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An ocular glymphatic clearance system removes β-amyloid from the rodent eye.

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaaw3210. doi: 10.1126/scitranslmed.aaw3210.


Interferon gamma inhibits CXCL8-CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer.

Zhang M, Huang L, Ding G, Huang H, Cao G, Sun X, Lou N, Wei Q, Shen T, Xu X, Cao L, Yan Q.

J Immunother Cancer. 2020 Feb;8(1). pii: e000308. doi: 10.1136/jitc-2019-000308.


Hydrogen sulfide protects against high glucose‑induced lipid metabolic disturbances in 3T3‑L1 adipocytes via the AMPK signaling pathway.

Pan Z, Wang J, Xu M, Chen S, Li X, Sun A, Lou N, Ni Y.

Mol Med Rep. 2019 Nov;20(5):4119-4124. doi: 10.3892/mmr.2019.10685. Epub 2019 Sep 16.


Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro.

Zhao CC, Jiang MY, Zhang LY, Hu YY, Hu ZJ, Zhang MY, Qi J, Su AC, Lou N, Xian XH, Zhang JG, Li WB, Zhang M.

J Neurochem. 2019 Dec;151(5):608-625. doi: 10.1111/jnc.14824. Epub 2019 Aug 27.


When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow.

Plog BA, Lou N, Pierre CA, Cove A, Kenney HM, Hitomi E, Kang H, Iliff JJ, Zeppenfeld DM, Nedergaard M, Vates GE.

J Neurosurg. 2019 May 17:1-14. doi: 10.3171/2019.2.JNS182675. [Epub ahead of print]


Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.

Monai H, Wang X, Yahagi K, Lou N, Mestre H, Xu Q, Abe Y, Yasui M, Iwai Y, Nedergaard M, Hirase H.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019. doi: 10.1073/pnas.1817347116. Epub 2019 May 16.


Functional definition of NrtR, a remnant regulator of NAD+ homeostasis in the zoonotic pathogen Streptococcus suis.

Wang Q, Hassan BH, Lou N, Merritt J, Feng Y.

FASEB J. 2019 May;33(5):6055-6068. doi: 10.1096/fj.201802179RR. Epub 2019 Feb 13.


The mechanism of GLT-1 mediating cerebral ischemic injury depends on the activation of p38 MAPK.

Zhang LY, Hu YY, Zhao CC, Qi J, Su AC, Lou N, Zhang MY, Li L, Xian XH, Gong JX, Zhao H, Zhang JG, Li WB, Zhang M.

Brain Res Bull. 2019 Apr;147:1-13. doi: 10.1016/j.brainresbull.2019.01.028. Epub 2019 Feb 4.


Molecular characteristics and virulence gene profiles of Staphylococcus aureus causing bloodstream infection.

Li X, Fang F, Zhao J, Lou N, Li C, Huang T, Li Y.

Braz J Infect Dis. 2018 Nov - Dec;22(6):487-494. doi: 10.1016/j.bjid.2018.12.001. Epub 2018 Dec 27.


Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes.

Wang Y, Sun HJ, Li RG, Wang XM, Cheng ZQ, Lou N.

Mol Med Rep. 2019 Feb;19(2):967-973. doi: 10.3892/mmr.2018.9753. Epub 2018 Dec 12.


Crizotinib in advanced non-small-cell lung cancer with concomitant ALK rearrangement and c-Met overexpression.

Chen RL, Zhao J, Zhang XC, Lou NN, Chen HJ, Yang X, Su J, Xie Z, Zhou Q, Tu HY, Zhong WZ, Yan HH, Guo WB, Wu YL, Yang JJ.

BMC Cancer. 2018 Nov 26;18(1):1171. doi: 10.1186/s12885-018-5078-y.


Sarcopenia is associated with the neutrophil/lymphocyte and platelet/lymphocyte ratios in operable gastric cancer patients: a prospective study.

Lin J, Zhang W, Huang Y, Chen W, Wu R, Chen X, Lou N, Wang P.

Cancer Manag Res. 2018 Oct 25;10:4935-4944. doi: 10.2147/CMAR.S175421. eCollection 2018.


Oxygen-Delivery Materials: Synthesis of an Open-Cage Fullerene Derivative Suitable for Encapsulation of H2 O2 and O2.

Li Y, Lou N, Xu D, Pan C, Lu X, Gan L.

Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14144-14148. doi: 10.1002/anie.201808926. Epub 2018 Oct 4.


miR-224/miR-141 ratio as a novel diagnostic biomarker in renal cell carcinoma.

Chen X, Lou N, Ruan A, Qiu B, Yan Y, Wang X, Du Q, Ruan H, Han W, Wei H, Yang H, Zhang X.

Oncol Lett. 2018 Aug;16(2):1666-1674. doi: 10.3892/ol.2018.8874. Epub 2018 Jun 1.


Sarcopenic Obesity Is Associated with Severe Postoperative Complications in Gastric Cancer Patients Undergoing Gastrectomy: a Prospective Study.

Zhang WT, Lin J, Chen WS, Huang YS, Wu RS, Chen XD, Lou N, Chi CH, Hu CY, Shen X.

J Gastrointest Surg. 2018 Nov;22(11):1861-1869. doi: 10.1007/s11605-018-3835-5. Epub 2018 Jun 25.


Cannula Implantation into the Cisterna Magna of Rodents.

Xavier ALR, Hauglund NL, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M.

J Vis Exp. 2018 May 23;(135). doi: 10.3791/57378.


[Spatial-temporal dynamics of rainstorm in East China based on spatial-temporal data mining technology].

Lou N.

Ying Yong Sheng Tai Xue Bao. 2017 Dec;28(12):4043-4050. doi: 10.13287/j.1001-9332.201712.012. Chinese.


Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M.

Sci Rep. 2018 Feb 2;8(1):2246. doi: 10.1038/s41598-018-20424-y.


Up-regulation of SR-BI promotes progression and serves as a prognostic biomarker in clear cell renal cell carcinoma.

Xu GH, Lou N, Shi HC, Xu YC, Ruan HL, Xiao W, Liu L, Li X, Xiao HB, Qiu B, Bao L, Yuan CF, Zhou YL, Hu WJ, Chen K, Yang HM, Zhang XP.

BMC Cancer. 2018 Jan 22;18(1):88. doi: 10.1186/s12885-017-3761-z.


A Novel Nomogram for Predicting Postsurgical Intra-abdominal Infection in Gastric Cancer Patients: a Prospective Study.

Mao CC, Chen XD, Lin J, Zhu-Ge WS, Xie ZD, Chen XY, Zhang FM, Wu RS, Zhang WT, Lou N, Shi L, Zhu GB, Shen X.

J Gastrointest Surg. 2018 Mar;22(3):421-429. doi: 10.1007/s11605-017-3580-1. Epub 2018 Jan 12.


Mir-144-3p Promotes Cell Proliferation, Metastasis, Sunitinib Resistance in Clear Cell Renal Cell Carcinoma by Downregulating ARID1A.

Xiao W, Lou N, Ruan H, Bao L, Xiong Z, Yuan C, Tong J, Xu G, Zhou Y, Qu Y, Hu W, Gao Y, Ru Z, Liu L, Xiao H, Chen K, Yang H, Zhang X.

Cell Physiol Biochem. 2017;43(6):2420-2433. doi: 10.1159/000484395. Epub 2017 Oct 27.


Arthroscopic Removal of Suprapatellar Fibroma of Tendon Sheath.

Lou N, Fang C, Leung F, Cheung F, Wong TM.

Surg J (N Y). 2017 Mar 30;3(2):e58-e61. doi: 10.1055/s-0037-1601368. eCollection 2017 Apr.


Overexpression of SOX4 promotes cell migration and invasion of renal cell carcinoma by inducing epithelial-mesenchymal transition.

Ruan H, Yang H, Wei H, Xiao W, Lou N, Qiu B, Xu G, Song Z, Xiao H, Liu L, Zhou Y, Hu W, Chen K, Chen X, Zhang X.

Int J Oncol. 2017 Jul;51(1):336-346. doi: 10.3892/ijo.2017.4010. Epub 2017 May 17.


Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells.

Liu L, Lou N, Li X, Xu G, Ruan H, Xiao W, Qiu B, Bao L, Yuan C, Huang X, Wang K, Cao Q, Chen K, Yang H, Zhang X.

Oncol Rep. 2017 Jun;37(6):3651-3659. doi: 10.3892/or.2017.5623. Epub 2017 May 4.


The Predictive Value of Coefficient of PCT × BG for Anastomotic Leak in Esophageal Carcinoma Patients With ARDS After Esophagectomy.

Li H, Wang D, Wei W, Ouyang L, Lou N.

J Intensive Care Med. 2019 Jul;34(7):572-577. doi: 10.1177/0885066617705108. Epub 2017 May 10.


Diagnostic and prognostic value of scavenger receptor class B type 1 in clear cell renal cell carcinoma.

Xu G, Lou N, Xu Y, Shi H, Ruan H, Xiao W, Liu L, Xiao H, Qiu B, Bao L, Yuan C, Chen K, Yang H, Zhang X.

Tumour Biol. 2017 May;39(5):1010428317699110. doi: 10.1177/1010428317699110.


Use of the combination of the preoperative platelet-to-lymphocyte ratio and tumor characteristics to predict peritoneal metastasis in patients with gastric cancer.

Chen XD, Mao CC, Wu RS, Zhang WT, Lin J, Sun XW, Chi CH, Lou N, Wang PF, Shen X, Zhu GB, Shen SR.

PLoS One. 2017 Apr 6;12(4):e0175074. doi: 10.1371/journal.pone.0175074. eCollection 2017.


SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Aalling N, Wang S, Benraiss A, Lou N, Goldman SA, Nedergaard M.

J Neurosci. 2017 Apr 26;37(17):4493-4507. doi: 10.1523/JNEUROSCI.3199-16.2017. Epub 2017 Mar 23.


Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation.

Zhou Y, Zhao Y, Gao Y, Hu W, Qu Y, Lou N, Zhu Y, Zhang X, Yang H.

J Exp Clin Cancer Res. 2017 Mar 10;36(1):42. doi: 10.1186/s13046-017-0510-8.


Urinary Microvesicle-Bound Uromodulin: A Potential Molecular Biomarker in Diabetic Kidney Disease.

Lou NJ, Ni YH, Jia HY, Deng JT, Jiang L, Zheng FJ, Sun AL.

J Diabetes Res. 2017;2017:3918681. doi: 10.1155/2017/3918681. Epub 2017 Jan 15.


Synthesis of C70 -Based Fluorophores through Sequential Functionalization to Form Isomerically Pure Multiadducts.

Lou N, Li Y, Gan L.

Angew Chem Int Ed Engl. 2017 Feb 20;56(9):2403-2407. doi: 10.1002/anie.201612054. Epub 2017 Jan 27.


Management of acute postoperative hypertension for reducing cardiovascular complications in cancer patients: when and how aggressively?

Lou N, Wang D, Wang Z, Ye W, Liu X.

Turk J Med Sci. 2016 Dec 20;46(6):1634-1640. doi: 10.3906/sag-1412-33.


A novel scoring system associating with preoperative platelet/lymphocyte and clinicopathologic features to predict lymph node metastasis in early gastric cancer.

Lou N, Zhang L, Chen XD, Pang WY, Arvine C, Huang YP, Zhuang CL, Shen X.

J Surg Res. 2017 Mar;209:153-161. doi: 10.1016/j.jss.2016.10.011. Epub 2016 Oct 15.


Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke.

Cotrina ML, Lou N, Tome-Garcia J, Goldman J, Nedergaard M.

Neuroscience. 2017 Feb 20;343:483-494. doi: 10.1016/j.neuroscience.2016.12.012. Epub 2016 Dec 18.


The Fli-1 transcription factor is a critical regulator for controlling the expression of chemokine C-X-C motif ligand 2 (CXCL2).

Lou N, Lennard Richard ML, Yu J, Kindy M, Zhang XK.

Mol Immunol. 2017 Jan;81:59-66. doi: 10.1016/j.molimm.2016.11.007. Epub 2016 Nov 24.


Comparative molecular analysis of early and late cancer cachexia-induced muscle wasting in mouse models.

Sun R, Zhang S, Lu X, Hu W, Lou N, Zhao Y, Zhou J, Zhang X, Yang H.

Oncol Rep. 2016 Dec;36(6):3291-3302. doi: 10.3892/or.2016.5165. Epub 2016 Oct 12.


Impact of different sarcopenia stages on the postoperative outcomes after radical gastrectomy for gastric cancer.

Huang DD, Zhou CJ, Wang SL, Mao ST, Zhou XY, Lou N, Zhang Z, Yu Z, Shen X, Zhuang CL.

Surgery. 2017 Mar;161(3):680-693. doi: 10.1016/j.surg.2016.08.030. Epub 2016 Oct 4.


Sarcopenia in overweight and obese patients is a predictive factor for postoperative complication in gastric cancer: A prospective study.

Lou N, Chi CH, Chen XD, Zhou CJ, Wang SL, Zhuang CL, Shen X.

Eur J Surg Oncol. 2017 Jan;43(1):188-195. doi: 10.1016/j.ejso.2016.09.006. Epub 2016 Sep 17.


miR-144-3p as a novel plasma diagnostic biomarker for clear cell renal cell carcinoma.

Lou N, Ruan AM, Qiu B, Bao L, Xu YC, Zhao Y, Sun RL, Zhang ST, Xu GH, Ruan HL, Yuan CF, Han WW, Shi HC, Yang HM, Zhang XP.

Urol Oncol. 2017 Jan;35(1):36.e7-36.e14. doi: 10.1016/j.urolonc.2016.07.012. Epub 2016 Sep 12.


Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.

Li JW, Xiao YL, Lai CF, Lou N, Ma HL, Zhu BY, Zhong WB, Yan DG.

Oncotarget. 2016 Oct 4;7(40):65849-65861. doi: 10.18632/oncotarget.11671.


Fullerene-Based Macro-Heterocycle Prepared through Selective Incorporation of Three N and Two O Atoms into C60.

Li Y, Zhang G, Wang D, Xu B, Xu D, Lou N, Gan L.

Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14590-14594. doi: 10.1002/anie.201606856. Epub 2016 Aug 19.


Clinical outcomes of advanced non-small-cell lung cancer patients with EGFR mutation, ALK rearrangement and EGFR/ALK co-alterations.

Lou NN, Zhang XC, Chen HJ, Zhou Q, Yan LX, Xie Z, Su J, Chen ZH, Tu HY, Yan HH, Wang Z, Xu CR, Jiang BY, Wang BC, Bai XY, Zhong WZ, Wu YL, Yang JJ.

Oncotarget. 2016 Oct 4;7(40):65185-65195. doi: 10.18632/oncotarget.11218.


Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol.

Li J, Zheng X, Lou N, Zhong W, Yan D.

J Lipid Res. 2016 Oct;57(10):1845-1853. Epub 2016 Aug 16.


Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.

Wei HS, Kang H, Rasheed ID, Zhou S, Lou N, Gershteyn A, McConnell ED, Wang Y, Richardson KE, Palmer AF, Xu C, Wan J, Nedergaard M.

Neuron. 2016 Aug 17;91(4):851-862. doi: 10.1016/j.neuron.2016.07.016. Epub 2016 Aug 4.


Soluble c-Met Levels Correlated With Tissue c-Met Protein Expression in Patients With Advanced Non-Small-Cell Lung Cancer.

Gao HF, Li AN, Yang JJ, Chen ZH, Xie Z, Zhang XC, Su J, Lou NN, Yan HH, Han JF, Wu YL.

Clin Lung Cancer. 2017 Jan;18(1):85-91. doi: 10.1016/j.cllc.2016.06.008. Epub 2016 Jun 23.


Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.

Lennard Richard ML, Brandon D, Lou N, Sato S, Caldwell T, Nowling TK, Gilkeson G, Zhang XK.

Eur J Immunol. 2016 Oct;46(10):2322-2332. doi: 10.1002/eji.201646315. Epub 2016 Aug 16.


The coexistence of MET over-expression and an EGFR T790M mutation is related to acquired resistance to EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer.

Gou LY, Li AN, Yang JJ, Zhang XC, Su J, Yan HH, Xie Z, Lou NN, Liu SY, Dong ZY, Gao HF, Zhou Q, Zhong WZ, Xu CR, Wu YL.

Oncotarget. 2016 Aug 9;7(32):51311-51319. doi: 10.18632/oncotarget.9697.


The Unique Characteristics of MET Exon 14 Mutation in Chinese Patients with NSCLC.

Liu SY, Gou LY, Li AN, Lou NN, Gao HF, Su J, Yang JJ, Zhang XC, Shao Y, Dong ZY, Zhou Q, Zhong WZ, Wu YL.

J Thorac Oncol. 2016 Sep;11(9):1503-10. doi: 10.1016/j.jtho.2016.05.016. Epub 2016 May 30.


Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia.

Sun R, Zhang S, Hu W, Lu X, Lou N, Yang Z, Chen S, Zhang X, Yang H.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C101-15. doi: 10.1152/ajpcell.00344.2015. Epub 2016 Apr 27.


Preparation of Azafullerene C59NR5 and Fullerene Derivative C60NAr5 with a Pyridine Moiety on the Cage Skeleton.

Lou N, Li Y, Cui C, Liu Y, Gan L.

Org Lett. 2016 May 6;18(9):2236-9. doi: 10.1021/acs.orglett.6b00872. Epub 2016 Apr 19.


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