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Items: 32


Ancestral reconstruction reveals mechanisms of ERK regulatory evolution.

Sang D, Pinglay S, Wiewiora RP, Selvan ME, Lou HJ, Chodera JD, Turk BE, Gümüş ZH, Holt LJ.

Elife. 2019 Aug 13;8. pii: e38805. doi: 10.7554/eLife.38805.


Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.

Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE.

PLoS Biol. 2019 Mar 21;17(3):e2006540. doi: 10.1371/journal.pbio.2006540. eCollection 2019 Mar.


Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase Interacts with a Subunit of the Parasite Proteasome.

Govindasamy K, Khan R, Snyder M, Lou HJ, Du P, Kudyba HM, Muralidharan V, Turk BE, Bhanot P.

Infect Immun. 2018 Dec 19;87(1). pii: e00523-18. doi: 10.1128/IAI.00523-18. Print 2019 Jan.


Substrate priming enhances phosphorylation by the budding yeast kinases Kin1 and Kin2.

Jeschke GR, Lou HJ, Weise K, Hammond CI, Demonch M, Brennwald P, Turk BE.

J Biol Chem. 2018 Nov 23;293(47):18353-18364. doi: 10.1074/jbc.RA118.005651. Epub 2018 Oct 10.


Kinase Substrate Profiling Using a Proteome-wide Serine-Oriented Human Peptide Library.

Barber KW, Miller CJ, Jun JW, Lou HJ, Turk BE, Rinehart J.

Biochemistry. 2018 Aug 7;57(31):4717-4725. doi: 10.1021/acs.biochem.8b00410. Epub 2018 Jun 19.


In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates.

Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL.

Biochemistry. 2018 Mar 27;57(12):1847-1851. doi: 10.1021/acs.biochem.8b00044. Epub 2018 Mar 12.


Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.

Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL.

Elife. 2018 Feb 26;7. pii: e33150. doi: 10.7554/eLife.33150.


Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.

Cobbaut M, Derua R, Döppler H, Lou HJ, Vandoninck S, Storz P, Turk BE, Seufferlein T, Waelkens E, Janssens V, Van Lint J.

Sci Rep. 2017 Apr 20;7(1):887. doi: 10.1038/s41598-017-00800-w.


Rational Redesign of a Functional Protein Kinase-Substrate Interaction.

Chen C, Nimlamool W, Miller CJ, Lou HJ, Turk BE.

ACS Chem Biol. 2017 May 19;12(5):1194-1198. doi: 10.1021/acschembio.7b00089. Epub 2017 Mar 29.


Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase.

Tio CW, Omerza G, Phillips T, Lou HJ, Turk BE, Winter E.

Mol Cell Biol. 2017 May 2;37(10). pii: e00607-16. doi: 10.1128/MCB.00607-16. Print 2017 May 15.


Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.

Goldberg AB, Cho E, Miller CJ, Lou HJ, Turk BE.

J Biol Chem. 2017 Jan 20;292(3):814-825. doi: 10.1074/jbc.M116.761734. Epub 2016 Dec 1.


Difference of Nonlinear Degree between Healthy and Diabetic Rat Erythocyte Fluorescence Spectrum.

Wang L, Liu GD, Liu L, Liu YJ, Lou HJ, Qi C, Xiao HB, Chi WC.

Guang Pu Xue Yu Guang Pu Fen Xi. 2016 Oct;36(10):3207-10. Chinese.


Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.

Hamill S, Lou HJ, Turk BE, Boggon TJ.

Mol Cell. 2016 May 5;62(3):397-408. doi: 10.1016/j.molcel.2016.04.001.


Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

Mathea S, Abdul Azeez KR, Salah E, Tallant C, Wolfreys F, Konietzny R, Fischer R, Lou HJ, Brennan PE, Schnapp G, Pautsch A, Kessler BM, Turk BE, Knapp S.

ACS Chem Biol. 2016 Jun 17;11(6):1595-602. doi: 10.1021/acschembio.6b00043. Epub 2016 Mar 31.


Unmasking determinants of specificity in the human kinome.

Creixell P, Palmeri A, Miller CJ, Lou HJ, Santini CC, Nielsen M, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):187-201. doi: 10.1016/j.cell.2015.08.057. Epub 2015 Sep 17.


Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.


Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.

Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ.

Mol Cell. 2015 Jul 16;59(2):285-97. doi: 10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25.


Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.

Osman KT, Lou HJ, Qiu W, Brand V, Edwards AM, Turk BE, Hui R.

Mol Biochem Parasitol. 2015 Jun;201(2):85-9. doi: 10.1016/j.molbiopara.2015.06.002. Epub 2015 Jun 22.


Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea.

Xu CY, Li DJ, Wu CL, Lou HJ, Jiang HW, Ding GQ.

Genet Test Mol Biomarkers. 2015 May;19(5):272-6. doi: 10.1089/gtmb.2015.0027. Epub 2015 Mar 31.


Ancestral resurrection reveals evolutionary mechanisms of kinase plasticity.

Howard CJ, Hanson-Smith V, Kennedy KJ, Miller CJ, Lou HJ, Johnson AD, Turk BE, Holt LJ.

Elife. 2014 Oct 13;3. doi: 10.7554/eLife.04126.


An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.

Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ.

Mol Cell. 2014 Aug 7;55(3):436-50. doi: 10.1016/j.molcel.2014.06.021. Epub 2014 Jul 17.


The Toxoplasma pseudokinase ROP5 forms complexes with ROP18 and ROP17 kinases that synergize to control acute virulence in mice.

Etheridge RD, Alaganan A, Tang K, Lou HJ, Turk BE, Sibley LD.

Cell Host Microbe. 2014 May 14;15(5):537-50. doi: 10.1016/j.chom.2014.04.002.


Modulation of the chromatin phosphoproteome by the Haspin protein kinase.

Maiolica A, de Medina-Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganathan S, Lou HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R, Aebersold R.

Mol Cell Proteomics. 2014 Jul;13(7):1724-40. doi: 10.1074/mcp.M113.034819. Epub 2014 Apr 14.


Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.

Chen C, Ha BH, Thévenin AF, Lou HJ, Zhang R, Yip KY, Peterson JR, Gerstein M, Kim PM, Filippakopoulos P, Knapp S, Boggon TJ, Turk BE.

Mol Cell. 2014 Jan 9;53(1):140-7. doi: 10.1016/j.molcel.2013.11.013. Epub 2013 Dec 26.


Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.

Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ.

PLoS One. 2013 Oct 28;8(10):e77818. doi: 10.1371/journal.pone.0077818. eCollection 2013.


mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin.

Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM.

Science. 2013 Jul 26;341(6144):1236566. doi: 10.1126/science.1236566.


Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17.


Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K.

Cell Signal. 2012 Nov;24(11):2085-94. doi: 10.1016/j.cellsig.2012.06.018. Epub 2012 Jul 11.


[Atypical ossifying fibromyxoid tumor: a case report and literature review].

Huang Y, Lou HJ, Mao WB, Gong W, Zhu YL.

Zhonghua Bing Li Xue Za Zhi. 2008 Mar;37(3):206-7. Review. Chinese. No abstract available.


Adeno-associated virus Rep78/Rep68 promotes localized melting of the rep binding element in the absence of adenosine triphosphate.

Lou HJ, Brister JR, Li JJ, Chen W, Muzyczka N, Tan W.

Chembiochem. 2004 Mar 5;5(3):324-32.


Probing intracellular dynamics in living cells with near-field optics.

Bui JD, Zelles T, Lou HJ, Gallion VL, Phillips MI, Tan W.

J Neurosci Methods. 1999 Jul 1;89(1):9-15.


Elbow joint medial collateral ligament injury. A preliminary report.

Ma YZ, Lou HJ, Ye YQ.

Chin Med J (Engl). 1983 Oct;96(10):795-9. No abstract available.


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