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Items: 1 to 50 of 411

1.

FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling.

Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y.

J Biol Chem. 2019 Oct 10. pii: jbc.RA119.009409. doi: 10.1074/jbc.RA119.009409. [Epub ahead of print]

2.

Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration.

Baek J, Lee E, Lotz MK, D'Lima DD.

Nanomedicine. 2019 Sep 4:102090. doi: 10.1016/j.nano.2019.102090. [Epub ahead of print]

PMID:
31493556
3.

Nanoimprinting reflow modified moth-eye structures in chalcogenide glass for enhanced broadband antireflection in the mid-infrared.

Lotz M, Needham J, Jakobsen MH, Taboryski R.

Opt Lett. 2019 Sep 1;44(17):4383-4386. doi: 10.1364/OL.44.004383.

PMID:
31465408
4.

TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding.

Wyseure T, Yang T, Zhou JY, Cooke EJ, Wanko B, Olmer M, Agashe R, Morodomi Y, Behrendt N, Lotz M, Morser J, von Drygalski A, Mosnier LO.

JCI Insight. 2019 Oct 3;4(19). pii: 128379. doi: 10.1172/jci.insight.128379.

5.

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

Nogueira-Recalde U, Lorenzo-Gómez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, Lotz M, Robbins PD, Domínguez E, Caramés B.

EBioMedicine. 2019 Jul;45:588-605. doi: 10.1016/j.ebiom.2019.06.049. Epub 2019 Jul 5.

6.

Wwp2 maintains cartilage homeostasis through regulation of Adamts5.

Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H.

Nat Commun. 2019 Jun 3;10(1):2429. doi: 10.1038/s41467-019-10177-1.

7.

Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis.

Carlson AK, Rawle RA, Wallace CW, Brooks EG, Adams E, Greenwood MC, Olmer M, Lotz MK, Bothner B, June RK.

Osteoarthritis Cartilage. 2019 Aug;27(8):1174-1184. doi: 10.1016/j.joca.2019.04.007. Epub 2019 Apr 25.

PMID:
31028882
8.

Simplifying surveillance for breast cancer survivors.

Pories SE, Myers LE, Dusenbery KL, Lotz M, Weissmann L.

Breast J. 2019 May;25(3):560-561. doi: 10.1111/tbj.13266. Epub 2019 Apr 7. No abstract available.

PMID:
30957343
9.

Core-Shell Nanofibrous Scaffolds for Repair of Meniscus Tears.

Baek J, Lotz MK, D'Lima DD.

Tissue Eng Part A. 2019 Aug 14. doi: 10.1089/ten.TEA.2018.0319. [Epub ahead of print]

PMID:
30950316
10.

Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.

Otsuki S, Alvarez-Garcia O, Lotz MK, Neo M.

Histol Histopathol. 2019 Sep;34(9):1051-1060. doi: 10.14670/HH-18-107. Epub 2019 Mar 29.

PMID:
30924907
11.

Adherence to oral chemotherapy: Challenges and opportunities.

Krikorian S, Pories S, Tataronis G, Caughey T, Chervinsky K, Lotz M, Shen AH, Weissmann L.

J Oncol Pharm Pract. 2019 Oct;25(7):1590-1598. doi: 10.1177/1078155218800384. Epub 2018 Sep 26.

PMID:
30253725
12.

Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis.

Fisch KM, Gamini R, Alvarez-Garcia O, Akagi R, Saito M, Muramatsu Y, Sasho T, Koziol JA, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2018 Nov;26(11):1531-1538. doi: 10.1016/j.joca.2018.07.012. Epub 2018 Aug 3.

PMID:
30081074
13.

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis.

Kumar P, Yao LJ, Saidin S, Paleja B, van Loosdregt J, Chua C, Arkachaisri T, Consolaro A, Gattorno M, Martini A, Pischel KD, Williams GW, Lotz M, Albani S.

J Autoimmun. 2018 Nov;94:90-98. doi: 10.1016/j.jaut.2018.07.014. Epub 2018 Aug 1.

14.

Uterus transplantation as radical reproduction: Taking the adoption alternative more seriously.

Lotz M.

Bioethics. 2018 Oct;32(8):499-508. doi: 10.1111/bioe.12490. Epub 2018 Jul 20.

PMID:
30027611
15.

FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK.

Aging Cell. 2018 Oct;17(5):e12800. doi: 10.1111/acel.12800. Epub 2018 Jul 2.

16.

HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles.

Lee D, Taniguchi N, Sato K, Choijookhuu N, Hishikawa Y, Kataoka H, Morinaga H, Lotz M, Chosa E.

Sci Rep. 2018 Jun 25;8(1):9601. doi: 10.1038/s41598-018-28023-7.

17.

Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes.

Chen LY, Lotz M, Terkeltaub R, Liu-Bryan R.

J Biol Chem. 2018 Aug 3;293(31):12259-12270. doi: 10.1074/jbc.RA118.002261. Epub 2018 Jun 21.

18.

Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears.

Lee KI, Olmer M, Baek J, D'Lima DD, Lotz MK.

Acta Biomater. 2018 Aug;76:126-134. doi: 10.1016/j.actbio.2018.06.021. Epub 2018 Jun 14.

19.

Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes.

Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, Lotz MK, Matsubara K, Miyaki S, Adachi N.

Eur J Pharmacol. 2018 Jul 5;830:1-8. doi: 10.1016/j.ejphar.2018.04.018. Epub 2018 Apr 17.

20.

Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan.

Serrano RL, Chen LY, Lotz MK, Liu-Bryan R, Terkeltaub R.

Arthritis Rheumatol. 2018 Jul;70(7):1030-1041. doi: 10.1002/art.40456. Epub 2018 May 27.

21.

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.

Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan0746. doi: 10.1126/scitranslmed.aan0746.

22.

Conductance quantization suppression in the quantum Hall regime.

Caridad JM, Power SR, Lotz MR, Shylau AA, Thomsen JD, Gammelgaard L, Booth TJ, Jauho AP, Bøggild P.

Nat Commun. 2018 Feb 13;9(1):659. doi: 10.1038/s41467-018-03064-8.

23.

Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering.

Grogan SP, Duffy SF, Pauli C, Lotz MK, D'Lima DD.

J Orthop Res. 2018 Jul;36(7):1947-1958. doi: 10.1002/jor.23864. Epub 2018 Mar 14.

24.

Extracellular vesicles in cartilage homeostasis and osteoarthritis.

Miyaki S, Lotz MK.

Curr Opin Rheumatol. 2018 Jan;30(1):129-135. doi: 10.1097/BOR.0000000000000454. Review.

25.

Electroconvulsive Therapy in a Patient With a Recent Subarachnoid Hemorrhage.

Doddi SR, Lotz M, Regenold WT, Adler L.

J ECT. 2018 Mar;34(1):e2-e4. doi: 10.1097/YCT.0000000000000453.

PMID:
28976440
26.

Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells.

Peeters JGC, de Graeff N, Lotz M, Albani S, de Roock S, van Loosdregt J.

Rheumatology (Oxford). 2017 Oct 1;56(10):1694-1699. doi: 10.1093/rheumatology/kex227.

27.

Transthyretin deposition promotes progression of osteoarthritis.

Matsuzaki T, Akasaki Y, Olmer M, Alvarez-Garcia O, Reixach N, Buxbaum JN, Lotz MK.

Aging Cell. 2017 Dec;16(6):1313-1322. doi: 10.1111/acel.12665. Epub 2017 Sep 22.

28.

HMGB proteins and arthritis.

Taniguchi N, Kawakami Y, Maruyama I, Lotz M.

Hum Cell. 2018 Jan;31(1):1-9. doi: 10.1007/s13577-017-0182-x. Epub 2017 Sep 15. Review.

29.

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.

Meckes JK, Caramés B, Olmer M, Kiosses WB, Grogan SP, Lotz MK, D'Lima DD.

Osteoarthritis Cartilage. 2017 Nov;25(11):1880-1889. doi: 10.1016/j.joca.2017.07.023. Epub 2017 Aug 8.

30.

Tendons and Ligaments: Connecting Developmental Biology to Musculoskeletal Disease Pathogenesis.

Asahara H, Inui M, Lotz MK.

J Bone Miner Res. 2017 Sep;32(9):1773-1782. doi: 10.1002/jbmr.3199. Epub 2017 Jul 13. Review.

31.

Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Masuda K, Lotz MK.

J Orthop Res. 2017 Dec;35(12):2682-2691. doi: 10.1002/jor.23583. Epub 2017 May 4.

32.

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis.

Alvarez-Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly JW, Lotz MK.

Arthritis Rheumatol. 2017 Jul;69(7):1418-1428. doi: 10.1002/art.40104. Epub 2017 Jun 2.

33.

TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes.

Hasei J, Teramura T, Takehara T, Onodera Y, Horii T, Olmer M, Hatada I, Fukuda K, Ozaki T, Lotz MK, Asahara H.

Sci Rep. 2017 Feb 21;7:42990. doi: 10.1038/srep42990.

34.

Relevance of meniscal cell regional phenotype to tissue engineering.

Grogan SP, Pauli C, Lotz MK, D'Lima DD.

Connect Tissue Res. 2017 May - Jul;58(3-4):259-270. doi: 10.1080/03008207.2016.1268604. Epub 2016 Dec 7.

35.

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.

Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2017 Jun;25(6):943-951. doi: 10.1016/j.joca.2016.11.007. Epub 2016 Nov 22.

36.

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK.

Osteoarthritis Cartilage. 2017 Feb;25(2):287-296. doi: 10.1016/j.joca.2016.09.017. Epub 2016 Sep 29.

37.

Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.

Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmorstein LY, Lotz MK.

Arthritis Rheumatol. 2017 Mar;69(3):576-585. doi: 10.1002/art.39963.

38.

Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues.

Yu X, Kawakami H, Tahara N, Olmer M, Hayashi S, Akiyama R, Bagchi A, Lotz M, Kawakami Y.

J Orthop Res. 2017 Aug;35(8):1671-1682. doi: 10.1002/jor.23463. Epub 2016 Nov 8.

39.

Increased autophagy in CD4+ T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance.

van Loosdregt J, Rossetti M, Spreafico R, Moshref M, Olmer M, Williams GW, Kumar P, Copeland D, Pischel K, Lotz M, Albani S.

Eur J Immunol. 2016 Dec;46(12):2862-2870. doi: 10.1002/eji.201646375. Epub 2016 Oct 5.

40.

Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs.

Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H.

Nat Commun. 2016 Aug 16;7:12503. doi: 10.1038/ncomms12503.

41.

Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1.

42.

Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy.

Alvarez-Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch KM, Shen T, Su AI, Lotz MK.

Osteoarthritis Cartilage. 2016 Sep;24(9):1639-47. doi: 10.1016/j.joca.2016.04.015. Epub 2016 Apr 23.

43.

Vulnerability and resilience: a critical nexus.

Lotz M.

Theor Med Bioeth. 2016 Feb;37(1):45-59. doi: 10.1007/s11017-016-9355-y.

PMID:
26965682
44.

Commentary on Nicola Williams and Stephen Wilkinson: 'Should Uterus Transplants Be Publicly Funded?'.

Lotz M.

J Med Ethics. 2016 Sep;42(9):570-1. doi: 10.1136/medethics-2015-103230. Epub 2016 Mar 9. No abstract available.

PMID:
26960350
45.

Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage.

Alvarez-Garcia O, Fisch KM, Wineinger NE, Akagi R, Saito M, Sasho T, Su AI, Lotz MK.

Arthritis Rheumatol. 2016 Aug;68(8):1876-86. doi: 10.1002/art.39643.

46.

MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins.

D'Adamo S, Alvarez-Garcia O, Muramatsu Y, Flamigni F, Lotz MK.

Osteoarthritis Cartilage. 2016 Jun;24(6):1082-91. doi: 10.1016/j.joca.2016.01.005. Epub 2016 Jan 19.

47.

Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration.

Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL.

Arthritis Res Ther. 2016 Jan 21;18:18. doi: 10.1186/s13075-016-0922-4.

48.

Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis.

Kwok J, Onuma H, Olmer M, Lotz MK, Grogan SP, D'Lima DD.

Osteoarthritis Cartilage. 2016 Apr;24(4):709-18. doi: 10.1016/j.joca.2015.11.006. Epub 2015 Nov 14.

49.

Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1.

Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, Lotz MK, Ochi M.

Arthritis Res Ther. 2015 Oct 13;17:285. doi: 10.1186/s13075-015-0792-1.

50.

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α.

Wang Y, Zhao X, Lotz M, Terkeltaub R, Liu-Bryan R.

Arthritis Rheumatol. 2015 May;67(8):2141-53. doi: 10.1002/art.39182.

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