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Items: 1 to 50 of 156


Detecting heterogeneity in and between breast cancer cell lines.

Shen Y, Schmidt BUS, Kubitschke H, Morawetz EW, Wolf B, Käs JA, Losert W.

Cancer Converg. 2020;4(1):1. doi: 10.1186/s41236-020-0010-1. Epub 2020 Feb 3.


Quantifying topography-guided actin dynamics across scales using optical flow.

Lee R, Campanello L, Hourwitz M, Alvarez P, Omidvar A, Fourkas J, Losert W.

Mol Biol Cell. 2020 Feb 5:mbcE19110614. doi: 10.1091/mbc.E19-11-0614. [Epub ahead of print]


Reversibility of granular rotations and translations.

Peshkov A, Girvan M, Richardson DC, Losert W.

Phys Rev E. 2019 Oct;100(4-1):042905. doi: 10.1103/PhysRevE.100.042905.


Dynamics phenotyping across length and time scales in collective cell migration.

Lee RM, Losert W.

Semin Cell Dev Biol. 2019 Sep;93:69-76. doi: 10.1016/j.semcdb.2018.10.010. Epub 2018 Oct 31. Review.


Actin Cytoskeleton and Focal Adhesions Regulate the Biased Migration of Breast Cancer Cells on Nanoscale Asymmetric Sawteeth.

Chen S, Hourwitz MJ, Campanello L, Fourkas JT, Losert W, Parent CA.

ACS Nano. 2019 Feb 26;13(2):1454-1468. doi: 10.1021/acsnano.8b07140. Epub 2019 Feb 6.


RefCell: multi-dimensional analysis of image-based high-throughput screens based on 'typical cells'.

Shen Y, Kubben N, Candia J, Morozov AV, Misteli T, Losert W.

BMC Bioinformatics. 2018 Nov 16;19(1):427. doi: 10.1186/s12859-018-2454-1.


CytoBinning: Immunological insights from multi-dimensional data.

Shen Y, Chaigne-Delalande B, Lee RWJ, Losert W.

PLoS One. 2018 Oct 31;13(10):e0205291. doi: 10.1371/journal.pone.0205291. eCollection 2018.


Intravital microscopy of collective invasion plasticity in breast cancer.

Ilina O, Campanello L, Gritsenko PG, Vullings M, Wang C, Bult P, Losert W, Friedl P.

Dis Model Mech. 2018 Aug 23;11(9). pii: dmm034330. doi: 10.1242/dmm.034330.


Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium.

Wang W, Chen S, Das S, Losert W, Parent CA.

J Cell Sci. 2018 May 4;131(9). pii: jcs216176. doi: 10.1242/jcs.216176.


Extracting microtentacle dynamics of tumor cells in a non-adherent environment.

Ory EC, Chen D, Chakrabarti KR, Zhang P, Andorko JI, Jewell CM, Losert W, Martin SS.

Oncotarget. 2017 Dec 4;8(67):111567-111580. doi: 10.18632/oncotarget.22874. eCollection 2017 Dec 19.


Lysophosphatidic acid regulates the motility of MCF10CA1a breast cancer cell sheets via two opposing signaling pathways.

Stuelten CH, Lee RM, Losert W, Parent CA.

Cell Signal. 2018 May;45:1-11. doi: 10.1016/j.cellsig.2018.01.005. Epub 2018 Jan 11.


Replication of biocompatible, nanotopographic surfaces.

Sun X, Hourwitz MJ, Baker EM, Schmidt BUS, Losert W, Fourkas JT.

Sci Rep. 2018 Jan 12;8(1):564. doi: 10.1038/s41598-017-19008-z.


Particle Tracking Facilitates Real Time Capable Motion Correction in 2D or 3D Two-Photon Imaging of Neuronal Activity.

Aghayee S, Winkowski DE, Bowen Z, Marshall EE, Harrington MJ, Kanold PO, Losert W.

Front Neural Circuits. 2017 Aug 15;11:56. doi: 10.3389/fncir.2017.00056. eCollection 2017.


Collective cell migration has distinct directionality and speed dynamics.

Zhang Y, Xu G, Lee RM, Zhu Z, Wu J, Liao S, Zhang G, Sun Y, Mogilner A, Losert W, Pan T, Lin F, Xu Z, Zhao M.

Cell Mol Life Sci. 2017 Oct;74(20):3841-3850. doi: 10.1007/s00018-017-2553-6. Epub 2017 Jun 13.


Lamin A and microtubules collaborate to maintain nuclear morphology.

Tariq Z, Zhang H, Chia-Liu A, Shen Y, Gete Y, Xiong ZM, Tocheny C, Campanello L, Wu D, Losert W, Cao K.

Nucleus. 2017 Jul 4;8(4):433-446. doi: 10.1080/19491034.2017.1320460. Epub 2017 May 30.


Adenylyl cyclase mRNA localizes to the posterior of polarized DICTYOSTELIUM cells during chemotaxis.

Das S, Parker JM, Guven C, Wang W, Kriebel PW, Losert W, Larson DR, Parent CA.

BMC Cell Biol. 2017 May 25;18(1):23. doi: 10.1186/s12860-017-0139-7.


Inferring single-cell behaviour from large-scale epithelial sheet migration patterns.

Lee RM, Yue H, Rappel WJ, Losert W.

J R Soc Interface. 2017 May;14(130). pii: 20170147. doi: 10.1098/rsif.2017.0147.


Cell Cycle and Cell Size Dependent Gene Expression Reveals Distinct Subpopulations at Single-Cell Level.

Dolatabadi S, Candia J, Akrap N, Vannas C, Tesan Tomic T, Losert W, Landberg G, Åman P, Ståhlberg A.

Front Genet. 2017 Jan 25;8:1. doi: 10.3389/fgene.2017.00001. eCollection 2017.


Analysis of microtubule growth dynamics arising from altered actin network structure and contractility in breast tumor cells.

Ory EC, Bhandary L, Boggs AE, Chakrabarti KR, Parker J, Losert W, Martin SS.

Phys Biol. 2017 Apr 20;14(2):026005. doi: 10.1088/1478-3975/aa59a2.


Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins.

de Menezes JP, Koushik A, Das S, Guven C, Siegel A, Laranjeira-Silva MF, Losert W, Andrews NW.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12668. Epub 2016 Oct 11.


Machine learning based methodology to identify cell shape phenotypes associated with microenvironmental cues.

Chen D, Sarkar S, Candia J, Florczyk SJ, Bodhak S, Driscoll MK, Simon CG Jr, Dunkers JP, Losert W.

Biomaterials. 2016 Oct;104:104-18. doi: 10.1016/j.biomaterials.2016.06.040. Epub 2016 Jun 25.


Uncovering low-dimensional, miR-based signatures of acute myeloid and lymphoblastic leukemias with a machine-learning-driven network approach.

Candia J, Cherukuri S, Guo Y, Doshi KA, Banavar JR, Civin CI, Losert W.

Converg Sci Phys Oncol. 2015 Dec;1(2). pii: 025002. Epub 2015 Dec 21.


Collective cell migration over long time scales reveals distinct phenotypes.

Lee RM, Stuelten CH, Parent CA, Losert W.

Converg Sci Phys Oncol. 2016 Jun;2(2). pii: 025001. doi: 10.1088/2057-1739/2/2/025001. Epub 2016 May 19.


svclassify: a method to establish benchmark structural variant calls.

Parikh H, Mohiyuddin M, Lam HY, Iyer H, Chen D, Pratt M, Bartha G, Spies N, Losert W, Zook JM, Salit M.

BMC Genomics. 2016 Jan 16;17:64. doi: 10.1186/s12864-016-2366-2.


Microstructural view of burrowing with a bioinspired digging robot.

Nordstrom KN, Dorsch DS, Losert W, Winter AG.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct;92(4):042204. doi: 10.1103/PhysRevE.92.042204. Epub 2015 Oct 22.


Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance.

Sun X, Driscoll MK, Guven C, Das S, Parent CA, Fourkas JT, Losert W.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12557-62. doi: 10.1073/pnas.1502970112. Epub 2015 Sep 28.


Spatiotemporal relationships between the cell shape and the actomyosin cortex of periodically protruding cells.

Driscoll MK, Losert W, Jacobson K, Kapustina M.

Cytoskeleton (Hoboken). 2015 Jun;72(6):268-81. doi: 10.1002/cm.21229.


Geometry-Driven Polarity in Motile Amoeboid Cells.

Nagel O, Guven C, Theves M, Driscoll M, Losert W, Beta C.

PLoS One. 2014 Dec 10;9(12):e113382. doi: 10.1371/journal.pone.0113382. eCollection 2014.


The interplay of cell-cell and cell-substrate adhesion in collective cell migration.

Wang C, Chowdhury S, Driscoll M, Parent CA, Gupta SK, Losert W.

J R Soc Interface. 2014 Nov 6;11(100):20140684. doi: 10.1098/rsif.2014.0684.


Granular dynamics during impact.

Nordstrom KN, Lim E, Harrington M, Losert W.

Phys Rev Lett. 2014 Jun 6;112(22):228002. Epub 2014 Jun 6.


Consequences of anomalous diffusion in disordered systems under cyclic forcing.

Mailman M, Harrington M, Girvan M, Losert W.

Phys Rev Lett. 2014 Jun 6;112(22):228001. Epub 2014 Jun 3.


Cellular contact guidance through dynamic sensing of nanotopography.

Driscoll MK, Sun X, Guven C, Fourkas JT, Losert W.

ACS Nano. 2014 Apr 22;8(4):3546-55. doi: 10.1021/nn406637c. Epub 2014 Mar 27.


Dictyostelium cells migrate similarly on surfaces of varying chemical composition.

McCann CP, Rericha EC, Wang C, Losert W, Parent CA.

PLoS One. 2014 Feb 6;9(2):e87981. doi: 10.1371/journal.pone.0087981. eCollection 2014.


Understanding health and disease with multidimensional single-cell methods.

Candia J, Banavar JR, Losert W.

J Phys Condens Matter. 2014 Feb 19;26(7):073102. doi: 10.1088/0953-8984/26/7/073102. Epub 2014 Jan 22. Review.


Coexistence and transition between shear zones in slow granular flows.

Moosavi R, Shaebani MR, Maleki M, Török J, Wolf DE, Losert W.

Phys Rev Lett. 2013 Oct 4;111(14):148301. Epub 2013 Oct 3.


Characterizing the rheology of fluidized granular matter.

Desmond KW, Villa U, Newey M, Losert W.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Sep;88(3):032202. Epub 2013 Sep 10.


From cellular characteristics to disease diagnosis: uncovering phenotypes with supercells.

Candia J, Maunu R, Driscoll M, Biancotto A, Dagur P, McCoy JP Jr, Sen HN, Wei L, Maritan A, Cao K, Nussenblatt RB, Banavar JR, Losert W.

PLoS Comput Biol. 2013;9(9):e1003215. doi: 10.1371/journal.pcbi.1003215. Epub 2013 Sep 5.


Automatic sorting of point pattern sets using Minkowski functionals.

Parker J, Sherman E, van de Raa M, van der Meer D, Samelson LE, Losert W.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Aug;88(2):022720. Epub 2013 Aug 29.


Suppression and emergence of granular segregation under cyclic shear.

Harrington M, Weijs JH, Losert W.

Phys Rev Lett. 2013 Aug 16;111(7):078001. Epub 2013 Aug 16.


Modeling and measuring signal relay in noisy directed migration of cell groups.

Guven C, Rericha E, Ott E, Losert W.

PLoS Comput Biol. 2013;9(5):e1003041. doi: 10.1371/journal.pcbi.1003041. Epub 2013 May 2.


Quantifying stretching and rearrangement in epithelial sheet migration.

Lee RM, Kelley DH, Nordstrom KN, Ouellette NT, Losert W.

New J Phys. 2013 Feb 25;15(2). pii: 025036.


Optical micromanipulation of active cells with minimal perturbations: direct and indirect pushing.

Wang C, Chowdhury S, Gupta SK, Losert W.

J Biomed Opt. 2013 Apr;18(4):045001. doi: 10.1117/1.JBO.18.4.045001.


Real-time motion analysis reveals cell directionality as an indicator of breast cancer progression.

Weiger MC, Vedham V, Stuelten CH, Shou K, Herrera M, Sato M, Losert W, Parent CA.

PLoS One. 2013;8(3):e58859. doi: 10.1371/journal.pone.0058859. Epub 2013 Mar 19.


Analysis of multiple physical parameters for mechanical phenotyping of living cells.

Kiessling TR, Herrera M, Nnetu KD, Balzer EM, Girvan M, Fritsch AW, Martin SS, Käs JA, Losert W.

Eur Biophys J. 2013 May;42(5):383-94. doi: 10.1007/s00249-013-0888-y. Epub 2013 Mar 17.


Granular convection in microgravity.

Murdoch N, Rozitis B, Nordstrom K, Green SF, Michel P, de Lophem TL, Losert W.

Phys Rev Lett. 2013 Jan 4;110(1):018307. Epub 2013 Jan 3. Erratum in: Phys Rev Lett. 2013 Jan 11;110(2):029902.


LTB4 is a signal-relay molecule during neutrophil chemotaxis.

Afonso PV, Janka-Junttila M, Lee YJ, McCann CP, Oliver CM, Aamer KA, Losert W, Cicerone MT, Parent CA.

Dev Cell. 2012 May 15;22(5):1079-91. doi: 10.1016/j.devcel.2012.02.003. Epub 2012 Apr 26.


Onset of irreversibility in cyclic shear of granular packings.

Slotterback S, Mailman M, Ronaszegi K, van Hecke M, Girvan M, Losert W.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Feb;85(2 Pt 1):021309. Epub 2012 Feb 27.


Cell shape dynamics: from waves to migration.

Driscoll MK, McCann C, Kopace R, Homan T, Fourkas JT, Parent C, Losert W.

PLoS Comput Biol. 2012;8(3):e1002392. doi: 10.1371/journal.pcbi.1002392. Epub 2012 Mar 15.


Microstructure evolution during impact on granular matter.

Kondic L, Fang X, Losert W, O'Hern CS, Behringer RP.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jan;85(1 Pt 1):011305. Epub 2012 Jan 18.


Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?

Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K.

Aging (Albany NY). 2012 Feb;4(2):119-32.

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