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Items: 38

1.

Muscle to Brain Partitioning as Measure of Transporter-Mediated Efflux at the Rat Blood-Brain Barrier and Its Implementation into Compound Optimization in Drug Discovery.

Cui Y, Lotz R, Rapp H, Klinder K, Himstedt A, Sauer A.

Pharmaceutics. 2019 Nov 11;11(11). pii: E595. doi: 10.3390/pharmaceutics11110595.

2.

Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib.

Wind S, Schmid U, Freiwald M, Marzin K, Lotz R, Ebner T, Stopfer P, Dallinger C.

Clin Pharmacokinet. 2019 Sep;58(9):1131-1147. doi: 10.1007/s40262-019-00766-0. Review.

3.

Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule.

Koziolek M, Grimm M, Bollmann T, Schäfer KJ, Blattner SM, Lotz R, Boeck G, Weitschies W.

Eur J Pharm Biopharm. 2019 Mar;136:221-230. doi: 10.1016/j.ejpb.2019.01.026. Epub 2019 Jan 28.

PMID:
30703546
4.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.

Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6.

PMID:
26112443
5.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29.

PMID:
26105194
6.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.

Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30.

PMID:
26077492
7.

Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy.

Bouyssou T, Hoenke C, Rudolf K, Lustenberger P, Pestel S, Sieger P, Lotz R, Heine C, Büttner FH, Schnapp A, Konetzki I.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1410-4. doi: 10.1016/j.bmcl.2009.12.087. Epub 2010 Jan 4.

PMID:
20096576
8.

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

Roth GJ, Heckel A, Colbatzky F, Handschuh S, Kley J, Lehmann-Lintz T, Lotz R, Tontsch-Grunt U, Walter R, Hilberg F.

J Med Chem. 2009 Jul 23;52(14):4466-80. doi: 10.1021/jm900431g.

PMID:
19522465
9.

3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.

Eckhardt M, Hauel N, Himmelsbach F, Langkopf E, Nar H, Mark M, Tadayyon M, Thomas L, Guth B, Lotz R.

Bioorg Med Chem Lett. 2008 Jun 1;18(11):3158-62. doi: 10.1016/j.bmcl.2008.04.075. Epub 2008 May 1.

PMID:
18485703
10.

8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.

Eckhardt M, Langkopf E, Mark M, Tadayyon M, Thomas L, Nar H, Pfrengle W, Guth B, Lotz R, Sieger P, Fuchs H, Himmelsbach F.

J Med Chem. 2007 Dec 27;50(26):6450-3. Epub 2007 Dec 1.

PMID:
18052023
11.

Determination of naphthodianthrones in plant extracts from Hypericum perforatum L. by liquid chromatography-electrospray mass spectrometry.

Piperopoulos G, Lotz R, Wixforth A, Schmierer T, Zeller KP.

J Chromatogr B Biomed Sci Appl. 1997 Aug 1;695(2):309-16.

PMID:
9300867
12.

Elucidation of phase I and phase II metabolic pathways of rhein: species differences and their potential relevance.

Dahms M, Lotz R, Lang W, Renner U, Bayer E, Spahn-Langguth H.

Drug Metab Dispos. 1997 Apr;25(4):442-52.

PMID:
9107544
13.

[Radiotherapy in HIV positive patients].

Lotz R, Rösler HP, Zapf S, Kutzner J, Thelen M.

Fortschr Med. 1990 Jan 20;108(2):35-6, 39. German.

PMID:
1690165
14.

[Duplex sonography of the portal vein. Procedure in healthy probands and patients with portal hypertension].

Lotz R, Mildenberger P, Kreitner KF, Rambow A, Schiedermeier P, Staritz M.

Fortschr Med. 1989 May 20;107(15):330-4. German.

PMID:
2661377
15.

[Rare generalized osteomyelitis].

Naegele-Woehrle B, Kessel KF, Weilemann LS, Lotz R, Hahn K.

Rofo. 1988 Feb;148(2):211-2. German. No abstract available.

PMID:
2831589
16.

[Duplex sonography of the normal portal vein].

Mildenberger P, Lotz R, Kreitner KF.

Dtsch Med Wochenschr. 1987 Dec 11;112(50):1936-9. German.

PMID:
3319475
17.

[Duplex sonography of abdominal vessels].

Mildenberger P, Lotz R, Kreitner KF.

Rofo. 1987 Oct;147(4):437-41. German.

PMID:
2825268
18.

[Tumor invasion of the vena cava inferior in adrenal carcinomas. The preoperative diagnosis].

Mildenberger P, Lotz R, Bierhoff E, Schmiedt W.

Rofo. 1987 Aug;147(2):160-5. German.

PMID:
2819970
19.
20.

[Metastatically induced colonic changes--a differential diagnosis from Crohn's disease].

Lotz R, Steinbrunn H, Schreyer T.

Rontgenpraxis. 1986 Jun;39(6):212-3. German. No abstract available.

PMID:
3738624
21.

[Calcinosis of the supraspinal ligament--a rare secondary finding].

Lotz R, Zocholl G, Schild H.

Rontgenblatter. 1986 Mar;39(3):72-3. German.

PMID:
3715336
22.
23.

Long-term biological investigations in space.

Lotz RG, Fuchs H, Bertsche U.

Acta Astronaut. 1975 Jan-Feb;2(1-2):41-8.

PMID:
11841093
24.

Test of a life support system with Hirudo medicinalis in a sounding rocket.

Lotz RG, Baum P, Bowman GH, Klein KD, von Lohr R, Schrotter L.

Life Sci Space Res. 1972;10:133-43.

PMID:
11898833
25.

Basic studies on Hirudo medicinalis for a space experiment. I. Behavior of Hirudo medicinalis in natural environment.

Lotz RG, Fuchs ME, Moyat PE.

Space Life Sci. 1970 May;2(1):40-4. No abstract available.

PMID:
5000750
26.

Basic studies on Hirudo medicinalis for a space experiment. II. Behavior of Hirudo medicinalis in unnatural environments.

Lotz RG, Bowman GH.

Space Life Sci. 1970 May;2(1):45-7. No abstract available.

PMID:
4399076
27.

Oxygen supply and carbon dioxide absorption in long-term life-support systems.

Lotz RG, Fuchs ME.

Life Sci Space Res. 1969;7:134-7.

PMID:
12197536
28.
29.

A life support system for satellite experiments over one year.

Lotz RG.

Life Sci Space Res. 1968;6:49-55.

PMID:
12216555
30.

Cell metabolism during melanophore activity.

Fuchs ME, Lotz RG.

Nature. 1966 Oct 1;212(5057):39-40. No abstract available.

PMID:
4290613
31.

[Dynamic regulation examination in objective evaluation of balneotherapy results].

LOTZ RG.

Arch Phys Ther (Leipz). 1959 Jan-Feb;11(1):29-35. German. No abstract available.

PMID:
13661927
32.

[Examination of vegetative regulation under the influence of depressants].

AMELUNG W, LOTZ R.

Medizinische. 1956 Oct 20;24(42):1507-9. German. No abstract available.

PMID:
13377976
33.

[New method for objective evaluation of autonomic nervous system regulation in clinical practice].

AMELUNG W, LOTZ R, ZETZSCHE G.

Dtsch Med Wochenschr. 1956 Oct 12;81(41):1635-9. German. No abstract available.

PMID:
13375257
34.

[Experimental studies and critical observations on the problem of autonomic lability].

AMELUNG W, LOTZ R, SCHMIDT L.

Arch Phys Ther (Leipz). 1955 May-Jun;7(3):221-4. German. No abstract available.

PMID:
13249562
35.

[Treatment of malocclusion with an activator with horizontal division].

LOTZ R.

Dtsch Zahnarztl Z. 1955 Feb 1;10(3):173-9. German. No abstract available.

PMID:
14365399
36.

[The diuretic effect of the butyl homologue of synephrine].

LOTZ R.

Z Arztl Fortbild (Jena). 1954 Oct 15;48(20):689-96. German. No abstract available.

PMID:
13227014
37.

[Analytical studies of the blood circulation for diagnosis and therapy of autonomic disorders].

AMELUNG W, LOTZ R, SCHMIDT L.

Dtsch Arch Klin Med. 1954;201(5):568-81. German. No abstract available.

PMID:
14352882
38.

[Radiation and metabolism; radiation in regulation of metabolism in mammals].

LOTZ RG.

Z Vgl Physiol. 1950;32(3):228-47. Undetermined Language. No abstract available.

PMID:
24537754

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