, Weisnagel SJ, Joanisse DR, Langin D, Bourlier V, Moro C.

Mol Metab. 2016 Apr 22;5(7):527-537. doi: 10.1016/j.molmet.2016.04.004. eCollection 2016 Jul.


Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice.

Badin PM, Vila IK, Sopariwala DH, Yadav V, Lorca S, Louche K, Kim ER, Tong Q, Song MS, Moro C, Narkar VA.

Sci Rep. 2016 May 25;6:26442. doi: 10.1038/srep26442.


Adipogenic progenitors from obese human skeletal muscle give rise to functional white adipocytes that contribute to insulin resistance.

Laurens C, Louche K, Sengenes C, Coué M, Langin D, Moro C, Bourlier V.

Int J Obes (Lond). 2016 Mar;40(3):497-506. doi: 10.1038/ijo.2015.193. Epub 2015 Sep 23.


Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes.

Coué M, Badin PM, Vila IK, Laurens C, Louche K, Marquès MA, Bourlier V, Mouisel E, Tavernier G, Rustan AC, Galgani JE, Joanisse DR, Smith SR, Langin D, Moro C.

Diabetes. 2015 Dec;64(12):4033-45. doi: 10.2337/db15-0305. Epub 2015 Aug 7.


Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.

Vila IK, Badin PM, Marques MA, Monbrun L, Lefort C, Mir L, Louche K, Bourlier V, Roussel B, Gui P, Grober J, Štich V, Rossmeislová L, Zakaroff-Girard A, Bouloumié A, Viguerie N, Moro C, Tavernier G, Langin D.

Cell Rep. 2014 May 22;7(4):1116-29. doi: 10.1016/j.celrep.2014.03.062. Epub 2014 May 1.


Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure.

Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L.

Diabetes. 2014 Oct;63(10):3253-65. doi: 10.2337/db13-1885. Epub 2014 May 1.


Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects.

Louche K, Badin PM, Montastier E, Laurens C, Bourlier V, de Glisezinski I, Thalamas C, Viguerie N, Langin D, Moro C.

J Clin Endocrinol Metab. 2013 Dec;98(12):4863-71. doi: 10.1210/jc.2013-2058. Epub 2013 Oct 31.


Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine.

Besse-Patin A, Montastier E, Vinel C, Castan-Laurell I, Louche K, Dray C, Daviaud D, Mir L, Marques MA, Thalamas C, Valet P, Langin D, Moro C, Viguerie N.

Int J Obes (Lond). 2014 May;38(5):707-13. doi: 10.1038/ijo.2013.158. Epub 2013 Aug 27.


Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.

Bourlier V, Saint-Laurent C, Louche K, Badin PM, Thalamas C, de Glisezinski I, Langin D, Sengenes C, Moro C.

J Clin Endocrinol Metab. 2013 Sep;98(9):3739-47. doi: 10.1210/jc.2013-1727. Epub 2013 Jul 24.


High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle.

Badin PM, Vila IK, Louche K, Mairal A, Marques MA, Bourlier V, Tavernier G, Langin D, Moro C.

Endocrinology. 2013 Apr;154(4):1444-53. doi: 10.1210/en.2012-2029. Epub 2013 Mar 7.


Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.

Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel AL, Houssier M, Roussel B, Besse-Patin A, Combes M, Mir L, Monbrun L, Bézaire V, Prunet-Marcassus B, Waget A, Vila I, Caspar-Bauguil S, Louche K, Marques MA, Mairal A, Renoud ML, Galitzky J, Holm C, Mouisel E, Thalamas C, Viguerie N, Sulpice T, Burcelin R, Arner P, Langin D.

PLoS Biol. 2013;11(2):e1001485. doi: 10.1371/journal.pbio.1001485. Epub 2013 Feb 19.


Natriuretic peptides enhance the oxidative capacity of human skeletal muscle.

Engeli S, Birkenfeld AL, Badin PM, Bourlier V, Louche K, Viguerie N, Thalamas C, Montastier E, Larrouy D, Harant I, de Glisezinski I, Lieske S, Reinke J, Beckmann B, Langin D, Jordan J, Moro C.

J Clin Invest. 2012 Dec;122(12):4675-9. doi: 10.1172/JCI64526. Epub 2012 Nov 1.


Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58.

Badin PM, Loubière C, Coonen M, Louche K, Tavernier G, Bourlier V, Mairal A, Rustan AC, Smith SR, Langin D, Moro C.

J Lipid Res. 2012 May;53(5):839-48. doi: 10.1194/jlr.M019182. Epub 2012 Feb 29.


Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans.

Badin PM, Louche K, Mairal A, Liebisch G, Schmitz G, Rustan AC, Smith SR, Langin D, Moro C.

Diabetes. 2011 Jun;60(6):1734-42. doi: 10.2337/db10-1364. Epub 2011 Apr 15.


Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.

Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Benani A, Jeanson Y, Louche K, Flajollet S, Ktorza A, Dacquet C, Pénicaud L, Casteilla L; Consortium of the French Ministry of Research and Technology: 'Molecules and New Therapeutic Targets'.

Int J Obes (Lond). 2009 Feb;33(2):204-11. doi: 10.1038/ijo.2008.265. Epub 2009 Jan 6.


S 26948: a new specific peroxisome proliferator activated receptor gamma modulator with potent antidiabetes and antiatherogenic effects.

Carmona MC, Louche K, Lefebvre B, Pilon A, Hennuyer N, Audinot-Bouchez V, Fievet C, Torpier G, Formstecher P, Renard P, Lefebvre P, Dacquet C, Staels B, Casteilla L, Pénicaud L; Consortium of the French Ministry of Research and Technology.

Diabetes. 2007 Nov;56(11):2797-808. Epub 2007 Aug 17.


Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists.

Blanc-Delmas E, Lebegue N, Wallez V, Leclerc V, Yous S, Carato P, Farce A, Bennejean C, Renard P, Caignard DH, Audinot-Bouchez V, Chomarat P, Boutin J, Hennuyer N, Louche K, Carmona MC, Staels B, Pénicaud L, Casteilla L, Lonchampt M, Dacquet C, Chavatte P, Berthelot P, Lesieur D.

Bioorg Med Chem. 2006 Nov 15;14(22):7377-91. Epub 2006 Aug 2.


Fenofibrate prevents Rosiglitazone-induced body weight gain in ob/ob mice.

Carmona MC, Louche K, Nibbelink M, Prunet B, Bross A, Desbazeille M, Dacquet C, Renard P, Casteilla L, Pénicaud L.

Int J Obes (Lond). 2005 Jul;29(7):864-71.


Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity.

Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, Casteilla L, Pénicaud L.

Endocrinology. 2003 Dec;144(12):5347-52. Epub 2003 Sep 11.


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