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Items: 1 to 50 of 53

1.

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.

Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A.

Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2.

PMID:
30940908
2.

Persistence of endothelial thrombomodulin in a patient with infectious purpura fulminans treated with protein C concentrate.

Bendapudi PK, Robbins A, LeBoeuf N, Pozdnyakova O, Bhatt A, Duke F, Sells R, McQuiston J, Humrighouse B, Rouaisnel B, Colling M, Stephenson KE, Saavedra A, Losman JA.

Blood Adv. 2018 Nov 13;2(21):2917-2921. doi: 10.1182/bloodadvances.2018024430. No abstract available.

3.

Haemophagocytic lymphohistiocytosis complicating pembrolizumab treatment for metastatic breast cancer in a patient with the PRF1A91V gene polymorphism.

Al-Samkari H, Snyder GD, Nikiforow S, Tolaney SM, Freedman RA, Losman JA.

J Med Genet. 2019 Jan;56(1):39-42. doi: 10.1136/jmedgenet-2018-105485. Epub 2018 Oct 4.

PMID:
30287596
4.

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.

McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3741-E3748. doi: 10.1073/pnas.1716029115. Epub 2018 Apr 2.

5.

Targeting Aberrant Signaling in Myeloid Malignancies: Promise Versus Reality.

Sellar R, Losman JA.

Hematol Oncol Clin North Am. 2017 Aug;31(4):565-576. doi: 10.1016/j.hoc.2017.04.001. Epub 2017 May 17. Review.

PMID:
28673388
6.

Cancer therapy: The leukaemia epigenome targeted.

Losman JA.

Nature. 2017 Mar 29;543(7647):634-635. doi: 10.1038/543634a. No abstract available.

PMID:
28358070
7.

Mutant Calreticulin Requires Both Its Mutant C-terminus and the Thrombopoietin Receptor for Oncogenic Transformation.

Elf S, Abdelfattah NS, Chen E, Perales-Patón J, Rosen EA, Ko A, Peisker F, Florescu N, Giannini S, Wolach O, Morgan EA, Tothova Z, Losman JA, Schneider RK, Al-Shahrour F, Mullally A.

Cancer Discov. 2016 Apr;6(4):368-81. doi: 10.1158/2159-8290.CD-15-1434. Epub 2016 Mar 7.

8.

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.

Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG Jr, Bardeesy N, Wong KK.

Genes Dev. 2014 Mar 1;28(5):479-90. doi: 10.1101/gad.231233.113.

9.

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

Losman JA, Kaelin WG Jr.

Genes Dev. 2013 Apr 15;27(8):836-52. doi: 10.1101/gad.217406.113. Review.

10.

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr.

Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7.

11.

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr.

Nature. 2012 Feb 15;483(7390):484-8. doi: 10.1038/nature10898.

12.

A bleeding heart.

Goldberg J, Losman JA, Cavanaugh K.

Am J Med. 2006 Dec;119(12):1029-32. No abstract available.

PMID:
17145243
13.

SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.

Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB.

Mol Cell Biol. 2004 Oct;24(20):9092-101. Erratum in: Mol Cell Biol. 2005 Sep;25(17):7927.

15.

Protein phosphatase 2A regulates the stability of Pim protein kinases.

Losman JA, Chen XP, Vuong BQ, Fay S, Rothman PB.

J Biol Chem. 2003 Feb 14;278(7):4800-5. Epub 2002 Dec 6.

16.

TRIM8/GERP RING finger protein interacts with SOCS-1.

Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P.

J Biol Chem. 2002 Oct 4;277(40):37315-22. Epub 2002 Aug 5.

17.

Pim serine/threonine kinases regulate the stability of Socs-1 protein.

Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2175-80.

18.

IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex.

Losman J, Chen XP, Jiang H, Pan PY, Kashiwada M, Giallourakis C, Cowan S, Foltenyi K, Rothman P.

Cold Spring Harb Symp Quant Biol. 1999;64:405-16. Review. No abstract available.

PMID:
11232315
19.

SOCS proteins, regulators of intracellular signaling.

Chen XP, Losman JA, Rothman P.

Immunity. 2000 Sep;13(3):287-90. Review. No abstract available.

20.

Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.

Losman JA, Chen XP, Hilton D, Rothman P.

J Immunol. 1999 Apr 1;162(7):3770-4.

21.

Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.

Danial NN, Losman JA, Lu T, Yip N, Krishnan K, Krolewski J, Goff SP, Wang JY, Rothman PB.

Mol Cell Biol. 1998 Nov;18(11):6795-804.

22.

Nucleosome-specific antibody from an autoimmune MRL/Mp-lpr/lpr mouse.

Losman JA, Fasy TM, Novick KE, Massa M, Monestier M.

Arthritis Rheum. 1993 Apr;36(4):552-60.

PMID:
8457229
23.

Antihistone antibodies in antinuclear antibody-positive juvenile arthritis.

Monestier M, Losman JA, Fasy TM, Debbas ME, Massa M, Albani S, Bohm L, Martini A.

Arthritis Rheum. 1990 Dec;33(12):1836-41.

PMID:
2261004
24.

Clinical heart transplantation.

Losman JG.

Transplant Proc. 1987 Feb;19(1 Pt 3):2500. No abstract available.

PMID:
3274546
25.

Heart-lung transplantation.

Losman JG.

J Thorac Cardiovasc Surg. 1985 May;89(5):807-9. No abstract available.

PMID:
3921773
26.

Myocardial surgical revascularization after streptokinase treatment for acute myocardial infarction.

Losman JG, Finchum RN, Nagle D, Dacumos GC, Jones CR, Wilensky AS, Martin RG, Bailey MT, Kahn DR.

J Thorac Cardiovasc Surg. 1985 Jan;89(1):25-34.

PMID:
3871237
27.

Heterotopic heart transplantation.

Losman JG.

J Thorac Cardiovasc Surg. 1983 Oct;86(4):632-3. No abstract available.

PMID:
6353080
28.

Heart transplantation, a challenge for the eighties.

Losman JG.

Acta Cardiol. 1983;38(3):163-82. No abstract available.

PMID:
6351515
29.

Joint transplantation of the heart and lungs. Past experience and present potentials.

Losman JG, Campbell CD, Replogle RL, Barnard CN.

J Cardiovasc Surg (Torino). 1982 Nov-Dec;23(6):440-52. Review.

PMID:
6759511
30.

Changes in indications for heart transplantation. An additional argument for the preservation of the recipient's own heart.

Losman JG, Levine H, Campbell CD, Replogle RL, Hassoulas J, Novitsky D, Cooper DK, Barnard CN.

J Thorac Cardiovasc Surg. 1982 Nov;84(5):716-26.

PMID:
6752589
31.

An alternative to the orthotopic artificial heart: a point of view.

Losman JG, Replogle RL, Kolff WJ.

Artif Organs. 1982 Aug;6(3):319-24. No abstract available.

PMID:
6758738
32.

Heterotopic heart transplantation: a valid alternative to orthotopic transplantation: results, advantages, and disadvantages.

Losman JG, Barnard CN.

J Surg Res. 1982 Apr;32(4):297-312. No abstract available.

PMID:
7040808
33.

Morphological changes in 49 chacma baboons after cardiac allografts.

Rose AG, Uys CJ, Losman JG, Barnard CN.

S Afr Med J. 1979 Nov 24;56(22):880-6.

PMID:
117558
34.

Cardiac surgical research and heart transplantation in Papio ursinus.

Losman JG.

J S Afr Vet Assoc. 1978 Sep;49(3):211-5.

PMID:
370387
35.

Normal cardiac function with a hybrid heart.

Losman JG, Curcio A, Barnard C.

Ann Thorac Surg. 1978 Aug;26(2):177-84.

PMID:
352288
36.
37.

Subvalvular left ventricular false aneurysm complicating mitral valve replacement.

Rose AG, Losman JG.

Arch Pathol Lab Med. 1978 Jun;102(6):285-6.

PMID:
580719
38.

Human heterotopic cardiac transplantation: current status.

Wolpowitz A, Losman JG, Curcio CA, Barnard MS, Sánchez HE, Barnard CN.

S Afr J Surg. 1978 Jun;16(2):99-102. No abstract available.

PMID:
362566
39.

Risk factors in surgical correction of congenital heart defects in early childhood.

Losman JG, Joffe HS, Barnard CN.

S Afr Med J. 1978 Mar 11;53(10):351-7.

PMID:
653469
40.

Use of a double atrial-triggered standby pacemaker system for a patient with a biventricular bypass heterotopic cardiac homograft.

Kennelly BM, Piller LW, Tarjan PP, Losman JG, Barnard CN, Beck W.

Am J Cardiol. 1978 Feb;41(2):341-4.

PMID:
341679
41.
42.

The advantage of heterotopic cardiac transplantation over orthotopic cardiac transplantation in the management of severe acute rejection.

Barnard CN, Losman JG, Curcio CA, Sanchez HE, Wolpowitz A, Barnard MS.

J Thorac Cardiovasc Surg. 1977 Dec;74(6):918-24.

PMID:
336984
43.

Hemodynamic evaluation of left ventricular bypass with a homologous cardiac graft.

Losman JG, Barnard C.

J Thorac Cardiovasc Surg. 1977 Nov;74(5):695-708. No abstract available.

PMID:
410998
44.
45.

Myocardial fibrinolytic activity in allogenic cardiac rejection.

Losman JG, Rose AG, Barnard CN.

Transplantation. 1977 May;23(5):414-22.

PMID:
405762
46.

Treatment of paraquat poisoning with the membrane oxygenator: a case report.

Klaff LJ, Levin PJ, Potgieter PD, Losman JG, Nochomovitz LE, Ferguson AD.

S Afr Med J. 1977 Feb 12;51(7):203-5.

PMID:
847571
47.

REVIEW OF THE CAPE TOWN EXPERIENCE WITH HETEROTOPIC CARDIAC TRANSPLANTATION.

Losman JG.

Cardiovasc Dis. 1977;4(3):243-255. No abstract available.

48.

Circadian rhythmic aspects of human cardiovascular function: a review by chronobiologic statistical methods.

Smolensky MH, Tatar SE, Bergman SA, Losman JG, Barnard CN, Dacso CC, Kraft IA.

Chronobiologia. 1976 Oct-Dec;3(4):337-71. No abstract available.

PMID:
1024808
49.

Arrhythmias in two patients with left ventricular bypass transplants.

Kennelly BM, Corte P, Losman J, Barnard CN.

Br Heart J. 1976 Jul;38(7):725-31.

50.

Left ventricular bypass.

Barnard CN, Losman JG.

S Afr Med J. 1975 Mar 1;49(9):303-12.

PMID:
1090016

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