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Items: 1 to 50 of 104

1.

Safe and Sustained Expression of Human Iduronidase After Intrathecal Administration of Adeno-Associated Virus Serotype 9 in Infant Rhesus Monkeys.

Hordeaux J, Hinderer C, Buza EL, Louboutin JP, Jahan T, Bell P, Chichester JA, Tarantal AF, Wilson JM.

Hum Gene Ther. 2019 Aug;30(8):957-966. doi: 10.1089/hum.2019.012. Epub 2019 Jun 10.

PMID:
31017018
2.

Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis.

Hinderer C, Katz N, Louboutin JP, Bell P, Tolar J, Orchard PJ, Lund TC, Nayal M, Weng L, Mesaros C, de Souza CFM, Dalla Corte A, Giugliani R, Wilson JM.

Hum Mol Genet. 2017 Oct 1;26(19):3837-3849. doi: 10.1093/hmg/ddx277.

3.

Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals.

Hinderer C, Bell P, Katz N, Vite CH, Louboutin JP, Bote E, Yu H, Zhu Y, Casal ML, Bagel J, O'Donnell P, Wang P, Haskins ME, Goode T, Wilson JM.

Hum Gene Ther. 2018 Jan;29(1):15-24. doi: 10.1089/hum.2017.026. Epub 2017 Oct 3.

4.

Neuroinflammatory targets and treatments for epilepsy validated in experimental models.

Aronica E, Bauer S, Bozzi Y, Caleo M, Dingledine R, Gorter JA, Henshall DC, Kaufer D, Koh S, Löscher W, Louboutin JP, Mishto M, Norwood BA, Palma E, Poulter MO, Terrone G, Vezzani A, Kaminski RM.

Epilepsia. 2017 Jul;58 Suppl 3:27-38. doi: 10.1111/epi.13783. Review.

5.

Delivery of an Adeno-Associated Virus Vector into Cerebrospinal Fluid Attenuates Central Nervous System Disease in Mucopolysaccharidosis Type II Mice.

Hinderer C, Katz N, Louboutin JP, Bell P, Yu H, Nayal M, Kozarsky K, O'Brien WT, Goode T, Wilson JM.

Hum Gene Ther. 2016 Nov;27(11):906-915. Epub 2016 Aug 10.

PMID:
27510804
6.

Neonatal tolerance induction enables accurate evaluation of gene therapy for MPS I in a canine model.

Hinderer C, Bell P, Louboutin JP, Katz N, Zhu Y, Lin G, Choa R, Bagel J, O'Donnell P, Fitzgerald CA, Langan T, Wang P, Casal ML, Haskins ME, Wilson JM.

Mol Genet Metab. 2016 Sep;119(1-2):124-30. doi: 10.1016/j.ymgme.2016.06.006. Epub 2016 Jun 8.

7.

Migration of bone marrow progenitor cells in the adult brain of rats and rabbits.

Dennie D, Louboutin JP, Strayer DS.

World J Stem Cells. 2016 Apr 26;8(4):136-57. doi: 10.4252/wjsc.v8.i4.136. Review.

8.

Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

Hinderer C, Bell P, Louboutin JP, Zhu Y, Yu H, Lin G, Choa R, Gurda BL, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Tarantal AF, Casal ML, Haskins ME, Wilson JM.

Mol Ther. 2015 Aug;23(8):1298-1307. doi: 10.1038/mt.2015.99. Epub 2015 May 29.

9.

Motor neuron transduction after intracisternal delivery of AAV9 in a cynomolgus macaque.

Bell P, Hinderer C, Louboutin JP, Yu H, Grant R, Bote E, Wilson JM.

Hum Gene Ther Methods. 2015 Apr;26(2):43-4. doi: 10.1089/hgtb.2015.041.

PMID:
25885277
10.

Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14894-9. doi: 10.1073/pnas.1413645111. Epub 2014 Sep 29.

11.

Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM.

Mol Ther. 2014 Dec;22(12):2018-27. doi: 10.1038/mt.2014.135. Epub 2014 Jul 16.

12.

Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant Enzymes.

Louboutin JP, Strayer D.

Antioxidants (Basel). 2014 Nov 18;3(4):770-97. doi: 10.3390/antiox3040770. Review.

13.

Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity.

Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS.

Antioxidants (Basel). 2014 May 16;3(2):414-38. doi: 10.3390/antiox3020414.

14.

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna.

Hinderer C, Bell P, Vite CH, Louboutin JP, Grant R, Bote E, Yu H, Pukenas B, Hurst R, Wilson JM.

Mol Ther Methods Clin Dev. 2014 Dec 10;1:14051. doi: 10.1038/mtm.2014.51. eCollection 2014.

16.

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.

Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES.

Cell Death Differ. 2013 Feb;20(2):259-69. doi: 10.1038/cdd.2012.117. Epub 2012 Sep 14.

17.

Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor.

Louboutin JP, Marusich E, Gao E, Agrawal L, Koch WJ, Strayer DS.

Alcohol. 2012 Aug;46(5):441-54. doi: 10.1016/j.alcohol.2012.02.001. Epub 2012 May 2.

PMID:
22560293
18.

Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases.

Louboutin JP, Agrawal L, Reyes BA, van Bockstaele EJ, Strayer DS.

Neuroscience. 2012 Jul 12;214:68-77. doi: 10.1016/j.neuroscience.2012.03.061. Epub 2012 Apr 21.

19.

Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications.

Louboutin JP, Strayer DS.

ScientificWorldJournal. 2012;2012:482575. doi: 10.1100/2012/482575. Epub 2012 Feb 1. Review.

20.

HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy.

Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS.

Eur J Neurosci. 2011 Dec;34(12):2015-23. doi: 10.1111/j.1460-9568.2011.07908.x. Epub 2011 Nov 17.

PMID:
22092673
21.

HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes.

Agrawal L, Louboutin JP, Reyes BA, Van Bockstaele EJ, Strayer DS.

Neurobiol Dis. 2012 Feb;45(2):657-70. doi: 10.1016/j.nbd.2011.10.005. Epub 2011 Oct 17.

PMID:
22036626
22.

Bone marrow-derived cells migrate to line the vessels of the CNS: opportunities for gene delivery to CNS vasculature.

Louboutin JP, Chekmasova AA, Reyes BA, Van Bockstaele EJ, Strayer DS.

Neuroscience. 2011 Nov 10;195:215-23. doi: 10.1016/j.neuroscience.2011.08.062. Epub 2011 Aug 31.

PMID:
21906658
23.

Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.

Wang L, Louboutin JP, Bell P, Greig JA, Li Y, Wu D, Wilson JM.

J Thromb Haemost. 2011 Oct;9(10):2009-19. doi: 10.1111/j.1538-7836.2011.04491.x.

24.

Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery.

Marusich E, Louboutin JP, Chekmasova AA, Strayer DS.

J Neurol Sci. 2011 Sep 15;308(1-2):25-7. doi: 10.1016/j.jns.2011.06.039. Epub 2011 Jul 13.

PMID:
21741662
25.

Intracisternal rSV40 administration provides effective pan-CNS transgene expression.

Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS.

Gene Ther. 2012 Jan;19(1):114-8. doi: 10.1038/gt.2011.75. Epub 2011 May 26.

PMID:
21614027
26.

Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe.

Louboutin JP, Marusich E, Fisher-Perkins J, Dufour JP, Bunnell BA, Strayer DS.

Gene Ther. 2011 Jul;18(7):682-91. doi: 10.1038/gt.2011.13. Epub 2011 Mar 3.

PMID:
21368898
27.

Efficient CNS gene delivery by intravenous injection.

Louboutin JP, Chekmasova AA, Marusich E, Chowdhury JR, Strayer DS.

Nat Methods. 2010 Nov;7(11):905-7. doi: 10.1038/nmeth.1518. Epub 2010 Oct 17.

PMID:
20953176
28.

Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.

Louboutin JP, Chekmasova A, Marusich E, Agrawal L, Strayer DS.

FASEB J. 2011 Feb;25(2):737-53. doi: 10.1096/fj.10-161851. Epub 2010 Oct 12.

29.

Gene transfer to the cerebellum.

Louboutin JP, Reyes BA, Van Bockstaele EJ, Strayer DS.

Cerebellum. 2010 Dec;9(4):587-97. doi: 10.1007/s12311-010-0202-9.

PMID:
20700772
30.

HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress.

Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS.

J Neuropathol Exp Neurol. 2010 Aug;69(8):801-16. doi: 10.1097/NEN.0b013e3181e8c96f.

31.

Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes.

Louboutin JP, Reyes BA, Agrawal L, Maxwell CR, Van Bockstaele EJ, Strayer DS.

Neurobiol Dis. 2010 May;38(2):313-25. doi: 10.1016/j.nbd.2010.02.007. Epub 2010 Feb 26.

PMID:
20219678
32.

HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes.

Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele EJ, Strayer DS.

Exp Neurol. 2010 Jan;221(1):231-45. doi: 10.1016/j.expneurol.2009.11.004. Epub 2009 Nov 11.

PMID:
19913017
33.

In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors.

Mueller C, Strayer MS, Sirninger J, Braag S, Branco F, Louboutin JP, Flotte TR, Strayer DS.

Gene Ther. 2010 Feb;17(2):227-37. doi: 10.1038/gt.2009.137. Epub 2009 Nov 5.

34.

Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates.

Agrawal L, Louboutin JP, Marusich E, Reyes BA, Van Bockstaele EJ, Strayer DS.

Brain Res. 2010 Jan 8;1306:116-30. doi: 10.1016/j.brainres.2009.09.113. Epub 2009 Oct 6.

PMID:
19815008
35.

A rat model of human immunodeficiency virus 1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors.

Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS.

J Neuropathol Exp Neurol. 2009 May;68(5):456-73. doi: 10.1097/NEN.0b013e3181a10f83.

36.

HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes.

Louboutin JP, Agrawal L, Reyes BA, Van Bockstaele EJ, Strayer DS.

Neurobiol Dis. 2009 Jun;34(3):462-76. doi: 10.1016/j.nbd.2009.03.003. Epub 2009 Mar 25.

PMID:
19327399
37.

In vivo gene transfer to the CNS using recombinant SV40-derived vectors.

Louboutin JP, Agrawal L, Liu B, Strayer DS.

Expert Opin Biol Ther. 2008 Sep;8(9):1319-35. doi: 10.1517/14712598.8.9.1319 . Review.

PMID:
18694352
38.
40.

Delivering genes to the organ-localized immune system: long-term results of direct intramarrow transduction.

Louboutin JP, Liu B, Chekmasova AA, Reyes BA, van Bockstaele EJ, Strayer DS.

J Gene Med. 2007 Oct;9(10):843-51.

PMID:
17694566
41.

Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors.

Louboutin JP, Reyes BA, Agrawal L, Van Bockstaele E, Strayer DS.

Gene Ther. 2007 Jun;14(12):939-49. Epub 2007 Apr 19.

PMID:
17443215
42.

Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications.

Agrawal L, Louboutin JP, Strayer DS.

Virology. 2007 Jul 5;363(2):462-72. Epub 2007 Mar 1.

43.

Long-term gene expression in dividing and nondividing cells using SV40-derived vectors.

Strayer DS, Agrawal L, Cordelier P, Liu B, Louboutin JP, Marusich E, McKee HJ, Ren CN, Strayer MS.

Mol Biotechnol. 2006 Oct;34(2):257-70. Review.

PMID:
17172671
44.

Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineages.

Louboutin JP, Liu B, Reyes BA, Van Bockstaele EJ, Strayer DS.

Stem Cells. 2006 Dec;24(12):2801-9. Epub 2006 Sep 7.

45.

Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis.

Agrawal L, Louboutin JP, Reyes BA, Van Bockstaele EJ, Strayer DS.

Gene Ther. 2006 Dec;13(23):1645-56. Epub 2006 Jul 27.

PMID:
16871233
46.

Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5.

Zhang Z, Louboutin JP, Weiner DJ, Goldberg JB, Wilson JM.

Infect Immun. 2005 Nov;73(11):7151-60.

47.

Pharmacologically regulated regeneration of functional human pancreatic islets.

Kobinger GP, Deng S, Louboutin JP, Vatamaniuk M, Rivera VM, Lian MM, Markmann JF, Clackson T, Raper SE, Matschinsky F, Wilson JM.

Mol Ther. 2005 Jan;11(1):105-11.

48.

Gene transfer into skeletal muscle using novel AAV serotypes.

Louboutin JP, Wang L, Wilson JM.

J Gene Med. 2005 Apr;7(4):442-51.

PMID:
15517544
49.

Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors.

MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW.

J Gene Med. 2005 Jan;7(1):50-8.

PMID:
15515139
50.

Novel adenoviral vectors coding for GFP-tagged wtCFTR and deltaF508-CFTR: characterization of expression and electrophysiological properties in A549 cells.

Vais H, Gao GP, Yang M, Tran P, Louboutin JP, Somanathan S, Wilson JM, Reenstra WW.

Pflugers Arch. 2004 Dec;449(3):278-87.

PMID:
15452712

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