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Items: 1 to 50 of 185

1.

Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism.

Czekay RP, Loskutoff DJ.

J Cell Physiol. 2009 Sep;220(3):655-63. doi: 10.1002/jcp.21806.

2.

Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2.

Dellas C, Schäfer K, Rohm IK, Lankeit M, Leifheit M, Loskutoff DJ, Hasenfuss G, Konstantinides SV.

Thromb Haemost. 2007 Nov;98(5):1063-71.

PMID:
18000612
3.

Contribution of leptin receptor N-linked glycans to leptin binding.

Kamikubo Y, Dellas C, Loskutoff DJ, Quigley JP, Ruggeri ZM.

Biochem J. 2008 Mar 15;410(3):595-604.

PMID:
17983356
4.

Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis.

Konstantinides S, Ware J, Marchese P, Almus-Jacobs F, Loskutoff DJ, Ruggeri ZM.

J Thromb Haemost. 2006 Sep;4(9):2014-21.

5.

The reduced, denatured somatomedin B domain of vitronectin refolds into a stable, biologically active molecule.

Kamikubo Y, Kroon G, Curriden SA, Dyson HJ, Loskutoff DJ.

Biochemistry. 2006 Mar 14;45(10):3297-306.

PMID:
16519524
6.

Thrombotic phenotype of mice with a combined deficiency in plasminogen activator inhibitor 1 and vitronectin.

Koschnick S, Konstantinides S, Schäfer K, Crain K, Loskutoff DJ.

J Thromb Haemost. 2005 Oct;3(10):2290-5.

7.

Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice.

Yamamoto K, Kojima T, Adachi T, Hayashi M, Matsushita T, Takamatsu J, Loskutoff DJ, Saito H.

J Thromb Haemost. 2005 Jul;3(7):1495-502.

8.

Molecular mechanisms of tumor necrosis factor-alpha-mediated plasminogen activator inhibitor-1 expression in adipocytes.

Pandey M, Loskutoff DJ, Samad F.

FASEB J. 2005 Aug;19(10):1317-9. Epub 2005 May 31.

PMID:
15928193
9.

The leptin receptor system of human platelets.

Giandomenico G, Dellas C, Czekay RP, Koschnick S, Loskutoff DJ.

J Thromb Haemost. 2005 May;3(5):1042-9.

10.

Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.

Degryse B, Resnati M, Czekay RP, Loskutoff DJ, Blasi F.

J Biol Chem. 2005 Jul 1;280(26):24792-803. Epub 2005 Apr 29.

11.

Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.

Dellas C, Loskutoff DJ.

Thromb Haemost. 2005 Apr;93(4):631-40. Review.

PMID:
15841306
12.

Unexpected role of plasminogen activator inhibitor 1 in cell adhesion and detachment.

Czekay RP, Loskutoff DJ.

Exp Biol Med (Maywood). 2004 Dec;229(11):1090-6. Review.

PMID:
15564434
13.

Inhibition of endogenous leptin protects mice from arterial and venous thrombosis.

Konstantinides S, Schäfer K, Neels JG, Dellas C, Loskutoff DJ.

Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2196-201. Epub 2004 Sep 30.

PMID:
15458978
14.

Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin.

Kamikubo Y, De Guzman R, Kroon G, Curriden S, Neels JG, Churchill MJ, Dawson P, Ołdziej S, Jagielska A, Scheraga HA, Loskutoff DJ, Dyson HJ.

Biochemistry. 2004 Jun 1;43(21):6519-34.

PMID:
15157085
15.

Angiogenesis in an in vivo model of adipose tissue development.

Neels JG, Thinnes T, Loskutoff DJ.

FASEB J. 2004 Jun;18(9):983-5. Epub 2004 Apr 14.

PMID:
15084517
16.

The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.

Degryse B, Neels JG, Czekay RP, Aertgeerts K, Kamikubo Y, Loskutoff DJ.

J Biol Chem. 2004 May 21;279(21):22595-604. Epub 2004 Mar 4.

17.

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.

Takeshita K, Hayashi M, Iino S, Kondo T, Inden Y, Iwase M, Kojima T, Hirai M, Ito M, Loskutoff DJ, Saito H, Murohara T, Yamamoto K.

Am J Pathol. 2004 Feb;164(2):449-56.

18.

Leptin promotes vascular remodeling and neointimal growth in mice.

Schäfer K, Halle M, Goeschen C, Dellas C, Pynn M, Loskutoff DJ, Konstantinides S.

Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):112-7. Epub 2003 Nov 13.

PMID:
14615386
20.

Enhanced thrombosis in atherosclerosis-prone mice is associated with increased arterial expression of plasminogen activator inhibitor-1.

Schafer K, Müller K, Hecke A, Mounier E, Goebel J, Loskutoff DJ, Konstantinides S.

Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2097-103. Epub 2003 Sep 25.

PMID:
14512369
21.

Monocyte chemoattractant protein 1 in obesity and insulin resistance.

Sartipy P, Loskutoff DJ.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7265-70. Epub 2003 May 19.

22.

Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signaling.

Tarui T, Andronicos N, Czekay RP, Mazar AP, Bdeir K, Parry GC, Kuo A, Loskutoff DJ, Cines DB, Takada Y.

J Biol Chem. 2003 Aug 8;278(32):29863-72. Epub 2003 May 15.

23.

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins.

Czekay RP, Aertgeerts K, Curriden SA, Loskutoff DJ.

J Cell Biol. 2003 Mar 3;160(5):781-91.

24.

Urokinase-type plasminogen activator plays a critical role in angiotensin II-induced abdominal aortic aneurysm.

Deng GG, Martin-McNulty B, Sukovich DA, Freay A, Halks-Miller M, Thinnes T, Loskutoff DJ, Carmeliet P, Dole WP, Wang YX.

Circ Res. 2003 Mar 21;92(5):510-7. Epub 2003 Feb 13.

PMID:
12600880
25.

Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse.

Takeshita K, Yamamoto K, Ito M, Kondo T, Matsushita T, Hirai M, Kojima T, Nishimura M, Nabeshima Y, Loskutoff DJ, Saito H, Murohara T.

Semin Thromb Hemost. 2002 Dec;28(6):545-54.

PMID:
12536348
26.

Do PAI-1 and vitronectin promote or inhibit neointima formation? The exact role of the fibrinolytic system in vascular remodeling remains uncertain.

Konstantinides S, Schäfer K, Loskutoff DJ.

Arterioscler Thromb Vasc Biol. 2002 Dec 1;22(12):1943-5. Review. No abstract available.

PMID:
12482815
27.

Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging.

Yamamoto K, Shimokawa T, Yi H, Isobe K, Kojima T, Loskutoff DJ, Saito H.

Am J Pathol. 2002 Nov;161(5):1805-14.

28.

Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse.

Yamamoto K, Shimokawa T, Yi H, Isobe K, Kojima T, Loskutoff DJ, Saito H.

Blood. 2002 Dec 1;100(12):4011-8. Epub 2002 Jul 25.

29.

Different mechanisms of increased luminal stenosis after arterial injury in mice deficient for urokinase- or tissue-type plasminogen activator.

Schäfer K, Konstantinides S, Riedel C, Thinnes T, Müller K, Dellas C, Hasenfuss G, Loskutoff DJ.

Circulation. 2002 Oct 1;106(14):1847-52.

PMID:
12356640
30.

Identification of the disulfide bonds in the recombinant somatomedin B domain of human vitronectin.

Kamikubo Y, Okumura Y, Loskutoff DJ.

J Biol Chem. 2002 Jul 26;277(30):27109-19. Epub 2002 May 17.

31.

Plasminogen has a broad extrahepatic distribution.

Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, Parmer RJ, Miles LA.

Thromb Haemost. 2002 Mar;87(3):493-501.

PMID:
11916082
32.

The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity.

Konstantinides S, Schafer K, Loskutoff DJ.

Ann N Y Acad Sci. 2001 Dec;947:134-41; discussion 141-2. Review.

PMID:
11795261
33.

Plasminogen activator inhibitor-1 is a major stress-regulated gene: implications for stress-induced thrombosis in aged individuals.

Yamamoto K, Takeshita K, Shimokawa T, Yi H, Isobe K, Loskutoff DJ, Saito H.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):890-5. Epub 2002 Jan 15.

34.

Kinetic analysis of the interaction between vitronectin and the urokinase receptor.

Okumura Y, Kamikubo Y, Curriden SA, Wang J, Kiwada T, Futaki S, Kitagawa K, Loskutoff DJ.

J Biol Chem. 2002 Mar 15;277(11):9395-404. Epub 2001 Dec 31.

35.

Regulation of tissue factor gene expression in obesity.

Samad F, Pandey M, Loskutoff DJ.

Blood. 2001 Dec 1;98(12):3353-8.

36.

Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity.

Konstantinides S, Schäfer K, Koschnick S, Loskutoff DJ.

J Clin Invest. 2001 Nov;108(10):1533-40.

37.

Tissue distribution of factor VIII gene expression in vivo--a closer look.

Hollestelle MJ, Thinnes T, Crain K, Stiko A, Kruijt JK, van Berkel TJ, Loskutoff DJ, van Mourik JA.

Thromb Haemost. 2001 Sep;86(3):855-61.

PMID:
11583319
38.

Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin.

Deng G, Curriden SA, Hu G, Czekay RP, Loskutoff DJ.

J Cell Physiol. 2001 Oct;189(1):23-33.

PMID:
11573201
40.

Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice.

Schäfer K, Fujisawa K, Konstantinides S, Loskutoff DJ.

FASEB J. 2001 Aug;15(10):1840-2. No abstract available.

PMID:
11481248
41.

Induction of plasminogen activator inhibitor 1 gene expression in adipocytes by thiazolidinediones.

Ihara H, Urano T, Takada A, Loskutoff DJ.

FASEB J. 2001 May;15(7):1233-5. No abstract available.

PMID:
11344098
42.

Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice.

Konstantinides S, Schäfer K, Thinnes T, Loskutoff DJ.

Circulation. 2001 Jan 30;103(4):576-83.

PMID:
11157725
43.

PAI-1, fibrosis, and the elusive provisional fibrin matrix.

Loskutoff DJ, Quigley JP.

J Clin Invest. 2000 Dec;106(12):1441-3. No abstract available.

44.
45.
46.

The fat mouse. A powerful genetic model to study hemostatic gene expression in obesity/NIDDM.

Loskutoff DJ, Fujisawa K, Samad F.

Ann N Y Acad Sci. 2000 May;902:272-81; discussion 281-2. Review.

PMID:
10865847
47.

Glomerular extracellular matrix accumulation in experimental anti-GBM Ab glomerulonephritis.

Tang WW, Feng L, Loskutoff DJ, Wilson CB.

Nephron. 2000 Jan;84(1):40-8.

PMID:
10644907
48.

Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice.

Samad F, Loskutoff DJ.

Thromb Haemost. 1999 Aug;82(2):742-7. Review. No abstract available.

PMID:
10605777
49.

Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta.

Yamamoto K, Shimokawa T, Kojima T, Loskutoff DJ, Saito H.

Thromb Haemost. 1999 Oct;82(4):1297-301.

PMID:
10544917
50.

Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1.

Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ.

Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6902-7.

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