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A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals.

Smutný T, Harjumäki R, Kanninen L, Yliperttula M, Pávek P, Lou YR.

Toxicol In Vitro. 2018 Jun 11;52:94-105. doi: 10.1016/j.tiv.2018.06.012. [Epub ahead of print]


Next generation organoids for biomedical research and applications.

Lou YR, Leung AW.

Biotechnol Adv. 2018 Jan - Feb;36(1):132-149. doi: 10.1016/j.biotechadv.2017.10.005. Epub 2017 Oct 19. Review.


Differences in definitive endoderm induction approaches using growth factors and small molecules.

Bogacheva MS, Khan S, Kanninen LK, Yliperttula M, Leung AW, Lou YR.

J Cell Physiol. 2018 Apr;233(4):3578-3589. doi: 10.1002/jcp.26214. Epub 2017 Nov 23.


Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems.

Laurén P, Somersalo P, Pitkänen I, Lou YR, Urtti A, Partanen J, Seppälä J, Madetoja M, Laaksonen T, Mäkitie A, Yliperttula M.

PLoS One. 2017 Aug 22;12(8):e0183487. doi: 10.1371/journal.pone.0183487. eCollection 2017.


Multicellular dosimetric chain for molecular radiotherapy exemplified with dose simulations on 3D cell spheroids.

Reijonen V, Kanninen LK, Hippeläinen E, Lou YR, Salli E, Sofiev A, Malinen M, Paasonen T, Yliperttula M, Kuronen A, Savolainen S.

Phys Med. 2017 Aug;40:72-78. doi: 10.1016/j.ejmp.2017.07.012. Epub 2017 Jul 20.


25-Hydroxyvitamin D3 induces osteogenic differentiation of human mesenchymal stem cells.

Lou YR, Toh TC, Tee YH, Yu H.

Sci Rep. 2017 Feb 17;7:42816. doi: 10.1038/srep42816.


Effect of glucocorticoid on cytokines TLR9 and TLR7 in peripheral blood for patients with uveitis.

Cui HP, Pei YX, Li GF, Lou YR.

Exp Ther Med. 2016 Dec;12(6):3893-3896. doi: 10.3892/etm.2016.3906. Epub 2016 Nov 15.


Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.

Liu Z, Kundu-Roy T, Matsuura I, Wang G, Lin Y, Lou YR, Barnard NJ, Wang XF, Huang MT, Suh N, Liu F.

Oncotarget. 2016 Oct 4;7(40):64878-64885. doi: 10.18632/oncotarget.11713.


Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

Baghirov H, Karaman D, Viitala T, Duchanoy A, Lou YR, Mamaeva V, Pryazhnikov E, Khiroug L, de Lange Davies C, Sahlgren C, Rosenholm JM.

PLoS One. 2016 Aug 22;11(8):e0160705. doi: 10.1371/journal.pone.0160705. eCollection 2016.


Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells.

Kanninen LK, Harjumäki R, Peltoniemi P, Bogacheva MS, Salmi T, Porola P, Niklander J, Smutný T, Urtti A, Yliperttula ML, Lou YR.

Biomaterials. 2016 Oct;103:86-100. doi: 10.1016/j.biomaterials.2016.06.054. Epub 2016 Jun 23.


Arabidopsis NATA1 Acetylates Putrescine and Decreases Defense-Related Hydrogen Peroxide Accumulation.

Lou YR, Bor M, Yan J, Preuss AS, Jander G.

Plant Physiol. 2016 Jun;171(2):1443-55. doi: 10.1104/pp.16.00446. Epub 2016 Apr 25.


Hepatic differentiation of human pluripotent stem cells on human liver progenitor HepaRG-derived acellular matrix.

Kanninen LK, Porola P, Niklander J, Malinen MM, Corlu A, Guguen-Guillouzo C, Urtti A, Yliperttula ML, Lou YR.

Exp Cell Res. 2016 Feb 15;341(2):207-17. doi: 10.1016/j.yexcr.2016.02.006. Epub 2016 Feb 8.


Alteration of Plant Primary Metabolism in Response to Insect Herbivory.

Zhou S, Lou YR, Tzin V, Jander G.

Plant Physiol. 2015 Nov;169(3):1488-98. doi: 10.1104/pp.15.01405. Epub 2015 Sep 16.


Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells.

Lou YR, Kanninen L, Kaehr B, Townson JL, Niklander J, Harjumäki R, Jeffrey Brinker C, Yliperttula M.

Sci Rep. 2015 Sep 1;5:13635. doi: 10.1038/srep13635.


Supporting Effect of Umbilical Cord Blood-Derived Mesenchymal Stem Cells on CD34+ Cell Proliferation and Its Mechanism.

Xu ZJ, Sheng LX, Lou YR, Mu QT, Zhang Y, Zhang YS, Ouyang GF.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Jun;23(3):802-8. doi: 10.7534/j.issn.1009-2137.2015.03.039.


Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells.

Bernard JJ, Lou YR, Peng QY, Li T, Vakil PR, Ding N, Laskin JD, Dong Z, Conney AH, Lu YP.

J Carcinog Mutagen. 2014 Jul 31;5(183):2157-2518.


Effect of differentiation on endocytic profiles of endothelial and epithelial cell culture models.

Ilina P, Partti S, Niklander J, Ruponen M, Lou YR, Yliperttula M.

Exp Cell Res. 2015 Mar 1;332(1):89-101. doi: 10.1016/j.yexcr.2015.01.002. Epub 2015 Jan 15.


PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis.

Bernard JJ, Lou YR, Peng QY, Li T, Lu YP.

PLoS One. 2014 Oct 16;9(10):e109862. doi: 10.1371/journal.pone.0109862. eCollection 2014.


Technetium-99m-labeled nanofibrillar cellulose hydrogel for in vivo drug release.

Laurén P, Lou YR, Raki M, Urtti A, Bergström K, Yliperttula M.

Eur J Pharm Sci. 2014 Dec 18;65:79-88. doi: 10.1016/j.ejps.2014.09.013. Epub 2014 Sep 20. Review.


A critical assessment of in vitro tissue models for ADME and drug delivery.

Vellonen KS, Malinen M, Mannermaa E, Subrizi A, Toropainen E, Lou YR, Kidron H, Yliperttula M, Urtti A.

J Control Release. 2014 Sep 28;190:94-114. doi: 10.1016/j.jconrel.2014.06.044. Epub 2014 Jun 30. Review.


Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels.

Malinen MM, Kanninen LK, Corlu A, Isoniemi HM, Lou YR, Yliperttula ML, Urtti AO.

Biomaterials. 2014 Jun;35(19):5110-21. doi: 10.1016/j.biomaterials.2014.03.020. Epub 2014 Apr 1.


The use of nanofibrillar cellulose hydrogel as a flexible three-dimensional model to culture human pluripotent stem cells.

Lou YR, Kanninen L, Kuisma T, Niklander J, Noon LA, Burks D, Urtti A, Yliperttula M.

Stem Cells Dev. 2014 Feb 15;23(4):380-92. doi: 10.1089/scd.2013.0314. Epub 2013 Dec 9.


Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice.

Bernard JJ, Lou YR, Peng QY, Li T, Conney AH, Lu YP.

Exp Mol Pathol. 2014 Feb;96(1):126-31. doi: 10.1016/j.yexmp.2013.10.011. Epub 2013 Oct 30.


Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites.

Tuohimaa P, Wang JH, Khan S, Kuuslahti M, Qian K, Manninen T, Auvinen P, Vihinen M, Lou YR.

PLoS One. 2013 Oct 8;8(10):e75338. doi: 10.1371/journal.pone.0075338. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/9cb2000b-a962-453c-ad8b-088f91095f6d.


Can yeast (S. cerevisiae) metabolic volatiles provide polymorphic signaling?

Arguello JR, Sellanes C, Lou YR, Raguso RA.

PLoS One. 2013 Aug 19;8(8):e70219. doi: 10.1371/journal.pone.0070219. eCollection 2013.


Mechanisms of Caffeine-Induced Inhibition of UVB Carcinogenesis.

Conney AH, Lu YP, Lou YR, Kawasumi M, Nghiem P.

Front Oncol. 2013 Jun 17;3:144. doi: 10.3389/fonc.2013.00144. eCollection 2013.


Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture.

Bhattacharya M, Malinen MM, Lauren P, Lou YR, Kuisma SW, Kanninen L, Lille M, Corlu A, GuGuen-Guillouzo C, Ikkala O, Laukkanen A, Urtti A, Yliperttula M.

J Control Release. 2012 Dec 28;164(3):291-8. doi: 10.1016/j.jconrel.2012.06.039. Epub 2012 Jul 7.


Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Conney AH, Lou YR, Nghiem P, Bernard JJ, Wagner GC, Lu YP.

Top Curr Chem. 2013;329:61-72. doi: 10.1007/128_2012_336.


Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Lu YP, Lou YR, Bernard JJ, Peng QY, Li T, Lin Y, Shih WJ, Nghiem P, Shapses S, Wagner GC, Conney AH.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9065-70. doi: 10.1073/pnas.1205810109. Epub 2012 May 21.


Optimal serum calcidiol concentration for cancer prevention.

Tuohimaa P, Lou YR.

Anticancer Res. 2012 Jan;32(1):373-81. Review.


Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers.

Yang L, Ruan LM, Ye HH, Cui HB, Mu QT, Lou YR, Ji YX, Li WZ, Sun DH, Chen XB.

Acta Neuropsychiatr. 2011 Oct;23(5):235-40. doi: 10.1111/j.1601-5215.2011.00577.x. No abstract available.


Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice.

Lou YR, Peng QY, Li T, Medvecky CM, Lin Y, Shih WJ, Conney AH, Shapses S, Wagner GC, Lu YP.

Carcinogenesis. 2011 Jul;32(7):1078-84. doi: 10.1093/carcin/bgr074. Epub 2011 Apr 27.


Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.

Lu YP, Lou YR, Peng QY, Nghiem P, Conney AH.

Cancer Prev Res (Phila). 2011 Jul;4(7):1118-25. doi: 10.1158/1940-6207.CAPR-11-0116. Epub 2011 Apr 19.


Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using microRNA as a marker.

Zhou H, Guo JM, Lou YR, Zhang XJ, Zhong FD, Jiang Z, Cheng J, Xiao BX.

J Mol Med (Berl). 2010 Jul;88(7):709-17. doi: 10.1007/s00109-010-0617-2. Epub 2010 Mar 28.


25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand.

Lou YR, Molnár F, Peräkylä M, Qiao S, Kalueff AV, St-Arnaud R, Carlberg C, Tuohimaa P.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):162-70. doi: 10.1016/j.jsbmb.2009.11.011. Epub 2009 Nov 26.


Premature aging in vitamin D receptor mutant mice.

Keisala T, Minasyan A, Lou YR, Zou J, Kalueff AV, Pyykkö I, Tuohimaa P.

J Steroid Biochem Mol Biol. 2009 Jul;115(3-5):91-7. doi: 10.1016/j.jsbmb.2009.03.007. Epub 2009 Mar 31.


Vestibular dysfunction in vitamin D receptor mutant mice.

Minasyan A, Keisala T, Zou J, Zhang Y, Toppila E, Syvälä H, Lou YR, Kalueff AV, Pyykkö I, Tuohimaa P.

J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):161-6. doi: 10.1016/j.jsbmb.2009.01.020. Epub 2009 Feb 6.


Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.

Lee HJ, Paul S, Atalla N, Thomas PE, Lin X, Yang I, Buckley B, Lu G, Zheng X, Lou YR, Conney AH, Maehr H, Adorini L, Uskokovic M, Suh N.

Cancer Prev Res (Phila). 2008 Nov;1(6):476-84. doi: 10.1158/1940-6207.CAPR-08-0084.


[Inducing-apoptosis effect of bortezomib on acute monocytic leukemia cell SHI-1 and its influence on expressions of Bcl2l12, Bcl-2 and Bax genes].

Mu QT, Ouyang GF, Lou YR, Chen XP, Lu Y, Liang W, Zhang Y, Xu W.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1016-20. Chinese.


Tumorigenic effect of some commonly used moisturizing creams when applied topically to UVB-pretreated high-risk mice.

Lu YP, Lou YR, Xie JG, Peng Q, Shih WJ, Lin Y, Conney AH.

J Invest Dermatol. 2009 Feb;129(2):468-75. doi: 10.1038/jid.2008.241. Epub 2008 Aug 14.


Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.

Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH.

Cancer Res. 2008 Apr 1;68(7):2523-9. doi: 10.1158/0008-5472.CAN-07-5955.


Progressive hearing loss in mice with a mutated vitamin D receptor gene.

Zou J, Minasyan A, Keisala T, Zhang Y, Wang JH, Lou YR, Kalueff A, Pyykkö I, Tuohimaa P.

Audiol Neurootol. 2008;13(4):219-30. doi: 10.1159/000115431. Epub 2008 Feb 7.


Effect of caffeine on UVB-induced carcinogenesis, apoptosis, and the elimination of UVB-induced patches of p53 mutant epidermal cells in SKH-1 mice.

Conney AH, Kramata P, Lou YR, Lu YP.

Photochem Photobiol. 2008 Mar-Apr;84(2):330-8. doi: 10.1111/j.1751-1097.2007.00263.x. Epub 2008 Jan 7. Review.


Voluntary exercise together with oral caffeine markedly stimulates UVB light-induced apoptosis and decreases tissue fat in SKH-1 mice.

Lu YP, Nolan B, Lou YR, Peng QY, Wagner GC, Conney AH.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12936-41. Epub 2007 Jul 30.


Neophobia, sensory and cognitive functions, and hedonic responses in vitamin D receptor mutant mice.

Minasyan A, Keisala T, Lou YR, Kalueff AV, Tuohimaa P.

J Steroid Biochem Mol Biol. 2007 May;104(3-5):274-80. Epub 2007 Mar 24.


Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice.

Conney AH, Zhou S, Lee MJ, Xie JG, Yang CS, Lou YR, Lu Y.

Toxicol Appl Pharmacol. 2007 Nov 1;224(3):209-13. Epub 2006 Nov 7. Review.


Stimulatory effect of voluntary exercise or fat removal (partial lipectomy) on apoptosis in the skin of UVB light-irradiated mice.

Lu YP, Lou YR, Nolan B, Peng QY, Xie JG, Wagner GC, Conney AH.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16301-6. Epub 2006 Oct 23.


The effects of all-trans-retinoic acid on cell cycle and alkaline phosphatase activity in pancreatic cancer cells.

Guo JM, Xiao BX, Lou YR, Wang DH, Yan CH, Zhan L, Zhao WH.

Med Chem. 2006 Sep;2(5):457-61.


Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice.

Lu YP, Lou YR, Xie JG, Peng QY, Zhou S, Lin Y, Shih WJ, Conney AH.

Carcinogenesis. 2007 Jan;28(1):199-206. Epub 2006 Jul 24.


Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice.

Michna L, Wagner GC, Lou YR, Xie JG, Peng QY, Lin Y, Carlson K, Shih WJ, Conney AH, Lu YP.

Carcinogenesis. 2006 Oct;27(10):2108-15. Epub 2006 May 13.


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