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Items: 1 to 50 of 86

1.

GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signalling.

Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Uchida T, Hayashida M, Tsushima H, Bekki H, Lotz MK, Nakashima Y.

Arthritis Rheumatol. 2019 Nov 6. doi: 10.1002/art.41152. [Epub ahead of print]

PMID:
31696655
2.

FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.

Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y.

J Biol Chem. 2019 Nov 15;294(46):17555-17569. doi: 10.1074/jbc.RA119.009409. Epub 2019 Oct 10.

PMID:
31601652
3.

Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration.

Baek J, Lee E, Lotz MK, D'Lima DD.

Nanomedicine. 2019 Sep 4;23:102090. doi: 10.1016/j.nano.2019.102090. [Epub ahead of print]

PMID:
31493556
4.

Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis.

Carlson AK, Rawle RA, Wallace CW, Brooks EG, Adams E, Greenwood MC, Olmer M, Lotz MK, Bothner B, June RK.

Osteoarthritis Cartilage. 2019 Aug;27(8):1174-1184. doi: 10.1016/j.joca.2019.04.007. Epub 2019 Apr 25.

PMID:
31028882
5.

Core-Shell Nanofibrous Scaffolds for Repair of Meniscus Tears.

Baek J, Lotz MK, D'Lima DD.

Tissue Eng Part A. 2019 Aug 14. doi: 10.1089/ten.TEA.2018.0319. [Epub ahead of print]

PMID:
30950316
6.

Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.

Otsuki S, Alvarez-Garcia O, Lotz MK, Neo M.

Histol Histopathol. 2019 Sep;34(9):1051-1060. doi: 10.14670/HH-18-107. Epub 2019 Mar 29.

PMID:
30924907
7.

Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis.

Fisch KM, Gamini R, Alvarez-Garcia O, Akagi R, Saito M, Muramatsu Y, Sasho T, Koziol JA, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2018 Nov;26(11):1531-1538. doi: 10.1016/j.joca.2018.07.012. Epub 2018 Aug 3.

8.

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK.

Aging Cell. 2018 Oct;17(5):e12800. doi: 10.1111/acel.12800. Epub 2018 Jul 2.

9.

Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears.

Lee KI, Olmer M, Baek J, D'Lima DD, Lotz MK.

Acta Biomater. 2018 Aug;76:126-134. doi: 10.1016/j.actbio.2018.06.021. Epub 2018 Jun 14.

10.

Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes.

Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, Lotz MK, Matsubara K, Miyaki S, Adachi N.

Eur J Pharmacol. 2018 Jul 5;830:1-8. doi: 10.1016/j.ejphar.2018.04.018. Epub 2018 Apr 17.

11.

Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan.

Serrano RL, Chen LY, Lotz MK, Liu-Bryan R, Terkeltaub R.

Arthritis Rheumatol. 2018 Jul;70(7):1030-1041. doi: 10.1002/art.40456. Epub 2018 May 27.

12.

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.

Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan0746. doi: 10.1126/scitranslmed.aan0746.

13.

Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering.

Grogan SP, Duffy SF, Pauli C, Lotz MK, D'Lima DD.

J Orthop Res. 2018 Jul;36(7):1947-1958. doi: 10.1002/jor.23864. Epub 2018 Mar 14.

14.

Extracellular vesicles in cartilage homeostasis and osteoarthritis.

Miyaki S, Lotz MK.

Curr Opin Rheumatol. 2018 Jan;30(1):129-135. doi: 10.1097/BOR.0000000000000454. Review.

15.

Transthyretin deposition promotes progression of osteoarthritis.

Matsuzaki T, Akasaki Y, Olmer M, Alvarez-Garcia O, Reixach N, Buxbaum JN, Lotz MK.

Aging Cell. 2017 Dec;16(6):1313-1322. doi: 10.1111/acel.12665. Epub 2017 Sep 22.

16.

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.

Meckes JK, Caramés B, Olmer M, Kiosses WB, Grogan SP, Lotz MK, D'Lima DD.

Osteoarthritis Cartilage. 2017 Nov;25(11):1880-1889. doi: 10.1016/j.joca.2017.07.023. Epub 2017 Aug 8.

17.

Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.

Asahara H, Inui M, Lotz MK.

J Bone Miner Res. 2017 Sep;32(9):1773-1782. doi: 10.1002/jbmr.3199. Epub 2017 Jul 13. Review.

18.

Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Masuda K, Lotz MK.

J Orthop Res. 2017 Dec;35(12):2682-2691. doi: 10.1002/jor.23583. Epub 2017 May 4.

19.

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK.

Arthritis Rheumatol. 2017 Jul;69(7):1418-1428. doi: 10.1002/art.40104. Epub 2017 Jun 2.

20.

TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.

Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz MK, Asahara H.

Sci Rep. 2017 Feb 21;7:42990. doi: 10.1038/srep42990.

21.

Relevance of meniscal cell regional phenotype to tissue engineering.

Grogan SP, Pauli C, Lotz MK, D'Lima DD.

Connect Tissue Res. 2017 May - Jul;58(3-4):259-270. doi: 10.1080/03008207.2016.1268604. Epub 2016 Dec 7.

22.

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.

Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2017 Jun;25(6):943-951. doi: 10.1016/j.joca.2016.11.007. Epub 2016 Nov 22.

23.

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK.

Osteoarthritis Cartilage. 2017 Feb;25(2):287-296. doi: 10.1016/j.joca.2016.09.017. Epub 2016 Sep 29.

24.

Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.

Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmorstein LY, Lotz MK.

Arthritis Rheumatol. 2017 Mar;69(3):576-585. doi: 10.1002/art.39963.

25.

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H.

Nat Commun. 2016 Aug 16;7:12503. doi: 10.1038/ncomms12503.

26.

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1.

27.

Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy.

Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch KM, Shen T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2016 Sep;24(9):1639-47. doi: 10.1016/j.joca.2016.04.015. Epub 2016 Apr 23.

28.

Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage.

Alvarez-Garcia O, Fisch KM, Wineinger NE, Akagi R, Saito M, Sasho T, Su AI, Lotz MK.

Arthritis Rheumatol. 2016 Aug;68(8):1876-86. doi: 10.1002/art.39643.

29.

MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins.

D'Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, Lotz MK.

Osteoarthritis Cartilage. 2016 Jun;24(6):1082-91. doi: 10.1016/j.joca.2016.01.005. Epub 2016 Jan 19.

30.

Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration.

Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL.

Arthritis Res Ther. 2016 Jan 21;18:18. doi: 10.1186/s13075-016-0922-4.

31.

Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis.

Kwok J, Onuma H, Olmer M, Lotz MK, Grogan SP, D'Lima DD.

Osteoarthritis Cartilage. 2016 Apr;24(4):709-18. doi: 10.1016/j.joca.2015.11.006. Epub 2015 Nov 14.

32.

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.

Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, Lotz MK, Ochi M.

Arthritis Res Ther. 2015 Oct 13;17:285. doi: 10.1186/s13075-015-0792-1.

33.

Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis.

Akasaki Y, Reixach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Iwamoto Y, Buxbaum JN, Lotz MK.

Arthritis Rheumatol. 2015 May;67(8):2097-107. doi: 10.1002/art.39178.

34.

The relationship of autophagy defects to cartilage damage during joint aging in a mouse model.

Caramés B, Olmer M, Kiosses WB, Lotz MK.

Arthritis Rheumatol. 2015 Jun;67(6):1568-76. doi: 10.1002/art.39073.

35.

Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells.

Hoshiyama Y, Otsuki S, Oda S, Kurokawa Y, Nakajima M, Jotoku T, Tamura R, Okamoto Y, Lotz MK, Neo M.

J Orthop Res. 2015 Apr;33(4):548-55. doi: 10.1002/jor.22782. Epub 2015 Feb 17.

36.

Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.

López de Figueroa P, Lotz MK, Blanco FJ, Caramés B.

Arthritis Rheumatol. 2015 Apr;67(4):966-76. doi: 10.1002/art.39025.

37.

FoxO transcription factors support oxidative stress resistance in human chondrocytes.

Akasaki Y, Alvarez-Garcia O, Saito M, Caramés B, Iwamoto Y, Lotz MK.

Arthritis Rheumatol. 2014 Dec;66(12):3349-58. doi: 10.1002/art.38868.

38.

Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes.

Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, Lotz MK, Ochi M.

Arthritis Res Ther. 2014 Aug 4;16(4):R163. doi: 10.1186/ar4679.

39.

Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1.

Alvarez-Garcia O, Rogers NH, Smith RG, Lotz MK.

Arthritis Rheumatol. 2014 Jul;66(7):1779-88. doi: 10.1002/art.38399.

40.

Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis.

Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, Lotz MK.

Osteoarthritis Cartilage. 2014 Jan;22(1):162-70. doi: 10.1016/j.joca.2013.11.004. Epub 2013 Nov 21.

41.

Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells.

Olee T, Grogan SP, Lotz MK, Colwell CW Jr, D'Lima DD, Snyder EY.

Tissue Eng Part A. 2014 Feb;20(3-4):683-92. doi: 10.1089/ten.TEA.2012.0751. Epub 2013 Oct 19.

42.

Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation.

Grogan SP, Chen X, Sovani S, Taniguchi N, Colwell CW Jr, Lotz MK, D'Lima DD.

Tissue Eng Part A. 2014 Jan;20(1-2):264-74. doi: 10.1089/ten.TEA.2012.0618. Epub 2013 Sep 25.

43.

Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation.

Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, Asahara H.

Arthritis Rheum. 2013 Aug;65(8):2081-9. doi: 10.1002/art.38020.

44.

Glucosamine activates autophagy in vitro and in vivo.

Caramés B, Kiosses WB, Akasaki Y, Brinson DC, Eap W, Koziol J, Lotz MK.

Arthritis Rheum. 2013 Jul;65(7):1843-52. doi: 10.1002/art.37977.

45.

Digital micromirror device projection printing system for meniscus tissue engineering.

Grogan SP, Chung PH, Soman P, Chen P, Lotz MK, Chen S, D'Lima DD.

Acta Biomater. 2013 Jul;9(7):7218-26. doi: 10.1016/j.actbio.2013.03.020. Epub 2013 Mar 21.

46.

Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis.

Hasegawa A, Nakahara H, Kinoshita M, Asahara H, Koziol J, Lotz MK.

Arthritis Res Ther. 2013 Feb 14;15(1):R29. doi: 10.1186/ar4165.

47.

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.

Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, Lotz MK, Asahara H, Ishiguro N.

Arthritis Res Ther. 2013 Feb 13;15(1):R28. doi: 10.1186/ar4164.

48.

Zone-specific gene expression patterns in articular cartilage.

Grogan SP, Duffy SF, Pauli C, Koziol JA, Su AI, D'Lima DD, Lotz MK.

Arthritis Rheum. 2013 Feb;65(2):418-28. doi: 10.1002/art.37760.

49.

Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: correlations with anterior cruciate ligament and cartilage changes.

Levy YD, Hasegawa A, Patil S, Koziol JA, Lotz MK, D'Lima DD.

Ann Rheum Dis. 2013 Feb;72(2):271-7. doi: 10.1136/annrheumdis-2012-201730. Epub 2012 Aug 7.

50.

Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels.

Grogan SP, Sovani S, Pauli C, Chen J, Hartmann A, Colwell CW Jr, Lotz MK, D'Lima DD.

Tissue Eng Part A. 2012 Sep;18(17-18):1784-92. doi: 10.1089/ten.TEA.2011.0506. Epub 2012 Jun 12.

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